EA200500898A1 - Способ получения оптически чистых активных соединений - Google Patents

Способ получения оптически чистых активных соединений

Info

Publication number
EA200500898A1
EA200500898A1 EA200500898A EA200500898A EA200500898A1 EA 200500898 A1 EA200500898 A1 EA 200500898A1 EA 200500898 A EA200500898 A EA 200500898A EA 200500898 A EA200500898 A EA 200500898A EA 200500898 A1 EA200500898 A1 EA 200500898A1
Authority
EA
Eurasian Patent Office
Prior art keywords
optically pure
active compounds
pure active
obtaining optically
obtaining
Prior art date
Application number
EA200500898A
Other languages
English (en)
Other versions
EA011771B1 (ru
Inventor
Бернхард Коль
Бернд МЮЛЛЕР
Ральф Штеффен Вайнгарт
Original Assignee
Алтана Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алтана Фарма Аг filed Critical Алтана Фарма Аг
Publication of EA200500898A1 publication Critical patent/EA200500898A1/ru
Publication of EA011771B1 publication Critical patent/EA011771B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

В заявке описан новый способ получения оптически чистого ИПН, содержащего сульфинильную структуру, с помощью хирального комплекса циркония или хирального комплекса гафния.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500898A 2002-12-06 2003-12-03 Способ получения оптически чистых ингибиторов протонного насоса EA011771B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02027273 2002-12-06
DE10340255 2003-08-29
PCT/EP2003/013605 WO2004052882A1 (en) 2002-12-06 2003-12-03 Process for preparing optically pure active compounds

Publications (2)

Publication Number Publication Date
EA200500898A1 true EA200500898A1 (ru) 2005-12-29
EA011771B1 EA011771B1 (ru) 2009-06-30

Family

ID=32509784

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500898A EA011771B1 (ru) 2002-12-06 2003-12-03 Способ получения оптически чистых ингибиторов протонного насоса

Country Status (28)

Country Link
US (1) US7452998B2 (ru)
EP (1) EP1578742B1 (ru)
JP (1) JP4612542B2 (ru)
KR (1) KR101062806B1 (ru)
CN (1) CN100482658C (ru)
AR (1) AR042277A1 (ru)
AU (1) AU2003289948B2 (ru)
BR (2) BRPI0310118B1 (ru)
CA (1) CA2507807C (ru)
CY (1) CY1114058T1 (ru)
DK (1) DK1578742T3 (ru)
EA (1) EA011771B1 (ru)
ES (1) ES2397380T3 (ru)
HK (1) HK1078864A1 (ru)
HR (1) HRP20050604B1 (ru)
IL (1) IL168456A (ru)
IS (1) IS2885B (ru)
ME (1) ME00563A (ru)
MX (1) MXPA05005762A (ru)
NO (1) NO330978B1 (ru)
NZ (1) NZ540815A (ru)
PL (1) PL375818A1 (ru)
PT (1) PT1578742E (ru)
RS (1) RS52667B (ru)
SI (1) SI1578742T1 (ru)
TW (1) TWI313268B (ru)
WO (1) WO2004052882A1 (ru)
ZA (1) ZA200503543B (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
US7301030B2 (en) 2002-12-06 2007-11-27 Nycomed Gmbh Process for preparing (S)-pantoprazole
FR2848555B1 (fr) * 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
WO2004056804A2 (en) * 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
CA2528993A1 (en) * 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
MXPA06013623A (es) * 2004-06-02 2007-02-28 Altana Pharma Ag Procedimiento para la preparacion de compuestos piridin-2-ilmetilsulfinil-1h-benzimidazol.
FR2871800B1 (fr) * 2004-06-17 2006-08-25 Sidem Pharma Sa Sa Sel de sodium monohydrate du s-tenatoprazole et application en therapeutique
CN103772360A (zh) * 2004-06-24 2014-05-07 阿斯利康(瑞典)有限公司 制备用于制备艾美拉唑钠盐的结晶修饰物的新方法
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
US7579476B2 (en) * 2006-02-24 2009-08-25 Praktikatalyst Pharma, Llc Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals
WO2008018091A1 (en) * 2006-08-08 2008-02-14 Jubilant Organosys Limited Process for producing sulphoxide compounds
JP5492417B2 (ja) 2006-10-13 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 胃酸分泌抑制作用を有するベンズイミダゾール化合物
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
EP2265605A4 (en) * 2008-03-18 2011-08-03 Reddys Lab Ltd Dr METHOD OF MANUFACTURING DEXLANSOPRAZOLE AND POLYMORPHIDE THEREOF
EP2143722A1 (en) 2008-07-09 2010-01-13 Lek Pharmaceuticals D.D. Process for preparation of esomeprazole sodium of high chemical purity and new forms of esomeprazole sodium
EP2264024A1 (en) 2008-10-14 2010-12-22 LEK Pharmaceuticals d.d. Process for the preparation of enantiomerically enriched proton pump inhibitors
US8071781B2 (en) * 2008-11-11 2011-12-06 Syn-Tech Chem. & Pharm. Co., Ltd. Process for preparing rabeprazole sodium
JP5714031B2 (ja) 2010-02-12 2015-05-07 エステヴェ キミカ， エス．エー． エソメプラゾールナトリウムのナトリウム塩の調製方法
CN103113351B (zh) * 2013-03-08 2015-01-21 苏州特瑞药业有限公司 一种光学纯手性亚砜类化合物的制备方法
CN103936714A (zh) * 2014-04-15 2014-07-23 北京华禧联合科技发展有限公司 一种埃索美拉唑镁的制备方法
CN107428726B (zh) * 2014-12-26 2021-03-16 国立大学法人东京大学 光学活性的质子泵抑制剂化合物的制备方法
CN105440018A (zh) * 2015-11-27 2016-03-30 福州闽海药业有限公司 一种锆催化的右旋兰索拉唑的不对称氧化合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
IL75400A (en) 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
FI90544C (fi) 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
SE465514B (sv) 1990-02-19 1991-09-23 Curt Pettersson Foerfarande och anvaendning av ett separationsmedium vid separation av enantiomerer
DE4035455A1 (de) 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
JPH08509738A (ja) 1993-04-27 1996-10-15 セプラコー，インコーポレイテッド 光学的に純粋な（＋）パントプラゾールを用いる胃の疾患治療の方法と組成
WO1994024867A1 (en) 1993-04-27 1994-11-10 Sepracor, Inc. Methods and compositions for treating gastric disorders using optically pure (-) pantoprazole
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423970D0 (en) 1994-11-28 1995-01-11 Astra Ab Oxidation
GB9423968D0 (en) 1994-11-28 1995-01-11 Astra Ab Resolution
HRP960232A2 (en) 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
US7301030B2 (en) 2002-12-06 2007-11-27 Nycomed Gmbh Process for preparing (S)-pantoprazole

Also Published As

Publication number Publication date
JP4612542B2 (ja) 2011-01-12
CA2507807A1 (en) 2004-06-24
WO2004052882A1 (en) 2004-06-24
ES2397380T3 (es) 2013-03-06
KR20050085224A (ko) 2005-08-29
EA011771B1 (ru) 2009-06-30
HRP20050604B1 (hr) 2013-09-30
MXPA05005762A (es) 2005-08-16
CY1114058T1 (el) 2016-07-27
AR042277A1 (es) 2005-06-15
RS20050423A (en) 2007-04-10
IL168456A (en) 2012-02-29
CA2507807C (en) 2013-10-22
TW200508219A (en) 2005-03-01
HRP20050604A2 (en) 2006-09-30
CN1717403A (zh) 2006-01-04
AU2003289948B2 (en) 2009-12-24
JP2006516261A (ja) 2006-06-29
ZA200503543B (en) 2006-08-30
DK1578742T3 (da) 2013-01-21
HK1078864A1 (en) 2006-03-24
CN100482658C (zh) 2009-04-29
NO330978B1 (no) 2011-08-29
TWI313268B (en) 2009-08-11
BR0317005A (pt) 2005-10-25
NO20053099L (no) 2005-06-24
US20050288334A1 (en) 2005-12-29
AU2003289948A1 (en) 2004-06-30
SI1578742T1 (sl) 2013-02-28
NZ540815A (en) 2008-03-28
EP1578742A1 (en) 2005-09-28
IS7909A (is) 2005-06-23
NO20053099D0 (no) 2005-06-24
KR101062806B1 (ko) 2011-09-07
EP1578742B1 (en) 2012-10-17
PT1578742E (pt) 2013-01-24
RS52667B (en) 2013-06-28
PL375818A1 (en) 2005-12-12
BRPI0310118B1 (pt) 2015-10-20
ME00563A (en) 2011-12-20
US7452998B2 (en) 2008-11-18
IS2885B (is) 2014-07-15

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU