EA200500649A1 - Форма дозировки натриевой соли ибупрофена - Google Patents

Форма дозировки натриевой соли ибупрофена

Info

Publication number
EA200500649A1
EA200500649A1 EA200500649A EA200500649A EA200500649A1 EA 200500649 A1 EA200500649 A1 EA 200500649A1 EA 200500649 A EA200500649 A EA 200500649A EA 200500649 A EA200500649 A EA 200500649A EA 200500649 A1 EA200500649 A1 EA 200500649A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ibuprofena
sodium salt
tablet
tablet base
water content
Prior art date
Application number
EA200500649A
Other languages
English (en)
Other versions
EA007914B1 (ru
Inventor
Петер Грубер
Маркус Рехер
Original Assignee
Байер Консьюмер Кэар Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28796671&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200500649(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Консьюмер Кэар Аг filed Critical Байер Консьюмер Кэар Аг
Publication of EA200500649A1 publication Critical patent/EA200500649A1/ru
Publication of EA007914B1 publication Critical patent/EA007914B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Нешипучая таблетка ибупрофена, содержащая основу таблетки и, по желанию, сахарное или пленочное покрытие, где основа таблетки в расчете на массу основы таблетки состоит на 50-100 мас.% из гидрата натрий-ибупрофена и на 50-0 мас.% из компонента вспомогательного материала и не содержит ни смазочного вещества, ни дезинтегрирующего агента и где гидрат натрий-ибупрофена имеет содержание воды в пределах от 8 до 16 мас.%, предпочтительно от 11 до 16 мас.%, обладает достаточной твердостью, имеет относительно малые размеры и приводит к исключительно быстрому увеличению содержания (препарата) в крови и за счет этого к ускоренному наступлению обезболивающего действия. Вопреки распространенному представлению гидрат натрий-ибупрофена, имеющий подходящее содержание воды, обладает достаточной прессуемостью.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500649A 2002-10-14 2003-10-09 Форма дозировки натриевой соли ибупрофена EA007914B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01703/02A CH693586A8 (de) 2002-10-14 2002-10-14 Darreichungsform von Ibuprofen-Natrium.
PCT/CH2003/000662 WO2004035024A1 (en) 2002-10-14 2003-10-09 Dosage form of sodium ibuprofen

Publications (2)

Publication Number Publication Date
EA200500649A1 true EA200500649A1 (ru) 2005-10-27
EA007914B1 EA007914B1 (ru) 2007-02-27

Family

ID=28796671

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500649A EA007914B1 (ru) 2002-10-14 2003-10-09 Форма дозировки натриевой соли ибупрофена

Country Status (32)

Country Link
US (1) US20040102522A1 (ru)
EP (1) EP1410793B1 (ru)
JP (1) JP4608316B2 (ru)
KR (1) KR101046894B1 (ru)
CN (1) CN100592909C (ru)
AR (1) AR041428A1 (ru)
AT (1) ATE309789T1 (ru)
AU (1) AU2003266094B2 (ru)
BR (1) BRPI0315248B1 (ru)
CA (1) CA2500987A1 (ru)
CH (1) CH693586A8 (ru)
CO (1) CO5700709A2 (ru)
DE (1) DE50301661D1 (ru)
DK (1) DK1410793T3 (ru)
EA (1) EA007914B1 (ru)
EC (1) ECSP055793A (ru)
ES (1) ES2249702T3 (ru)
HR (1) HRP20050429A2 (ru)
IL (1) IL167357A (ru)
MA (1) MA27490A1 (ru)
MX (1) MXPA05003592A (ru)
MY (1) MY132858A (ru)
NO (1) NO20052343L (ru)
NZ (1) NZ539405A (ru)
PA (1) PA8586101A1 (ru)
PE (1) PE20040417A1 (ru)
PL (1) PL376177A1 (ru)
SI (1) SI1410793T1 (ru)
TW (1) TWI262800B (ru)
UA (1) UA86751C2 (ru)
WO (1) WO2004035024A1 (ru)
ZA (1) ZA200502925B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3920358A1 (de) * 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US6705028B2 (en) * 2001-09-12 2004-03-16 Honda Giken Kogyo Kabushiki Kaisha Self-propelled snowplow vehicle
US20050176809A1 (en) * 2004-02-05 2005-08-11 Rodlen Laboratories, Inc. Method and compositions for treatment of painful disorders
KR101232114B1 (ko) * 2004-08-12 2013-02-13 레킷트 벵키저 헬스케어(유케이)리미티드 용융 압출에 의해 제조된, 파라세타몰, ｎｓａｉｄ 및 당알콜 함유 과립
US20070077297A1 (en) 2004-09-30 2007-04-05 Scolr Pharma, Inc. Modified release ibuprofen dosage form
CA2610343A1 (en) 2005-03-03 2006-09-08 Takeda Pharmaceutical Company Limited Release-control composition
EP1800667A1 (en) 2005-12-23 2007-06-27 Losan Pharma GmbH Rapidly solubilizing ibuprofen granulate
RU2403033C2 (ru) 2005-03-22 2010-11-10 Лозан Фарма Гмбх Солюбилизированный ибупрофен
DE102006029233A1 (de) * 2006-06-26 2007-12-27 Liedtke, Rainer K., Dr. Formulierungen zur Verbesserung der Verträglichkeit nichtsteroidaler Antiphlogistika
CL2007002425A1 (es) 2006-08-22 2008-06-27 Albermarle Corp Procedimiento de preparacion controlado de sal sodica de ibuprofeno de tamano de particula mediano; y dichas particulas de sal sodica.
FI20080348A0 (fi) * 2008-02-15 2008-05-09 Atacama Labs Oy Uudenlainen farmaseuttinen formulaatio
US7749537B2 (en) * 2006-12-04 2010-07-06 Scolr Pharma, Inc. Method of forming a tablet
US9629809B2 (en) 2008-07-21 2017-04-25 Si Group, Inc. High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms
US9629806B2 (en) 2008-07-21 2017-04-25 Si Group, Inc. High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms
WO2011001228A1 (en) * 2008-08-14 2011-01-06 Shasun Chemicals And Drugs Limited Aryl alkyl carboxylic acid salts, process for preparation and dosage forms
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
AU2014200704C1 (en) * 2009-06-22 2018-12-06 Pf Consumer Healthcare 1 Llc Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen
EP2445486B1 (en) 2009-06-22 2017-11-08 Wyeth LLC Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen
AU2015264861C1 (en) * 2009-06-22 2017-11-16 Pf Consumer Healthcare 1 Llc Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen
FR2997856B1 (fr) * 2012-11-14 2015-04-24 Pf Medicament Pastille medicamenteuse a base d'ibuprofene sodique dihydrate
EP2965746B1 (en) 2014-07-10 2019-03-13 Santa Farma Ilaç Sanayi A.S. An oral pharmaceutical composition comprising ibuprofen, ibuprofen sodium dihydrate, pseudoephedrine hydrochloride and chlorpheniramine maleate
US20180078516A1 (en) * 2016-09-19 2018-03-22 Innovazone Labs LLC Pharmaceutical Composition of Ibuprofen Sodium for Oral Administration
CN113893227B (zh) * 2021-11-18 2023-04-14 山东则正医药技术有限公司 布洛芬片的制备原料、制备方法和布洛芬片

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104648A (en) * 1989-02-02 1992-04-14 Mallinckrodt Specialty Chemicals Company High ibuprofen content granulations
GB8920693D0 (en) * 1989-09-13 1989-10-25 Nicholas Kiwi Pty Ltd Non-effervescent ibuprofen compositions
CA2061520C (en) * 1991-03-27 2003-04-22 Lawrence J. Daher Delivery system for enhanced onset and increased potency
GB9224021D0 (en) * 1992-11-16 1993-01-06 Boots Co Plc Effervescent compositions
US6083430A (en) * 1994-10-28 2000-07-04 Fuisz Technologies Ltd. Method of preparing a dosage unit by direct tableting and product therefrom
GB9603699D0 (en) * 1996-02-21 1996-04-17 Boots Co Plc Therapeutic composition
IT1301966B1 (it) * 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica

Also Published As

Publication number Publication date
AU2003266094A1 (en) 2004-05-04
UA86751C2 (ru) 2009-05-25
NZ539405A (en) 2006-12-22
AU2003266094B2 (en) 2009-04-23
JP2006505558A (ja) 2006-02-16
BR0315248A (pt) 2005-08-23
EP1410793A1 (de) 2004-04-21
ZA200502925B (en) 2006-02-22
MA27490A1 (fr) 2005-08-01
TW200407175A (en) 2004-05-16
MY132858A (en) 2007-10-31
PE20040417A1 (es) 2004-07-14
MXPA05003592A (es) 2005-09-30
CO5700709A2 (es) 2006-11-30
CN100592909C (zh) 2010-03-03
ECSP055793A (es) 2005-08-11
SI1410793T1 (sl) 2006-04-30
BRPI0315248B1 (pt) 2016-08-02
PA8586101A1 (es) 2005-05-10
DE50301661D1 (de) 2005-12-22
PL376177A1 (en) 2005-12-27
DK1410793T3 (da) 2006-04-03
ES2249702T3 (es) 2006-04-01
JP4608316B2 (ja) 2011-01-12
EP1410793B1 (de) 2005-11-16
KR101046894B1 (ko) 2011-07-06
CH693586A8 (de) 2003-12-15
HRP20050429A2 (en) 2005-06-30
CA2500987A1 (en) 2004-04-29
TWI262800B (en) 2006-10-01
NO20052343L (no) 2005-06-02
ATE309789T1 (de) 2005-12-15
IL167357A (en) 2009-05-04
CN1705470A (zh) 2005-12-07
AR041428A1 (es) 2005-05-18
WO2004035024A1 (en) 2004-04-29
US20040102522A1 (en) 2004-05-27
EA007914B1 (ru) 2007-02-27
CH693586A5 (de) 2003-10-31
KR20050083760A (ko) 2005-08-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU