EA201791112A1 - Новые связывающиеся с pd-l1 полипептиды для визуализации - Google Patents
Новые связывающиеся с pd-l1 полипептиды для визуализацииInfo
- Publication number
- EA201791112A1 EA201791112A1 EA201791112A EA201791112A EA201791112A1 EA 201791112 A1 EA201791112 A1 EA 201791112A1 EA 201791112 A EA201791112 A EA 201791112A EA 201791112 A EA201791112 A EA 201791112A EA 201791112 A1 EA201791112 A1 EA 201791112A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- visualization
- polypeptides
- new bonding
- new
- bonding
- Prior art date
Links
- 102000008096 B7-H1 Antigen Human genes 0.000 title abstract 2
- 108010074708 B7-H1 Antigen Proteins 0.000 title abstract 2
- 238000012800 visualization Methods 0.000 title 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70532—B7 molecules, e.g. CD80, CD86
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
Abstract
В данном документе представлены новыеFn3 домены, которые специфично связываются с PD-L1, а также визуализирующие средства на их основе для диагностики.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462084298P | 2014-11-25 | 2014-11-25 | |
PCT/US2015/062485 WO2016086021A1 (en) | 2014-11-25 | 2015-11-24 | Novel pd-l1 binding polypeptides for imaging |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201791112A1 true EA201791112A1 (ru) | 2017-10-31 |
EA037590B1 EA037590B1 (ru) | 2021-04-19 |
Family
ID=54834952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791112A EA037590B1 (ru) | 2014-11-25 | 2015-11-24 | Связывающиеся с pd-l1 полипептиды на основе 10fn3 домена для визуализации |
Country Status (14)
Country | Link |
---|---|
US (3) | US10406251B2 (ru) |
EP (2) | EP3702367B1 (ru) |
JP (2) | JP6622814B2 (ru) |
KR (1) | KR102632418B1 (ru) |
CN (2) | CN114591420A (ru) |
AU (1) | AU2015353573B2 (ru) |
BR (1) | BR112017010137A2 (ru) |
CA (1) | CA2969067A1 (ru) |
EA (1) | EA037590B1 (ru) |
ES (1) | ES2822990T3 (ru) |
IL (1) | IL252354B (ru) |
MX (1) | MX2017006530A (ru) |
SG (1) | SG11201703760WA (ru) |
WO (1) | WO2016086021A1 (ru) |
Families Citing this family (30)
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KR102494646B1 (ko) | 2014-03-20 | 2023-01-31 | 브리스톨-마이어스 스큅 컴퍼니 | 안정화된 피브로넥틴 기반 스캐폴드 분자 |
US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
KR102632418B1 (ko) | 2014-11-25 | 2024-01-31 | 브리스톨-마이어스 스큅 컴퍼니 | 영상화를 위한 신규 pd-l1 결합 폴리펩티드 |
US11229713B2 (en) * | 2014-11-25 | 2022-01-25 | Bristol-Myers Squibb Company | Methods and compositions for 18F-radiolabeling of biologics |
LT3458111T (lt) * | 2016-05-19 | 2021-05-25 | Bristol-Myers Squibb Company | Pet vizualizacijos imunomoduliatoriai |
US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
EP3463486A1 (en) * | 2016-06-01 | 2019-04-10 | Bristol-Myers Squibb Company | Pet imaging with pd-l1 binding polypeptides |
MA46952A (fr) | 2016-12-01 | 2019-10-09 | Regeneron Pharma | Anticorps anti-pd-l1 radiomarqués pour imagerie immuno-pet |
EP3932432A1 (en) | 2016-12-14 | 2022-01-05 | Janssen Biotech, Inc. | Cd8a-binding fibronectin type iii domains |
EP3554561B1 (en) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
US10597438B2 (en) | 2016-12-14 | 2020-03-24 | Janssen Biotech, Inc. | PD-L1 binding fibronectin type III domains |
CA3048229A1 (en) | 2016-12-23 | 2018-06-28 | The Johns Hopkins University | Tumor and immune cell imaging based on pd-l1 expression |
JP7167041B2 (ja) | 2017-02-10 | 2022-11-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 免疫petイメージングのための放射標識抗lag3抗体 |
CN108503691B (zh) * | 2017-02-25 | 2021-07-23 | 复旦大学 | 一种人pd-l1蛋白高亲和性肽及其应用 |
US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
CN110891614A (zh) | 2017-05-05 | 2020-03-17 | 融合制药公司 | Igf-1r单克隆抗体及其用途 |
WO2018204869A1 (en) | 2017-05-05 | 2018-11-08 | Fusion Pharmaceuticals Inc. | Pharmacokinetic enhancements of bifunctional chelates and uses thereof |
EP3642220A1 (en) | 2017-06-23 | 2020-04-29 | Bristol-Myers Squibb Company | Immunomodulators acting as antagonists of pd-1 |
KR20200031645A (ko) | 2017-07-24 | 2020-03-24 | 리제너론 파마슈티칼스 인코포레이티드 | 항cd8 항체 및 이의 용도 |
US20190099506A1 (en) | 2017-10-02 | 2019-04-04 | Bristol-Myers Squibb Company | Methods and compositions for deuterated biologics |
CN111051332A (zh) | 2017-10-03 | 2020-04-21 | 百时美施贵宝公司 | 免疫调节剂 |
US11858960B2 (en) | 2018-03-01 | 2024-01-02 | Vrije Universiteit Brussel | Human PD-L1-binding immunoglobulins |
US11987629B2 (en) | 2018-06-01 | 2024-05-21 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and uses thereof for treating disease or condition |
WO2020001526A1 (zh) * | 2018-06-29 | 2020-01-02 | 苏州智核生物医药科技有限公司 | Pd-l1结合多肽及其用途 |
CN109991843B (zh) * | 2019-04-30 | 2021-11-23 | 广州齐志生物工程设备有限公司 | 一种生物反应器的温度控制方法 |
WO2021076574A2 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
WO2021076546A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Cd71 binding fibronectin type iii domains |
CN116568341A (zh) | 2020-02-28 | 2023-08-08 | 百时美施贵宝公司 | 基于纤连蛋白的放射性标记的支架和抗体及其治疗诊断用途 |
US20230235007A1 (en) * | 2020-06-15 | 2023-07-27 | Ming-Che Shih | Humanized ace2-fc fusion protein for treatment and prevention of sars-cov-2 infection |
CN113509562B (zh) * | 2021-04-22 | 2023-04-07 | 苏州智核生物医药科技有限公司 | 包含pd-l1结合多肽组合物的制剂及其制备方法 |
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JP7127008B6 (ja) | 2023-12-22 |
EP3224277B1 (en) | 2020-08-26 |
SG11201703760WA (en) | 2017-06-29 |
EA037590B1 (ru) | 2021-04-19 |
US20220001040A1 (en) | 2022-01-06 |
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CN114591420A (zh) | 2022-06-07 |
ES2822990T3 (es) | 2021-05-05 |
IL252354A0 (en) | 2017-07-31 |
CN107406494A (zh) | 2017-11-28 |
EP3224277A1 (en) | 2017-10-04 |
IL252354B (en) | 2021-07-29 |
EP3702367A1 (en) | 2020-09-02 |
BR112017010137A2 (pt) | 2018-02-06 |
EP3702367B1 (en) | 2024-05-15 |
MX2017006530A (es) | 2017-08-10 |
CA2969067A1 (en) | 2016-06-02 |
WO2016086021A1 (en) | 2016-06-02 |
KR102632418B1 (ko) | 2024-01-31 |
CN107406494B (zh) | 2022-03-25 |
JP7127008B2 (ja) | 2022-08-29 |
AU2015353573B2 (en) | 2020-09-03 |
AU2015353573A1 (en) | 2017-05-25 |
JP2018508213A (ja) | 2018-03-29 |
US20190343972A1 (en) | 2019-11-14 |
KR20170085588A (ko) | 2017-07-24 |
US11173219B2 (en) | 2021-11-16 |
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