PE20080261A1 - Sales y modificaciones del cristal de las mismas - Google Patents

Sales y modificaciones del cristal de las mismas

Info

Publication number
PE20080261A1
PE20080261A1 PE2007000619A PE2007000619A PE20080261A1 PE 20080261 A1 PE20080261 A1 PE 20080261A1 PE 2007000619 A PE2007000619 A PE 2007000619A PE 2007000619 A PE2007000619 A PE 2007000619A PE 20080261 A1 PE20080261 A1 PE 20080261A1
Authority
PE
Peru
Prior art keywords
salt
phenyl
refers
salts
glass
Prior art date
Application number
PE2007000619A
Other languages
English (en)
Inventor
Lili Feng
Xinglong Jiang
Piotr H Karpinski
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20080261A1 publication Critical patent/PE20080261A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UNA SAL DE MONOHIDRATO DE BESILATO DE 1-(2-FLUORO-FENIL)-3-(2-OXO-5-FENIL-2,3-DIHIDRO-1H-BENZO-[e]-[1,4]-DIAZEPIN-3-IL)-UREA CRISTALINO CARACTERIZADO POR UN PATRON DE RAYOS-X EN UN ANGULO DE DIFRACCION 2-THETA DE 7.5 +-0.5, 21.3+-0.5. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE DICHA SAL QUE COMPRENDE DE CRISTALIZAR O RECRISTALIZAR LA SAL DE BESILATO EN UNA SOLUCION QUE COMPRENDE ACETONA, ACETONICTRILO, ACETATO DE ETILO O TERBUTIL-METIL-ETER
PE2007000619A 2006-05-23 2007-05-21 Sales y modificaciones del cristal de las mismas PE20080261A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80283606P 2006-05-23 2006-05-23

Publications (1)

Publication Number Publication Date
PE20080261A1 true PE20080261A1 (es) 2008-04-18

Family

ID=38704747

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000619A PE20080261A1 (es) 2006-05-23 2007-05-21 Sales y modificaciones del cristal de las mismas

Country Status (28)

Country Link
US (1) US7977330B2 (es)
EP (1) EP2029556B1 (es)
JP (2) JP2009538330A (es)
KR (1) KR20090009898A (es)
CN (1) CN101448796B (es)
AR (1) AR061056A1 (es)
AT (1) ATE486858T1 (es)
AU (1) AU2007267671A1 (es)
BR (1) BRPI0712556A2 (es)
CA (1) CA2650514A1 (es)
CL (1) CL2007001454A1 (es)
CR (1) CR10431A (es)
DE (1) DE602007010286D1 (es)
EC (1) ECSP088900A (es)
ES (1) ES2355166T3 (es)
GT (1) GT200800253A (es)
IL (1) IL195008A0 (es)
MA (1) MA30482B1 (es)
MX (1) MX2008014836A (es)
NO (1) NO20085000L (es)
PE (1) PE20080261A1 (es)
PL (1) PL2029556T3 (es)
PT (1) PT2029556E (es)
RU (1) RU2008150627A (es)
TN (1) TNSN08477A1 (es)
TW (1) TW200815375A (es)
WO (1) WO2007140154A2 (es)
ZA (1) ZA200809096B (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0314595A (pt) * 2002-09-20 2005-08-09 Arrow Therapeutics Ltd Uso de um derivado de benzodiazepina ou um sal farmaceuticamente aceitável deste, inalador ou nebulisador, produto, usos de um produto e de um composto ou sal farmaceuticamente aceitável deste, derivado de benzodiazepina, composto, e, composição farmacêutica

Also Published As

Publication number Publication date
ZA200809096B (en) 2009-11-25
ES2355166T3 (es) 2011-03-23
DE602007010286D1 (de) 2010-12-16
KR20090009898A (ko) 2009-01-23
BRPI0712556A2 (pt) 2013-07-02
CN101448796A (zh) 2009-06-03
TW200815375A (en) 2008-04-01
JP2009538330A (ja) 2009-11-05
CN101448796B (zh) 2012-09-26
NO20085000L (no) 2008-12-23
IL195008A0 (en) 2009-08-03
MX2008014836A (es) 2008-12-01
US20090163478A1 (en) 2009-06-25
GT200800253A (es) 2009-04-29
CR10431A (es) 2009-01-07
ECSP088900A (es) 2008-12-30
MA30482B1 (fr) 2009-06-01
JP2013075910A (ja) 2013-04-25
ATE486858T1 (de) 2010-11-15
AR061056A1 (es) 2008-07-30
AU2007267671A1 (en) 2007-12-06
PT2029556E (pt) 2011-01-31
PL2029556T3 (pl) 2011-04-29
WO2007140154A2 (en) 2007-12-06
US7977330B2 (en) 2011-07-12
CL2007001454A1 (es) 2008-05-16
EP2029556A2 (en) 2009-03-04
WO2007140154A3 (en) 2008-03-20
TNSN08477A1 (en) 2010-04-14
RU2008150627A (ru) 2010-06-27
EP2029556B1 (en) 2010-11-03
CA2650514A1 (en) 2007-12-06

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