EA201070123A1 - Устройство доставки в кожу с изолирующим слоем in situ - Google Patents

Устройство доставки в кожу с изолирующим слоем in situ

Info

Publication number
EA201070123A1
EA201070123A1 EA201070123A EA201070123A EA201070123A1 EA 201070123 A1 EA201070123 A1 EA 201070123A1 EA 201070123 A EA201070123 A EA 201070123A EA 201070123 A EA201070123 A EA 201070123A EA 201070123 A1 EA201070123 A1 EA 201070123A1
Authority
EA
Eurasian Patent Office
Prior art keywords
layer
perimeter
contact
skin
volatile component
Prior art date
Application number
EA201070123A
Other languages
English (en)
Other versions
EA020208B1 (ru
Inventor
Агис Кидоньеус
Роберт Г. Конвей
Томас М. Росси
Original Assignee
Эджайл Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эджайл Терапьютикс, Инк. filed Critical Эджайл Терапьютикс, Инк.
Publication of EA201070123A1 publication Critical patent/EA201070123A1/ru
Publication of EA020208B1 publication Critical patent/EA020208B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00544—Plasters form or structure
    • A61F2013/00646—Medication patches, e.g. transcutaneous

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Данное изобретение относится к трансдермальному устройству доставки лекарственных средств, которое содержит слой активного ингредиента (AI) , имеющий контактирующую с кожей поверхность и не контактирующую с кожей поверхность и содержащий летучий компонент, антиадгезионный материал, не проницаемый для летучего компонента, примыкающий к контактирующей с кожей поверхности слоя AI, имеющий периметр, который простирается за пределы периметра слоя AI во всех направлениях, и верхний слой, содержащий склеивающий при надавливании клей (PSA), который не поглощает летучий компонент, примыкающий к не контактирующей с кожей поверхности слоя AI, периметр которого простирается за пределы периметра слоя AI во всех направлениях, где антиадгезионный материал и PSA верхнего слоя находятся в контакте с и приклеены друг к другу по периметру слоя AI, чтобы образовать изолирующий слой, который уменьшает или предотвращает потерю летучего компонента.
EA201070123A 2007-07-10 2008-07-10 Устройство доставки в кожу с изолирующим слоем in situ EA020208B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94875707P 2007-07-10 2007-07-10
PCT/US2008/069618 WO2009009649A1 (en) 2007-07-10 2008-07-10 Dermal delivery device with in situ seal

Publications (2)

Publication Number Publication Date
EA201070123A1 true EA201070123A1 (ru) 2010-06-30
EA020208B1 EA020208B1 (ru) 2014-09-30

Family

ID=40229053

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070123A EA020208B1 (ru) 2007-07-10 2008-07-10 Устройство доставки в кожу с изолирующим слоем in situ

Country Status (13)

Country Link
US (3) US8246978B2 (ru)
EP (1) EP2167002B1 (ru)
JP (2) JP5603235B2 (ru)
CN (1) CN101801321B (ru)
AU (1) AU2008275101B2 (ru)
BR (1) BRPI0814697B8 (ru)
CA (1) CA2692884C (ru)
EA (1) EA020208B1 (ru)
ES (1) ES2581652T3 (ru)
GE (1) GEP20125717B (ru)
HK (1) HK1142798A1 (ru)
NZ (1) NZ582565A (ru)
WO (1) WO2009009649A1 (ru)

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JP2010533199A (ja) 2010-10-21
WO2009009649A1 (en) 2009-01-15
US20130018337A1 (en) 2013-01-17
CA2692884C (en) 2016-09-20
JP6072725B2 (ja) 2017-02-01
US20100255072A1 (en) 2010-10-07
US8246978B2 (en) 2012-08-21
CA2692884A1 (en) 2009-01-15
US20140350493A1 (en) 2014-11-27
NZ582565A (en) 2012-07-27
BRPI0814697B8 (pt) 2021-05-25
EP2167002A4 (en) 2012-11-28
CN101801321A (zh) 2010-08-11
CN101801321B (zh) 2014-07-02
JP2014159468A (ja) 2014-09-04
GEP20125717B (en) 2012-12-25
ES2581652T3 (es) 2016-09-06
US8747888B2 (en) 2014-06-10
BRPI0814697A2 (pt) 2017-06-06
AU2008275101A1 (en) 2009-01-15
JP5603235B2 (ja) 2014-10-08
BRPI0814697B1 (pt) 2020-11-17
HK1142798A1 (zh) 2010-12-17
AU2008275101B2 (en) 2014-08-21
EA020208B1 (ru) 2014-09-30
EP2167002B1 (en) 2016-04-20
EP2167002A1 (en) 2010-03-31

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