PL3204378T3 - Pochodne n-pirydynylo acetamidu jako inhibitory szlaku sygnałowego wnt - Google Patents

Pochodne n-pirydynylo acetamidu jako inhibitory szlaku sygnałowego wnt

Info

Publication number
PL3204378T3
PL3204378T3 PL15782041T PL15782041T PL3204378T3 PL 3204378 T3 PL3204378 T3 PL 3204378T3 PL 15782041 T PL15782041 T PL 15782041T PL 15782041 T PL15782041 T PL 15782041T PL 3204378 T3 PL3204378 T3 PL 3204378T3
Authority
PL
Poland
Prior art keywords
inhibitors
signalling pathway
wnt signalling
acetamide derivatives
pyridinyl
Prior art date
Application number
PL15782041T
Other languages
English (en)
Other versions
PL3204378T6 (pl
PL3204378T4 (pl
Inventor
Inder Bhamra
Matilda Bingham
Richard TESTAR
Louise SARGENT
Craig DONOGHUE
Original Assignee
Redx Pharma Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1417829.7A external-priority patent/GB201417829D0/en
Priority claimed from GBGB1511387.1A external-priority patent/GB201511387D0/en
Application filed by Redx Pharma Plc filed Critical Redx Pharma Plc
Publication of PL3204378T3 publication Critical patent/PL3204378T3/pl
Publication of PL3204378T4 publication Critical patent/PL3204378T4/pl
Publication of PL3204378T6 publication Critical patent/PL3204378T6/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
PL15782041.6T 2014-10-08 2015-10-08 Pochodne n-pirydynylo acetamidu jako inhibitory szlaku sygnałowego wnt PL3204378T6 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1417829.7A GB201417829D0 (en) 2014-10-08 2014-10-08 Compounds
GBGB1511387.1A GB201511387D0 (en) 2015-06-29 2015-06-29 Compounds
PCT/GB2015/052939 WO2016055786A1 (en) 2014-10-08 2015-10-08 N-pyridinyl acetamide derivatives as inhibitors of the wnt signalling pathway
EP15782041.6A EP3204378B3 (en) 2014-10-08 2015-10-08 N-pyridinyl acetamide derivatives as inhibitors of the wnt signalling pathway

Publications (3)

Publication Number Publication Date
PL3204378T3 true PL3204378T3 (pl) 2020-03-31
PL3204378T4 PL3204378T4 (pl) 2020-03-31
PL3204378T6 PL3204378T6 (pl) 2022-09-12

Family

ID=54337304

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15782041.6T PL3204378T6 (pl) 2014-10-08 2015-10-08 Pochodne n-pirydynylo acetamidu jako inhibitory szlaku sygnałowego wnt

Country Status (23)

Country Link
US (4) US10047079B2 (pl)
EP (1) EP3204378B3 (pl)
JP (2) JP6722178B2 (pl)
KR (1) KR102525131B1 (pl)
CN (1) CN107108565B (pl)
AU (1) AU2015329784C1 (pl)
CA (1) CA2960446C (pl)
CY (1) CY1122243T1 (pl)
DK (1) DK3204378T6 (pl)
EA (1) EA034822B9 (pl)
ES (1) ES2754349T7 (pl)
HR (1) HRP20191826T4 (pl)
HU (1) HUE046914T2 (pl)
IL (1) IL251131B (pl)
LT (1) LT3204378T (pl)
MX (1) MX2017004637A (pl)
PH (1) PH12017500611A1 (pl)
PL (1) PL3204378T6 (pl)
PT (1) PT3204378T (pl)
SG (1) SG11201701837UA (pl)
SI (1) SI3204378T1 (pl)
WO (1) WO2016055786A1 (pl)
ZA (1) ZA201701842B (pl)

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JP6588976B2 (ja) 2014-10-08 2019-10-09 レッドエックス ファーマ ピーエルシー Ｗｎｔシグナル経路阻害剤としてのＮ‐ピリジニルアセトアミド誘導体
CN107108565B (zh) 2014-10-08 2019-08-23 莱德克斯制药公共有限公司 作为wnt信号传送途径的抑制剂的n-吡啶基乙酰胺衍生物
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
WO2018045182A1 (en) 2016-09-01 2018-03-08 The Board Of Regents Of Hte University Of Texas System Disubstituted and trisubtituted 1,2,3-triazoles as wnt inhibitors
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
JP2019064975A (ja) * 2017-10-03 2019-04-25 国立大学法人 熊本大学 抗がん剤
CN111741944A (zh) 2018-02-01 2020-10-02 悉尼大学 抗癌化合物
PT3762368T (pt) 2018-03-08 2022-05-06 Incyte Corp Compostos de aminopirazina diol como inibidores de pi3k-y
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
US10961534B2 (en) 2018-07-13 2021-03-30 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating porphyria
KR20220119653A (ko) 2019-12-20 2022-08-30 테나야 테라퓨틱스, 인코포레이티드 플루오로알킬-옥사디아졸 및 이의 용도
EP4237093A4 (en) * 2020-11-02 2024-06-12 Icahn School of Medicine at Mount Sinai METHODS OF TREATING TUMORS AND CANCERS WITH DEREGULATED WNT SIGNALING PATHWAYS
GB202100526D0 (en) 2021-01-15 2021-03-03 Redx Pharma Plc Pharmaceutical formulation

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DE69720773T2 (de) 1996-12-23 2004-01-29 Bristol Myers Squibb Pharma Co SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER
ATE443698T1 (de) 1996-12-23 2009-10-15 Bristol Myers Squibb Pharma Co Stickstoffhaltige heterocyclen als faktor xa- hemmer
GB0226583D0 (en) 2002-11-14 2002-12-18 Cyclacel Ltd Compounds
SE0203654D0 (sv) 2002-12-09 2002-12-09 Astrazeneca Ab New compounds
AU2004210711B2 (en) * 2003-02-12 2010-07-08 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
JP2008515961A (ja) * 2004-10-12 2008-05-15 アストラゼネカ アクチボラグ 癌に対する使用のためのキナゾリン誘導体
JP2010526078A (ja) * 2007-04-30 2010-07-29 ジェネンテック， インコーポレイテッド Ｗｎｔシグナル伝達のピラゾールインヒビター
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UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
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UY33469A (es) * 2010-06-29 2012-01-31 Irm Llc Y Novartis Ag Composiciones y metodos para modular la via de señalizacion de wnt
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GB2513403A (en) 2013-04-26 2014-10-29 Agency Science Tech & Res WNT pathway modulators
CN107108565B (zh) 2014-10-08 2019-08-23 莱德克斯制药公共有限公司 作为wnt信号传送途径的抑制剂的n-吡啶基乙酰胺衍生物
JP6588976B2 (ja) 2014-10-08 2019-10-09 レッドエックス ファーマ ピーエルシー Ｗｎｔシグナル経路阻害剤としてのＮ‐ピリジニルアセトアミド誘導体

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DK3204378T6 (da) 2022-07-18
KR102525131B1 (ko) 2023-04-24
MX2017004637A (es) 2017-06-30
US11643408B2 (en) 2023-05-09
HUE046914T2 (hu) 2020-04-28
AU2015329784B2 (en) 2019-08-22
AU2015329784C1 (en) 2020-10-15
ES2754349T7 (es) 2022-09-19
BR112017006476A2 (pt) 2017-12-19
HRP20191826T4 (hr) 2022-08-05
NZ729820A (en) 2023-09-29
EP3204378B3 (en) 2022-05-25
ES2754349T3 (es) 2020-04-17
CY1122243T1 (el) 2020-11-25
CA2960446A1 (en) 2016-04-14
US10047079B2 (en) 2018-08-14
EA034822B1 (ru) 2020-03-25
PL3204378T6 (pl) 2022-09-12
CN107108565A (zh) 2017-08-29
IL251131B (en) 2020-07-30
AU2015329784A1 (en) 2017-03-30
SI3204378T1 (sl) 2019-12-31
US10793560B2 (en) 2020-10-06
HRP20191826T1 (hr) 2020-01-10
DK3204378T3 (da) 2019-10-21
ZA201701842B (en) 2022-05-25
PL3204378T4 (pl) 2020-03-31
US20170275276A1 (en) 2017-09-28
SG11201701837UA (en) 2017-04-27
EP3204378A1 (en) 2017-08-16
US20230365549A1 (en) 2023-11-16
US20180319788A1 (en) 2018-11-08
KR20170063906A (ko) 2017-06-08
CA2960446C (en) 2023-09-19
PH12017500611A1 (en) 2017-09-25
CN107108565B (zh) 2019-08-23
LT3204378T (lt) 2019-10-25
US20210046076A1 (en) 2021-02-18
JP2020090542A (ja) 2020-06-11
EA201790637A1 (ru) 2017-10-31
JP2017530183A (ja) 2017-10-12
WO2016055786A1 (en) 2016-04-14
PT3204378T (pt) 2019-11-12
IL251131A0 (en) 2017-04-30
JP6722178B2 (ja) 2020-07-15
EA034822B9 (ru) 2020-10-23
EP3204378B1 (en) 2019-07-10

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