ECSP12012026A - Formas cristalinas de 3-(2,6-dicloro-3,5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas - Google Patents

Formas cristalinas de 3-(2,6-dicloro-3,5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas

Info

Publication number
ECSP12012026A
ECSP12012026A ECSP12012026A ECSP12012026A EC SP12012026 A ECSP12012026 A EC SP12012026A EC SP12012026 A ECSP12012026 A EC SP12012026A EC SP12012026 A ECSP12012026 A EC SP12012026A
Authority
EC
Ecuador
Prior art keywords
phenyl
piperazin
urea
amino
methyl
Prior art date
Application number
Other languages
English (en)
Inventor
Joel Slade
Joseph Mckenna
Prasad Koteswara Kapa
Frank Stowasser
Joerg Berghausen
Raeann Wu
Zhengming Du
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43983750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12012026(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP12012026A publication Critical patent/ECSP12012026A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente tecnología proporciona novedosas formas cristalinas anhidras e hidratadas de 3-(2,6-dicloro-3,5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea, polimorfos amorfos y cristalinos anhidros de su sal de ácido monofosfórico, y la sal de clorhidrato, incluyendo su dihidrato. La presente tecnología proporciona además métodos para la preparación de las diferentes formas, composiciones que las contienen, y métodos para el tratamiento mediante el empleo de las mismas.
ECSP12012026 2009-12-07 2012-07-05 Formas cristalinas de 3-(2,6-dicloro-3,5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas ECSP12012026A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26715509P 2009-12-07 2009-12-07

Publications (1)

Publication Number Publication Date
ECSP12012026A true ECSP12012026A (es) 2012-08-31

Family

ID=43983750

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12012026 ECSP12012026A (es) 2009-12-07 2012-07-05 Formas cristalinas de 3-(2,6-dicloro-3,5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas

Country Status (33)

Country Link
US (1) US9067896B2 (es)
EP (1) EP2509963B1 (es)
JP (2) JP5714024B2 (es)
KR (1) KR101787784B1 (es)
CN (5) CN105061332A (es)
AR (2) AR079257A1 (es)
AU (1) AU2010328391B2 (es)
BR (1) BR112012013784B1 (es)
CA (1) CA2781431C (es)
CL (1) CL2012001480A1 (es)
DK (1) DK2509963T3 (es)
EC (1) ECSP12012026A (es)
ES (1) ES2562462T3 (es)
GT (1) GT201200181A (es)
HK (1) HK1171016A1 (es)
HR (1) HRP20160126T1 (es)
HU (1) HUE026983T2 (es)
IL (1) IL220012B (es)
JO (1) JO3061B1 (es)
MA (1) MA33849B1 (es)
MX (1) MX2012006562A (es)
MY (1) MY158333A (es)
NZ (3) NZ600070A (es)
PE (1) PE20121499A1 (es)
PH (1) PH12014502593A1 (es)
PL (1) PL2509963T3 (es)
RU (1) RU2572848C2 (es)
SG (1) SG10201408063SA (es)
SI (1) SI2509963T1 (es)
TN (1) TN2012000263A1 (es)
TW (1) TWI526440B (es)
WO (1) WO2011071821A1 (es)
ZA (1) ZA201203612B (es)

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WO2016055916A1 (en) 2014-10-06 2016-04-14 Novartis Ag Therapeutic combination for the treatment of cancer
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
CN113004278B (zh) 2015-02-20 2023-07-21 因赛特控股公司 作为fgfr抑制剂的双环杂环
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
JP2018509448A (ja) * 2015-03-25 2018-04-05 ノバルティス アーゲー 組合せ医薬
MX2017013248A (es) 2015-04-14 2018-07-06 Eisai R&D Man Co Ltd Compuesto del inhibidor fgfr4 cristalino y usos del mismo.
CN104803925B (zh) * 2015-04-16 2018-01-12 温州医科大学 一类以fgfr为靶点的2，4，5‑三取代嘧啶类化合物及其制备方法和用途
WO2016189472A1 (en) 2015-05-28 2016-12-01 Novartis Ag Fgfr inhibitor for use in the treatment of the phosphaturic mesenchymal tumor
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Publication number Publication date
HK1171016A1 (zh) 2013-03-15
KR20130028045A (ko) 2013-03-18
US9067896B2 (en) 2015-06-30
HUE026983T2 (en) 2016-08-29
EP2509963A1 (en) 2012-10-17
NZ700778A (en) 2015-04-24
ZA201203612B (en) 2013-01-30
SG10201408063SA (en) 2015-01-29
TN2012000263A1 (en) 2013-12-12
AU2010328391A1 (en) 2012-06-07
BR112012013784A2 (pt) 2016-05-03
AR079257A1 (es) 2012-01-04
CA2781431C (en) 2017-10-31
AR114946A2 (es) 2020-11-11
AU2010328391B2 (en) 2014-07-03
MA33849B1 (fr) 2012-12-03
EP2509963B1 (en) 2015-11-25
TW201144297A (en) 2011-12-16
ES2562462T3 (es) 2016-03-04
PE20121499A1 (es) 2012-11-15
IL220012A0 (en) 2012-07-31
BR112012013784A8 (pt) 2017-12-26
JP6019142B2 (ja) 2016-11-02
PL2509963T3 (pl) 2016-05-31
DK2509963T3 (en) 2016-02-29
JP5714024B2 (ja) 2015-05-07
US20120245182A1 (en) 2012-09-27
NZ624315A (en) 2014-11-28
KR101787784B1 (ko) 2017-10-18
MY158333A (en) 2016-09-30
CN111269186A (zh) 2020-06-12
NZ600070A (en) 2014-06-27
CN105061332A (zh) 2015-11-18
CN111100077A (zh) 2020-05-05
JP2015107996A (ja) 2015-06-11
WO2011071821A1 (en) 2011-06-16
BR112012013784B1 (pt) 2021-11-03
RU2012128351A (ru) 2014-01-20
CL2012001480A1 (es) 2014-09-05
CN111100078A (zh) 2020-05-05
CN102639510A (zh) 2012-08-15
JO3061B1 (ar) 2017-03-15
TWI526440B (zh) 2016-03-21
IL220012B (en) 2018-02-28
JP2013512956A (ja) 2013-04-18
CA2781431A1 (en) 2011-06-16
HRP20160126T1 (hr) 2016-03-25
SI2509963T1 (sl) 2016-05-31
PH12014502593A1 (en) 2015-09-21
MX2012006562A (es) 2012-07-04
GT201200181A (es) 2013-12-03
RU2572848C2 (ru) 2016-01-20

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