MX2018015032A - Composicion y metodo para reparacion y regeneracion muscular. - Google Patents
Composicion y metodo para reparacion y regeneracion muscular.Info
- Publication number
- MX2018015032A MX2018015032A MX2018015032A MX2018015032A MX2018015032A MX 2018015032 A MX2018015032 A MX 2018015032A MX 2018015032 A MX2018015032 A MX 2018015032A MX 2018015032 A MX2018015032 A MX 2018015032A MX 2018015032 A MX2018015032 A MX 2018015032A
- Authority
- MX
- Mexico
- Prior art keywords
- stem cells
- regeneration
- agonist
- rar
- muscle
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La invención proporciona métodos para reparación o regeneración muscular que comprenden administrar cantidades terapéuticamente efectivas de agonistas de RAR o células madre que se pretratan con el contacto con un agonista de RAR a un sujeto en un sitio de daño muscular. Adicionalmente, la invención proporciona composiciones que comprenden células madre tratadas con el agonista de RAR y métodos de uso de las células para reparación o regeneración muscular. En una modalidad, las células madre son células madre mesenquimales. En una modalidad, el agonista de RAR es un agonista de RAR?. En una modalidad, la administración del agonista de RAR se comienza durante un período de señalización retinoide endógena incrementada en el sujeto que resulta de la incurrencia o contracción del tejido muscular dañado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37899610P | 2010-09-01 | 2010-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018015032A true MX2018015032A (es) | 2021-12-08 |
Family
ID=45773490
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013002275A MX361414B (es) | 2010-09-01 | 2011-08-31 | Composición y método para reparación y regeneración muscular. |
MX2018015032A MX2018015032A (es) | 2010-09-01 | 2013-02-26 | Composicion y metodo para reparacion y regeneracion muscular. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013002275A MX361414B (es) | 2010-09-01 | 2011-08-31 | Composición y método para reparación y regeneración muscular. |
Country Status (20)
Country | Link |
---|---|
US (5) | US9789074B2 (es) |
EP (3) | EP2613776B1 (es) |
JP (1) | JP5986570B2 (es) |
CN (2) | CN103200937B (es) |
AU (1) | AU2011296080B2 (es) |
BR (1) | BR112013004685B1 (es) |
CA (1) | CA2809374C (es) |
CL (1) | CL2013000580A1 (es) |
CO (1) | CO6680694A2 (es) |
DK (2) | DK2613776T3 (es) |
EA (1) | EA026251B1 (es) |
ES (2) | ES2912593T3 (es) |
HU (2) | HUE059024T2 (es) |
IL (1) | IL224973B (es) |
MX (2) | MX361414B (es) |
NZ (1) | NZ607547A (es) |
PL (2) | PL3721880T3 (es) |
PT (1) | PT2613776T (es) |
WO (1) | WO2012030919A2 (es) |
ZA (1) | ZA201301536B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2613776B1 (en) | 2010-09-01 | 2020-07-29 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
US11963964B2 (en) | 2011-06-16 | 2024-04-23 | President And Fellows Of Harvard College | Small molecules for mouse satellite cell proliferation |
US9782417B2 (en) | 2011-06-16 | 2017-10-10 | Presidents And Fellows Of Harvard College | Methods of increasing satellite cell proliferation with kinase inhibitors |
US11026952B2 (en) | 2011-06-16 | 2021-06-08 | President And Fellows Of Harvard College | Small molecules for mouse satellite cell proliferation |
EP2918290B1 (en) | 2012-11-08 | 2020-09-02 | Yamaguchi University | Therapeutic agent for keratoconjunctive disorders |
JP6509126B2 (ja) * | 2013-01-09 | 2019-05-08 | インターナショナル ステム セル コーポレイション | 皮膚の再生を促進する小分子 |
EP3446690A1 (en) * | 2013-05-22 | 2019-02-27 | Yamaguchi University | Inhibitor for retinochoroidal disorders |
WO2015188015A1 (en) | 2014-06-04 | 2015-12-10 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
US9784665B1 (en) * | 2014-12-29 | 2017-10-10 | Flagship Biosciences, Inc. | Methods for quantitative assessment of muscle fibers in muscular dystrophy |
RU2724525C2 (ru) * | 2015-05-06 | 2020-06-23 | Юниверсити Оф Саутерн Калифорния | Способ лечения повышенных уровней инсулина или глюкозы с использованием гипокалорийного или бескалорийного рациона или рациона, имитирующего воздержание от пищи |
EP3091084A1 (en) * | 2015-05-08 | 2016-11-09 | Université Catholique De Louvain | Methods for assessing the purity of a mesenchymal stem cells preparation |
JP2019507186A (ja) * | 2016-02-01 | 2019-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | マウス衛星細胞の増殖のための小分子 |
EP4249490A3 (en) | 2016-06-08 | 2023-12-13 | Clementia Pharmaceuticals Inc. | Methods for treating heterotopic ossification |
KR20190100187A (ko) | 2016-11-16 | 2019-08-28 | 클레멘티아 파마슈티컬즈, 인크. | 다중 골연골종(mo)을 치료하는 방법 |
CA3019069A1 (en) * | 2018-04-02 | 2019-10-02 | Hubit Genomix, Inc. | Prophylactic and/or therapeutic drug for diabetic nephropathy |
WO2023241717A1 (zh) * | 2022-06-16 | 2023-12-21 | 中国科学院动物研究所 | 促进哺乳动物器官再生修复的物质及其应用 |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3270960A (en) | 1964-09-11 | 1966-09-06 | Sperry Rand Corp | Fluid sensor |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
JPS60500864A (ja) | 1983-02-04 | 1985-06-06 | ワドリ、テクナラジズ、インコーパレイティド | 近縁関係にあるが別個のタンパク質間に存在する共通決定基に対して特異的なハイブリド−マ抗体の製造および特性づけ |
GB2148299B (en) | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
JPS6253981A (ja) | 1985-09-02 | 1987-03-09 | Koichi Shiyudo | 新規安息香酸誘導体 |
KR0139216B1 (ko) | 1988-04-11 | 1998-05-01 | 제임스 엠. 캐내지 | 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 |
CA2129773C (en) | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
US5408002A (en) | 1993-09-09 | 1995-04-18 | Minnesota Mining And Manufacturing Company | Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both |
US5498795A (en) | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US5807900A (en) | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
US5624957A (en) | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
FR2739557B1 (fr) | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
FR2739777B1 (fr) * | 1995-10-11 | 1997-11-14 | Cird Galderma | Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose |
US5726191A (en) | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
FR2747041B1 (fr) | 1996-04-05 | 1998-05-22 | Cird Galderma | Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies |
US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
CA2288690A1 (en) * | 1997-05-13 | 1998-11-19 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration using human mesenchymal stem cells |
US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
DK1082410T3 (da) | 1998-05-29 | 2007-11-26 | Osiris Therapeutics Inc | Humane CD45 - og/eller fibroblast mesenchymale stamceller |
US6331570B1 (en) | 1998-09-24 | 2001-12-18 | Bristol-Myers Squibb Company | Active enantiomer of RARγ-specific agonist |
JO2178B1 (en) | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of invasive diseases, using selected anti-PAR materials |
US20030114482A1 (en) | 1999-12-15 | 2003-06-19 | Maurizio Pacifici | Use of retinoid receptor antagonists or agonists in the treatment of cartilage and bone pathologies |
US6313168B1 (en) | 1999-12-15 | 2001-11-06 | Allergan Sales, Inc. | Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies |
CA2402413A1 (en) | 2000-03-14 | 2001-09-20 | The University Of Western Ontario | Compositions and methods for affecting osteogenesis |
ATE328067T1 (de) | 2000-04-28 | 2006-06-15 | Childrens Medical Center | Isolierung von mesenchymalen stammzellen und deren verwendung |
ATE413375T1 (de) | 2000-10-02 | 2008-11-15 | Hoffmann La Roche | Retinoide zur behandlung von emphysem |
US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
EP1430024A1 (en) | 2001-09-18 | 2004-06-23 | F. Hoffmann-La Roche Ag | Alkyl urea retinoid agonists i |
CN1301968C (zh) | 2001-09-18 | 2007-02-28 | 霍夫曼-拉罗奇有限公司 | 取代的脲的类维生素a激动剂ⅱ |
AUPR892501A0 (en) * | 2001-11-16 | 2001-12-13 | Peter Maccallum Cancer Institute, The | Method of enhancing self renewal of stem cells and uses thereof |
US7592174B2 (en) | 2002-05-31 | 2009-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Isolation of mesenchymal stem cells |
RU2004138292A (ru) * | 2002-06-04 | 2005-06-10 | Галдерма Ресерч Энд Девелопмент, С.Н.С. (Fr) | Новые лиганды в качестве ингибиторов рецепторов rar, способы их получения и применение в медицине и косметике для человека |
KR20050054907A (ko) * | 2002-07-03 | 2005-06-10 | 폰다지오네 센트로 산 라파엘 델 몬테 테이보 | 조직 손상의 치료 및/또는 조직 회복의 촉진에서hmgb1 단백질의 용도 |
CA2493871A1 (en) | 2002-07-16 | 2004-01-22 | Hadi Aslan | Methods of implanting mesenchymal stem cells for tissue repair and formation |
US20050101581A1 (en) | 2002-08-28 | 2005-05-12 | Reading Christopher L. | Therapeutic treatment methods 2 |
NZ547157A (en) | 2003-12-10 | 2009-07-31 | Medarex Inc | Interferon Alpha Antibodies and their uses |
JP2005206544A (ja) | 2004-01-23 | 2005-08-04 | Yasuyoshi Uchida | 筋肉再生剤 |
AU2005240078A1 (en) * | 2004-04-30 | 2005-11-17 | Allergan, Inc. | Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing |
WO2005115304A2 (en) | 2004-05-24 | 2005-12-08 | Ab Science | Use of c-kit inhibitors for treating fibrodysplasia |
US7345931B2 (en) | 2005-08-01 | 2008-03-18 | Infineon Technologies Ag | Maintaining internal voltages of an integrated circuit in response to a clocked standby mode |
FR2894960B1 (fr) | 2005-12-15 | 2008-02-29 | Galderma Res & Dev | Derives biphenyliques agonistes selectifs du recepteurs rar-gamma |
FR2894959B1 (fr) | 2005-12-15 | 2008-02-29 | Galderma Res & Dev | Derives biphenyliques agonistes selectifs du recepteur rar-gamma |
US20090117203A1 (en) * | 2006-03-23 | 2009-05-07 | Tmrc Co., Ltd. | Kit for cancer treatment and pharmaceutical composition for cancer treatment |
DK2026778T3 (en) | 2006-05-16 | 2019-01-07 | Io Therapeutics Llc | RAR ANTAGONIST OR INVERSE AGONIST FOR USE IN THE TREATMENT OF CHEMOTHERAPY AND / OR RADIATION THERAPY SIDE EFFECTS |
US9119777B2 (en) | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
EP2265603B1 (en) | 2008-03-13 | 2014-05-07 | The General Hospital Corporation | Inhibitors of the bmp signaling pathway |
US8969350B2 (en) | 2008-12-18 | 2015-03-03 | Astrazeneca Ab | Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient |
EP2393915A4 (en) * | 2009-02-05 | 2012-12-26 | Regenertech Pty Ltd | PROCESS FOR THE PREPARATION OF PRECURSOR CELLS FROM DIFFERENTIATED CELLS |
WO2011011513A1 (en) | 2009-07-21 | 2011-01-27 | University Of Washington Through Its Center For Commercialization | Inhibition of pathological bone formation |
UA50725U (ru) * | 2009-12-01 | 2010-06-25 | Институт Нейрохирургии Им. Акад. А.П. Ромоданова Амн Украины | Способ лечения больных с прогрессирующей мышечной дистрофией трансплантацией миобластов эмбриона человека |
EP2613776B1 (en) | 2010-09-01 | 2020-07-29 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
US10485780B2 (en) | 2011-03-14 | 2019-11-26 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the treatment of proliferative disorders |
US9464065B2 (en) | 2011-03-24 | 2016-10-11 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
WO2013006372A1 (en) | 2011-07-01 | 2013-01-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of treating pathologic heterotopic ossification |
KR102092988B1 (ko) | 2012-09-28 | 2020-03-25 | 벤더르빌트 유니버시티 | 선택성 bmp 저해제로써 융합된 헤테로 고리 화합물들 |
JP2016510745A (ja) | 2013-03-04 | 2016-04-11 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | Bmp阻害剤およびその使用方法 |
WO2014160203A2 (en) | 2013-03-14 | 2014-10-02 | The Brigham And Women's Hospital, Inc. | Bmp inhibitors and methods of use thereof |
EP3446690A1 (en) | 2013-05-22 | 2019-02-27 | Yamaguchi University | Inhibitor for retinochoroidal disorders |
US20170305883A1 (en) | 2014-10-01 | 2017-10-26 | The Brigham And Women's Hospital, Inc. | Compositions and Methods for Inhibiting BMP |
WO2017070194A1 (en) | 2015-10-19 | 2017-04-27 | The Children's Medical Center Corporation | Method to inhibit endothelial-to-mesenchymal transition |
JP6589119B2 (ja) | 2015-12-24 | 2019-10-16 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンThe Regents Of The University Of Michigan | 異所性骨化を治療する方法 |
EP4249490A3 (en) | 2016-06-08 | 2023-12-13 | Clementia Pharmaceuticals Inc. | Methods for treating heterotopic ossification |
JP6630255B2 (ja) | 2016-09-30 | 2020-01-15 | 株式会社沖データ | 画像形成装置及び通信システム |
-
2011
- 2011-08-31 EP EP11822537.4A patent/EP2613776B1/en active Active
- 2011-08-31 PL PL20171639T patent/PL3721880T3/pl unknown
- 2011-08-31 ES ES20171639T patent/ES2912593T3/es active Active
- 2011-08-31 PL PL11822537T patent/PL2613776T3/pl unknown
- 2011-08-31 EA EA201370051A patent/EA026251B1/ru unknown
- 2011-08-31 PT PT118225374T patent/PT2613776T/pt unknown
- 2011-08-31 ES ES11822537T patent/ES2823234T3/es active Active
- 2011-08-31 EP EP22154427.3A patent/EP4066826B1/en active Active
- 2011-08-31 DK DK11822537.4T patent/DK2613776T3/da active
- 2011-08-31 WO PCT/US2011/049905 patent/WO2012030919A2/en active Application Filing
- 2011-08-31 JP JP2013527250A patent/JP5986570B2/ja active Active
- 2011-08-31 DK DK20171639.6T patent/DK3721880T3/da active
- 2011-08-31 EP EP20171639.6A patent/EP3721880B1/en active Active
- 2011-08-31 HU HUE20171639A patent/HUE059024T2/hu unknown
- 2011-08-31 AU AU2011296080A patent/AU2011296080B2/en active Active
- 2011-08-31 NZ NZ607547A patent/NZ607547A/en unknown
- 2011-08-31 CN CN201180052926.XA patent/CN103200937B/zh active Active
- 2011-08-31 CA CA2809374A patent/CA2809374C/en active Active
- 2011-08-31 HU HUE11822537A patent/HUE051664T2/hu unknown
- 2011-08-31 BR BR112013004685-6A patent/BR112013004685B1/pt active IP Right Grant
- 2011-08-31 CN CN202010493245.8A patent/CN111773213B/zh active Active
- 2011-08-31 US US13/819,914 patent/US9789074B2/en active Active
- 2011-08-31 MX MX2013002275A patent/MX361414B/es active IP Right Grant
-
2013
- 2013-02-26 MX MX2018015032A patent/MX2018015032A/es unknown
- 2013-02-28 CL CL2013000580A patent/CL2013000580A1/es unknown
- 2013-02-28 IL IL224973A patent/IL224973B/en active IP Right Grant
- 2013-02-28 ZA ZA2013/01536A patent/ZA201301536B/en unknown
- 2013-03-05 CO CO13044010A patent/CO6680694A2/es not_active Application Discontinuation
-
2014
- 2014-06-18 US US14/308,570 patent/US9314439B2/en active Active
-
2017
- 2017-08-10 US US15/674,357 patent/US10292954B2/en active Active
-
2019
- 2019-04-09 US US16/379,178 patent/US11433039B2/en active Active
-
2022
- 2022-08-04 US US17/881,207 patent/US20230201146A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2018015032A (es) | Composicion y metodo para reparacion y regeneracion muscular. | |
ZA202208792B (en) | Methods of treating and preventing graft versus host disease | |
EA201291309A1 (ru) | ПРИМЕНЕНИЕ sGC СТИМУЛЯТОРОВ, sGC АКТИВАТОРОВ, ОДНИХ И В КОМБИНАЦИИ С PDE5 ИНГИБИТОРАМИ, ДЛЯ ЛЕЧЕНИЯ СИСТЕМНОГО СКЛЕРОЗА (SSc) | |
EA201491008A1 (ru) | Комбинация антагониста crth2 и ингибитора протонного насоса для лечения эозинофильного эзофагита | |
MX2021008610A (es) | Tratamiento del cancer usando combinaciones de inhibidores de erk y raf. | |
NI201600051A (es) | Combinaciones de inhibidores de histona desacetilasa y farmacos inmunomoduladores | |
MX2017000307A (es) | Tratamiento de leucemia con inhibidores de histona deacetilasa. | |
WO2019006005A3 (en) | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MELANOMA | |
MX2015016100A (es) | Inhibidores de criopirina para prevenir y tratar la inflamacion. | |
MX2012001310A (es) | Metodos para proporcionar efectos beneficos en la cavidad bucal. | |
NZ702415A (en) | Methods for treating neutropenia using retinoid agonists | |
MX2013002390A (es) | Tratamiento de infarto de miocardio usando antagonistas de tgf-beta. | |
MX339198B (es) | Composicion y metodo para tratar condiciones de la piel. | |
DOP2013000131A (es) | Composiciones y métodos para tratar el cáncer usando un inhibidor de pi3k y un inhibidor de mek | |
MX2020002741A (es) | Uso de gaboxadol en el tratamiento de narcolepsia. | |
MX2015001488A (es) | Tratamiento de la inflamacion utilizando serelaxina. | |
WO2017087754A3 (en) | Compositions and methods of mechanically inducing tissue regeneration | |
CY1120920T1 (el) | Συνθεσεις υψηλης δοσης βουπρενορφινης και χρηση ως αναλγητικο | |
MX2016016039A (es) | Formulacion farmaceutica para reducir la frecuencia de micción y método para su utilización.. | |
MX2018007964A (es) | Metodos de uso de inhibidores de caspasas en el tratamiento de la enfermedad hepatica. | |
EA201071350A1 (ru) | Композиции и способы для лечения воспаления роговицы | |
MX2017015297A (es) | Metodos para reducir o prevenir daño a la intima provocado por estimulacion mecanica de celulas endoteliales. | |
AR097287A1 (es) | Modulador de los receptores de somatostatina para tratar la infertilidad | |
BR112017012134A2 (pt) | prevenção e tratamento de condições inflamatórias | |
MX2017003878A (es) | Formulacion farmaceutica para reducir contracciones de la vejiga y metodo para utilizar la misma. |