EA201890257A1 - Комбинированное лечение, предусматривающее введение 2-амино-3,5,5-трифтор-3,4,5,6-тетрагидропиридинов - Google Patents
Комбинированное лечение, предусматривающее введение 2-амино-3,5,5-трифтор-3,4,5,6-тетрагидропиридиновInfo
- Publication number
- EA201890257A1 EA201890257A1 EA201890257A EA201890257A EA201890257A1 EA 201890257 A1 EA201890257 A1 EA 201890257A1 EA 201890257 A EA201890257 A EA 201890257A EA 201890257 A EA201890257 A EA 201890257A EA 201890257 A1 EA201890257 A1 EA 201890257A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- triftor
- tetrahydropyridines
- amino
- combined treatment
- treatment providing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Настоящее изобретение направлено на комбинированное применение ингибитора BACE1 формулы (I)и соединения, применимого в активной или пассивной иммунотерапии, направленной против тау-белка, соединения, применимого в активной или пассивной иммунотерапии, направленной против пептида Aβ, антагонистов рецептора NMDA, ингибитора ацетилхолинэстеразы, противоэпилептического средства, противовоспалительного лекарственного средства, ингибитора агрегации тау-белка или SSRI для лечения нейродегенеративных или когнитивных нарушений.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201500456 | 2015-08-10 | ||
DKPA201500707 | 2015-11-10 | ||
PCT/EP2016/068947 WO2017025532A1 (en) | 2015-08-10 | 2016-08-09 | Combination treatment comprising administration of 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201890257A1 true EA201890257A1 (ru) | 2018-07-31 |
Family
ID=56799425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201890257A EA201890257A1 (ru) | 2015-08-10 | 2016-08-09 | Комбинированное лечение, предусматривающее введение 2-амино-3,5,5-трифтор-3,4,5,6-тетрагидропиридинов |
Country Status (26)
Country | Link |
---|---|
US (1) | US10004738B2 (ru) |
EP (1) | EP3334461A1 (ru) |
JP (1) | JP2018529647A (ru) |
KR (1) | KR20180035843A (ru) |
CN (1) | CN107921138A (ru) |
AR (1) | AR105656A1 (ru) |
AU (1) | AU2016305260A1 (ru) |
BR (1) | BR112017007306A2 (ru) |
CA (1) | CA2993623A1 (ru) |
CL (1) | CL2018000339A1 (ru) |
CO (1) | CO2018000711A2 (ru) |
CR (1) | CR20180093A (ru) |
DO (1) | DOP2018000039A (ru) |
EA (1) | EA201890257A1 (ru) |
EC (1) | ECSP18010534A (ru) |
HK (1) | HK1254354A1 (ru) |
IL (1) | IL257072A (ru) |
MA (1) | MA42611A (ru) |
MX (1) | MX2018001636A (ru) |
PE (1) | PE20180696A1 (ru) |
PH (1) | PH12018500300A1 (ru) |
RU (1) | RU2018104867A (ru) |
SV (1) | SV2018005628A (ru) |
TN (1) | TN2018000041A1 (ru) |
TW (1) | TW201717948A (ru) |
WO (1) | WO2017025532A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CR20170187A (es) | 2014-11-10 | 2018-02-01 | H Lundbeck As | 2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer |
JO3458B1 (ar) | 2014-11-10 | 2020-07-05 | H Lundbeck As | 2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1 |
MA40941A (fr) | 2014-11-10 | 2017-09-19 | H Lundbeck As | 2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1 |
MX2018001699A (es) | 2015-08-12 | 2018-05-07 | H Lundbeck As | 2-amino-3-fluoro-3-(fluorometil)-6-meti-6-fenil-3,4,5,6-tetrahidr opiridinas como inhibidores de bace1. |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002100399A1 (en) | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
GB0124928D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
MXPA04007838A (es) | 2002-02-12 | 2004-10-15 | Smithkline Beecham Corp | Derivados de nicotamida utiles como inhibidores p38. |
AR077277A1 (es) | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
SG185651A1 (en) | 2010-06-09 | 2012-12-28 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
MX2013008111A (es) | 2011-01-12 | 2013-10-30 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de transtornos neurologicos. |
EA024059B1 (ru) | 2011-01-13 | 2016-08-31 | Новартис Аг | Гетероциклические производные и их применение в лечении неврологических расстройств |
US8754075B2 (en) | 2011-04-11 | 2014-06-17 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE1 and/or BACE2 inhibitors |
WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
US8987255B2 (en) | 2011-06-07 | 2015-03-24 | Hoffmann-La Roche Inc. | Halogen-alkyl-1,3 oxazines as BACE1 and/or BACE2 inhibitors |
UY34278A (es) | 2011-08-25 | 2013-04-05 | Novartis Ag | Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades |
JP2015531401A (ja) * | 2011-10-10 | 2015-11-02 | ハー・ルンドベック・アクチエゼルスカベット | イミダゾピラジノン骨格を有するpde9i |
US8338413B1 (en) | 2012-03-07 | 2012-12-25 | Novartis Ag | Oxazine derivatives and their use in the treatment of neurological disorders |
BR112014023384A8 (pt) | 2012-03-20 | 2018-01-16 | R Artis Dean | inibidores de bace espirocíclicos de di-hidro-tiazina e di-hidro-oxazina, e composições e usos dos mesmos. |
WO2014056816A1 (en) | 2012-10-10 | 2014-04-17 | F. Hoffmann-La Roche Ag | COMBINATION OF AN Aβ ANTIBODY AND A BACE INHIBITOR |
WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
WO2014134341A1 (en) | 2013-03-01 | 2014-09-04 | Amgen Inc. | Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
JO3318B1 (ar) | 2013-06-18 | 2019-03-13 | Lilly Co Eli | مثبطات bace |
MA39225A1 (fr) | 2014-02-19 | 2017-04-28 | H Lundbeck As | 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tétrahydropyridines utilisées en tant qu'inhibiteurs de bace1 dans le traitement de la maladie d'alzheimer |
TW201623295A (zh) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | 具有bace1抑制活性之二氫噻及二氫衍生物 |
MA40941A (fr) | 2014-11-10 | 2017-09-19 | H Lundbeck As | 2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1 |
JO3458B1 (ar) | 2014-11-10 | 2020-07-05 | H Lundbeck As | 2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1 |
CR20170187A (es) | 2014-11-10 | 2018-02-01 | H Lundbeck As | 2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer |
MX2018001699A (es) | 2015-08-12 | 2018-05-07 | H Lundbeck As | 2-amino-3-fluoro-3-(fluorometil)-6-meti-6-fenil-3,4,5,6-tetrahidr opiridinas como inhibidores de bace1. |
-
2016
- 2016-08-04 TW TW105124755A patent/TW201717948A/zh unknown
- 2016-08-08 US US15/231,182 patent/US10004738B2/en not_active Expired - Fee Related
- 2016-08-09 EA EA201890257A patent/EA201890257A1/ru unknown
- 2016-08-09 CA CA2993623A patent/CA2993623A1/en not_active Abandoned
- 2016-08-09 MA MA042611A patent/MA42611A/fr unknown
- 2016-08-09 TN TNP/2018/000041A patent/TN2018000041A1/en unknown
- 2016-08-09 MX MX2018001636A patent/MX2018001636A/es unknown
- 2016-08-09 JP JP2018506913A patent/JP2018529647A/ja active Pending
- 2016-08-09 CN CN201680045247.2A patent/CN107921138A/zh active Pending
- 2016-08-09 PE PE2018000223A patent/PE20180696A1/es not_active Application Discontinuation
- 2016-08-09 KR KR1020187005381A patent/KR20180035843A/ko unknown
- 2016-08-09 RU RU2018104867A patent/RU2018104867A/ru not_active Application Discontinuation
- 2016-08-09 CR CR20180093A patent/CR20180093A/es unknown
- 2016-08-09 AR ARP160102441A patent/AR105656A1/es unknown
- 2016-08-09 BR BR112017007306A patent/BR112017007306A2/pt not_active Application Discontinuation
- 2016-08-09 AU AU2016305260A patent/AU2016305260A1/en not_active Abandoned
- 2016-08-09 WO PCT/EP2016/068947 patent/WO2017025532A1/en active Application Filing
- 2016-08-09 EP EP16756631.4A patent/EP3334461A1/en not_active Withdrawn
-
2018
- 2018-01-22 IL IL257072A patent/IL257072A/en unknown
- 2018-01-25 CO CONC2018/0000711A patent/CO2018000711A2/es unknown
- 2018-02-06 CL CL2018000339A patent/CL2018000339A1/es unknown
- 2018-02-07 SV SV2018005628A patent/SV2018005628A/es unknown
- 2018-02-08 DO DO2018000039A patent/DOP2018000039A/es unknown
- 2018-02-09 PH PH12018500300A patent/PH12018500300A1/en unknown
- 2018-02-09 EC ECIEPI201810534A patent/ECSP18010534A/es unknown
- 2018-10-19 HK HK18113430.1A patent/HK1254354A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1254354A1 (zh) | 2019-07-19 |
KR20180035843A (ko) | 2018-04-06 |
CR20180093A (es) | 2018-06-05 |
AR105656A1 (es) | 2017-10-25 |
WO2017025532A1 (en) | 2017-02-16 |
PE20180696A1 (es) | 2018-04-23 |
CN107921138A (zh) | 2018-04-17 |
PH12018500300A1 (en) | 2018-08-29 |
US10004738B2 (en) | 2018-06-26 |
AU2016305260A1 (en) | 2018-02-15 |
TN2018000041A1 (en) | 2019-07-08 |
ECSP18010534A (es) | 2018-04-30 |
MA42611A (fr) | 2018-06-20 |
MX2018001636A (es) | 2018-05-07 |
CA2993623A1 (en) | 2017-02-16 |
US20170042895A1 (en) | 2017-02-16 |
RU2018104867A (ru) | 2019-09-12 |
DOP2018000039A (es) | 2018-04-30 |
CL2018000339A1 (es) | 2018-07-06 |
EP3334461A1 (en) | 2018-06-20 |
SV2018005628A (es) | 2018-04-19 |
CO2018000711A2 (es) | 2018-05-10 |
IL257072A (en) | 2018-03-29 |
JP2018529647A (ja) | 2018-10-11 |
TW201717948A (zh) | 2017-06-01 |
BR112017007306A2 (pt) | 2018-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12016501355B1 (en) | Bicyclic heterocyclic derivatives as bromodomain inhibitors | |
EA201790425A1 (ru) | Новые соединения спиро[3h-индол-3,2'-пирролидин]-2(1h)-она и производные в качестве ингибиторов mdm2-p53 | |
CL2016002072A1 (es) | 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahidropiridinas como inhibidores de bace1 para el tratamiento de la enfermedad de alzheimer | |
MX2018013472A (es) | Tratamiento de combinacion de trastornos y enfermedades inflamatorios oculares. | |
EA201691584A1 (ru) | Новые соли и их фармацевтические композиции для лечения воспалительных заболеваний | |
EA201890257A1 (ru) | Комбинированное лечение, предусматривающее введение 2-амино-3,5,5-трифтор-3,4,5,6-тетрагидропиридинов | |
EA201990424A1 (ru) | Спиролактамовые модуляторы nmda-рецептора и их применение | |
EA201792157A1 (ru) | Имидазопиразиноны в качестве ингибиторов pde1 | |
EA201990428A1 (ru) | Спиролактамовые модуляторы nmda-рецептора и их применение | |
EA201990400A1 (ru) | Соединения и композиции и их применение | |
EA201891644A1 (ru) | Антибактериальные соединения и их применение | |
MX2020005483A (es) | Antagonistas de ildr2 y combinaciones de los mismos. | |
EA201792057A1 (ru) | Конденсированные бициклические гетероарильные производные с активностью ингибиторов пролилгидроксилазы | |
EA202091337A1 (ru) | Ингибиторы гистонацетилтрансфераз семейства myst | |
EA201792262A1 (ru) | Пироглутамат вортиоксетина | |
NZ738990A (en) | Cgrp receptor antagonists | |
MX2019003458A (es) | Cristal no solvatado, metodo de preparacion y aplicacion del mismo. | |
EA202090424A1 (ru) | Бициклические ингибиторы гистондеацетилазы | |
MX2019001634A (es) | Compuestos amidas, composiciones farmacéuticas de estos y métodos para utilizarlos. | |
EA201891782A1 (ru) | Гетероциклическое сульфонамидное производное и содержащее его лекарственное средство | |
EA201892529A1 (ru) | Комбинация чистых антагонистов 5-htрецепторов с ингибиторами ацетилхолинэстеразы | |
EA201691796A1 (ru) | П-замещенные асимметричные мочевины и их применение в медицине | |
PH12017502017A1 (en) | Pharmaceutical compositions | |
MX2015013048A (es) | Forma cristalina de un compuesto ansiolitico. | |
EA201791450A1 (ru) | 3,5-диаминопиразоловые ингибиторы киназы |