EA201071100A1 - Пиридилсодержащие ингибиторы передачи сигнала через белок hedgehog - Google Patents

Пиридилсодержащие ингибиторы передачи сигнала через белок hedgehog

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Publication number
EA201071100A1
EA201071100A1 EA201071100A EA201071100A EA201071100A1 EA 201071100 A1 EA201071100 A1 EA 201071100A1 EA 201071100 A EA201071100 A EA 201071100A EA 201071100 A EA201071100 A EA 201071100A EA 201071100 A1 EA201071100 A1 EA 201071100A1
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EA
Eurasian Patent Office
Prior art keywords
signal transmission
inhibitors
hedgehog
pyridyl
containing signal
Prior art date
Application number
EA201071100A
Other languages
English (en)
Other versions
EA020192B1 (ru
Inventor
Джанет Л. Гунцнер
Даниэл П. Сатерлин
Марк С. Стэнли
Лян Бао
Джорджетт Кастанедо
Ребекка Л. Лалонд
Шумэй Ван
Марк И. Рейнолдс
Скотт Дж. Сэвидж
Кимберли Малески
Майкл С. Дайна
Original Assignee
Дженентек, Инк.
Кьюрис, Инк.
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41162633&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201071100(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дженентек, Инк., Кьюрис, Инк. filed Critical Дженентек, Инк.
Publication of EA201071100A1 publication Critical patent/EA201071100A1/ru
Publication of EA020192B1 publication Critical patent/EA020192B1/ru

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07F9/58—Pyridine rings

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  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Согласно настоящему изобретению предложены новые ингибиторы передачи сигнала с участием белка hedgehog, которые можно применять в качестве терапевтического агента для лечения злокачественных новообразований, причем указанные соединения имеют общую формулу (I)где А, X, Y, R, R, R, R, m и n определены в настоящем описании.
EA201071100A 2008-04-11 2009-04-10 Пиридилсодержащие ингибиторы передачи сигнала через белок hedgehog EA020192B1 (ru)

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PCT/US2009/040165 WO2009126863A2 (en) 2008-04-11 2009-04-10 Pyridyl inhibitors of hedgehog signalling

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