EA201691584A1 - Новые соли и их фармацевтические композиции для лечения воспалительных заболеваний - Google Patents

Новые соли и их фармацевтические композиции для лечения воспалительных заболеваний

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Publication number
EA201691584A1
EA201691584A1 EA201691584A EA201691584A EA201691584A1 EA 201691584 A1 EA201691584 A1 EA 201691584A1 EA 201691584 A EA201691584 A EA 201691584A EA 201691584 A EA201691584 A EA 201691584A EA 201691584 A1 EA201691584 A1 EA 201691584A1
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EA
Eurasian Patent Office
Prior art keywords
treatment
inflammatory diseases
pharmaceutical compositions
diseases
new salts
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EA201691584A
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English (en)
Other versions
EA032596B1 (ru
Inventor
Николя Люк Сабуро
Фавери Карла Де
Ахмад Шейх
Original Assignee
Галапагос Нв
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Application filed by Галапагос Нв filed Critical Галапагос Нв
Publication of EA201691584A1 publication Critical patent/EA201691584A1/ru
Publication of EA032596B1 publication Critical patent/EA032596B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L63/00—Network architectures or network communication protocols for network security
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
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    • H04L63/20—Network architectures or network communication protocols for network security for managing network security; network security policies in general
    • H04L63/205—Network architectures or network communication protocols for network security for managing network security; network security policies in general involving negotiation or determination of the one or more network security mechanisms to be used, e.g. by negotiation between the client and the server or between peers or by selection according to the capabilities of the entities involved
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    • H04L67/51—Discovery or management thereof, e.g. service location protocol [SLP] or web services
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    • H04W—WIRELESS COMMUNICATION NETWORKS
    • H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
    • H04W4/80—Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04W—WIRELESS COMMUNICATION NETWORKS
    • H04W8/00—Network data management
    • H04W8/22—Processing or transfer of terminal data, e.g. status or physical capabilities
    • H04W8/24—Transfer of terminal data
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    • H—ELECTRICITY
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    • H04W92/18—Interfaces between hierarchically similar devices between terminal devices

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Computer Networks & Wireless Communication (AREA)
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  • Rheumatology (AREA)
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  • Biomedical Technology (AREA)
  • Databases & Information Systems (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение раскрывает соли соединения 1полезные в профилактике и/или лечении воспалительных заболеваний, аутоиммунных заболеваний, пролиферативных заболеваний, аллергии, отторжения трансплантата, заболеваний, связанных с разрушением и/или нарушением гомеостаза хрящевой ткани, врожденных дефектов хряща и/или заболеваний, связанных с гиперсекрецией IL6 или интерферонов.
EA201691584A 2014-02-07 2015-02-04 Соли, способ их получения и их применение для лечения воспалительных заболеваний EA032596B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1402071.3A GB201402071D0 (en) 2014-02-07 2014-02-07 Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
PCT/EP2015/052242 WO2015117981A1 (en) 2014-02-07 2015-02-04 Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Publications (2)

Publication Number Publication Date
EA201691584A1 true EA201691584A1 (ru) 2017-01-30
EA032596B1 EA032596B1 (ru) 2019-06-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
EA201691584A EA032596B1 (ru) 2014-02-07 2015-02-04 Соли, способ их получения и их применение для лечения воспалительных заболеваний
EA201990330A EA201990330A1 (ru) 2014-02-07 2015-02-04 Новые соли и их фармацевтические композиции для лечения воспалительных заболеваний

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EA201990330A EA201990330A1 (ru) 2014-02-07 2015-02-04 Новые соли и их фармацевтические композиции для лечения воспалительных заболеваний

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US (6) US9382247B2 (ru)
EP (2) EP3102575B1 (ru)
JP (2) JP2017505329A (ru)
KR (1) KR102478614B1 (ru)
CN (2) CN111499630A (ru)
AR (1) AR099307A1 (ru)
AU (4) AU2015215045B2 (ru)
CA (1) CA2938219C (ru)
CY (1) CY1124349T1 (ru)
DK (1) DK3102575T3 (ru)
EA (2) EA032596B1 (ru)
ES (1) ES2853375T3 (ru)
GB (1) GB201402071D0 (ru)
HR (1) HRP20210194T1 (ru)
HU (1) HUE053309T2 (ru)
IL (1) IL246833B (ru)
LT (1) LT3102575T (ru)
MX (2) MX2016010068A (ru)
NZ (1) NZ722603A (ru)
PL (1) PL3102575T3 (ru)
PT (1) PT3102575T (ru)
RS (1) RS61450B1 (ru)
SG (2) SG11201606433PA (ru)
SI (1) SI3102575T1 (ru)
TW (2) TWI792593B (ru)
UY (1) UY35984A (ru)
WO (1) WO2015117981A1 (ru)

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