DK2076132T3 - P-toluensulfonsyresalt af 5-amino-3-(2´-o-acetyl-3´desoxy-beta-d-ribofuranosyl)-3h-thiazol[4,5-d]pyrimidin-2-on og fremgangsmåder til fremstilling deraf - Google Patents

P-toluensulfonsyresalt af 5-amino-3-(2´-o-acetyl-3´desoxy-beta-d-ribofuranosyl)-3h-thiazol[4,5-d]pyrimidin-2-on og fremgangsmåder til fremstilling deraf

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Publication number
DK2076132T3
DK2076132T3 DK07873546.1T DK07873546T DK2076132T3 DK 2076132 T3 DK2076132 T3 DK 2076132T3 DK 07873546 T DK07873546 T DK 07873546T DK 2076132 T3 DK2076132 T3 DK 2076132T3
Authority
DK
Denmark
Prior art keywords
desoxy
ribofuranosyl
pyrimidin
thiazole
acetyl
Prior art date
Application number
DK07873546.1T
Other languages
English (en)
Inventor
David Kucera
Gregory J Haley
Erik J Rueden
Tingman Wang
Martin Viertelhaus
Fritz Blatter
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2076132T3 publication Critical patent/DK2076132T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK07873546.1T 2006-10-17 2007-10-16 P-toluensulfonsyresalt af 5-amino-3-(2´-o-acetyl-3´desoxy-beta-d-ribofuranosyl)-3h-thiazol[4,5-d]pyrimidin-2-on og fremgangsmåder til fremstilling deraf DK2076132T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85200206P 2006-10-17 2006-10-17
US89940507P 2007-02-05 2007-02-05
US95359707P 2007-08-02 2007-08-02
PCT/US2007/081526 WO2008140549A1 (en) 2006-10-17 2007-10-16 P-TOLUENE SULFONIC ACID SALT OF 5-AMINO-3-(2'-O-ACETYL-3'-DEOXY-β-D-RIBOFURANOSYL)-3H-THIAZOLE [4, 5-D] PYRIMIDINE-2-ONE AND METHODS FOR PREPARATION

Publications (1)

Publication Number Publication Date
DK2076132T3 true DK2076132T3 (da) 2012-09-10

Family

ID=39472747

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07873546.1T DK2076132T3 (da) 2006-10-17 2007-10-16 P-toluensulfonsyresalt af 5-amino-3-(2´-o-acetyl-3´desoxy-beta-d-ribofuranosyl)-3h-thiazol[4,5-d]pyrimidin-2-on og fremgangsmåder til fremstilling deraf

Country Status (25)

Country Link
US (2) US7928085B2 (da)
EP (1) EP2076132B1 (da)
JP (2) JP5279715B2 (da)
KR (2) KR101515077B1 (da)
AR (1) AR063484A1 (da)
AU (1) AU2007353381B2 (da)
BR (1) BRPI0717741A2 (da)
CA (2) CA2666537C (da)
CY (1) CY1113368T1 (da)
DK (1) DK2076132T3 (da)
DO (1) DOP2007000131A (da)
EA (1) EA017005B1 (da)
ES (1) ES2390930T3 (da)
HK (1) HK1132429A1 (da)
IL (2) IL198180A (da)
MX (1) MX2009004028A (da)
MY (1) MY150408A (da)
NO (1) NO20091598L (da)
NZ (1) NZ576408A (da)
PE (1) PE20081105A1 (da)
PL (1) PL2076132T3 (da)
PT (1) PT2076132E (da)
TW (1) TWI415854B (da)
UY (1) UY30650A1 (da)
WO (1) WO2008140549A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101461604B1 (ko) 2006-06-22 2014-11-18 애나디스 파마슈티칼스, 인코포레이티드 5-아미노-3-(3''-데옥시-β-Ｄ-리보퓨라노실)-티아졸로［4,5-ｄ］파이리미딘-2,7-다이온의 프로드럭
WO2009026292A1 (en) * 2007-08-20 2009-02-26 Anadys Pharmaceuticals, Inc. Dosing methods for treating disease
MX2017007044A (es) 2014-12-08 2017-11-08 Hoffmann La Roche Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales.
US9676793B2 (en) 2014-12-23 2017-06-13 Hoffmann-Laroche Inc. Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
KR20170113658A (ko) 2015-03-16 2017-10-12 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료
EP3294745B1 (en) 2015-05-08 2020-01-01 H. Hoffnabb-La Roche Ag Novel oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection
WO2016180743A1 (en) 2015-05-12 2016-11-17 F. Hoffmann-La Roche Ag Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
JP6839104B2 (ja) 2015-06-30 2021-03-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ウイルス感染の治療及び予防のための新規な置換アミノチアゾロピリミジンジオン
US11142534B2 (en) 2017-01-06 2021-10-12 Hoffmann-La Roche Inc. Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds
CN110007010A (zh) * 2018-01-05 2019-07-12 大鹏药品工业株式会社 源自曲氟尿苷的类似物质的检测方法

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JPH07224081A (ja) * 1994-02-10 1995-08-22 Kobayashi Koryo Kk デオキシリボフラノシルハライド誘導体の製造方法
US5532374A (en) * 1995-06-06 1996-07-02 Hitachi Chemical Company, Ltd. Method of preparation of bis-quinolines
JP4067226B2 (ja) * 1999-04-01 2008-03-26 三井化学株式会社 １―ハロゲノ−２−デオキシリボフラノース誘導体の製造方法
JP2000327693A (ja) * 1999-05-21 2000-11-28 Mitsui Chemicals Inc ２’−デオキシ−β−シチジン誘導体の製造方法
US6649761B2 (en) * 2001-05-30 2003-11-18 Merck & Co., Inc. Process for preparing piperazinepentaneamide HIV protease inhibitors
ES2333945T3 (es) * 2001-11-27 2010-03-03 Anadys Pharmaceuticals, Inc. Nucleosidos de 3-beta-d-ribofurano-siltiazolo(4,5-delta)pirimidina y usos de los mismos.
WO2004052892A1 (en) 2002-12-09 2004-06-24 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
DE602004026891D1 (de) * 2003-09-05 2010-06-10 Anadys Pharmaceuticals Inc Tlr7-liganden zur behandlung von hepatitis c
ES2399891T3 (es) * 2004-06-07 2013-04-04 Anadys Pharmaceuticals, Inc. Nucleosidos de 3-?-D-ribofuranosiltiazolo[4,5-d]pirimidina y usos de los mismos
JP5303149B2 (ja) * 2004-12-17 2013-10-02 アナディス ファーマシューティカルズ インク ３，５−二置換及び３，５，７−三置換−３Ｈ−オキサゾロ及び３Ｈ−チアゾロ［４，５−ｄ］ピリミジン−２−オン化合物及びそのプロドラッグ
US7501526B2 (en) * 2005-01-20 2009-03-10 Taigen Biotechnology Synthesis of polyamine compounds
KR101461604B1 (ko) * 2006-06-22 2014-11-18 애나디스 파마슈티칼스, 인코포레이티드 5-아미노-3-(3''-데옥시-β-Ｄ-리보퓨라노실)-티아졸로［4,5-ｄ］파이리미딘-2,7-다이온의 프로드럭
JP5550234B2 (ja) * 2006-12-08 2014-07-16 株式会社エーピーアイ コーポレーション フラノース誘導体の製造方法

Also Published As

Publication number Publication date
CA2898225A1 (en) 2008-11-20
IL223126A (en) 2016-08-31
TWI415854B (zh) 2013-11-21
KR20140119203A (ko) 2014-10-08
CA2666537A1 (en) 2008-11-20
JP5279715B2 (ja) 2013-09-04
EP2076132B1 (en) 2012-07-11
EP2076132A4 (en) 2011-05-04
MY150408A (en) 2014-01-15
TW200833699A (en) 2008-08-16
PE20081105A1 (es) 2008-08-15
AU2007353381B2 (en) 2013-07-04
EA200970387A1 (ru) 2009-10-30
MX2009004028A (es) 2009-05-11
UY30650A1 (es) 2008-05-31
EP2076132A1 (en) 2009-07-08
AU2007353381A1 (en) 2008-11-20
US20110172447A1 (en) 2011-07-14
JP2010506947A (ja) 2010-03-04
HK1132429A1 (da) 2010-02-26
CY1113368T1 (el) 2016-06-22
NZ576408A (en) 2012-04-27
NO20091598L (no) 2009-07-10
BRPI0717741A2 (pt) 2014-04-08
EA017005B1 (ru) 2012-09-28
PL2076132T3 (pl) 2013-01-31
AR063484A1 (es) 2009-01-28
JP2013166782A (ja) 2013-08-29
US7928085B2 (en) 2011-04-19
US20090197826A1 (en) 2009-08-06
ES2390930T3 (es) 2012-11-19
US8193342B2 (en) 2012-06-05
IL198180A (en) 2015-06-30
DOP2007000131A (es) 2008-09-15
KR20090074237A (ko) 2009-07-06
KR101486444B1 (ko) 2015-01-26
WO2008140549A1 (en) 2008-11-20
JP5703334B2 (ja) 2015-04-15
IL223126A0 (en) 2012-12-31
IL198180A0 (en) 2009-12-24
PT2076132E (pt) 2012-10-03
KR101515077B1 (ko) 2015-04-24
CA2666537C (en) 2015-12-08

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