CO6680694A2 - Composición y método para la reparación y regeneración muscular - Google Patents
Composición y método para la reparación y regeneración muscularInfo
- Publication number
- CO6680694A2 CO6680694A2 CO13044010A CO13044010A CO6680694A2 CO 6680694 A2 CO6680694 A2 CO 6680694A2 CO 13044010 A CO13044010 A CO 13044010A CO 13044010 A CO13044010 A CO 13044010A CO 6680694 A2 CO6680694 A2 CO 6680694A2
- Authority
- CO
- Colombia
- Prior art keywords
- rar agonist
- muscle
- regeneration
- repair
- composition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La invención proporciona métodos para la regeneración o reparación muscular que comprenden la administración de una cantidad terapéuticamente efectiva de un agonista de RARs o célula madres que han sido pre-tratadas mediante contacto con un agonista de RARa un sujeto en el sitio de la lesión muscular. De forma adicional, la invención proporciona composiciones que comprenden célula madres tratadas con un agonista de RARy métodos para el uso de dichas células para la regeneración o reparación muscular. En una realización, la célula madres son células madre mesenquimales. En una realización, el agonista de RAR es un agonista de RAR?. En una realización, la administración del agonista de RAR es iniciada durante el periodo de incremento de la señalización del retinoide endógeno en el sujeto, lo que ocurre a partir de la lesión del tejido muscular.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37899610P | 2010-09-01 | 2010-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6680694A2 true CO6680694A2 (es) | 2013-05-31 |
Family
ID=45773490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13044010A CO6680694A2 (es) | 2010-09-01 | 2013-03-05 | Composición y método para la reparación y regeneración muscular |
Country Status (20)
Country | Link |
---|---|
US (5) | US9789074B2 (es) |
EP (3) | EP2613776B1 (es) |
JP (1) | JP5986570B2 (es) |
CN (2) | CN103200937B (es) |
AU (1) | AU2011296080B2 (es) |
BR (1) | BR112013004685B1 (es) |
CA (1) | CA2809374C (es) |
CL (1) | CL2013000580A1 (es) |
CO (1) | CO6680694A2 (es) |
DK (2) | DK2613776T3 (es) |
EA (1) | EA026251B1 (es) |
ES (2) | ES2912593T3 (es) |
HU (2) | HUE059024T2 (es) |
IL (1) | IL224973B (es) |
MX (2) | MX361414B (es) |
NZ (1) | NZ607547A (es) |
PL (2) | PL3721880T3 (es) |
PT (1) | PT2613776T (es) |
WO (1) | WO2012030919A2 (es) |
ZA (1) | ZA201301536B (es) |
Families Citing this family (16)
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EP2613776B1 (en) | 2010-09-01 | 2020-07-29 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
US11963964B2 (en) | 2011-06-16 | 2024-04-23 | President And Fellows Of Harvard College | Small molecules for mouse satellite cell proliferation |
US9782417B2 (en) | 2011-06-16 | 2017-10-10 | Presidents And Fellows Of Harvard College | Methods of increasing satellite cell proliferation with kinase inhibitors |
US11026952B2 (en) | 2011-06-16 | 2021-06-08 | President And Fellows Of Harvard College | Small molecules for mouse satellite cell proliferation |
EP2918290B1 (en) | 2012-11-08 | 2020-09-02 | Yamaguchi University | Therapeutic agent for keratoconjunctive disorders |
JP6509126B2 (ja) * | 2013-01-09 | 2019-05-08 | インターナショナル ステム セル コーポレイション | 皮膚の再生を促進する小分子 |
EP3446690A1 (en) * | 2013-05-22 | 2019-02-27 | Yamaguchi University | Inhibitor for retinochoroidal disorders |
WO2015188015A1 (en) | 2014-06-04 | 2015-12-10 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
US9784665B1 (en) * | 2014-12-29 | 2017-10-10 | Flagship Biosciences, Inc. | Methods for quantitative assessment of muscle fibers in muscular dystrophy |
RU2724525C2 (ru) * | 2015-05-06 | 2020-06-23 | Юниверсити Оф Саутерн Калифорния | Способ лечения повышенных уровней инсулина или глюкозы с использованием гипокалорийного или бескалорийного рациона или рациона, имитирующего воздержание от пищи |
EP3091084A1 (en) * | 2015-05-08 | 2016-11-09 | Université Catholique De Louvain | Methods for assessing the purity of a mesenchymal stem cells preparation |
JP2019507186A (ja) * | 2016-02-01 | 2019-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | マウス衛星細胞の増殖のための小分子 |
EP4249490A3 (en) | 2016-06-08 | 2023-12-13 | Clementia Pharmaceuticals Inc. | Methods for treating heterotopic ossification |
KR20190100187A (ko) | 2016-11-16 | 2019-08-28 | 클레멘티아 파마슈티컬즈, 인크. | 다중 골연골종(mo)을 치료하는 방법 |
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WO2023241717A1 (zh) * | 2022-06-16 | 2023-12-21 | 中国科学院动物研究所 | 促进哺乳动物器官再生修复的物质及其应用 |
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2011
- 2011-08-31 EP EP11822537.4A patent/EP2613776B1/en active Active
- 2011-08-31 PL PL20171639T patent/PL3721880T3/pl unknown
- 2011-08-31 ES ES20171639T patent/ES2912593T3/es active Active
- 2011-08-31 PL PL11822537T patent/PL2613776T3/pl unknown
- 2011-08-31 EA EA201370051A patent/EA026251B1/ru unknown
- 2011-08-31 PT PT118225374T patent/PT2613776T/pt unknown
- 2011-08-31 ES ES11822537T patent/ES2823234T3/es active Active
- 2011-08-31 EP EP22154427.3A patent/EP4066826B1/en active Active
- 2011-08-31 DK DK11822537.4T patent/DK2613776T3/da active
- 2011-08-31 WO PCT/US2011/049905 patent/WO2012030919A2/en active Application Filing
- 2011-08-31 JP JP2013527250A patent/JP5986570B2/ja active Active
- 2011-08-31 DK DK20171639.6T patent/DK3721880T3/da active
- 2011-08-31 EP EP20171639.6A patent/EP3721880B1/en active Active
- 2011-08-31 HU HUE20171639A patent/HUE059024T2/hu unknown
- 2011-08-31 AU AU2011296080A patent/AU2011296080B2/en active Active
- 2011-08-31 NZ NZ607547A patent/NZ607547A/en unknown
- 2011-08-31 CN CN201180052926.XA patent/CN103200937B/zh active Active
- 2011-08-31 CA CA2809374A patent/CA2809374C/en active Active
- 2011-08-31 HU HUE11822537A patent/HUE051664T2/hu unknown
- 2011-08-31 BR BR112013004685-6A patent/BR112013004685B1/pt active IP Right Grant
- 2011-08-31 CN CN202010493245.8A patent/CN111773213B/zh active Active
- 2011-08-31 US US13/819,914 patent/US9789074B2/en active Active
- 2011-08-31 MX MX2013002275A patent/MX361414B/es active IP Right Grant
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- 2013-02-26 MX MX2018015032A patent/MX2018015032A/es unknown
- 2013-02-28 CL CL2013000580A patent/CL2013000580A1/es unknown
- 2013-02-28 IL IL224973A patent/IL224973B/en active IP Right Grant
- 2013-02-28 ZA ZA2013/01536A patent/ZA201301536B/en unknown
- 2013-03-05 CO CO13044010A patent/CO6680694A2/es not_active Application Discontinuation
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2014
- 2014-06-18 US US14/308,570 patent/US9314439B2/en active Active
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2017
- 2017-08-10 US US15/674,357 patent/US10292954B2/en active Active
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2019
- 2019-04-09 US US16/379,178 patent/US11433039B2/en active Active
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2022
- 2022-08-04 US US17/881,207 patent/US20230201146A1/en active Pending
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