EA201790637A1 - ПРОИЗВОДНЫЕ N-ПИРИДИНИЛАЦЕТАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ СИГНАЛЬНОГО ПУТИ Wnt - Google Patents

ПРОИЗВОДНЫЕ N-ПИРИДИНИЛАЦЕТАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ СИГНАЛЬНОГО ПУТИ Wnt

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EA201790637A1
EA201790637A1 EA201790637A EA201790637A EA201790637A1 EA 201790637 A1 EA201790637 A1 EA 201790637A1 EA 201790637 A EA201790637 A EA 201790637A EA 201790637 A EA201790637 A EA 201790637A EA 201790637 A1 EA201790637 A1 EA 201790637A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
relates
present
pyridinilacetamide
derivatives
Prior art date
Application number
EA201790637A
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English (en)
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EA034822B1 (ru
EA034822B9 (ru
Inventor
Индер Бхамра
Матильда Бингхэм
Ричард Тестар
Луис Саржент
Крейг Донахъю
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РЭДКС ФАРМА ПиЭлСи
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Priority claimed from GBGB1417829.7A external-priority patent/GB201417829D0/en
Priority claimed from GBGB1511387.1A external-priority patent/GB201511387D0/en
Application filed by РЭДКС ФАРМА ПиЭлСи filed Critical РЭДКС ФАРМА ПиЭлСи
Publication of EA201790637A1 publication Critical patent/EA201790637A1/ru
Publication of EA034822B1 publication Critical patent/EA034822B1/ru
Publication of EA034822B9 publication Critical patent/EA034822B9/ru

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Abstract

Настоящее изобретение относится к соединениям. Более конкретно, настоящее изобретение относится к соединениям, применимым в качестве ингибиторов сигнального пути Wnt. В частности, настоящее изобретение относится к ингибиторам поркупина (Porcn). Кроме того, изобретение относится к способам получения соединений и применениям соединений. Таким образом, соединения по настоящему изобретению могут применяться в лечении состояний, опосредуемых сигнальным путем Wnt, например для лечения рака, саркомы, меланомы, рака кожи, гематологических опухолей, лимфомы, рака и лейкоза или повышения эффективности противоракового лечения.
EA201790637A 2014-10-08 2015-10-08 Производные n-пиридинилацетамида в качестве ингибиторов сигнального пути wnt EA034822B9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1417829.7A GB201417829D0 (en) 2014-10-08 2014-10-08 Compounds
GBGB1511387.1A GB201511387D0 (en) 2015-06-29 2015-06-29 Compounds
PCT/GB2015/052939 WO2016055786A1 (en) 2014-10-08 2015-10-08 N-pyridinyl acetamide derivatives as inhibitors of the wnt signalling pathway

Publications (3)

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EA201790637A1 true EA201790637A1 (ru) 2017-10-31
EA034822B1 EA034822B1 (ru) 2020-03-25
EA034822B9 EA034822B9 (ru) 2020-10-23

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EP (1) EP3204378B3 (ru)
JP (2) JP6722178B2 (ru)
KR (1) KR102525131B1 (ru)
CN (1) CN107108565B (ru)
AU (1) AU2015329784C1 (ru)
CA (1) CA2960446C (ru)
CY (1) CY1122243T1 (ru)
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EA (1) EA034822B9 (ru)
ES (1) ES2754349T7 (ru)
HR (1) HRP20191826T4 (ru)
HU (1) HUE046914T2 (ru)
IL (1) IL251131B (ru)
LT (1) LT3204378T (ru)
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PH (1) PH12017500611A1 (ru)
PL (1) PL3204378T6 (ru)
PT (1) PT3204378T (ru)
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SI (1) SI3204378T1 (ru)
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US20210046076A1 (en) 2021-02-18
HUE046914T2 (hu) 2020-04-28
MX2017004637A (es) 2017-06-30
ZA201701842B (en) 2022-05-25
BR112017006476A2 (pt) 2017-12-19
SI3204378T1 (sl) 2019-12-31
PL3204378T6 (pl) 2022-09-12
IL251131B (en) 2020-07-30
PL3204378T3 (pl) 2020-03-31
NZ729820A (en) 2023-09-29
CN107108565B (zh) 2019-08-23
CN107108565A (zh) 2017-08-29
AU2015329784A1 (en) 2017-03-30
HRP20191826T1 (hr) 2020-01-10
DK3204378T6 (da) 2022-07-18
EA034822B1 (ru) 2020-03-25
WO2016055786A1 (en) 2016-04-14
US20180319788A1 (en) 2018-11-08
SG11201701837UA (en) 2017-04-27
HRP20191826T4 (hr) 2022-08-05
US10793560B2 (en) 2020-10-06
KR20170063906A (ko) 2017-06-08
CA2960446C (en) 2023-09-19
ES2754349T3 (es) 2020-04-17
JP2017530183A (ja) 2017-10-12
PL3204378T4 (pl) 2020-03-31
KR102525131B1 (ko) 2023-04-24
PT3204378T (pt) 2019-11-12
CA2960446A1 (en) 2016-04-14
JP6722178B2 (ja) 2020-07-15
US10047079B2 (en) 2018-08-14
JP2020090542A (ja) 2020-06-11
IL251131A0 (en) 2017-04-30
EP3204378B1 (en) 2019-07-10
US20170275276A1 (en) 2017-09-28
US11643408B2 (en) 2023-05-09
US20230365549A1 (en) 2023-11-16
DK3204378T3 (da) 2019-10-21
EP3204378A1 (en) 2017-08-16
AU2015329784B2 (en) 2019-08-22
CY1122243T1 (el) 2020-11-25
LT3204378T (lt) 2019-10-25
PH12017500611A1 (en) 2017-09-25
EP3204378B3 (en) 2022-05-25
AU2015329784C1 (en) 2020-10-15
ES2754349T7 (es) 2022-09-19
EA034822B9 (ru) 2020-10-23

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