EA201300585A1 - Иммуномодулирующие олигонуклеотиды - Google Patents

Иммуномодулирующие олигонуклеотиды

Info

Publication number
EA201300585A1
EA201300585A1 EA201300585A EA201300585A EA201300585A1 EA 201300585 A1 EA201300585 A1 EA 201300585A1 EA 201300585 A EA201300585 A EA 201300585A EA 201300585 A EA201300585 A EA 201300585A EA 201300585 A1 EA201300585 A1 EA 201300585A1
Authority
EA
Eurasian Patent Office
Prior art keywords
immunomodulatory oligonucleotides
compositions
immunomodulatory
oligonucleotides
disclosed
Prior art date
Application number
EA201300585A
Other languages
English (en)
Other versions
EA030096B1 (ru
Inventor
Грэйсон Б. Липфорд
Кристофер Фрейзер
Original Assignee
Селекта Байосайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селекта Байосайенсиз, Инк. filed Critical Селекта Байосайенсиз, Инк.
Publication of EA201300585A1 publication Critical patent/EA201300585A1/ru
Publication of EA030096B1 publication Critical patent/EA030096B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Раскрыты композиции, которые содержат иммуностимулирующие нуклеиновые кислоты, вместе с применением таких композиций для индукции иммунных ответов.
EA201300585A 2010-11-16 2011-11-16 Способы, композиции и нуклеиновые кислоты для стимуляции гуморального иммунного ответа EA030096B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41419410P 2010-11-16 2010-11-16
PCT/US2011/061056 WO2012068295A1 (en) 2010-11-16 2011-11-16 Immunostimulatory oligonucleotides

Publications (2)

Publication Number Publication Date
EA201300585A1 true EA201300585A1 (ru) 2013-11-29
EA030096B1 EA030096B1 (ru) 2018-06-29

Family

ID=46084406

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300585A EA030096B1 (ru) 2010-11-16 2011-11-16 Способы, композиции и нуклеиновые кислоты для стимуляции гуморального иммунного ответа

Country Status (14)

Country Link
US (1) US8546550B2 (ru)
EP (1) EP2640426B1 (ru)
JP (3) JP5933577B2 (ru)
KR (1) KR20130116890A (ru)
CN (2) CN105327363A (ru)
AU (2) AU2011329850B2 (ru)
BR (1) BR112013012195A2 (ru)
CA (1) CA2817746A1 (ru)
DK (1) DK2640426T3 (ru)
EA (1) EA030096B1 (ru)
ES (1) ES2569857T3 (ru)
IL (2) IL226299A (ru)
MX (1) MX344972B (ru)
WO (1) WO2012068295A1 (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
HUE058896T2 (hu) 2010-10-01 2022-09-28 Modernatx Inc N1-metil-pszeudo-uracilt tartalmazó ribonukleinsavak és azok felhasználásai
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
EP2791160B1 (en) 2011-12-16 2022-03-02 ModernaTX, Inc. Modified mrna compositions
AU2013243951A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of secreted proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
EP2922554B1 (en) 2012-11-26 2022-02-23 ModernaTX, Inc. Terminally modified rna
BR112015021970A2 (pt) 2013-03-14 2017-07-18 Massachusetts Inst Technology composições à base de nanopartículas
US10258698B2 (en) 2013-03-14 2019-04-16 Modernatx, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
CN105925583B (zh) * 2013-11-08 2019-05-17 上海交通大学 被修饰的含CpG序列单元的寡聚脱氧核苷酸分子及其用途
PT3134131T (pt) 2014-04-23 2022-03-24 Modernatx Inc Vacinas de ácidos nucleicos
US20170204152A1 (en) 2014-07-16 2017-07-20 Moderna Therapeutics, Inc. Chimeric polynucleotides
CA3004363A1 (en) * 2015-11-06 2017-05-11 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Composition comprising a biocompatible and biodegradable polymer, nanocarries and a drug and methods of making and using the same
CN108014333B (zh) * 2017-10-11 2020-10-20 江苏省农业科学院 动物用粘膜靶向免疫增强剂及其在兽用疫苗中的应用
WO2019164872A2 (en) * 2018-02-20 2019-08-29 University Of Florida Research Foundation, Inc. Composition and method for targeting natural killer cells in immunotherapy to overcome tumor suppression with manganese dioxide nanoparticles
BR112020017715A2 (pt) * 2018-03-16 2020-12-29 Zoetis Services Llc Vacinas de peptídeo contra interleucina-31
CA3208643A1 (en) 2021-01-18 2022-07-21 Conserv Bioscience Limited Coronavirus immunogenic compositions, methods and uses thereof
CN114796476A (zh) * 2021-09-24 2022-07-29 中国医学科学院医学生物学研究所 一种亚单位疫苗新型核酸佐剂系统及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028784A1 (en) * 2000-03-10 2002-03-07 Nest Gary Van Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences
US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
ATE411054T1 (de) * 2001-08-17 2008-10-15 Coley Pharm Gmbh Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung
US8158768B2 (en) * 2002-12-23 2012-04-17 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
AU2003297483B2 (en) * 2002-12-23 2010-11-18 Trisalus Life Sciences, Inc. Immunostimulatory sequence oligonucleotides and methods of using the same
CN1296378C (zh) * 2004-05-17 2007-01-24 中国人民解放军第三军医大学 高免疫活性 CpG－S ODN 和拮抗 CpG－S ODN 作用的 CpG－N ODN 的基因序列及其应用
DK1796650T3 (da) * 2004-09-14 2009-03-09 Nanodel Technologies Gmbh Transport- og afgivelsesvehikel indeholdende nanopartikler
US20080009455A9 (en) * 2005-02-24 2008-01-10 Coley Pharmaceutical Group, Inc. Immunostimulatory oligonucleotides
PL2034015T3 (pl) * 2006-05-31 2012-11-30 Toray Industries Immunostymulujący oligonukleotyd i jego zastosowanie farmaceutyczne
US9023395B2 (en) * 2007-04-13 2015-05-05 University Of North Texas Health Science Center At Fort Worth Formulation of active agent loaded activated PLGA nanoparticles for targeted cancer nano-therapeutics
US10736848B2 (en) * 2007-10-12 2020-08-11 Massachusetts Institute Of Technology Vaccine nanotechnology
US8343497B2 (en) * 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
BRPI1011836A2 (pt) * 2009-04-21 2017-05-16 Selecta Biosciences Inc imunonanoterapêuticos que fornecem uma resposta induzida por th1
EA023897B1 (ru) * 2009-08-26 2016-07-29 Селекта Байосайенсиз, Инк. Композиции, которые индуцируют хелперное действие т-клеток

Also Published As

Publication number Publication date
AU2011329850A1 (en) 2013-06-06
EP2640426A4 (en) 2014-11-05
WO2012068295A1 (en) 2012-05-24
EA030096B1 (ru) 2018-06-29
CN103347542B (zh) 2015-09-16
CA2817746A1 (en) 2012-05-24
JP2018023389A (ja) 2018-02-15
US20120213812A1 (en) 2012-08-23
JP2016189777A (ja) 2016-11-10
US8546550B2 (en) 2013-10-01
CN103347542A (zh) 2013-10-09
CN105327363A (zh) 2016-02-17
EP2640426B1 (en) 2016-02-03
ES2569857T3 (es) 2016-05-12
IL226299A0 (en) 2013-07-31
AU2017203714A1 (en) 2017-06-22
EP2640426A1 (en) 2013-09-25
DK2640426T3 (en) 2016-05-02
IL252061A0 (en) 2017-07-31
MX2013005544A (es) 2013-09-26
KR20130116890A (ko) 2013-10-24
IL226299A (en) 2017-05-29
AU2011329850B2 (en) 2017-03-02
JP2014501504A (ja) 2014-01-23
JP5933577B2 (ja) 2016-06-15
JP6203897B2 (ja) 2017-09-27
BR112013012195A2 (pt) 2018-07-10
MX344972B (es) 2017-01-12

Similar Documents

Publication Publication Date Title
EA201300585A1 (ru) Иммуномодулирующие олигонуклеотиды
CY1125029T1 (el) Τροποποιημενοι νουκλεοζιτες, νουκλεοτιδια, και νουκλεϊκα οξεα και χρησεις αυτων
MX2017008819A (es) Anticuerpos anti-cd47 y usos de los mismos.
WO2016019134A8 (en) Flagellin-based agents and uses including effective vaccination
EA201291157A1 (ru) Мультивалентные вакцины с синтетическими наноносителями
MX2017007731A (es) Composiciones de detergente, variantes de lipasa y polinucleotidos que codifican las mismas.
MX2020001159A (es) Composiciones y metodos que comprenden una variante de enzima lipolitica.
IL247469B (en) Methods for refining conjugates based on alpha il-15/il-15r, preparations containing products produced in this way and their uses
PH12015502216A1 (en) Compositions and methods for improving the health of aquatic animals
EP3698631A3 (en) Methods of delivering oligonucleotides to immune cells
PL2986726T3 (pl) Nowe kompozycje szczepów bacillus
PH12015501059A1 (en) Anti-hemagglutinin antibodies and methods of use
GB2537077A (en) Methods for sequencing nucleic acids
MX340259B (es) Formulaciones de testosterona.
BR112013014204A2 (pt) composições de sucops espumantes
CY1120759T1 (el) Παρασκευη διγλυκοζιτη (s,s)-σεκοϊσολαρικιρεσινολης και διγλυκοζιτη (r,r)-σεκοϊσολαρικιρεσινολης
TR201905787T4 (tr) Liyofilize TAT-NR2B9C formülasyonu.
EA201290642A1 (ru) Соединения и способы
UY34702A (es) Composiciones y métodos agrícolas u hortícolas
EP4227685A3 (en) Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
HK1219426A1 (zh) 包含免疫刺激性寡核苷酸的新穎疫苗組合物
UY34613A (es) Composición de limpieza
BR112013032223A2 (pt) molécula de ácido nucleico isolada, e, composição
EP3054945A4 (en) 3,3'-disubstituted indolines as inhibitors of cholesterol ester transfer protein
IN2014DN07270A (ru)

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU