EA200500511A1 - Производные бензодиазепина, содержащие их продукт и фармацевтическая композиция и их применение - Google Patents

Производные бензодиазепина, содержащие их продукт и фармацевтическая композиция и их применение

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Publication number
EA200500511A1
EA200500511A1 EA200500511A EA200500511A EA200500511A1 EA 200500511 A1 EA200500511 A1 EA 200500511A1 EA 200500511 A EA200500511 A EA 200500511A EA 200500511 A EA200500511 A EA 200500511A EA 200500511 A1 EA200500511 A1 EA 200500511A1
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EA
Eurasian Patent Office
Prior art keywords
alkyl
aryl
heterocyclyl
heteroaryl
carbocyclyl
Prior art date
Application number
EA200500511A
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English (en)
Other versions
EA012387B1 (ru
Inventor
Малькольм Картер
Элиза Хендерсон
Ричард Келси
Лара Уилсон
Фил Чемберс
Дебра Тэйлор
Стэн Тимз
Original Assignee
Эрроу Терапьютикс Лимитед
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Publication date
Priority claimed from GBGB0221923.6A external-priority patent/GB0221923D0/en
Priority claimed from GB0302078A external-priority patent/GB0302078D0/en
Application filed by Эрроу Терапьютикс Лимитед filed Critical Эрроу Терапьютикс Лимитед
Publication of EA200500511A1 publication Critical patent/EA200500511A1/ru
Publication of EA012387B1 publication Critical patent/EA012387B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Обнаружено, что производное бензодиазепина формулы (I) и его фармацевтически приемлемые соли являются активными против RSVгде Rпредставляет собой Cалкил, арил или гетероарил; Rпредставляет собой водород или Cалкил; Rявляются одинаковыми или различными, и каждый представляет собой галоген, гидрокси, Cалкил, Cалкокси, Cалкилтио, Cгалогеналкил, Cгалогеналкокси, амино, моно(Cалкил)амино, ди(Cалкил)амино, нитро, циано, -COR', -CONR'R", -NH-CO-R', -S(O)R', -S(O)R', -NH-S(O)R', -S(O)NR'R" или -S(O)NR'R", где R' и R" являются одинаковыми или различными, и каждый представляет собой водород или Cалкил; n равно 0-3;Rпредставляет собой водород или Cалкил; Rпредставляет собой Cалкил, арил, гетероарил, карбоциклил, гетероциклил, арил(Cалкил)-, гетероарил(Cалкил)-, карбоциклил(Cалкил)-, гетероциклил(Cалкил)-, арил-C(O)-C(O)-, гетероарил-C(O)-C(O)-, карбоциклил-C(O)-C(O)-, гетероциклил-C(O)-C(O)- или -XR; X представляет собой -CO-, -S(O) или -S(O)- и Rпредставляет собой Cалкил, гидрокси, Cалкокси, Cалкилтио, арил, гетероарил, карбоциклил, гетероциклил, арил(Cалкил)-, гетероарил(Cалкил)-, карбоциклил(Cалкил)-, гетероциклил(Cалкил)-, арил(Cгидроксиалкил)-, гетероарил(Cгидроксиалкил)-, карбоциклил(Cгидроксиалкил)-, гетероциклил(Cгидроксиалкил)-, арил(Cалкил)-O-, гетероарил(Cалкил)-O-, карбоциклил(Cалкил)-O-, гетероциклил(Cалкил)-O- или -NR'R", где R' и R" являются одинаковыми или различными, и каждый представляет собой водород, Cалкил, карбоциклил, гетероциклил, арил, гетероарил, арил(Cалкил)-, гетероарил(Cалкил)-, карбоциклил(Cалкил)-или гетероциклил(Cалкил)-.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500511A 2002-09-20 2003-09-22 Производные бензодиазепина, содержащие их продукт и фармацевтическая композиция и их применение EA012387B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0221923.6A GB0221923D0 (en) 2002-09-20 2002-09-20 Chemical compounds
GB0302078A GB0302078D0 (en) 2003-01-29 2003-01-29 Chemical compounds
PCT/GB2003/004050 WO2004026843A1 (en) 2002-09-20 2003-09-22 Benzodiazepine derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
EA200500511A1 true EA200500511A1 (ru) 2006-02-24
EA012387B1 EA012387B1 (ru) 2009-10-30

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EA200500511A EA012387B1 (ru) 2002-09-20 2003-09-22 Производные бензодиазепина, содержащие их продукт и фармацевтическая композиция и их применение

Country Status (16)

Country Link
US (2) US7582624B2 (ru)
EP (1) EP1539716A1 (ru)
JP (2) JP4719466B2 (ru)
KR (1) KR101125899B1 (ru)
AU (1) AU2003267587B2 (ru)
BR (1) BR0314595A (ru)
CA (1) CA2499322C (ru)
EA (1) EA012387B1 (ru)
IL (1) IL167332A (ru)
IS (1) IS7735A (ru)
MX (1) MXPA05002871A (ru)
NO (2) NO20051908L (ru)
NZ (2) NZ538870A (ru)
PL (1) PL375860A1 (ru)
WO (1) WO2004026843A1 (ru)
ZA (1) ZA200502001B (ru)

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AU2003267587B2 (en) 2010-05-20
MXPA05002871A (es) 2005-10-05
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IL167332A (en) 2013-10-31
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