MA39827A - Sels d'addition de (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile - Google Patents

Sels d'addition de (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile

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Publication number
MA39827A
MA39827A MA039827A MA39827A MA39827A MA 39827 A MA39827 A MA 39827A MA 039827 A MA039827 A MA 039827A MA 39827 A MA39827 A MA 39827A MA 39827 A MA39827 A MA 39827A
Authority
MA
Morocco
Prior art keywords
cyanopyrimidin
dihydropyrrolo
ylamino
carbonitrile
triazine
Prior art date
Application number
MA039827A
Other languages
English (en)
Inventor
Carrera Francesc Carrera
Garcia Juan Bautista Perez
Izquierdo Francisco Sanchez
Coma Maria Carme Serra
Juan Bernat Vidal
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of MA39827A publication Critical patent/MA39827A/fr

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
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    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
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Abstract

Cette invention concerne de nouveaux sels d'addition pharmaceutiquement acceptables de (s)-2-(1-(6-amino-5-cyano-pyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f] [1,2,4] triazine-5-carbonitrile avec des dérivés d'acide sulfonique, en particulier avec de l'acide méthanesulfonique, de l'acide naphtalène-2-sulfonique et de l'acide para-toluènesulfonique, leurs solvates pharmaceutiquement acceptables, et leur utilisation à titre d'inhibiteurs de phosphoinositide 3-kinase (pi3k).
MA039827A 2014-05-27 2015-05-21 Sels d'addition de (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile MA39827A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14382192 2014-05-27
EP14382400 2014-10-17
EP14382401 2014-10-17

Publications (1)

Publication Number Publication Date
MA39827A true MA39827A (fr) 2015-12-03

Family

ID=53269467

Family Applications (3)

Application Number Title Priority Date Filing Date
MA039829A MA39829A (fr) 2014-05-27 2015-05-21 Combinaison
MA039828A MA39828A (fr) 2014-05-27 2015-05-21 Usage médical
MA039827A MA39827A (fr) 2014-05-27 2015-05-21 Sels d'addition de (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MA039829A MA39829A (fr) 2014-05-27 2015-05-21 Combinaison
MA039828A MA39828A (fr) 2014-05-27 2015-05-21 Usage médical

Country Status (21)

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US (3) US20170151264A1 (fr)
EP (3) EP3148999A1 (fr)
JP (3) JP2017516798A (fr)
KR (3) KR20170012236A (fr)
CN (3) CN106414449A (fr)
AU (3) AU2015266191A1 (fr)
BR (1) BR112016024538A2 (fr)
CA (3) CA2944611A1 (fr)
CL (2) CL2016002970A1 (fr)
CR (3) CR20160536A (fr)
EA (3) EA201692435A1 (fr)
IL (3) IL247072A0 (fr)
MA (3) MA39829A (fr)
MD (3) MD20160137A2 (fr)
MX (3) MX2016014864A (fr)
PE (2) PE20170385A1 (fr)
PH (3) PH12016502255A1 (fr)
SG (3) SG11201606762PA (fr)
TW (3) TW201625259A (fr)
UY (3) UY36153A (fr)
WO (3) WO2015181053A1 (fr)

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EP2240452B1 (fr) 2008-01-04 2019-05-29 Intellikine, LLC Dérivés de 1h-pyrazolo[3,4-d]pyrimidin-4-amine en tant que modulateurs de kinase pi3, leurs compositions et utilisations
NZ612909A (en) 2011-01-10 2015-09-25 Infinity Pharmaceuticals Inc Processes for preparing isoquinolinones and solid forms of isoquinolinones
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
ES2797376T3 (es) 2013-01-24 2020-12-02 Palvella Therapeutics Inc Composiciones para la administración transdérmica de inhibidores de mTOR
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
LT3831833T (lt) 2015-02-27 2023-02-27 Incyte Holdings Corporation Pi3k inhibitoriaus gamybos būdai
US10993947B2 (en) 2016-05-18 2021-05-04 Torqur Treatment of skin lesions
GB201608797D0 (en) * 2016-05-19 2016-07-06 Ucb Biopharma Sprl Therapeutic use
CN107456454A (zh) * 2016-06-06 2017-12-12 先声药业有限公司 一种预防或治疗炎性疾病的药物组合物
SG11201811237WA (en) 2016-06-24 2019-01-30 Infinity Pharmaceuticals Inc Combination therapies
EP3565520A4 (fr) 2017-01-06 2020-08-19 Palvella Therapeutics, Inc. Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
GB201708856D0 (en) * 2017-06-02 2017-07-19 Ucb Biopharma Sprl Seletalisib crystalline forms
RU2020115351A (ru) * 2017-11-23 2021-12-23 Пикур Терапьютикс Аг Лечение кожных заболеваний
JP2021530463A (ja) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物および使用方法
US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
CN113440614A (zh) * 2020-03-26 2021-09-28 长沙晶易医药科技有限公司 一种用于治疗类风湿性关节炎的组合物及其应用
KR20230065591A (ko) * 2021-11-05 2023-05-12 연세대학교 산학협력단 피부-특이적 T 세포(skin-specific T cell)의 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물
WO2023114369A2 (fr) * 2021-12-16 2023-06-22 Incyte Corporation Formulations topiques d'inhibiteurs de pi3k-delta
TWI823476B (zh) * 2022-07-15 2023-11-21 中化合成生技股份有限公司 托法替尼檸檬酸鹽的製備方法

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JP5226513B2 (ja) * 2005-08-26 2013-07-03 メルク セローノ ソシエテ アノニム ピラジン誘導体及びその使用
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EP2518070A1 (fr) * 2011-04-29 2012-10-31 Almirall, S.A. Dérivés de pyrrolotriazinon en tant qu'inhibiteurs PI3K

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PH12016502256A1 (en) 2017-02-06
KR20170010369A (ko) 2017-01-31
UY36152A (es) 2016-01-08
CR20160537A (es) 2017-03-17
MX2016014864A (es) 2017-04-06
SG11201606763VA (en) 2016-09-29
WO2015181052A1 (fr) 2015-12-03
MX2016014861A (es) 2017-04-06
CR20160536A (es) 2017-01-02
TW201625258A (zh) 2016-07-16
MA39829A (fr) 2015-12-03
KR20170012236A (ko) 2017-02-02
BR112016024538A2 (pt) 2017-08-15
EP3148585A1 (fr) 2017-04-05
CL2016002971A1 (es) 2017-02-17
EP3148586A1 (fr) 2017-04-05
JP2017516799A (ja) 2017-06-22
CN106456777A (zh) 2017-02-22
CL2016002970A1 (es) 2017-02-10
MD20160138A2 (ro) 2017-05-31
AU2015266190A1 (en) 2016-10-20
TW201625260A (zh) 2016-07-16
IL247901A0 (en) 2016-11-30
CN107074862A (zh) 2017-08-18
SG11201606762PA (en) 2016-09-29
SG11201607950SA (en) 2016-10-28
IL247072A0 (en) 2016-09-29
WO2015181053A1 (fr) 2015-12-03
JP2017516798A (ja) 2017-06-22
PE20170385A1 (es) 2017-04-09
PE20170145A1 (es) 2017-03-10
EA201692437A1 (ru) 2017-04-28
UY36151A (es) 2016-01-08
JP2017516797A (ja) 2017-06-22
MA39828A (fr) 2015-12-03
PH12016502252A1 (en) 2017-02-06
CA2944611A1 (fr) 2015-12-03
AU2015266191A1 (en) 2016-09-15
EP3148999A1 (fr) 2017-04-05
CA2941429A1 (fr) 2015-12-03
CR20160538A (es) 2017-01-02
CA2941436A1 (fr) 2015-12-03
PH12016502255A1 (en) 2017-02-06
IL247073A0 (en) 2016-09-29
MD20160132A2 (ro) 2017-05-31
EA201692435A1 (ru) 2017-04-28
US20170151264A1 (en) 2017-06-01
CN106414449A (zh) 2017-02-15
EA201692436A1 (ru) 2017-04-28
MD20160137A2 (ro) 2017-05-31
US20170158699A1 (en) 2017-06-08
UY36153A (es) 2016-01-08
KR20170007760A (ko) 2017-01-20
AU2015266193A1 (en) 2016-09-15
WO2015181055A1 (fr) 2015-12-03
MX2016014904A (es) 2017-02-28
TW201625259A (zh) 2016-07-16
US20170189409A1 (en) 2017-07-06

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