EA202190116A1 - Агент для профилактики или лечения спинальной мышечной атрофии - Google Patents

Агент для профилактики или лечения спинальной мышечной атрофии

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EA202190116A1
EA202190116A1 EA202190116A EA202190116A EA202190116A1 EA 202190116 A1 EA202190116 A1 EA 202190116A1 EA 202190116 A EA202190116 A EA 202190116A EA 202190116 A EA202190116 A EA 202190116A EA 202190116 A1 EA202190116 A1 EA 202190116A1
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Eurasian Patent Office
Prior art keywords
aliphatic heterocycle
optionally substituted
prevention
agent
treatment
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EA202190116A
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English (en)
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Кодзи Фудзи
Такеси Ямасаки
Сунья Судзуки
Кодзи Оно
Хироки Такахаги
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Реборна Биосайенсиз, Инк.
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Application filed by Реборна Биосайенсиз, Инк. filed Critical Реборна Биосайенсиз, Инк.
Publication of EA202190116A1 publication Critical patent/EA202190116A1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Агент для профилактики или лечения спинальной мышечной атрофии по настоящему изобретению включает соединение, представленное формулой (I), или его сольгде каждый из W1, W2 и W3 независимо выбран из группы, состоящей из C-R2, C-R3, C-Rc и C-Rd, и определяется одним из следующих пунктов от (i) до (iv): (i) когда W3 представляет собой C-R2, тогда W1 представляет собой C-R3, W2 представляет собой C-Rc или N, и R1 представляет собой атом водорода; (ii) когда W3 представляет собой C-R3, тогда W1 представляет собой C-R2, W2 представляет собой C-Rc или N, и R1 представляет собой атом водорода, C1-8алкил или C1-8алкокси; (iii) когда W1 представляет собой C-R2, тогда W2 представляет собой C-Rc или N, W3 представляет собой C-Rd, и R1 представляет собой алифатический гетероцикл, содержащий один или более атомов азота, причем алифатический гетероцикл необязательно замещен неароматическим заместителем; и (iv) когда W2 представляет собой C-R2, тогда W1 представляет собой C-Rc, W3 представляет собой C-Rd, и R1 представляет собой алифатический гетероцикл, содержащий один или более атомов азота, причем алифатический гетероцикл необязательно замещен неароматическим заместителем; R2 представляет собой 6-членное или более ароматическое кольцо, необязательно замещенное неароматическим заместителем; R3 представляет собой алифатический гетероцикл, содержащий один или более атомов азота, причем алифатический гетероцикл необязательно замещен неароматическим заместителем; Q1 выбран из C-Ra и N; Q2 выбран из C-Rb и N; и каждый из Ra, Rb, Rc и Rd независимо выбран из группы, состоящей из атома водорода, галогена, C1-8алкила, C1-8алкокси и цианогруппы.
EA202190116A 2018-06-27 2019-06-27 Агент для профилактики или лечения спинальной мышечной атрофии EA202190116A1 (ru)

Applications Claiming Priority (2)

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JP2018122551 2018-06-27
PCT/JP2019/025732 WO2020004594A1 (ja) 2018-06-27 2019-06-27 脊髄性筋萎縮症の予防または治療剤

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US (1) US20220287748A1 (ru)
EP (1) EP3816160A4 (ru)
JP (1) JP7427252B2 (ru)
KR (1) KR20210025625A (ru)
CN (1) CN112469707A (ru)
AU (2) AU2019293757B2 (ru)
BR (1) BR112020026637A2 (ru)
CA (1) CA3105174A1 (ru)
CL (1) CL2020003386A1 (ru)
CO (1) CO2021000808A2 (ru)
CR (1) CR20210050A (ru)
EA (1) EA202190116A1 (ru)
IL (1) IL279786A (ru)
JO (1) JOP20200338A1 (ru)
MX (1) MX2020014116A (ru)
PE (1) PE20211585A1 (ru)
PH (1) PH12020552263A1 (ru)
SG (1) SG11202013088YA (ru)
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Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
EP3661509A4 (en) 2017-08-04 2021-01-13 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING THE SPLICE
SI3814348T1 (sl) 2018-06-27 2023-10-30 Bristol-Myers Squibb Company Substituirane naftiridinonske spojine, uporabne kot aktivatorji t celic
KR20210039368A (ko) * 2018-07-26 2021-04-09 도메인 테라퓨틱스 치환된 퀴나졸리논 유도체 및 mGluR4의 양성 알로스테릭 조절인자로서의 이의 용도
CA3169709A1 (en) * 2020-02-28 2021-09-02 Remix Therapeutics Inc. Heterocyclic amides and their use for modulating splicing
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