PE20170385A1 - Sales de adicion de (s)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-carbonitrilo - Google Patents

Sales de adicion de (s)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-carbonitrilo

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Publication number
PE20170385A1
PE20170385A1 PE2016002230A PE2016002230A PE20170385A1 PE 20170385 A1 PE20170385 A1 PE 20170385A1 PE 2016002230 A PE2016002230 A PE 2016002230A PE 2016002230 A PE2016002230 A PE 2016002230A PE 20170385 A1 PE20170385 A1 PE 20170385A1
Authority
PE
Peru
Prior art keywords
cyanopyrimidin
dihydropyrrolo
carbonitrile
triazine
oxo
Prior art date
Application number
PE2016002230A
Other languages
English (en)
Inventor
Carrera Francesc Carrera
Garcia Juan Bautista Perez
Juan Bernat Vidal
Coma Maria Carme Serra
Izquierdo Francisco Sanchez
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of PE20170385A1 publication Critical patent/PE20170385A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
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    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35—Naphthalene sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se refiere a nuevas sales de adicion, farmaceuticamente aceptables, de (S)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-carbonitrilo con derivados de acido sulfonico en particular con acido metanosulfonico, acido naftaleno-2-sulfonico y acido paratoluenosulfonico, y a los solvatos farmaceuticamente aceptables de las mismas, y su uso como inhibidores de Fosfoinositido 3-quinasa (PI3K)
PE2016002230A 2014-05-27 2015-05-21 Sales de adicion de (s)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-carbonitrilo PE20170385A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14382192 2014-05-27
EP14382401 2014-10-17
EP14382400 2014-10-17

Publications (1)

Publication Number Publication Date
PE20170385A1 true PE20170385A1 (es) 2017-04-09

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ID=53269467

Family Applications (2)

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PE2016002230A PE20170385A1 (es) 2014-05-27 2015-05-21 Sales de adicion de (s)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-carbonitrilo
PE2016002228A PE20170145A1 (es) 2014-05-27 2015-05-21 Combinacion

Family Applications After (1)

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PE2016002228A PE20170145A1 (es) 2014-05-27 2015-05-21 Combinacion

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US (3) US20170158699A1 (es)
EP (3) EP3148585A1 (es)
JP (3) JP2017516799A (es)
KR (3) KR20170007760A (es)
CN (3) CN107074862A (es)
AU (3) AU2015266191A1 (es)
BR (1) BR112016024538A2 (es)
CA (3) CA2941429A1 (es)
CL (2) CL2016002970A1 (es)
CR (3) CR20160537A (es)
EA (3) EA201692436A1 (es)
IL (3) IL247072A0 (es)
MA (3) MA39827A (es)
MD (3) MD20160138A2 (es)
MX (3) MX2016014861A (es)
PE (2) PE20170385A1 (es)
PH (3) PH12016502256A1 (es)
SG (3) SG11201606762PA (es)
TW (3) TW201625258A (es)
UY (3) UY36153A (es)
WO (3) WO2015181055A1 (es)

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JP2014501790A (ja) 2011-01-10 2014-01-23 インフィニティー ファーマシューティカルズ， インコーポレイテッド イソキノリノンの調製方法及びイソキノリノンの固体形態
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
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TWI748941B (zh) 2015-02-27 2021-12-11 美商英塞特公司 Ｐｉ３ｋ抑制劑之鹽及製備方法
KR102483630B1 (ko) 2016-05-18 2023-01-02 토르쿠르 아게 피부 병변의 치료
GB201608797D0 (en) * 2016-05-19 2016-07-06 Ucb Biopharma Sprl Therapeutic use
CN107456454A (zh) * 2016-06-06 2017-12-12 先声药业有限公司 一种预防或治疗炎性疾病的药物组合物
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JP7108631B2 (ja) 2017-01-06 2022-07-28 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物およびその使用方法
GB201708856D0 (en) * 2017-06-02 2017-07-19 Ucb Biopharma Sprl Seletalisib crystalline forms
RU2020115351A (ru) * 2017-11-23 2021-12-23 Пикур Терапьютикс Аг Лечение кожных заболеваний
JP2021530463A (ja) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物および使用方法
US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
CN113440614A (zh) * 2020-03-26 2021-09-28 长沙晶易医药科技有限公司 一种用于治疗类风湿性关节炎的组合物及其应用
KR20230065591A (ko) * 2021-11-05 2023-05-12 연세대학교 산학협력단 피부-특이적 T 세포(skin-specific T cell)의 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물
TW202329976A (zh) * 2021-12-16 2023-08-01 美商英塞特公司 Ｐ１３Ｋ—δ抑制劑之局部調配物
TWI823476B (zh) * 2022-07-15 2023-11-21 中化合成生技股份有限公司 托法替尼檸檬酸鹽的製備方法

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MA39827A (fr) 2015-12-03
TW201625258A (zh) 2016-07-16
SG11201606762PA (en) 2016-09-29
JP2017516798A (ja) 2017-06-22
MD20160132A2 (ro) 2017-05-31
EP3148585A1 (en) 2017-04-05
EA201692436A1 (ru) 2017-04-28
AU2015266191A1 (en) 2016-09-15
BR112016024538A2 (pt) 2017-08-15
UY36153A (es) 2016-01-08
WO2015181055A1 (en) 2015-12-03
MD20160138A2 (ro) 2017-05-31
KR20170010369A (ko) 2017-01-31
KR20170012236A (ko) 2017-02-02
US20170158699A1 (en) 2017-06-08
IL247901A0 (en) 2016-11-30
SG11201606763VA (en) 2016-09-29
MD20160137A2 (ro) 2017-05-31
AU2015266190A1 (en) 2016-10-20
CN107074862A (zh) 2017-08-18
JP2017516799A (ja) 2017-06-22
EP3148999A1 (en) 2017-04-05
EA201692435A1 (ru) 2017-04-28
WO2015181052A1 (en) 2015-12-03
CA2944611A1 (en) 2015-12-03
WO2015181053A1 (en) 2015-12-03
CL2016002970A1 (es) 2017-02-10
TW201625259A (zh) 2016-07-16
UY36152A (es) 2016-01-08
PH12016502252A1 (en) 2017-02-06
CR20160537A (es) 2017-03-17
US20170189409A1 (en) 2017-07-06
UY36151A (es) 2016-01-08
CR20160538A (es) 2017-01-02
PH12016502255A1 (en) 2017-02-06
PH12016502256A1 (en) 2017-02-06
CN106414449A (zh) 2017-02-15
IL247073A0 (en) 2016-09-29
MX2016014861A (es) 2017-04-06
TW201625260A (zh) 2016-07-16
MA39829A (fr) 2015-12-03
EP3148586A1 (en) 2017-04-05
CR20160536A (es) 2017-01-02
AU2015266193A1 (en) 2016-09-15
PE20170145A1 (es) 2017-03-10
CA2941436A1 (en) 2015-12-03
US20170151264A1 (en) 2017-06-01
IL247072A0 (en) 2016-09-29
SG11201607950SA (en) 2016-10-28
EA201692437A1 (ru) 2017-04-28
KR20170007760A (ko) 2017-01-20
MX2016014904A (es) 2017-02-28
MX2016014864A (es) 2017-04-06
CA2941429A1 (en) 2015-12-03
CL2016002971A1 (es) 2017-02-17
CN106456777A (zh) 2017-02-22
JP2017516797A (ja) 2017-06-22
MA39828A (fr) 2015-12-03

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