EA201370051A1 - Композиция и способ восстановления и регенерации мышц - Google Patents
Композиция и способ восстановления и регенерации мышцInfo
- Publication number
- EA201370051A1 EA201370051A1 EA201370051A EA201370051A EA201370051A1 EA 201370051 A1 EA201370051 A1 EA 201370051A1 EA 201370051 A EA201370051 A EA 201370051A EA 201370051 A EA201370051 A EA 201370051A EA 201370051 A1 EA201370051 A1 EA 201370051A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- muscle
- stem cells
- regeneration
- agonist
- rar
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Настоящее изобретение относится к способам восстановления или регенерации мышц, предусматривающим введение терапевтически эффективных количеств агонистов RAR или стволовых клеток, которые предварительно обработали путем контактирования с агонистом RAR, субъекту в участок мышечного повреждения. Кроме того, настоящее изобретение относится к композициям, содержащим обработанные агонистом RAR стволовые клетки, и способам применения указанных клеток для восстановления или регенерации мышц. Согласно одному варианту осуществления стволовые клетки представляют собой мезенхимальные стволовые клетки. Согласно одному варианту осуществления агонист RAR представляет собой агонист RARγ. Согласно одному варианту осуществления введение агониста RAR начинают в течение периода повышенной передачи сигнала эндогенного ретиноида у субъекта, которая является результатом возникновения поврежденной мышечной ткани.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37899610P | 2010-09-01 | 2010-09-01 | |
PCT/US2011/049905 WO2012030919A2 (en) | 2010-09-01 | 2011-08-31 | Composition and method for muscle repair and regeneration |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201370051A1 true EA201370051A1 (ru) | 2014-03-31 |
EA026251B1 EA026251B1 (ru) | 2017-03-31 |
Family
ID=45773490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201370051A EA026251B1 (ru) | 2010-09-01 | 2011-08-31 | Способ восстановления и регенерации мышц |
Country Status (20)
Country | Link |
---|---|
US (4) | US9789074B2 (ru) |
EP (3) | EP2613776B1 (ru) |
JP (1) | JP5986570B2 (ru) |
CN (2) | CN103200937B (ru) |
AU (1) | AU2011296080B2 (ru) |
BR (1) | BR112013004685B1 (ru) |
CA (1) | CA2809374C (ru) |
CL (1) | CL2013000580A1 (ru) |
CO (1) | CO6680694A2 (ru) |
DK (2) | DK2613776T3 (ru) |
EA (1) | EA026251B1 (ru) |
ES (2) | ES2912593T3 (ru) |
HU (2) | HUE051664T2 (ru) |
IL (1) | IL224973B (ru) |
MX (2) | MX361414B (ru) |
NZ (1) | NZ607547A (ru) |
PL (2) | PL3721880T3 (ru) |
PT (1) | PT2613776T (ru) |
WO (1) | WO2012030919A2 (ru) |
ZA (1) | ZA201301536B (ru) |
Families Citing this family (17)
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EP2613776B1 (en) | 2010-09-01 | 2020-07-29 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
US11963964B2 (en) | 2011-06-16 | 2024-04-23 | President And Fellows Of Harvard College | Small molecules for mouse satellite cell proliferation |
US11026952B2 (en) | 2011-06-16 | 2021-06-08 | President And Fellows Of Harvard College | Small molecules for mouse satellite cell proliferation |
US9782417B2 (en) | 2011-06-16 | 2017-10-10 | Presidents And Fellows Of Harvard College | Methods of increasing satellite cell proliferation with kinase inhibitors |
JP6254529B2 (ja) | 2012-11-08 | 2017-12-27 | 国立大学法人山口大学 | 角結膜障害の治療剤 |
WO2014110177A2 (en) * | 2013-01-09 | 2014-07-17 | International Stem Cell Corporation | Small molecules that promote skin regeneration |
SI3000466T1 (sl) * | 2013-05-22 | 2019-02-28 | Yamaguchi University | Inhibitor za retinohoroidalne motnje |
WO2015188015A1 (en) | 2014-06-04 | 2015-12-10 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
US9784665B1 (en) * | 2014-12-29 | 2017-10-10 | Flagship Biosciences, Inc. | Methods for quantitative assessment of muscle fibers in muscular dystrophy |
JP2018520645A (ja) | 2015-05-06 | 2018-08-02 | ユニヴァーシティ オブ サザン カリフォルニアUniversity of Southern California | 高血圧および脂質障害を処置するための絶食模倣促進食(fasting mimicking and enhancing diet) |
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WO2023241715A1 (zh) * | 2022-06-16 | 2023-12-21 | 中国科学院动物研究所 | 视黄酸受体激活剂及其组合在哺乳动物再生修复中的应用 |
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- 2011-08-31 CN CN201180052926.XA patent/CN103200937B/zh active Active
- 2011-08-31 EP EP22154427.3A patent/EP4066826B1/en active Active
- 2011-08-31 CN CN202010493245.8A patent/CN111773213B/zh active Active
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- 2011-08-31 DK DK20171639.6T patent/DK3721880T3/da active
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- 2013-03-05 CO CO13044010A patent/CO6680694A2/es not_active Application Discontinuation
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