BR112017006476A2 - derivados de n-piridinil acetamida como inibidores da série de reação de sinalização de wnt - Google Patents

derivados de n-piridinil acetamida como inibidores da série de reação de sinalização de wnt

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Publication number
BR112017006476A2
BR112017006476A2 BR112017006476A BR112017006476A BR112017006476A2 BR 112017006476 A2 BR112017006476 A2 BR 112017006476A2 BR 112017006476 A BR112017006476 A BR 112017006476A BR 112017006476 A BR112017006476 A BR 112017006476A BR 112017006476 A2 BR112017006476 A2 BR 112017006476A2
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Brazil
Prior art keywords
inhibitors
wnt signaling
compounds
reaction series
signaling reaction
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Application number
BR112017006476A
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English (en)
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BR112017006476B1 (pt
Inventor
Donoghue Craig
Bhamra Inder
SARGENT Louise
Bingham Matilda
Testar Richard
Original Assignee
Redx Pharma Plc
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Publication date
Priority claimed from GBGB1417829.7A external-priority patent/GB201417829D0/en
Priority claimed from GBGB1511387.1A external-priority patent/GB201511387D0/en
Application filed by Redx Pharma Plc filed Critical Redx Pharma Plc
Publication of BR112017006476A2 publication Critical patent/BR112017006476A2/pt
Publication of BR112017006476B1 publication Critical patent/BR112017006476B1/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

esta invenção refere-se aos compostos. mais especificamente, a invenção refere-se aos compostos úteis como inibidores da série de reação de sinalização de wnt. especificamente, os inibidores de porco-espinho (porcn) são contemplados pela invenção. além disso, a invenção contempla processos para preparar os compostos e usos dos compostos. os compostos da invenção podem, portanto, ser usados no tratamento de condições mediadas pela série de reação de sinalização de wnt, por exemplo, tratamento de câncer, sarcoma, melanoma, câncer de pele, tumores hematológicos, linfoma, carcinoma, e leucemia; ou no realce da eficácia de um tratamento anticâncer.
BR112017006476-6A 2014-10-08 2015-10-08 Composto derivado de n-piridinil acetamida, seu uso, formulação farmacêutica e composição farmacêutica BR112017006476B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1417829.7 2014-10-08
GBGB1417829.7A GB201417829D0 (en) 2014-10-08 2014-10-08 Compounds
GBGB1511387.1A GB201511387D0 (en) 2015-06-29 2015-06-29 Compounds
GB1511387.1 2015-06-29
PCT/GB2015/052939 WO2016055786A1 (en) 2014-10-08 2015-10-08 N-pyridinyl acetamide derivatives as inhibitors of the wnt signalling pathway

Publications (2)

Publication Number Publication Date
BR112017006476A2 true BR112017006476A2 (pt) 2017-12-19
BR112017006476B1 BR112017006476B1 (pt) 2023-08-15

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JP2020090542A (ja) 2020-06-11
EA201790637A1 (ru) 2017-10-31
AU2015329784A1 (en) 2017-03-30
US10047079B2 (en) 2018-08-14
CA2960446C (en) 2023-09-19
US10793560B2 (en) 2020-10-06
US20210046076A1 (en) 2021-02-18
JP2017530183A (ja) 2017-10-12
HRP20191826T1 (hr) 2020-01-10
SI3204378T1 (sl) 2019-12-31
PH12017500611A1 (en) 2017-09-25
DK3204378T3 (da) 2019-10-21
WO2016055786A1 (en) 2016-04-14
KR102525131B1 (ko) 2023-04-24
US20170275276A1 (en) 2017-09-28
CA2960446A1 (en) 2016-04-14
PL3204378T6 (pl) 2022-09-12
US11643408B2 (en) 2023-05-09
JP6722178B2 (ja) 2020-07-15
PL3204378T3 (pl) 2020-03-31
CN107108565B (zh) 2019-08-23
EP3204378B3 (en) 2022-05-25
EA034822B9 (ru) 2020-10-23
EP3204378B1 (en) 2019-07-10
EP3204378A1 (en) 2017-08-16
AU2015329784B2 (en) 2019-08-22
AU2015329784C1 (en) 2020-10-15
KR20170063906A (ko) 2017-06-08
US20180319788A1 (en) 2018-11-08
MX2017004637A (es) 2017-06-30
DK3204378T6 (da) 2022-07-18
HUE046914T2 (hu) 2020-04-28
SG11201701837UA (en) 2017-04-27
PL3204378T4 (pl) 2020-03-31
ES2754349T7 (es) 2022-09-19
CN107108565A (zh) 2017-08-29
NZ729820A (en) 2023-09-29
IL251131B (en) 2020-07-30
HRP20191826T4 (hr) 2022-08-05
ZA201701842B (en) 2022-05-25
ES2754349T3 (es) 2020-04-17
PT3204378T (pt) 2019-11-12
US20230365549A1 (en) 2023-11-16
LT3204378T (lt) 2019-10-25
EA034822B1 (ru) 2020-03-25
IL251131A0 (en) 2017-04-30
CY1122243T1 (el) 2020-11-25

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