EA200970783A1 - Соединения хиноксалина и их применение - Google Patents

Соединения хиноксалина и их применение

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Publication number
EA200970783A1
EA200970783A1 EA200970783A EA200970783A EA200970783A1 EA 200970783 A1 EA200970783 A1 EA 200970783A1 EA 200970783 A EA200970783 A EA 200970783A EA 200970783 A EA200970783 A EA 200970783A EA 200970783 A1 EA200970783 A1 EA 200970783A1
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EA
Eurasian Patent Office
Prior art keywords
diseases
quinoxaline compounds
application
transplantation
bacterial
Prior art date
Application number
EA200970783A
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English (en)
Inventor
Паскаль Гайяр
Венсан Помель
Изабелль Жанклод-Эттер
Жером Дорбэ
Ясна Кличич
Сирил Монтань
Original Assignee
Мерк Сероно С.А.
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Publication date
Application filed by Мерк Сероно С.А. filed Critical Мерк Сероно С.А.
Publication of EA200970783A1 publication Critical patent/EA200970783A1/ru

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    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
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Abstract

Настоящее изобретение относится к соединениям хиноксалина формулы (I), в частности, для лечения аутоиммунных нарушений и/или воспалительных заболеваний, сердечно-сосудистых заболеваний, нейродегенеративных заболеваний, бактериальных или вирусных инфекций, заболеваний почек, агрегации тромбоцитов, рака, трансплантации, отторжения трансплантата или повреждений легкого.
EA200970783A 2007-02-22 2008-02-21 Соединения хиноксалина и их применение EA200970783A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89105807P 2007-02-22 2007-02-22
EP07102873 2007-02-22
PCT/EP2008/052102 WO2008101979A1 (en) 2007-02-22 2008-02-21 Quinoxaline compounds and use thereof

Publications (1)

Publication Number Publication Date
EA200970783A1 true EA200970783A1 (ru) 2010-04-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970783A EA200970783A1 (ru) 2007-02-22 2008-02-21 Соединения хиноксалина и их применение

Country Status (15)

Country Link
US (1) US8614215B2 (ru)
EP (1) EP2118076B1 (ru)
JP (1) JP5508027B2 (ru)
KR (1) KR20090110950A (ru)
CN (1) CN101663283B (ru)
AU (1) AU2008219297B2 (ru)
BR (1) BRPI0808013A2 (ru)
CA (1) CA2675884C (ru)
EA (1) EA200970783A1 (ru)
EC (1) ECSP099640A (ru)
IL (1) IL200206A (ru)
MX (1) MX2009009031A (ru)
NZ (1) NZ578229A (ru)
WO (1) WO2008101979A1 (ru)
ZA (1) ZA200904857B (ru)

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AU2008343813B2 (en) 2007-12-19 2012-04-12 Amgen Inc. Inhibitors of PI3 kinase
PL2374802T3 (pl) 2008-11-10 2014-09-30 Kyowa Hakko Kirin Co Ltd Inhibitor wytwarzania kinureniny
US9969751B2 (en) * 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
TWI535442B (zh) * 2010-05-10 2016-06-01 Kyowa Hakko Kirin Co Ltd A nitrogen-containing heterocyclic compound having an action of inhibiting the production of canine erythritine
CN101921238B (zh) * 2010-08-04 2012-04-04 苏州大学附属第一医院 取代苯并氮杂环类衍生物的制备及其药理用途
KR20130141528A (ko) 2010-10-20 2013-12-26 메르크 세로노 에스에이 제네바 치환 ｎ-(3-아미노-퀴녹살린-2-일)-술폰아미드 및 이들의 중간체인 ｎ-(3-클로로-퀴녹살린-2-일)술폰아미드의 제조 방법
DE102010048800A1 (de) * 2010-10-20 2012-05-10 Merck Patent Gmbh Chinoxalinderivate
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EA037361B1 (ru) 2016-06-16 2021-03-18 Янссен Фармацевтика Нв Производные бициклического пиридина, пиразина и пиримидина в качестве ингибиторов pi3k бета
DE102016212378A1 (de) 2016-07-07 2018-01-11 Evonik Degussa Gmbh Synthese von Triacetondiaminverbindungen durch reduktive Aminierung ausgehend von Triacetondiamin und dessen Derivaten
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CN110698418B (zh) * 2019-09-11 2022-07-01 广西师范大学 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用
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KR20240024842A (ko) * 2021-06-23 2024-02-26 에프. 호프만-라 로슈 아게 Nlrp3 억제제의 제조 공정
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CA2675884A1 (en) 2008-08-28
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EP2118076B1 (en) 2019-09-04
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