EA201692536A1 - Диспергируемая таблетка мизопростола - Google Patents

Диспергируемая таблетка мизопростола

Info

Publication number
EA201692536A1
EA201692536A1 EA201692536A EA201692536A EA201692536A1 EA 201692536 A1 EA201692536 A1 EA 201692536A1 EA 201692536 A EA201692536 A EA 201692536A EA 201692536 A EA201692536 A EA 201692536A EA 201692536 A1 EA201692536 A1 EA 201692536A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tablet
mizoprostol
dispertable
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
EA201692536A
Other languages
English (en)
Other versions
EA039069B1 (ru
Inventor
Секар Селварадж
Баскар Елумалай
Малаиарасан Аруначалам
Прабхакаран Венугопал
Original Assignee
Асанта Данмарк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/329,023 external-priority patent/US20160008310A1/en
Priority claimed from EP14176821.8A external-priority patent/EP2965750B1/en
Application filed by Асанта Данмарк А/С filed Critical Асанта Данмарк А/С
Publication of EA201692536A1 publication Critical patent/EA201692536A1/ru
Publication of EA039069B1 publication Critical patent/EA039069B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к твердой фармацевтической композиции, содержащей мизопростол или его фармацевтически приемлемую соль. В частности, изобретение относится к диспергируемой таблетке, содержащей мизопростол или его фармацевтически приемлемую соль, обеспечивающей альтернативные пути введения. Таблетка является особенно подходящей для созревания шейки матки, стимулирования родов, предупреждения и/или лечения послеродового или постабортного кровотечения.
EA201692536A 2014-07-11 2015-07-10 Способ обеспечения созревания шейки матки или стимулирования родов, включающий введение фармацевтической композиции мизопростола, и применение мизопростола для изготовления такой композиции EA039069B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/329,023 US20160008310A1 (en) 2014-07-11 2014-07-11 Misoprostol dispersible tablet
EP14176821.8A EP2965750B1 (en) 2014-07-11 2014-07-11 Misoprostol dispersible tablet
PCT/DK2015/050216 WO2016004960A2 (en) 2014-07-11 2015-07-10 Misoprostol dispersible tablet

Publications (2)

Publication Number Publication Date
EA201692536A1 true EA201692536A1 (ru) 2017-06-30
EA039069B1 EA039069B1 (ru) 2021-11-30

Family

ID=53879283

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692536A EA039069B1 (ru) 2014-07-11 2015-07-10 Способ обеспечения созревания шейки матки или стимулирования родов, включающий введение фармацевтической композиции мизопростола, и применение мизопростола для изготовления такой композиции

Country Status (12)

Country Link
US (2) US11406615B2 (ru)
EP (1) EP3166597A2 (ru)
JP (2) JP6532529B2 (ru)
AU (1) AU2015287186B2 (ru)
BR (1) BR112017000529A2 (ru)
CA (1) CA2954086C (ru)
EA (1) EA039069B1 (ru)
MX (1) MX2017000399A (ru)
NZ (1) NZ727876A (ru)
RU (1) RU2017104233A (ru)
TN (1) TN2017000003A1 (ru)
WO (1) WO2016004960A2 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108434110B (zh) * 2018-04-28 2019-09-10 浙江仙琚制药股份有限公司 米索前列醇组合物、片剂及其用途

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB994518A (en) 1962-07-18 1965-06-10 Needle Industries Ltd Improvements relating to shavers
US4335097A (en) 1981-01-15 1982-06-15 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Stabilized, prostaglandin-containing tablets with controlled rate of solubility, for local use and process for the preparation thereof
ATE157652T1 (de) 1992-06-08 1997-09-15 Newpharma International Corp Pge1-analoge
JPH06199779A (ja) 1992-06-08 1994-07-19 Newpharma Internatl Corp トランス−▲δ２▼−１５−デオキシ−１６−ヒドロキシ−１６−メチル−ｐｇ▲ｅ１▼のメチルエステル（ｂ−４０７）
GB9419566D0 (en) 1994-09-27 1994-11-16 El Refaey Hazem Oral prostagladins for the routine management of the third stage of labour
US5993856A (en) 1997-01-24 1999-11-30 Femmepharma Pharmaceutical preparations and methods for their administration
US6228213B1 (en) 1997-09-19 2001-05-08 University Of Nebraska-Lincoln Production of microcrystalline cellulose by reactive extrusion
US7815937B2 (en) 1998-10-27 2010-10-19 Biovail Laboratories International Srl Quick dissolve compositions and tablets based thereon
WO2001013836A1 (en) 1999-08-26 2001-03-01 West Virginia University Cervical agent delivery system
MXPA02005562A (es) * 1999-12-06 2004-09-10 Penwest Pharmaceuticals Co Superdesintegrante farmaceutico.
GB2375303A (en) 2001-05-11 2002-11-13 Medical Res Council Method of inducing cervical ripening
GB0204771D0 (en) * 2002-02-28 2002-04-17 Phoqus Ltd Fast disintegrating tablets
SI21221A (sl) 2002-06-21 2003-12-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Hitro razpadljive tablete
TW200502000A (en) * 2003-03-28 2005-01-16 Kyowa Hakko Kogyo Kk Dividing tablet
WO2006125450A1 (en) 2005-05-26 2006-11-30 Atef Mohammed Mostafa Darwish Rectal and vaginal suppositories containing misoprostol
WO2006133048A2 (en) 2005-06-03 2006-12-14 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
EP1906937B1 (en) * 2005-07-22 2016-10-19 Rubicon Research Pvt Ltd. Novel dispersible tablet composition
US8148560B2 (en) * 2005-09-23 2012-04-03 Teva Women's Health, Inc. Vaginal tablets comprising misoprostol and methods of making and using the same
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
CN1939308A (zh) 2005-09-28 2007-04-04 应圣俊 一种米索前列醇栓剂
EP1987820A1 (en) 2007-05-04 2008-11-05 Christian Fiala, Ph. D. Slow release misoprostol for obstetric and/or gynaecological applications
JP2010540588A (ja) 2007-10-01 2010-12-24 ラボラトリオス、レスビ、ソシエダッド、リミターダ 口腔内崩壊錠剤
WO2009154810A2 (en) * 2008-02-25 2009-12-23 Dr. Reddy's Laboratories Ltd. Delivery systems for multiple active agents
WO2010036878A1 (en) 2008-09-26 2010-04-01 The Trustees Of Columbia University In The City Of New York Use of trpv1 receptor agonists in cervical pain and labor
WO2010109019A1 (en) 2009-03-26 2010-09-30 Royal College Of Surgeons In Ireland Orodispersible tablets
US20100260825A1 (en) 2009-04-13 2010-10-14 Nair Madhavan G Antifolates for the treatment of cardiovascular, inflammatory, neoplastic, autoimmune and related diseases in sublingual dosage units, film strips, or skin patches
RU2394814C1 (ru) 2009-05-22 2010-07-20 Учреждение Российской академии наук Институт органической химии Уфимского научного центра РАН Средство, представляющее собой этиловый эфир (±)-11,15-дидезокси-16-метил-16-гидроксипростагландина e1, проявляющее утеротоническую активность
AU2011265222B2 (en) 2010-06-11 2015-04-02 Ferring B.V. Intravaginal administration of misoprostol
CN102302443B (zh) 2011-09-21 2014-04-23 天津市聚星康华医药科技有限公司 一种米索前列醇阴道缓释栓剂及其制备方法
CN102697746B (zh) * 2012-06-11 2014-03-19 广州朗圣药业有限公司 一种快速融变的米索前列醇阴道用组合物及其制备方法和应用
EP2877181A1 (en) 2012-07-26 2015-06-03 Ferring BV Misprostol composition
EP2877182A1 (en) 2012-07-26 2015-06-03 Ferring B.V. Misoprostol formulation
EP2689781A1 (en) 2012-07-26 2014-01-29 Ferring B.V. Misoprostol composition
EP2689802A1 (en) 2012-07-26 2014-01-29 Ferring B.V. Misoprostol formulation
CN102872024B (zh) * 2012-09-28 2015-06-17 天津市聚星康华医药科技有限公司 口腔内使用的米索前列醇药物组合物
CN103040842B (zh) 2012-12-08 2014-11-12 浙江圣博康药业有限公司 一种前列腺素类药物组合物及其制成的前列腺素类药物栓剂
CN103340837B (zh) * 2013-07-08 2018-04-27 天津市聚星康华医药科技有限公司 一种米索前列醇阴道泡腾片及其制备方法

Also Published As

Publication number Publication date
WO2016004960A3 (en) 2016-03-17
US11406615B2 (en) 2022-08-09
RU2017104233A (ru) 2018-08-13
JP6532529B2 (ja) 2019-06-19
RU2017104233A3 (ru) 2018-12-18
CA2954086A1 (en) 2016-01-14
TN2017000003A1 (en) 2018-07-04
MX2017000399A (es) 2017-08-10
US12005041B2 (en) 2024-06-11
WO2016004960A2 (en) 2016-01-14
US20210322356A1 (en) 2021-10-21
JP2017520628A (ja) 2017-07-27
EP3166597A2 (en) 2017-05-17
JP6921894B2 (ja) 2021-08-18
EA039069B1 (ru) 2021-11-30
US20220347145A1 (en) 2022-11-03
CA2954086C (en) 2020-03-31
JP2019147831A (ja) 2019-09-05
NZ727876A (en) 2018-05-25
BR112017000529A2 (pt) 2017-11-14
AU2015287186B2 (en) 2018-05-31
AU2015287186A1 (en) 2017-01-19

Similar Documents

Publication Publication Date Title
PH12018502251A1 (en) Formulations of an lsd1 inhibitor
PH12016501830A1 (en) Inhibitors of c5a for the treatment of viral pneumonia
MA39710A (fr) Composition topique destinée à être utilisée dans le traitement d'une maladie inflammatoire de l'intestin
MX2017002816A (es) Derivados de pirazolopiridina y su uso en terapia.
EA201792591A1 (ru) Фармацевтические препараты
MX2017003928A (es) Composiciones farmaceuticas de accion prolongada.
PH12016502233A1 (en) (s)-pirlindole or its pharmaceutically acceptable salts for use in medicine
EA201791009A1 (ru) Композиции, содержащие циклоспорин
PH12016502243A1 (en) Pharmaceutical compositions for treating infectious diseases
PH12016502236A1 (en) (r)-pirlindole and its pharmaceutically acceptable salts for use in medicine
MX370436B (es) Composicion farmaceutica para usarse en el tratamiento o la prevencion de deficiencias de vitaminas y minerales en pacientes que han sido sometidos a cirugia de derivacion gastrica.
MD4763C1 (ru) Фармацевтическая композиция
PH12019501820A1 (en) Pharmaceutical compositions for combination therapy
EA201692536A1 (ru) Диспергируемая таблетка мизопростола
EA201790020A1 (ru) Соединения, фармацевтические композиции и их применение при лечении нейродегенеративных заболеваний
MX2018015240A (es) Composiciones que comprenden timolol y su uso en el tratamiento de rosacea mediante administracion topica.
JO3321B1 (ar) قرص قابل للتشتت من ميزوبروستول
NZ739679A (en) Cholecalciferol sulfate salts and their use for the treatment of vitamin d deficiency
MX2018003564A (es) 1,4-benzodiazepinas biheteroarilo sustituidas y usos de las mismas para el tratamiento del cancer.
WO2016083315A8 (en) Use of ox1r antagonists for the treatment of inflammatory bowel diseases
MX2016012553A (es) Composiciones farmaceuticas de mazindol con metformina para perdida de peso.
TH167850B (th) (r)-เพอร์ลินโดล และเกลือที่ยอมรับได้ทางเภสัชกรรมของมันสำหรับการใช้ ในยารักษาโรค
PH12015502305A1 (en) Use of pidotimod to treat inflammatory bowel disease
UA88138U (ru) Лекарственное средство в форме перорального раствора для лечения и профилактики ишемии тканей организма