PE20170385A1 - (S) -2- (1- (6-AMINO-5-CYANOPYRIMIDIN-4-ILAMINE) ETHYL) -4-OXO-3-PHENYL-3,4-DIHYDROPYRROLO [1,2-F] [ 1,2,4] TRIAZINE-5-CARBONITRILE - Google Patents
(S) -2- (1- (6-AMINO-5-CYANOPYRIMIDIN-4-ILAMINE) ETHYL) -4-OXO-3-PHENYL-3,4-DIHYDROPYRROLO [1,2-F] [ 1,2,4] TRIAZINE-5-CARBONITRILEInfo
- Publication number
- PE20170385A1 PE20170385A1 PE2016002230A PE2016002230A PE20170385A1 PE 20170385 A1 PE20170385 A1 PE 20170385A1 PE 2016002230 A PE2016002230 A PE 2016002230A PE 2016002230 A PE2016002230 A PE 2016002230A PE 20170385 A1 PE20170385 A1 PE 20170385A1
- Authority
- PE
- Peru
- Prior art keywords
- cyanopyrimidin
- dihydropyrrolo
- carbonitrile
- triazine
- oxo
- Prior art date
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
- C07C309/35—Naphthalene sulfonic acids
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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Abstract
La presente invencion se refiere a nuevas sales de adicion, farmaceuticamente aceptables, de (S)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-carbonitrilo con derivados de acido sulfonico en particular con acido metanosulfonico, acido naftaleno-2-sulfonico y acido paratoluenosulfonico, y a los solvatos farmaceuticamente aceptables de las mismas, y su uso como inhibidores de Fosfoinositido 3-quinasa (PI3K)The present invention relates to new pharmaceutically acceptable addition salts of (S) -2- (1- (6-amino-5-cyanopyrimidin-4-ylamino) ethyl) -4-oxo-3-phenyl-3, 4-dihydropyrrolo [1,2-f] [1,2,4] triazine-5-carbonitrile with derivatives of sulfonic acid in particular with methanesulfonic acid, naphthalene-2-sulfonic acid and paratoluenesulfonic acid, and to the pharmaceutically acceptable solvates of the themselves, and their use as Phosphoinositide 3-kinase (PI3K) inhibitors
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14382192 | 2014-05-27 | ||
| EP14382400 | 2014-10-17 | ||
| EP14382401 | 2014-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20170385A1 true PE20170385A1 (en) | 2017-04-09 |
Family
ID=53269467
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016002228A PE20170145A1 (en) | 2014-05-27 | 2015-05-21 | COMBINATION |
| PE2016002230A PE20170385A1 (en) | 2014-05-27 | 2015-05-21 | (S) -2- (1- (6-AMINO-5-CYANOPYRIMIDIN-4-ILAMINE) ETHYL) -4-OXO-3-PHENYL-3,4-DIHYDROPYRROLO [1,2-F] [ 1,2,4] TRIAZINE-5-CARBONITRILE |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016002228A PE20170145A1 (en) | 2014-05-27 | 2015-05-21 | COMBINATION |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20170151264A1 (en) |
| EP (3) | EP3148586A1 (en) |
| JP (3) | JP2017516797A (en) |
| KR (3) | KR20170010369A (en) |
| CN (3) | CN107074862A (en) |
| AU (3) | AU2015266191A1 (en) |
| BR (1) | BR112016024538A2 (en) |
| CA (3) | CA2944611A1 (en) |
| CL (2) | CL2016002970A1 (en) |
| CR (3) | CR20160536A (en) |
| EA (3) | EA201692437A1 (en) |
| IL (3) | IL247072A0 (en) |
| MA (3) | MA39828A (en) |
| MD (3) | MD20160138A2 (en) |
| MX (3) | MX2016014864A (en) |
| PE (2) | PE20170145A1 (en) |
| PH (3) | PH12016502255A1 (en) |
| SG (3) | SG11201606762PA (en) |
| TW (3) | TW201625259A (en) |
| UY (3) | UY36151A (en) |
| WO (3) | WO2015181055A1 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| NZ613219A (en) | 2008-01-04 | 2014-11-28 | Intellikine Llc | Heterocyclic containing entities, compositions and methods |
| UA115767C2 (en) | 2011-01-10 | 2017-12-26 | Інфініті Фармасьютікалз, Інк. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| AU2014209141B2 (en) | 2013-01-24 | 2018-05-10 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mTOR inhibitors |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| US10993947B2 (en) | 2016-05-18 | 2021-05-04 | Torqur | Treatment of skin lesions |
| GB201608797D0 (en) * | 2016-05-19 | 2016-07-06 | Ucb Biopharma Sprl | Therapeutic use |
| CN107456454A (en) * | 2016-06-06 | 2017-12-12 | 先声药业有限公司 | A kind of pharmaceutical composition prevented or treat inflammatory disease |
| KR20190033526A (en) | 2016-06-24 | 2019-03-29 | 인피니티 파마슈티칼스, 인코포레이티드 | Combination therapy |
| AU2018205253B2 (en) | 2017-01-06 | 2022-01-13 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| GB201708856D0 (en) * | 2017-06-02 | 2017-07-19 | Ucb Biopharma Sprl | Seletalisib crystalline forms |
| IL274132B2 (en) * | 2017-11-23 | 2024-02-01 | Piqur Therapeutics Ag | Treatment of skin disorders |
| US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
| CN113440614A (en) * | 2020-03-26 | 2021-09-28 | 长沙晶易医药科技有限公司 | Composition for treating rheumatoid arthritis and application thereof |
| KR20230065591A (en) * | 2021-11-05 | 2023-05-12 | 연세대학교 산학협력단 | A Composition for Preventing or Treating Atopic Dermatitis Comprising an Inhibitor of AKT Signaling Pathway as an Active Ingredient |
| WO2023114369A2 (en) * | 2021-12-16 | 2023-06-22 | Incyte Corporation | Topical formulations of pi3k-delta inhibitors |
| TWI823476B (en) * | 2022-07-15 | 2023-11-21 | 中化合成生技股份有限公司 | Method of preparing tofacitinib citrate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1750715A1 (en) * | 2004-06-04 | 2007-02-14 | Icos Corporation | Methods for treating mast cell disorders |
| NZ565749A (en) * | 2005-08-26 | 2010-12-24 | Serono Lab | Pyrazine derivatives and use as PI3K inhibitors |
| EA019499B1 (en) * | 2009-03-24 | 2014-04-30 | ГИЛИЭД КАЛИСТОГА ЭлЭлСи | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| EP2518070A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
-
2015
- 2015-05-21 MD MDA20160138A patent/MD20160138A2/en not_active Application Discontinuation
- 2015-05-21 US US15/313,737 patent/US20170151264A1/en not_active Abandoned
- 2015-05-21 JP JP2016569768A patent/JP2017516797A/en active Pending
- 2015-05-21 KR KR1020167033156A patent/KR20170010369A/en unknown
- 2015-05-21 MX MX2016014864A patent/MX2016014864A/en unknown
- 2015-05-21 MX MX2016014904A patent/MX2016014904A/en unknown
- 2015-05-21 CA CA2944611A patent/CA2944611A1/en not_active Abandoned
- 2015-05-21 MD MDA20160132A patent/MD20160132A2/en not_active Application Discontinuation
- 2015-05-21 PE PE2016002228A patent/PE20170145A1/en not_active Application Discontinuation
- 2015-05-21 SG SG11201606762PA patent/SG11201606762PA/en unknown
- 2015-05-21 PE PE2016002230A patent/PE20170385A1/en not_active Application Discontinuation
- 2015-05-21 CR CR20160536A patent/CR20160536A/en unknown
- 2015-05-21 AU AU2015266191A patent/AU2015266191A1/en not_active Abandoned
- 2015-05-21 BR BR112016024538A patent/BR112016024538A2/en not_active Application Discontinuation
- 2015-05-21 JP JP2016569769A patent/JP2017516798A/en active Pending
- 2015-05-21 EA EA201692437A patent/EA201692437A1/en unknown
- 2015-05-21 MX MX2016014861A patent/MX2016014861A/en unknown
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