EA201692435A1 - Соли присоединения (s)-2-(1-(6-амино-5-цианопиримидин-4-иламино)этил)-4-оксо-3-фенил-3,4-дигидропирроло[1,2-f][1,2,4]триазин-5-карбонитрила - Google Patents

Соли присоединения (s)-2-(1-(6-амино-5-цианопиримидин-4-иламино)этил)-4-оксо-3-фенил-3,4-дигидропирроло[1,2-f][1,2,4]триазин-5-карбонитрила

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Publication number
EA201692435A1
EA201692435A1 EA201692435A EA201692435A EA201692435A1 EA 201692435 A1 EA201692435 A1 EA 201692435A1 EA 201692435 A EA201692435 A EA 201692435A EA 201692435 A EA201692435 A EA 201692435A EA 201692435 A1 EA201692435 A1 EA 201692435A1
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EA
Eurasian Patent Office
Prior art keywords
cyanopyrimidin
carbonitrile
oxo
phenyl
amino
Prior art date
Application number
EA201692435A
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English (en)
Inventor
Франсеск Каррера-Каррера
Хуан-Баутиста Перес-Гарсиа
Бернат Видаль-Хуан
Франсиско Санчес-Искиэрдо
Мария-Карме Серра-Кома
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Альмираль, С.А.
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Application filed by Альмираль, С.А. filed Critical Альмираль, С.А.
Publication of EA201692435A1 publication Critical patent/EA201692435A1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Настоящее изобретение относится к новым фармацевтически приемлемым солям присоединения (S)-2-(1-(6-амино-5-цианопиримидин-4-иламино)этил)-4-оксо-3-фенил-3,4-дигидропирроло[1,2-f][1,2,4]триазин-5-карбонитрила с производными сульфоновой кислоты, в частности с метансульфоновой кислотой, нафталин-2-сульфоновой кислотой и паратолуолсульфоновой кислотой, и к их фармацевтически приемлемым сольватам, и к их применению в качестве ингибиторов фосфоинозитид-3-киназы (PI3K).
EA201692435A 2014-05-27 2015-05-21 Соли присоединения (s)-2-(1-(6-амино-5-цианопиримидин-4-иламино)этил)-4-оксо-3-фенил-3,4-дигидропирроло[1,2-f][1,2,4]триазин-5-карбонитрила EA201692435A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14382192 2014-05-27
EP14382401 2014-10-17
EP14382400 2014-10-17
PCT/EP2015/061307 WO2015181052A1 (en) 2014-05-27 2015-05-21 Addition salts of (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile

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EA201692435A1 true EA201692435A1 (ru) 2017-04-28

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EA201692436A EA201692436A1 (ru) 2014-05-27 2015-05-21 Медицинское применение
EA201692437A EA201692437A1 (ru) 2014-05-27 2015-05-21 Комбинация
EA201692435A EA201692435A1 (ru) 2014-05-27 2015-05-21 Соли присоединения (s)-2-(1-(6-амино-5-цианопиримидин-4-иламино)этил)-4-оксо-3-фенил-3,4-дигидропирроло[1,2-f][1,2,4]триазин-5-карбонитрила

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EA201692436A EA201692436A1 (ru) 2014-05-27 2015-05-21 Медицинское применение
EA201692437A EA201692437A1 (ru) 2014-05-27 2015-05-21 Комбинация

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US (3) US20170151264A1 (ru)
EP (3) EP3148999A1 (ru)
JP (3) JP2017516799A (ru)
KR (3) KR20170007760A (ru)
CN (3) CN106414449A (ru)
AU (3) AU2015266191A1 (ru)
BR (1) BR112016024538A2 (ru)
CA (3) CA2941429A1 (ru)
CL (2) CL2016002970A1 (ru)
CR (3) CR20160538A (ru)
EA (3) EA201692436A1 (ru)
IL (3) IL247072A0 (ru)
MA (3) MA39828A (ru)
MD (3) MD20160138A2 (ru)
MX (3) MX2016014864A (ru)
PE (2) PE20170145A1 (ru)
PH (3) PH12016502256A1 (ru)
SG (3) SG11201606763VA (ru)
TW (3) TW201625259A (ru)
UY (3) UY36153A (ru)
WO (3) WO2015181052A1 (ru)

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