EA201792217A1 - Гетеромультимеры alk4:actriib и их использование - Google Patents
Гетеромультимеры alk4:actriib и их использованиеInfo
- Publication number
- EA201792217A1 EA201792217A1 EA201792217A EA201792217A EA201792217A1 EA 201792217 A1 EA201792217 A1 EA 201792217A1 EA 201792217 A EA201792217 A EA 201792217A EA 201792217 A EA201792217 A EA 201792217A EA 201792217 A1 EA201792217 A1 EA 201792217A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alk4
- actriib
- certain aspects
- complexes
- tissues
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
Abstract
В определенных аспектах, раскрытие предусматривает растворимые гетеромерные полипептидные комплексы, содержащие внеклеточный домен рецептора ALK4 и внеклеточный домен ActRIIB. В определенных аспектах такие растворимые комплексы ALK4:ActRIIB можно использовать для того, чтобы регулировать (стимулировать или ингибировать) рост тканей или клеток, включая, например, мышечную, костную, хрящевую, жировую, нервную ткань, опухоли и/или злокачественные клетки. В определенных аспектах такие комплексы ALK4:ActRIIB можно использовать для того, чтобы усовершенствовать формирование мышцы, формирование кости, метаболические параметры и нарушения, связанные с этими тканями, клеточными сетями, почечной и эндокринной системами.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562143579P | 2015-04-06 | 2015-04-06 | |
US201562220836P | 2015-09-18 | 2015-09-18 | |
PCT/US2016/026269 WO2016164497A1 (en) | 2015-04-06 | 2016-04-06 | Alk4:actriib heteromultimers and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201792217A1 true EA201792217A1 (ru) | 2018-04-30 |
Family
ID=57015141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792217A EA201792217A1 (ru) | 2015-04-06 | 2016-04-06 | Гетеромультимеры alk4:actriib и их использование |
Country Status (15)
Country | Link |
---|---|
US (5) | US10196434B2 (ru) |
EP (2) | EP3929211A1 (ru) |
JP (2) | JP7055637B2 (ru) |
KR (1) | KR20180002660A (ru) |
CN (1) | CN107709357B (ru) |
AU (2) | AU2016246703B2 (ru) |
BR (1) | BR112017021525A2 (ru) |
CA (1) | CA2981831A1 (ru) |
EA (1) | EA201792217A1 (ru) |
ES (1) | ES2882105T3 (ru) |
HK (2) | HK1248734A1 (ru) |
MA (2) | MA41919A (ru) |
MX (2) | MX2017012845A (ru) |
SG (1) | SG11201708176UA (ru) |
WO (1) | WO2016164497A1 (ru) |
Families Citing this family (17)
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US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
KR20180002659A (ko) | 2015-04-06 | 2018-01-08 | 악셀레론 파마 인코포레이티드 | Tgf-베타 슈퍼패밀리 유형 i 및 유형 ii 수용체 이형다합체들과 이의 용도 |
MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
AU2016246602B2 (en) | 2015-04-06 | 2020-11-19 | Acceleron Pharma Inc. | Single-arm type I and type II receptor fusion proteins and uses thereof |
PT3286206T (pt) | 2015-04-22 | 2021-04-01 | Biogen Ma Inc | Novas proteínas híbridas bloqueadoras de ligando actriib para tratar doenças de desgaste muscular |
US20170240639A1 (en) * | 2016-02-22 | 2017-08-24 | Acceleron Pharma Inc. | Actrii antagonists for use in increasing immune activity |
EP3928784A1 (en) | 2016-07-15 | 2021-12-29 | Acceleron Pharma Inc. | Compositions comprising actriia polypeptides for use in treating pulmonary hypertension |
KR20230152811A (ko) | 2016-10-05 | 2023-11-03 | 악셀레론 파마 인코포레이티드 | 변이체 actriib 단백질 및 이의 용도 |
AU2017338915A1 (en) | 2016-10-05 | 2019-04-18 | Acceleron Pharma Inc. | TGF-beta superfamily type I and type II receptor heteromultimers and uses thereof |
EP3522934A4 (en) * | 2016-10-05 | 2020-04-15 | Acceleron Pharma Inc. | COMPOSITIONS AND METHOD FOR THE TREATMENT OF RENOPATHY |
AU2017338921A1 (en) * | 2016-10-05 | 2019-04-18 | Acceleron Pharma Inc. | ALK4:ActRIIB heteromultimers and uses thereof |
JOP20190085A1 (ar) * | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
US11857599B2 (en) * | 2017-04-03 | 2024-01-02 | Acceleron Pharma Inc. | Compositions and methods for treating spinal muscular atrophy |
BR112022025473A2 (pt) * | 2020-06-17 | 2023-03-07 | Acceleron Pharma Inc | Antagonistas de actrii-alk4 e métodos de tratamento de insuficiência cardíaca |
EP4243933A2 (en) * | 2020-11-13 | 2023-09-20 | The Jackson Laboratory | Therapeutics targeting transforming growth factor beta family signaling |
MX2023010442A (es) * | 2021-03-10 | 2023-11-22 | Acceleron Pharma Inc | Antagonistas de actrii-alk4 y métodos para el tratamiento contra la insuficiencia cardíaca. |
JP2024511316A (ja) * | 2021-03-10 | 2024-03-13 | アクセルロン ファーマ インコーポレイテッド | Actrii-alk4アンタゴニスト及び心不全の治療方法 |
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- 2016-04-06 KR KR1020177031990A patent/KR20180002660A/ko not_active Application Discontinuation
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