EA200970387A1 - Соль п-толуолсульфокислоты 5-амино-3-(2`-о-ацетил-3`-дезокси-бета-d-рибофуранозил)-3н-тиазоло[4,5-d]пиримидин-2-она и способы получения - Google Patents
Соль п-толуолсульфокислоты 5-амино-3-(2`-о-ацетил-3`-дезокси-бета-d-рибофуранозил)-3н-тиазоло[4,5-d]пиримидин-2-она и способы полученияInfo
- Publication number
- EA200970387A1 EA200970387A1 EA200970387A EA200970387A EA200970387A1 EA 200970387 A1 EA200970387 A1 EA 200970387A1 EA 200970387 A EA200970387 A EA 200970387A EA 200970387 A EA200970387 A EA 200970387A EA 200970387 A1 EA200970387 A1 EA 200970387A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- deoxy
- acetyl
- beta
- amino
- salt
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к соли п-толуолсульфокислоты 5-амино-3-(2'-О-ацетил-3'-дезокси-бета-D-рибофуранозил)-3Н-тиазоло[4,5-d]пиримидин-2-она и ее применению при лечении состояний, таких как вирусные инфекции, опухоли и злокачественные заболевания. Также раскрывается способ получения соли п-толуолсульфокислоты 5-амино-3-(2'-О-ацетил-3'-дезокси-бета-D-рибофуранозил)-3Н-тиазоло[4,5-d]пиримидин-2-она и способы получения производных фуранозы, которые являются пригодными промежуточными соединениями при получении фармацевтических соединений, таких как соль п-толуолсульфокислоты 5-амино-3-(2'-О-ацетил-3'-дезокси-бета-D-рибофуранозил)-3Н-тиазоло[4,5-d]пиримидин-2-она и тому подобное.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85200206P | 2006-10-17 | 2006-10-17 | |
US89940507P | 2007-02-05 | 2007-02-05 | |
US95359707P | 2007-08-02 | 2007-08-02 | |
PCT/US2007/081526 WO2008140549A1 (en) | 2006-10-17 | 2007-10-16 | P-TOLUENE SULFONIC ACID SALT OF 5-AMINO-3-(2'-O-ACETYL-3'-DEOXY-β-D-RIBOFURANOSYL)-3H-THIAZOLE [4, 5-D] PYRIMIDINE-2-ONE AND METHODS FOR PREPARATION |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970387A1 true EA200970387A1 (ru) | 2009-10-30 |
EA017005B1 EA017005B1 (ru) | 2012-09-28 |
Family
ID=39472747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970387A EA017005B1 (ru) | 2006-10-17 | 2007-10-16 | СОЛЬ П-ТОЛУОЛСУЛЬФОКИСЛОТЫ 5-АМИНО-3-(2'-О-АЦЕТИЛ-3'-ДЕЗОКСИ-β-D-РИБОФУРАНОЗИЛ)-3Н-ТИАЗОЛО[4,5-d]ПИРИМИДИН-2-ОНА И СПОСОБЫ ПОЛУЧЕНИЯ |
Country Status (25)
Country | Link |
---|---|
US (2) | US7928085B2 (ru) |
EP (1) | EP2076132B1 (ru) |
JP (2) | JP5279715B2 (ru) |
KR (2) | KR101486444B1 (ru) |
AR (1) | AR063484A1 (ru) |
AU (1) | AU2007353381B2 (ru) |
BR (1) | BRPI0717741A2 (ru) |
CA (2) | CA2898225A1 (ru) |
CY (1) | CY1113368T1 (ru) |
DK (1) | DK2076132T3 (ru) |
DO (1) | DOP2007000131A (ru) |
EA (1) | EA017005B1 (ru) |
ES (1) | ES2390930T3 (ru) |
HK (1) | HK1132429A1 (ru) |
IL (2) | IL198180A (ru) |
MX (1) | MX2009004028A (ru) |
MY (1) | MY150408A (ru) |
NO (1) | NO20091598L (ru) |
NZ (1) | NZ576408A (ru) |
PE (1) | PE20081105A1 (ru) |
PL (1) | PL2076132T3 (ru) |
PT (1) | PT2076132E (ru) |
TW (1) | TWI415854B (ru) |
UY (1) | UY30650A1 (ru) |
WO (1) | WO2008140549A1 (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101461604B1 (ko) | 2006-06-22 | 2014-11-18 | 애나디스 파마슈티칼스, 인코포레이티드 | 5-아미노-3-(3''-데옥시-β-D-리보퓨라노실)-티아졸로[4,5-d]파이리미딘-2,7-다이온의 프로드럭 |
US20110166092A1 (en) * | 2007-08-20 | 2011-07-07 | Anadys Pharmaceuticals, Inc. | Dosing methods for treating disease |
CA2963717C (en) | 2014-12-08 | 2023-10-10 | F. Hoffmann-La Roche Ag | 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection |
US9676793B2 (en) | 2014-12-23 | 2017-06-13 | Hoffmann-Laroche Inc. | Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same |
WO2016146598A1 (en) | 2015-03-16 | 2016-09-22 | F. Hoffmann-La Roche Ag | Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor |
WO2016180691A1 (en) | 2015-05-08 | 2016-11-17 | F. Hoffmann-La Roche Ag | Novel oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection |
WO2016180743A1 (en) | 2015-05-12 | 2016-11-17 | F. Hoffmann-La Roche Ag | Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection |
WO2017001307A1 (en) | 2015-06-30 | 2017-01-05 | F. Hoffmann-La Roche Ag | Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection |
CA3048768A1 (en) * | 2017-01-06 | 2018-07-12 | F. Hoffmann-La Roche Ag | Process for the preparation of 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds |
CN110007010A (zh) * | 2018-01-05 | 2019-07-12 | 大鹏药品工业株式会社 | 源自曲氟尿苷的类似物质的检测方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH07224081A (ja) * | 1994-02-10 | 1995-08-22 | Kobayashi Koryo Kk | デオキシリボフラノシルハライド誘導体の製造方法 |
US5532374A (en) | 1995-06-06 | 1996-07-02 | Hitachi Chemical Company, Ltd. | Method of preparation of bis-quinolines |
JP4067226B2 (ja) * | 1999-04-01 | 2008-03-26 | 三井化学株式会社 | 1―ハロゲノ−2−デオキシリボフラノース誘導体の製造方法 |
JP2000327693A (ja) * | 1999-05-21 | 2000-11-28 | Mitsui Chemicals Inc | 2’−デオキシ−β−シチジン誘導体の製造方法 |
US6649761B2 (en) * | 2001-05-30 | 2003-11-18 | Merck & Co., Inc. | Process for preparing piperazinepentaneamide HIV protease inhibitors |
BR0214407A (pt) * | 2001-11-27 | 2004-10-19 | Anadys Pharmaceuticals Inc | Compostos, composições farmacêuticas e método de modulação das imunoatividades da citocina |
EP1575953A1 (en) * | 2002-12-09 | 2005-09-21 | Texcontor Etablissement | Anhydrous crystalline form of valacyclovir hydrochloride |
ATE465742T1 (de) * | 2003-09-05 | 2010-05-15 | Anadys Pharmaceuticals Inc | Tlr7-liganden zur behandlung von hepatitis c |
US20080070852A1 (en) * | 2004-06-07 | 2008-03-20 | Averett Devron R | 3-Beta-D-Ribofuranosylthiazolo[ 4,5-D] Pyridimine Nucleosides and Uses Thereof |
DK1824482T3 (en) * | 2004-12-17 | 2014-03-24 | Anadys Pharmaceuticals Inc | AND 3,5-disubstituted 3,5,7-trisubstituted-3H-oxazolo AND 3H-thiazolo [4,5-d] pyrimidin-2-one compounds and prodrugs thereof |
US7501526B2 (en) * | 2005-01-20 | 2009-03-10 | Taigen Biotechnology | Synthesis of polyamine compounds |
KR101461604B1 (ko) * | 2006-06-22 | 2014-11-18 | 애나디스 파마슈티칼스, 인코포레이티드 | 5-아미노-3-(3''-데옥시-β-D-리보퓨라노실)-티아졸로[4,5-d]파이리미딘-2,7-다이온의 프로드럭 |
CN101595117B (zh) * | 2006-12-08 | 2014-01-22 | 株式会社Api | 呋喃糖衍生物的制造方法 |
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2007
- 2007-10-06 BR BRPI0717741-0A2A patent/BRPI0717741A2/pt not_active Application Discontinuation
- 2007-10-16 KR KR1020097010038A patent/KR101486444B1/ko active IP Right Grant
- 2007-10-16 TW TW096138583A patent/TWI415854B/zh not_active IP Right Cessation
- 2007-10-16 WO PCT/US2007/081526 patent/WO2008140549A1/en active Application Filing
- 2007-10-16 EA EA200970387A patent/EA017005B1/ru not_active IP Right Cessation
- 2007-10-16 MY MYPI20091559 patent/MY150408A/en unknown
- 2007-10-16 US US11/873,202 patent/US7928085B2/en not_active Expired - Fee Related
- 2007-10-16 MX MX2009004028A patent/MX2009004028A/es active IP Right Grant
- 2007-10-16 DK DK07873546.1T patent/DK2076132T3/da active
- 2007-10-16 CA CA2898225A patent/CA2898225A1/en not_active Abandoned
- 2007-10-16 ES ES07873546T patent/ES2390930T3/es active Active
- 2007-10-16 PT PT07873546T patent/PT2076132E/pt unknown
- 2007-10-16 JP JP2009533481A patent/JP5279715B2/ja not_active Expired - Fee Related
- 2007-10-16 KR KR1020147026217A patent/KR101515077B1/ko active IP Right Grant
- 2007-10-16 PL PL07873546T patent/PL2076132T3/pl unknown
- 2007-10-16 PE PE2007001399A patent/PE20081105A1/es not_active Application Discontinuation
- 2007-10-16 NZ NZ576408A patent/NZ576408A/en not_active IP Right Cessation
- 2007-10-16 CA CA2666537A patent/CA2666537C/en not_active Expired - Fee Related
- 2007-10-16 AU AU2007353381A patent/AU2007353381B2/en not_active Ceased
- 2007-10-16 EP EP07873546A patent/EP2076132B1/en not_active Not-in-force
- 2007-10-17 DO DO2007000131A patent/DOP2007000131A/es unknown
- 2007-10-17 UY UY30650A patent/UY30650A1/es not_active Application Discontinuation
- 2007-10-17 AR ARP070104611A patent/AR063484A1/es unknown
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2009
- 2009-04-16 IL IL198180A patent/IL198180A/en active IP Right Grant
- 2009-04-22 NO NO20091598A patent/NO20091598L/no not_active Application Discontinuation
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2010
- 2010-01-05 HK HK10100028.4A patent/HK1132429A1/xx not_active IP Right Cessation
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2011
- 2011-03-23 US US13/069,426 patent/US8193342B2/en active Active
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2012
- 2012-09-28 CY CY20121100897T patent/CY1113368T1/el unknown
- 2012-11-19 IL IL223126A patent/IL223126A/en active IP Right Grant
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2013
- 2013-05-21 JP JP2013107302A patent/JP5703334B2/ja not_active Expired - Fee Related
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