EA202090596A1 - Производные 6-хроманола и их синтез - Google Patents

Производные 6-хроманола и их синтез

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Publication number
EA202090596A1
EA202090596A1 EA202090596A EA202090596A EA202090596A1 EA 202090596 A1 EA202090596 A1 EA 202090596A1 EA 202090596 A EA202090596 A EA 202090596A EA 202090596 A EA202090596 A EA 202090596A EA 202090596 A1 EA202090596 A1 EA 202090596A1
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EA
Eurasian Patent Office
Prior art keywords
synthesis
chromanol
derivatives
chromanol derivatives
new
Prior art date
Application number
EA202090596A
Other languages
English (en)
Inventor
Рафаэль Бёмер
Вернер Бонрат
Жан-Марк Дельфо
Марсель Жорэ
Джонатан Алан Медлок
Томас Нетчер
Доменико Сориано
Рене Тобиас Штемлер
Original Assignee
ДСМ АйПи АССЕТС Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by ДСМ АйПи АССЕТС Б.В. filed Critical ДСМ АйПи АССЕТС Б.В.
Publication of EA202090596A1 publication Critical patent/EA202090596A1/ru

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    • A—HUMAN NECESSITIES
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    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/202—Aliphatic compounds
    • A23L27/2024—Aliphatic compounds having oxygen as the only hetero atom
    • A23L27/2026—Hydroxy compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/202—Aliphatic compounds
    • A23L27/2024—Aliphatic compounds having oxygen as the only hetero atom
    • A23L27/2028—Carboxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C07C33/025—Acyclic alcohols with carbon-to-carbon double bonds with only one double bond
    • C07C33/03—Acyclic alcohols with carbon-to-carbon double bonds with only one double bond in beta-position, e.g. allyl alcohol, methallyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
    • C07C33/042—Acyclic alcohols with carbon-to-carbon triple bonds with only one triple bond
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
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    • C07C47/21—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
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    • C11B9/00—Essential oils; Perfumes
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    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
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    • A23L33/15—Vitamins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Настоящее изобретение касается новых соединений, которые могут применяться для синтеза новых производных хроманола. Данные соединения имеют интересные свойства. В частности, данные новые производные хроманола имеют интересные антиоксидантные свойства.
EA202090596A 2017-09-04 2018-09-04 Производные 6-хроманола и их синтез EA202090596A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17189276 2017-09-04
PCT/EP2018/073745 WO2019043251A1 (en) 2017-09-04 2018-09-04 CHROMANOL DERIVATIVES AND THEIR SYNTHESIS

Publications (1)

Publication Number Publication Date
EA202090596A1 true EA202090596A1 (ru) 2020-06-26

Family

ID=59772533

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090596A EA202090596A1 (ru) 2017-09-04 2018-09-04 Производные 6-хроманола и их синтез

Country Status (7)

Country Link
US (1) US11078178B2 (ru)
EP (1) EP3679021B1 (ru)
JP (1) JP7260186B2 (ru)
CN (1) CN111032636B (ru)
EA (1) EA202090596A1 (ru)
ES (1) ES2925229T3 (ru)
WO (1) WO2019043251A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111065634A (zh) * 2017-07-12 2020-04-24 帝斯曼知识产权资产管理有限公司 用于制备α-生育酚的中间体的新型合成

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
US4028385A (en) 1974-09-02 1977-06-07 Kuraray Co., Ltd. Process for preparing stereospecific farnesylacetic acid and ester thereof
EP0044771B1 (fr) 1980-07-10 1984-05-02 Rhone-Poulenc Sante Procédé d'addition sélective d'un composé ayant un atome de carbone activé sur un diène conjugué substitué
DE3027269A1 (de) * 1980-07-18 1982-03-04 Basf Ag, 6700 Ludwigshafen 3,6-dimethyl-3-hydroxy-1-octine und -1-octene sowie derivate davon und ihre verwendung als riechstoffe und verfahren zur herstellung von 3,6-dimethyl-3-hydroxy-octan
FR2541675B1 (fr) 1983-02-24 1985-06-14 Rhone Poulenc Sante Procede chimique de purification d'un melange de trimeres de l'isoprene
FR2657871B1 (fr) 1990-02-08 1993-02-05 Rhone Poulenc Sante Procede de preparation de cetones terpeniques.
EP0970953B1 (en) 1998-07-10 2004-09-29 DSM IP Assets B.V. Manufacture of d,1-alpha-tocopherol
DE10022076A1 (de) * 2000-05-06 2001-11-08 Cognis Deutschland Gmbh Trimethyldecen-Verbindungen
US6949685B2 (en) 2001-09-28 2005-09-27 Werner Bonrath Ethynylation process
RU2323201C2 (ru) 2002-08-16 2008-04-27 Дсм Ип Ассетс Б.В. Способ этинилирования
GB0321313D0 (en) * 2003-09-12 2003-10-15 Givaudan Sa Organic compound
KR101140519B1 (ko) 2004-06-11 2012-04-30 디에스엠 아이피 어셋츠 비.브이. 크로만 유도체, 특히 α-토코페롤 및 그의 알카노에이트의제조 방법
EP2522647B1 (en) 2011-05-10 2014-04-30 DSM IP Assets B.V. Process of separating chiral isomers of chroman compounds and their derivatives and precursors
JP6476475B2 (ja) 2012-10-08 2019-03-06 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 香味香気配合物（ｉ）
WO2015117893A1 (en) * 2014-02-07 2015-08-13 Dsm Ip Assets B.V. Flavor and fragrance formulation (vii)
CN106458819B (zh) 2014-04-30 2020-03-27 巴斯夫欧洲公司 制备金合欢基丙酮的方法
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CN105859534A (zh) 2016-04-07 2016-08-17 能特科技有限公司 一种连续循环催化反应合成酮类化合物的方法

Also Published As

Publication number Publication date
CN111032636A (zh) 2020-04-17
EP3679021B1 (en) 2022-06-29
US20200190051A1 (en) 2020-06-18
BR112020004202A2 (pt) 2020-09-01
ES2925229T3 (es) 2022-10-14
JP7260186B2 (ja) 2023-04-18
JP2020532602A (ja) 2020-11-12
EP3679021A1 (en) 2020-07-15
US11078178B2 (en) 2021-08-03
CN111032636B (zh) 2023-06-27
WO2019043251A1 (en) 2019-03-07

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