EA200702601A1 - Производные тиазола и их применение - Google Patents

Производные тиазола и их применение

Info

Publication number
EA200702601A1
EA200702601A1 EA200702601A EA200702601A EA200702601A1 EA 200702601 A1 EA200702601 A1 EA 200702601A1 EA 200702601 A EA200702601 A EA 200702601A EA 200702601 A EA200702601 A EA 200702601A EA 200702601 A1 EA200702601 A1 EA 200702601A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diseases
application
tiazole
derivatives
tiazole derivatives
Prior art date
Application number
EA200702601A
Other languages
English (en)
Other versions
EA017166B1 (ru
Inventor
Анна Кваттропани
Давид Ковини
Венсан Помель
Жером Дорбэ
Томас Рюкле
Original Assignee
Лаборатуар Сероно С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лаборатуар Сероно С.А. filed Critical Лаборатуар Сероно С.А.
Publication of EA200702601A1 publication Critical patent/EA200702601A1/ru
Publication of EA017166B1 publication Critical patent/EA017166B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P37/02—Immunomodulators
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)

Abstract

Настоящее изобретение относится к производным тиазола формулы (I), в частности, для лечения и/или профилактики аутоиммунных нарушений и/или воспалительных заболеваний, сердечно-сосудистых заболеваний, нейродегенеративных заболеваний, бактериальных или вирусных инфекций, заболеваний почек, агрегации тромбоцитов, злокачественной опухоли, трансплантации, отторжения трансплантата или повреждений легких.
EA200702601A 2005-05-24 2006-05-24 Производные тиазола и их применение EA017166B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05104418 2005-05-24
US68626605P 2005-06-01 2005-06-01
PCT/EP2006/062602 WO2006125807A1 (en) 2005-05-24 2006-05-24 Thiazole derivatives and use thereof

Publications (2)

Publication Number Publication Date
EA200702601A1 true EA200702601A1 (ru) 2008-06-30
EA017166B1 EA017166B1 (ru) 2012-10-30

Family

ID=35134467

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200702599A EA014350B1 (ru) 2005-05-24 2006-05-24 Производные тиазола и их применение
EA200702601A EA017166B1 (ru) 2005-05-24 2006-05-24 Производные тиазола и их применение

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200702599A EA014350B1 (ru) 2005-05-24 2006-05-24 Производные тиазола и их применение

Country Status (19)

Country Link
US (4) US7879888B2 (ru)
EP (2) EP1888573A1 (ru)
JP (2) JP5203937B2 (ru)
KR (2) KR20080015114A (ru)
CN (2) CN101258149B (ru)
AU (2) AU2006251161B2 (ru)
BR (2) BRPI0611029A2 (ru)
CA (2) CA2608153C (ru)
DK (1) DK1885716T3 (ru)
EA (2) EA014350B1 (ru)
ES (1) ES2399101T3 (ru)
HK (1) HK1121161A1 (ru)
IL (2) IL187391A (ru)
MX (2) MX2007014884A (ru)
NO (2) NO20076558L (ru)
PT (1) PT1885716E (ru)
UA (2) UA93374C2 (ru)
WO (2) WO2006125803A1 (ru)
ZA (2) ZA200710105B (ru)

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AR044519A1 (es) 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
JP5203937B2 (ja) * 2005-05-24 2013-06-05 メルク セローノ ソシエテ アノニム チアゾール誘導体及びその使用
WO2006125805A1 (en) 2005-05-24 2006-11-30 Laboratoires Serono S.A. Thiazole derivatives and use thereof
JP2009524677A (ja) * 2006-01-25 2009-07-02 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連使用用のチアゾールおよびチアジアゾール化合物
US8940771B2 (en) 2007-12-20 2015-01-27 Novartis Ag Organic compounds
UA104147C2 (ru) 2008-09-10 2014-01-10 Новартис Аг Производная пирролидиндикарбоновой кислоты и ее применение в лечении пролиферативных заболеваний
EP2440556A1 (en) * 2009-06-10 2012-04-18 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatidylinositol 3-kinase
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
WO2011048936A1 (ja) 2009-10-19 2011-04-28 大正製薬株式会社 アミノチアゾール誘導体
JP6236481B2 (ja) * 2016-02-17 2017-11-22 東京エレクトロン株式会社 パターン形成方法
RU2618621C1 (ru) * 2016-03-22 2017-05-04 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный университет" Способ фармакологической коррекции экспериментальной ишемии скелетной мышцы силденафилом и пентоксифиллином в условиях комбинированной терапии
RU2618622C1 (ru) * 2016-03-22 2017-05-04 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный университет" Способ фармакологической коррекции экспериментальной ишемии скелетной мышцы варденафилом и пентоксифиллином в условиях комбинированной терапии
RU2717104C1 (ru) * 2019-06-26 2020-03-18 Общество с ограниченной ответственностью "Иван-поле" Способ получения алкил- и ацил-замещенных тиазолов

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AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
GB0320197D0 (en) * 2003-08-28 2003-10-01 Novartis Ag Organic compounds
GB0326601D0 (en) * 2003-11-14 2003-12-17 Novartis Ag Organic compounds
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JP5203937B2 (ja) * 2005-05-24 2013-06-05 メルク セローノ ソシエテ アノニム チアゾール誘導体及びその使用
WO2007082956A1 (en) * 2006-01-23 2007-07-26 Laboratoires Serono S.A. Thiazole derivatives and use thereof

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AU2006251161B2 (en) 2011-06-30
CN101304995A (zh) 2008-11-12
NO20076558L (no) 2007-12-19
EP1888573A1 (en) 2008-02-20
US7888379B2 (en) 2011-02-15
AU2006251161A1 (en) 2006-11-30
BRPI0611176A2 (pt) 2010-08-17
US8399497B2 (en) 2013-03-19
US20080200463A1 (en) 2008-08-21
UA93374C2 (en) 2011-02-10
EP1885716B1 (en) 2012-11-07
CA2608153A1 (en) 2006-11-30
CA2608153C (en) 2014-09-23
US20110086843A1 (en) 2011-04-14
MX2007014884A (es) 2008-02-19
MX2007014886A (es) 2008-02-19
HK1121161A1 (en) 2009-04-17
CA2608143A1 (en) 2006-11-30
NO20076559L (no) 2007-12-19
EA200702599A1 (ru) 2008-06-30
JP2008542239A (ja) 2008-11-27
US7879888B2 (en) 2011-02-01
EA017166B1 (ru) 2012-10-30
WO2006125803A1 (en) 2006-11-30
ZA200710105B (en) 2009-04-29
EA014350B1 (ru) 2010-10-29
JP5203937B2 (ja) 2013-06-05
DK1885716T3 (da) 2013-02-11
CN101258149A (zh) 2008-09-03
UA92489C2 (en) 2010-11-10
ES2399101T3 (es) 2013-03-25
IL187391A0 (en) 2008-02-09
IL187391A (en) 2013-01-31
KR20080015114A (ko) 2008-02-18
EP1885716A1 (en) 2008-02-13
KR20080031190A (ko) 2008-04-08
AU2006251157B2 (en) 2011-09-01
CN101258149B (zh) 2012-09-19
US20110071113A1 (en) 2011-03-24
WO2006125807A1 (en) 2006-11-30
PT1885716E (pt) 2013-01-14
AU2006251157A1 (en) 2006-11-30
IL187534A (en) 2012-07-31
BRPI0611029A2 (pt) 2010-08-10
JP2008542240A (ja) 2008-11-27
IL187534A0 (en) 2008-03-20
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ZA200710104B (en) 2009-03-25
US20080221180A1 (en) 2008-09-11

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