MX2017015297A - Metodos para reducir o prevenir daño a la intima provocado por estimulacion mecanica de celulas endoteliales. - Google Patents

Metodos para reducir o prevenir daño a la intima provocado por estimulacion mecanica de celulas endoteliales.

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Publication number
MX2017015297A
MX2017015297A MX2017015297A MX2017015297A MX2017015297A MX 2017015297 A MX2017015297 A MX 2017015297A MX 2017015297 A MX2017015297 A MX 2017015297A MX 2017015297 A MX2017015297 A MX 2017015297A MX 2017015297 A MX2017015297 A MX 2017015297A
Authority
MX
Mexico
Prior art keywords
mechanical stimulation
endothelial cells
damage caused
methods
reducing
Prior art date
Application number
MX2017015297A
Other languages
English (en)
Inventor
Jacobson Sven
Marc Simard J
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Publication of MX2017015297A publication Critical patent/MX2017015297A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/104—Balloon catheters used for angioplasty
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Modalidades de la descripción abarcan métodos y/o composiciones para mejorar o prevenir daño a la íntima provocado por estimulación mecánica de células endoteliales. El daño puede ser provocado mediante el uso de un dispositivo dentro de una arteria, vena o capilar de un individuo, tal como para remover un trombo, un émbolo o una placa aterosclerótica en el vaso. Modalidades de tratamiento y prevención conciernen a cantidades terapéuticamente efectivas de uno o más antagonistas del canal SUR1 - TRPM4 que es sobrerregulado sobre la estimulación mecánica.
MX2017015297A 2015-05-29 2016-05-25 Metodos para reducir o prevenir daño a la intima provocado por estimulacion mecanica de celulas endoteliales. MX2017015297A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562168589P 2015-05-29 2015-05-29
PCT/US2016/034066 WO2016196113A1 (en) 2015-05-29 2016-05-25 Methods of reducing or preventing intimal damage caused by mechanical stimulation of endothelial cells

Publications (1)

Publication Number Publication Date
MX2017015297A true MX2017015297A (es) 2018-06-19

Family

ID=57441652

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017015297A MX2017015297A (es) 2015-05-29 2016-05-25 Metodos para reducir o prevenir daño a la intima provocado por estimulacion mecanica de celulas endoteliales.

Country Status (14)

Country Link
US (1) US10900040B2 (es)
EP (1) EP3302514B1 (es)
JP (2) JP6973752B2 (es)
KR (1) KR102618123B1 (es)
CN (1) CN108348567B (es)
AU (1) AU2016271576B2 (es)
CA (1) CA2988417C (es)
EA (1) EA038398B1 (es)
ES (1) ES2927482T3 (es)
HK (1) HK1252532A1 (es)
IL (1) IL255875A (es)
MA (1) MA45307A (es)
MX (1) MX2017015297A (es)
WO (1) WO2016196113A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX363473B (es) 2012-05-08 2019-03-25 Aeromics Inc Uso de fenilbenzamidas para tratar condiciones mediadas por acuaporina.
US20160279155A1 (en) 2013-11-06 2016-09-29 Aeromics, Inc. Novel formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057651A1 (en) * 1997-06-18 1998-12-23 Discovery Therapeutics, Inc. Compositions and methods for preventing restenosis following revascularization procedures
WO2006036278A2 (en) * 2004-09-18 2006-04-06 University Of Maryland, Baltimore THERAPEUTIC AGENTS TARGETING THE NCCa-ATP CHANNEL AND METHODS OF USE THEREOF
EP2114160B1 (en) * 2007-02-09 2016-11-16 University of Maryland, Baltimore Antagonists of a non-selective cation channel in neural cells
US8557867B2 (en) * 2007-06-22 2013-10-15 The United States Of America As Represented By The Department Of Veterans Affairs Inhibitors of NCCa-ATP channels for therapy
WO2009073711A1 (en) 2007-12-04 2009-06-11 Remedy Pharmaceuticals, Inc. Improved formulations and methods for lyophilization and lyophilates provided thereby
KR20220000943A (ko) 2010-07-19 2022-01-04 바이오젠 체사피크 엘엘씨 글리부리드 및 다른 약물의 정맥내 투여를 위한 방법

Also Published As

Publication number Publication date
JP2018516981A (ja) 2018-06-28
US20180155727A1 (en) 2018-06-07
AU2016271576A1 (en) 2018-01-04
CN108348567B (zh) 2022-03-01
CN108348567A (zh) 2018-07-31
US10900040B2 (en) 2021-01-26
CA2988417C (en) 2022-10-11
EA038398B1 (ru) 2021-08-23
EA201792569A1 (ru) 2018-04-30
MA45307A (fr) 2018-04-11
JP2021167335A (ja) 2021-10-21
IL255875A (en) 2018-01-31
EP3302514B1 (en) 2022-07-06
EP3302514A4 (en) 2019-04-24
KR102618123B1 (ko) 2023-12-27
AU2016271576B2 (en) 2021-10-07
EP3302514A1 (en) 2018-04-11
KR20180035741A (ko) 2018-04-06
ES2927482T3 (es) 2022-11-07
HK1252532A1 (zh) 2019-05-31
JP6973752B2 (ja) 2021-12-01
CA2988417A1 (en) 2016-12-08
WO2016196113A1 (en) 2016-12-08

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