EA201791527A1 - Биспецифические антитела против плазменного калликреина и фактора xii - Google Patents

Биспецифические антитела против плазменного калликреина и фактора xii

Info

Publication number
EA201791527A1
EA201791527A1 EA201791527A EA201791527A EA201791527A1 EA 201791527 A1 EA201791527 A1 EA 201791527A1 EA 201791527 A EA201791527 A EA 201791527A EA 201791527 A EA201791527 A EA 201791527A EA 201791527 A1 EA201791527 A1 EA 201791527A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bispecific antibodies
light
plasma kallikrein
chain
factor xii
Prior art date
Application number
EA201791527A
Other languages
English (en)
Russian (ru)
Inventor
Стивен Р. Комо
Эндрю Никсон
Никса Кастрапели
Джон А. Кеннистон
Грегори П. Конли
Шона Мэйсон
Эллисон П. Линдберг
Кристофер Копач
Берт Эйделман
Original Assignee
Дайэкс Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайэкс Корп. filed Critical Дайэкс Корп.
Publication of EA201791527A1 publication Critical patent/EA201791527A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EA201791527A 2015-01-02 2015-12-31 Биспецифические антитела против плазменного калликреина и фактора xii EA201791527A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562099236P 2015-01-02 2015-01-02
US201562200363P 2015-08-03 2015-08-03
US201562261609P 2015-12-01 2015-12-01
PCT/US2015/068238 WO2016109774A1 (en) 2015-01-02 2015-12-31 Bispecific antibodies against plasma kallikrein and factor xii

Publications (1)

Publication Number Publication Date
EA201791527A1 true EA201791527A1 (ru) 2017-12-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791527A EA201791527A1 (ru) 2015-01-02 2015-12-31 Биспецифические антитела против плазменного калликреина и фактора xii

Country Status (13)

Country Link
US (2) US11390687B2 (enExample)
EP (1) EP3240570B1 (enExample)
JP (4) JP6744313B2 (enExample)
KR (2) KR20240091031A (enExample)
CN (2) CN107405399B (enExample)
AU (2) AU2015373910B2 (enExample)
CA (1) CA2972800A1 (enExample)
CO (1) CO2017007123A2 (enExample)
EA (1) EA201791527A1 (enExample)
IL (2) IL253180B2 (enExample)
MX (2) MX2017008541A (enExample)
NZ (1) NZ771568A (enExample)
WO (1) WO2016109774A1 (enExample)

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US12415866B2 (en) 2015-07-21 2025-09-16 Takeda Pharmaceutical Company Limited Monoclonal antibody inhibitor of Factor XIIa

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11390687B2 (en) 2015-01-02 2022-07-19 Takeda Pharmaceutical Company Limited Bispecific antibodies against plasma kallikrein and Factor XII
US12240918B2 (en) 2015-01-02 2025-03-04 Takeda Pharmaceutical Company Limited Bispecific antibodies against plasma kallikrein and factor XII
US12415866B2 (en) 2015-07-21 2025-09-16 Takeda Pharmaceutical Company Limited Monoclonal antibody inhibitor of Factor XIIa

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CN114316061B (zh) 2024-11-01
IL253180B2 (en) 2023-04-01
AU2022201076B2 (en) 2025-05-15
IL298086B1 (en) 2024-07-01
US20230117565A1 (en) 2023-04-20
EP3240570A1 (en) 2017-11-08
IL253180B (en) 2022-12-01
JP6744313B2 (ja) 2020-08-26
CO2017007123A2 (es) 2017-12-15
JP2020186248A (ja) 2020-11-19
US12240918B2 (en) 2025-03-04
JP2018502572A (ja) 2018-02-01
CN114316061A (zh) 2022-04-12
NZ771568A (en) 2024-11-29
CN107405399A (zh) 2017-11-28
EP3240570B1 (en) 2025-09-24
IL298086A (en) 2023-01-01
CN107405399B (zh) 2022-02-08
JP7003347B2 (ja) 2022-02-04
JP2022023038A (ja) 2022-02-07
IL298086B2 (en) 2024-11-01
MX2017008541A (es) 2017-12-04
NZ733580A (en) 2024-02-23
AU2015373910A1 (en) 2017-07-27
JP7635285B2 (ja) 2025-02-25
BR112017014308A2 (pt) 2018-03-06
CA2972800A1 (en) 2016-07-07
EP3240570A4 (en) 2018-08-08
KR102670705B1 (ko) 2024-05-31
EP3240570C0 (en) 2025-09-24
US11390687B2 (en) 2022-07-19
KR20170118058A (ko) 2017-10-24
WO2016109774A1 (en) 2016-07-07
JP2023065659A (ja) 2023-05-12
AU2015373910B2 (en) 2021-11-18
IL253180A0 (en) 2017-08-31
MX2024000317A (es) 2024-01-25
JP7241827B2 (ja) 2023-03-17
KR20240091031A (ko) 2024-06-21
US20180118851A1 (en) 2018-05-03
AU2022201076A1 (en) 2022-03-10

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