EA200901270A1 - Стимуляция иммунной реакции катионными липидами - Google Patents
Стимуляция иммунной реакции катионными липидамиInfo
- Publication number
- EA200901270A1 EA200901270A1 EA200901270A EA200901270A EA200901270A1 EA 200901270 A1 EA200901270 A1 EA 200901270A1 EA 200901270 A EA200901270 A EA 200901270A EA 200901270 A EA200901270 A EA 200901270A EA 200901270 A1 EA200901270 A1 EA 200901270A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- stimulation
- immune reactions
- cation lipids
- lipids
- cation
- Prior art date
Links
- -1 CATION LIPIDS Chemical class 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 230000000638 stimulation Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение предлагает композиции и способы стимуляции иммунной реакции с применением катионных липидов самостоятельно либо в комбинации с антигенами.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89641207P | 2007-03-22 | 2007-03-22 | |
US91154907P | 2007-04-13 | 2007-04-13 | |
US94851207P | 2007-07-09 | 2007-07-09 | |
US98379907P | 2007-10-30 | 2007-10-30 | |
US12/049,957 US8877206B2 (en) | 2007-03-22 | 2008-03-17 | Stimulation of an immune response by cationic lipids |
PCT/US2008/057678 WO2008116078A2 (en) | 2007-03-22 | 2008-03-20 | Stimulation of an immune response by cationic lipids |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200901270A1 true EA200901270A1 (ru) | 2010-04-30 |
Family
ID=39766768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200901270A EA200901270A1 (ru) | 2007-03-22 | 2008-03-20 | Стимуляция иммунной реакции катионными липидами |
Country Status (10)
Country | Link |
---|---|
US (4) | US8877206B2 (ru) |
EP (1) | EP2125011B1 (ru) |
JP (2) | JP2010522206A (ru) |
CN (2) | CN101702882A (ru) |
AU (1) | AU2008228798B2 (ru) |
EA (1) | EA200901270A1 (ru) |
ES (1) | ES2562714T3 (ru) |
PL (1) | PL2125011T3 (ru) |
TW (1) | TWI558412B (ru) |
WO (1) | WO2008116078A2 (ru) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60117164T2 (de) * | 2000-11-07 | 2006-08-03 | Immuno Vaccine Technologies Inc., Halifax | Impfstoffe mit erhöhter immunantwort und verfahren zur deren herstellung |
DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
WO2009039628A1 (en) | 2007-09-27 | 2009-04-02 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
WO2009129227A1 (en) | 2008-04-17 | 2009-10-22 | Pds Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
US8927227B2 (en) * | 2008-05-06 | 2015-01-06 | Colgate-Palmolive Company | Method of measuring effects of components on cell reactive oxygen species production |
CA2723918C (en) * | 2008-06-05 | 2018-01-09 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
JP2011184344A (ja) * | 2010-03-08 | 2011-09-22 | Kao Corp | p21発現促進剤 |
MX2013000164A (es) | 2010-07-06 | 2013-03-05 | Novartis Ag | Liposomas con lipidos que tienen valor de pka ventajoso para suministro de arn. |
JP5940064B2 (ja) | 2010-07-06 | 2016-06-29 | ノバルティス アーゲー | 低用量のrnaを用いた大型哺乳動物の免疫化 |
WO2012006376A2 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Virion-like delivery particles for self-replicating rna molecules |
JP6025721B2 (ja) | 2010-07-06 | 2016-11-16 | ノバルティス アーゲー | カチオン性水中油型エマルジョン |
EP2590670B1 (en) | 2010-07-06 | 2017-08-23 | GlaxoSmithKline Biologicals SA | Methods of raising an immune response by delivery of rna |
RS63984B1 (sr) | 2010-08-31 | 2023-03-31 | Glaxosmithkline Biologicals Sa | Mali lipozomi za isporuku rnk koja kodira imunogen |
HRP20220695T1 (hr) | 2010-08-31 | 2022-07-08 | Glaxosmithkline Biologicals Sa | Pegilirani liposomi za isporuku rnk kodirane za imunogen |
KR102162111B1 (ko) | 2010-10-11 | 2020-10-07 | 노파르티스 아게 | 항원 전달 플랫폼 |
CA2836494C (en) | 2011-05-24 | 2023-01-03 | Biontech Ag | Individualized vaccines for cancer |
MX350198B (es) | 2011-07-06 | 2017-08-30 | Novartis Ag | Emulsiones aceite en agua que contienen acidos nucleicos. |
WO2013006837A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Cationic oil-in-water emulsions |
EP2729165B1 (en) | 2011-07-06 | 2017-11-08 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
ES2689799T3 (es) * | 2011-09-12 | 2018-11-15 | Pds Biotechnology Corporation | Formulaciones de vacunas particuladas |
SG11201401177WA (en) | 2011-10-06 | 2014-04-28 | Immunovaccine Technologies Inc | Liposome compositions comprising an adjuvant that activates or increases the activity of tlr2 and uses thereof |
WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
EP2861245B1 (en) | 2012-06-15 | 2019-10-16 | PDS Biotechnology Corporation | Cationic lipid vaccine compositions and methods of use |
TWI672149B (zh) * | 2012-09-21 | 2019-09-21 | 美商Pds生技公司 | 改良之疫苗組成物及使用方法 |
US10155031B2 (en) | 2012-11-28 | 2018-12-18 | Biontech Rna Pharmaceuticals Gmbh | Individualized vaccines for cancer |
WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
EP3030900A2 (en) | 2013-08-08 | 2016-06-15 | Institut Pasteur | Correlation of disease activity with clonal expansions of human papillomavirus 16-specific cd8+ t-cells in patients with severe erosive oral lichen planus |
EP3981437A1 (en) | 2014-04-23 | 2022-04-13 | ModernaTX, Inc. | Nucleic acid vaccines |
WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
WO2017070623A1 (en) * | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Herpes simplex virus vaccine |
JP2019500021A (ja) * | 2015-11-13 | 2019-01-10 | ピーディーエス バイオテクノロジー コーポレイションPds Biotechnology Corporation | 樹状細胞療法においてex vivoでの抗原のプロセシングと提示を亢進させるための合成ベクターとしての脂質 |
WO2017083820A1 (en) | 2015-11-13 | 2017-05-18 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
WO2017186711A1 (en) | 2016-04-25 | 2017-11-02 | Invivogen | Novel complexes of immunostimulatory compounds, and uses thereof |
US20180221475A1 (en) * | 2016-10-05 | 2018-08-09 | Pds Biotechnology Corporation | Methods to alter the tumor microenvironment for effective cancer immunotherapy |
JP6980780B2 (ja) | 2016-10-21 | 2021-12-15 | モデルナティーエックス, インコーポレイテッド | ヒトサイトメガロウイルスワクチン |
US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
US20190321321A1 (en) * | 2017-12-05 | 2019-10-24 | Pds Biotechnology Coporation | Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes |
JP7385206B2 (ja) * | 2018-12-04 | 2023-11-22 | 国立大学法人大阪大学 | 免疫賦活剤 |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
Family Cites Families (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2167480A (en) | 1927-11-02 | 1939-07-25 | Rca Corp | Signaling |
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
US6214804B1 (en) * | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US6183745B1 (en) | 1990-12-12 | 2001-02-06 | The University Of Queensland | Subunit papilloma virus vaccine and peptides for use therein |
WO1993003709A1 (en) | 1991-08-16 | 1993-03-04 | Vical, Inc. | Composition and method for treating cystic fibrosis |
WO1993003764A1 (en) | 1991-08-26 | 1993-03-04 | Cytel Corporation | Hla-restricted hepatitis b virus ctl epitopes |
US6419931B1 (en) * | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
IL105554A (en) | 1992-05-05 | 1999-08-17 | Univ Leiden | Peptides of human papillomavirus for use in preparations elicit a human T cell response |
WO1993024640A2 (en) * | 1992-06-04 | 1993-12-09 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
US7105574B1 (en) * | 1999-03-26 | 2006-09-12 | Vical Incorporated | Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines |
US5334761A (en) * | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
US9266930B1 (en) | 1993-03-05 | 2016-02-23 | Epimmune Inc. | Inducing cellular immune responses to Plasmodium falciparum using peptide and nucleic acid compositions |
CA2168582A1 (en) | 1993-08-06 | 1995-02-16 | John D. Fikes | Cloning and characterization of the complete mage-1 gene |
AUPM500494A0 (en) * | 1994-04-12 | 1994-05-05 | Minister For Agriculture & Rural Affairs For The State Of New South Wales, The | Composition for use in increasing mucosal immunity |
FR2726764B1 (fr) * | 1994-11-14 | 1997-01-31 | Pasteur Merieux Serums Vacc | Adjuvant pour composition vaccinale |
US6008202A (en) * | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
FR2732895B1 (fr) * | 1995-04-11 | 1997-05-16 | Pasteur Merieux Serums Vacc | Utilisation d'un compose amphipathique cationique comme agent de transfection, comme adjuvant de vaccin, ou comme medicament |
CA2227065A1 (en) | 1995-07-21 | 1997-02-06 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity |
EP0910343A1 (en) * | 1996-07-03 | 1999-04-28 | University Of Pittsburgh | Emulsion formulations for hydrophilic active agents |
US7001614B2 (en) * | 1996-08-19 | 2006-02-21 | The United States Of America As Represented By The Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
US7288266B2 (en) * | 1996-08-19 | 2007-10-30 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
US20030229040A1 (en) | 1997-03-21 | 2003-12-11 | Georgetown University | Cationic liposomal delivery system and therapeutic use thereof |
US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
US20030022854A1 (en) * | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
US6693086B1 (en) * | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
EP1146907A2 (en) | 1999-02-05 | 2001-10-24 | Genzyme Corporation | Use of cationic lipids to generate anti-tumor immunity |
AU2875700A (en) * | 1999-02-26 | 2000-09-14 | Chiron Corporation | Microemulsions with adsorbed macromoelecules and microparticles |
DK1459766T3 (da) * | 1999-03-26 | 2008-10-13 | Vical Inc | Adjuvanssammensætninger til forstærkning af immunresponser på polynukleotidbaserede vacciner |
CA2370690A1 (en) * | 1999-04-20 | 2000-10-26 | The University Of British Columbia | Cationic peg-lipids and methods of use |
US6852334B1 (en) * | 1999-04-20 | 2005-02-08 | The University Of British Columbia | Cationic peg-lipids and methods of use |
US6649170B1 (en) * | 1999-05-12 | 2003-11-18 | Statens Serum Institut | Adjuvant combinations for immunization composition and vaccines |
FR2794370B1 (fr) | 1999-06-03 | 2003-10-17 | Biovector Therapeutics | Fragments proteiques polyepitopiques, leur obtention et leurs utilisations notamment en vaccination |
CZ20014392A3 (cs) | 1999-06-10 | 2002-06-12 | Merial | Vakcína AND pro domácí a sportovní zvířata |
CA2309313A1 (en) | 1999-08-05 | 2001-02-05 | Board Of Trustees Of The University Of Arkansas | Stimulation of the immune response by human dendritic cell manipulation |
PT1214097E (pt) | 1999-09-16 | 2009-10-19 | Eisai Inc | Ácidos nucleicos que codificam polipéptidos de poliepitopos |
US20030008813A1 (en) | 1999-12-17 | 2003-01-09 | Felgner Philip L. | Intracellular protein delivery compositions and methods of use |
CA2394831A1 (en) | 2000-01-11 | 2001-07-19 | Maxygen, Inc. | Monocyte-derived dendritic cell subsets |
JP2003533181A (ja) | 2000-02-01 | 2003-11-11 | ジ・オースティン・リサーチ・インスティテュート | ムチン−1誘導抗原および免疫療法におけるその使用 |
AU2001254548B2 (en) * | 2000-04-20 | 2006-09-28 | The University Of British Columbia | Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane |
EP1350262B8 (en) | 2000-12-08 | 2008-08-13 | Coley Pharmaceuticals GmbH | Cpg-like nucleic acids and methods of use thereof |
JP2004537501A (ja) | 2001-02-01 | 2004-12-16 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | 肺への遺伝子送達のための安定化ポリマーエアロゾル |
CA2441947C (en) | 2001-03-23 | 2014-05-13 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Human papilloma virus immunoreactive peptides |
FR2824326B1 (fr) | 2001-05-04 | 2004-03-19 | Commissariat Energie Atomique | Melange de peptides issus des proteines e6 et/ou e7 de papillomavirus et leurs applications |
US7514098B2 (en) | 2001-05-30 | 2009-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Use of targeted cross-linked nanoparticles for in vivo gene delivery |
WO2002102407A1 (en) | 2001-06-15 | 2002-12-27 | Nordic Vaccine Technology A/S | Therapeutical vaccination |
FR2826293B1 (fr) | 2001-06-21 | 2004-01-30 | Elf Antar France | Procede d'obtention de gaz de synthese par oxydation catalytique partielle |
EP2014300B1 (en) * | 2001-06-29 | 2011-01-12 | Chugai Seiyaku Kabushiki Kaisha | Cancer vaccine comprising a cancer antigen based on the product of a tumor suppressor gene WT1 and a cationic liposome |
EP1458242A4 (en) | 2001-07-06 | 2006-06-07 | Sloan Kettering Inst Cancer | COMPREHENSIVE CONJUGATED VACCINE AGAINST CANCER |
GB0118517D0 (en) | 2001-07-30 | 2001-09-19 | Mitsubishi Tokyo Pharm Inc | Compound |
DK1453471T3 (da) | 2001-11-07 | 2011-03-28 | Mannkind Corp | Ekspressionsvektorer, der koder for epitoper af antigener, og fremgangsmåde til deres konstruktion |
US7598421B2 (en) * | 2002-05-08 | 2009-10-06 | Ucl Biomedica Plc | Materials for the delivery of biologically-active material to cells |
DE60310562T2 (de) | 2002-07-05 | 2007-10-11 | Lipoxen Technologies Ltd. | Verfahren zur verstärkung einer immunantwort von nukleinsäureimpfungen |
KR101151368B1 (ko) * | 2002-08-12 | 2012-06-08 | 더 카운실 오브 더 퀸스랜드 인스티튜트 오브 메디칼 리서어치 | T-헬퍼 및 세포독성 t 림프구(ctl) 에피토프를포함하는 신규한 면역원성 리포펩타이드 |
US20050031587A1 (en) | 2002-10-04 | 2005-02-10 | Yamanouchi Pharmaceutical Co., Ltd. | Immune response induction method |
AU2003284239B2 (en) | 2002-10-21 | 2008-08-21 | Eisai Inc. | Compositions and methods for treating human papillomavirus-mediated disease |
SE0301109D0 (sv) | 2003-04-14 | 2003-04-14 | Mallen Huang | Nucleotide vaccine composition |
EP1628637A2 (en) * | 2003-05-30 | 2006-03-01 | Alza Corporation | Method of pulmonary administration of an agent |
US7541035B2 (en) | 2003-06-05 | 2009-06-02 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Immunogenic peptides for the treatment of prostate and breast cancer |
JP4695075B2 (ja) | 2003-06-18 | 2011-06-08 | イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム | トランスフェクションで使用するためのスフィンゴ脂質ポリアルキルアミン抱合体 |
US7906122B2 (en) | 2003-06-18 | 2011-03-15 | Yissum Research Development Company Of The Hebrew University Of Jersusalem | Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination |
US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
CA2544240A1 (en) * | 2003-07-22 | 2005-02-17 | Cytos Biotechnology Ag | Cpg-packaged liposomes |
JP5097400B2 (ja) | 2003-09-03 | 2012-12-12 | デンドリセラピューティクス、インク. | 複合ワクチン |
US20050112559A1 (en) | 2003-09-29 | 2005-05-26 | The Chinese University Of Hong Kong | Compositions and methods for diagnosing and preventing severe acute respiratory syndrome (SARS) |
JP4801594B2 (ja) | 2003-12-10 | 2011-10-26 | カンジ,インコーポレイテッド | インターフェロン耐性腫瘍の処置のための方法および組成物 |
CN1559607A (zh) | 2004-02-20 | 2005-01-05 | �й�ũҵ��ѧ | 一种核酸物质与蛋白质类组合物及其生产方法和在免疫调节中的应用 |
KR20090051129A (ko) | 2004-04-05 | 2009-05-20 | 화이자 프로덕츠 인코포레이티드 | 미세유체화된 수중유 유화액 및 백신 조성물 |
GB0716992D0 (en) | 2007-08-31 | 2007-10-10 | Immune Targeting Systems Its L | Influenza antigen delivery vectors and constructs |
US7303881B2 (en) * | 2004-04-30 | 2007-12-04 | Pds Biotechnology Corporation | Antigen delivery compositions and methods of use |
JP4764426B2 (ja) * | 2004-06-07 | 2011-09-07 | プロチバ バイオセラピューティクス インコーポレイティッド | カチオン性脂質および使用方法 |
RU2007103343A (ru) | 2004-06-30 | 2008-08-10 | АйДи БАЙОМЕДИКАЛ КОРПОРЕЙШН ОФ КВЕБЕК (CA) | Вакцинная композиция и способы лечения коронавирусной инфекции |
US20060051405A1 (en) * | 2004-07-19 | 2006-03-09 | Protiva Biotherapeutics, Inc. | Compositions for the delivery of therapeutic agents and uses thereof |
GB0417430D0 (en) | 2004-08-05 | 2004-09-08 | Uc3 | A novel HPV vaccine comprising peptides from host cell proteins |
DE102004057303A1 (de) | 2004-11-26 | 2006-06-01 | Merck Patent Gmbh | Stabile Kristallmodifikationen von DOTAP Chlorid |
NZ583157A (en) | 2004-12-13 | 2011-12-22 | Leo Lab Ltd | Treatment of solid cancers with angeloyl substituted ingenanes |
WO2006065960A2 (en) | 2004-12-14 | 2006-06-22 | Applera Corporation | Cationic liposomes comprising a charge neutral compound and a cationic phospholipid |
CA2595704A1 (en) | 2005-01-21 | 2006-07-27 | Introgen Therapeutics, Inc. | Topical administration permitting prolonged exposure of target cells to therapeutic and prophylactic nucleic acids |
JP2009501237A (ja) * | 2005-03-14 | 2009-01-15 | ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 生物活性fus1ペプチドおよびナノ粒子−ポリペプチド複合体 |
CN101142851B (zh) | 2005-03-18 | 2012-12-05 | 唯听助听器公司 | 助听器的远程控制系统 |
KR20150032915A (ko) | 2005-04-08 | 2015-03-30 | 아르고스 쎄라퓨틱스 인코포레이티드 | 수지상 세포 조성물 및 방법 |
AU2006236910B2 (en) | 2005-04-11 | 2012-06-07 | Purdue Research Foundation | Vaccine against pandemic strains of influenza viruses |
US20060275777A1 (en) * | 2005-06-03 | 2006-12-07 | Waelti Ernst R | Novel strategies for protein vaccines |
WO2007022152A2 (en) | 2005-08-15 | 2007-02-22 | The Research Foundation Of State University Of New York | Lipid nano particulates containing antigens as cancer vaccines |
US20110305713A1 (en) | 2005-10-21 | 2011-12-15 | Medical College Of Georgia Research Institute, Inc | Methods and compositions to enhance vaccine efficacy by reprogramming regulatory t cells |
EP2360175B1 (en) | 2005-11-22 | 2014-07-16 | Novartis Vaccines and Diagnostics, Inc. | Norovirus and Sapovirus virus-like particles (VLPs) |
WO2007106073A2 (en) | 2006-03-02 | 2007-09-20 | University Of Massachusetts | Modified pathogens for use as vaccines |
JP2007238559A (ja) | 2006-03-10 | 2007-09-20 | Nagoya City Univ | 未成熟樹状細胞活性化剤及びその使用 |
RU2008145712A (ru) | 2006-04-21 | 2010-05-27 | Трансжене С.А (Fr) | Вакцина против папилломовирусной инфекции на основе вируса папиломы человека впч-16 |
US20080014251A1 (en) | 2006-07-14 | 2008-01-17 | Advanced Vascular Dynamics | Hemostatic compound and its use |
EP1894941A1 (en) | 2006-09-01 | 2008-03-05 | Institut Pasteur | Treatment of cervical carcinoma with a recombinant adenylate cyclase carrying HPV antigens |
WO2008039874A2 (en) | 2006-09-26 | 2008-04-03 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
CA2666357A1 (en) | 2006-10-18 | 2008-04-24 | The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services, Centers For Disea | Enhancing disease resistance against rna viral infections with intracytoplasmic pathogen sensors |
KR100817024B1 (ko) | 2006-11-09 | 2008-03-26 | 재단법인 목암생명공학연구소 | 핵산 또는 약물을 간에 특이적으로 전달하는 복합체 및이를 포함하는 약학적 조성물 |
US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
WO2008148057A2 (en) | 2007-05-23 | 2008-12-04 | Vical Incorporated | Cationic lipids compositions and methods for enhancing immune responses to vaccines |
CA3167595A1 (en) | 2007-05-31 | 2008-12-04 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines |
US7832751B2 (en) | 2007-06-29 | 2010-11-16 | Harley-Davidson Motor Company Group, Inc. | Rear fender assembly |
CN113559253A (zh) | 2007-11-02 | 2021-10-29 | 约翰霍普金斯大学 | 用于治疗或预防人乳头瘤病毒感染的多型hpv肽的组合物和方法 |
WO2009129227A1 (en) | 2008-04-17 | 2009-10-22 | Pds Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
CA2724408A1 (en) | 2008-05-19 | 2009-11-26 | The University Of North Carolina At Chapel Hill | Methods and compositions comprising novel cationic lipids |
WO2010033863A2 (en) | 2008-09-18 | 2010-03-25 | Juvaris Biotherapeutics, Inc. | Vaccine compositions of m2e, ha0 and bm2 multiple antigenic peptides |
WO2010101663A2 (en) | 2009-03-06 | 2010-09-10 | Mount Sinai School Of Medicine Of New York University | Live attenuated influenza virus vaccines comprising microrna response elements |
WO2010132867A1 (en) | 2009-05-15 | 2010-11-18 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
WO2011109294A1 (en) | 2010-03-01 | 2011-09-09 | Dicerna Pharmaceuticals, Inc. | Lipid delivery formulations |
AU2011235220B2 (en) | 2010-03-30 | 2016-03-10 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
JP5902616B2 (ja) | 2010-04-28 | 2016-04-13 | 協和発酵キリン株式会社 | カチオン性脂質 |
AR087380A1 (es) | 2011-07-27 | 2014-03-19 | Baylor Res Inst | Vacunas de celulas dendriticas (cd) para la terapia del cancer de pancreas |
ES2689799T3 (es) | 2011-09-12 | 2018-11-15 | Pds Biotechnology Corporation | Formulaciones de vacunas particuladas |
EP2638896A1 (en) | 2012-03-14 | 2013-09-18 | Bioneer A/S | Cationic liposomal drug delivery system for specific targeting of human cd14+ monocytes in whole blood |
EP2639299A1 (en) | 2012-03-16 | 2013-09-18 | Invectys | Universal cancer peptides derived from telomerase |
EP2861245B1 (en) | 2012-06-15 | 2019-10-16 | PDS Biotechnology Corporation | Cationic lipid vaccine compositions and methods of use |
TWI672149B (zh) | 2012-09-21 | 2019-09-21 | 美商Pds生技公司 | 改良之疫苗組成物及使用方法 |
HUE046469T2 (hu) | 2013-08-21 | 2020-03-30 | Curevac Ag | Készítmény és vakcina tüdõrák kezelésére |
EP3412304A3 (en) | 2013-10-23 | 2019-03-20 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use |
CN104189897A (zh) | 2014-05-21 | 2014-12-10 | 深圳先进技术研究院 | 一种树突状细胞高效负载抗原的制备方法 |
SG11201707540QA (en) | 2015-03-16 | 2017-10-30 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library |
CN105920599B (zh) | 2015-09-17 | 2020-02-11 | 武汉生物制品研究所有限责任公司 | 以阳离子脂质体dotap为佐剂的疫苗及其制备方法 |
WO2017083820A1 (en) | 2015-11-13 | 2017-05-18 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
US20180221475A1 (en) | 2016-10-05 | 2018-08-09 | Pds Biotechnology Corporation | Methods to alter the tumor microenvironment for effective cancer immunotherapy |
JP7165652B2 (ja) | 2016-10-05 | 2022-11-04 | ピーディーエス バイオテクノロジー コーポレイション | 新規hpv16非hla拘束性t細胞ワクチン、その組成物及び使用方法 |
US20190321321A1 (en) | 2017-12-05 | 2019-10-24 | Pds Biotechnology Coporation | Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes |
CN111217918B (zh) | 2020-03-04 | 2020-11-10 | 中山大学 | 一种基于2,4-二氧四氢喋啶合酶的新型冠状病毒s蛋白双区域亚单位纳米疫苗 |
-
2008
- 2008-03-17 US US12/049,957 patent/US8877206B2/en active Active
- 2008-03-20 PL PL08799629T patent/PL2125011T3/pl unknown
- 2008-03-20 EP EP08799629.4A patent/EP2125011B1/en active Active
- 2008-03-20 CN CN200880017151A patent/CN101702882A/zh active Pending
- 2008-03-20 JP JP2009554742A patent/JP2010522206A/ja active Pending
- 2008-03-20 CN CN201710819740.1A patent/CN107670031A/zh active Pending
- 2008-03-20 AU AU2008228798A patent/AU2008228798B2/en active Active
- 2008-03-20 ES ES08799629.4T patent/ES2562714T3/es active Active
- 2008-03-20 WO PCT/US2008/057678 patent/WO2008116078A2/en active Application Filing
- 2008-03-20 EA EA200901270A patent/EA200901270A1/ru unknown
- 2008-03-24 TW TW097110452A patent/TWI558412B/zh active
-
2013
- 2013-10-18 JP JP2013217819A patent/JP6211383B2/ja active Active
-
2014
- 2014-11-03 US US14/531,469 patent/US11911359B2/en active Active
-
2021
- 2021-07-22 US US17/383,182 patent/US20210346333A1/en not_active Abandoned
- 2021-07-22 US US17/383,104 patent/US20220031650A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2125011A2 (en) | 2009-12-02 |
US20220031650A1 (en) | 2022-02-03 |
US20090017057A1 (en) | 2009-01-15 |
US11911359B2 (en) | 2024-02-27 |
US20210346333A1 (en) | 2021-11-11 |
AU2008228798B2 (en) | 2014-05-15 |
ES2562714T3 (es) | 2016-03-07 |
WO2008116078A2 (en) | 2008-09-25 |
TW200902060A (en) | 2009-01-16 |
JP2014058525A (ja) | 2014-04-03 |
JP2010522206A (ja) | 2010-07-01 |
WO2008116078A9 (en) | 2008-11-20 |
WO2008116078A8 (en) | 2009-07-16 |
EP2125011A4 (en) | 2010-04-07 |
US8877206B2 (en) | 2014-11-04 |
JP6211383B2 (ja) | 2017-10-11 |
AU2008228798A1 (en) | 2008-09-25 |
EP2125011B1 (en) | 2015-11-11 |
WO2008116078A3 (en) | 2009-06-04 |
WO2008116078A4 (en) | 2009-10-15 |
CN107670031A (zh) | 2018-02-09 |
TWI558412B (zh) | 2016-11-21 |
US20150093410A1 (en) | 2015-04-02 |
PL2125011T3 (pl) | 2016-05-31 |
CN101702882A (zh) | 2010-05-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200901270A1 (ru) | Стимуляция иммунной реакции катионными липидами | |
MX2021014448A (es) | Modulacion de celulas mieloides estimulantes y no estimulantes. | |
EA201400625A1 (ru) | Антитела против pd-l1 и их применение | |
CY1118943T1 (el) | Anti-pd-l1 αντισωματα και χρηση αυτων για την ενισχυση της λειτουργιας τ-κυτταρων | |
GT201200189A (es) | Antagonistas de pcsk9 | |
MX2009008918A (es) | Activacion de celulas que presentan antigeno humano a traves de clec-6. | |
MX2009008926A (es) | Aplicaciones terapeuticas de activacion de celulas que presentan antigeno humano por medio de detectina a-1. | |
EA201290209A1 (ru) | Новые модуляторы бензопиран киназы | |
UA118332C2 (uk) | Білок, що зв'язує антиген cd27l | |
MX341076B (es) | Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados. | |
EA201391351A1 (ru) | Способы повышения эффективности folr1 терапии рака | |
EP3964527A3 (en) | Combination therapy for cancer | |
MX2019013670A (es) | Formulaciones de anticuerpos y proteinas. | |
MX2009008430A (es) | Anticuerpos anti-robo4 y sus usos. | |
EA201590822A1 (ru) | Адъювантная терапия ингибитором киназы семейства tec | |
PL1830881T3 (pl) | Terapie skojarzone celowane na wiele receptorów Toll-podobnych i ich zastosowanie | |
JO3118B1 (ar) | تراكيب وطرق لبروتين c5 المتمم يستهدف الأجسام المضادة | |
AR080685A1 (es) | Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) | |
WO2009026574A3 (en) | Immunogenic compositions and uses thereof | |
EA201590987A1 (ru) | Соединения и способы их применения | |
EA201300585A1 (ru) | Иммуномодулирующие олигонуклеотиды | |
MX2020003503A (es) | Proteinas de union al antigeno del receptor de oncostatina m. | |
EA200970737A1 (ru) | Оксабициклогептаны и оксабициклогептены, их получение и применение | |
EA201070636A1 (ru) | Ингибирование рецептора белка, стимулирующего макрофаги (ron), и способы его лечения | |
SG10201900041VA (en) | Meningococcus vaccines |