AR100620A1 - ADDITION SALTS OF (S) -2- (1- (6-AMINO-5-CYANOPIRIMIDIN-4-ILAMINO) ETIL) -4-OXO-3-PHENYL-3,4-DIHYDROPIRROLO [1,2-F] [ 1,2,4] TRIAZINE-5-CARBONITRILE - Google Patents

ADDITION SALTS OF (S) -2- (1- (6-AMINO-5-CYANOPIRIMIDIN-4-ILAMINO) ETIL) -4-OXO-3-PHENYL-3,4-DIHYDROPIRROLO [1,2-F] [ 1,2,4] TRIAZINE-5-CARBONITRILE

Info

Publication number
AR100620A1
AR100620A1 ARP150101656A ARP150101656A AR100620A1 AR 100620 A1 AR100620 A1 AR 100620A1 AR P150101656 A ARP150101656 A AR P150101656A AR P150101656 A ARP150101656 A AR P150101656A AR 100620 A1 AR100620 A1 AR 100620A1
Authority
AR
Argentina
Prior art keywords
carbonitrile
triazine
oxo
phenyl
amino
Prior art date
Application number
ARP150101656A
Other languages
Spanish (es)
Inventor
Carme Serra Coma Maria
Sanchez Izquierdo Francisco
Vidal Juan Bernat
Bautista Perez Garcia Juan
Carrera Carrera Francesc
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of AR100620A1 publication Critical patent/AR100620A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Sales de adición, farmacéuticamente aceptables, de (S)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-carbonitrilo con derivados de acido sulfónico, en particular con ácido metanosulfónico, ácido naftaleno-2-sulfónico y ácido para-toluenosulfónico, y a los solvatos farmacéuticamente aceptables de las mismas, y su uso como inhibidores de Fosfoinosítido 3-quinasa (Pl3K).Pharmaceutically acceptable addition salts of (S) -2- (1- (6-amino-5-cyanopyrimidin-4-ylamino) ethyl) -4-oxo-3-phenyl-3,4-dihydropyrrolo [1,2 -f] [1,2,4] triazine-5-carbonitrile with sulfonic acid derivatives, in particular with methanesulfonic acid, naphthalene-2-sulfonic acid and para-toluenesulfonic acid, and to the pharmaceutically acceptable solvates thereof, and their use as phosphinosinoside 3-kinase inhibitors (Pl3K).

ARP150101656A 2014-05-27 2015-05-27 ADDITION SALTS OF (S) -2- (1- (6-AMINO-5-CYANOPIRIMIDIN-4-ILAMINO) ETIL) -4-OXO-3-PHENYL-3,4-DIHYDROPIRROLO [1,2-F] [ 1,2,4] TRIAZINE-5-CARBONITRILE AR100620A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14382192 2014-05-27

Publications (1)

Publication Number Publication Date
AR100620A1 true AR100620A1 (en) 2016-10-19

Family

ID=50828850

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP150101656A AR100620A1 (en) 2014-05-27 2015-05-27 ADDITION SALTS OF (S) -2- (1- (6-AMINO-5-CYANOPIRIMIDIN-4-ILAMINO) ETIL) -4-OXO-3-PHENYL-3,4-DIHYDROPIRROLO [1,2-F] [ 1,2,4] TRIAZINE-5-CARBONITRILE
ARP150101655A AR100619A1 (en) 2014-05-27 2015-05-27 PHARMACEUTICAL COMPOSITION THAT COMBINES 3-QUINASA D PHOSFOINOSITE INHIBITORS AND CORTICOESTEROIDS FOR THE TREATMENT OF IMMUNOAMPOLOUS CUTANEOUS DISEASES

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP150101655A AR100619A1 (en) 2014-05-27 2015-05-27 PHARMACEUTICAL COMPOSITION THAT COMBINES 3-QUINASA D PHOSFOINOSITE INHIBITORS AND CORTICOESTEROIDS FOR THE TREATMENT OF IMMUNOAMPOLOUS CUTANEOUS DISEASES

Country Status (1)

Country Link
AR (2) AR100620A1 (en)

Also Published As

Publication number Publication date
AR100619A1 (en) 2016-10-19

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