AR057347A1 - Compuesto sulfonilamino-aril bifenilo sustituido, formulacion farmaceutica que lo comprende, su uso para la manufactura de un medicamento y compuesto de utilidad como intermediario en la sintesis del mismo - Google Patents
Compuesto sulfonilamino-aril bifenilo sustituido, formulacion farmaceutica que lo comprende, su uso para la manufactura de un medicamento y compuesto de utilidad como intermediario en la sintesis del mismoInfo
- Publication number
- AR057347A1 AR057347A1 ARP060102320A ARP060102320A AR057347A1 AR 057347 A1 AR057347 A1 AR 057347A1 AR P060102320 A ARP060102320 A AR P060102320A AR P060102320 A ARP060102320 A AR P060102320A AR 057347 A1 AR057347 A1 AR 057347A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halo
- group
- cyano
- substituent selected
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 2
- -1 -CONH2 Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Formulacion farmacéutica que lo comprende y su uso para la manufactura de medicamentos para el tratamiento de la enfermedad de Alzheimer, la enfermedad de Parkinson o del deterioro cognitivo medio. Compuesto de utilidad como intermediario en la síntesis del compuesto de formula (1) descripto. Reivindicacion 1: Un compuesto de sulfonilamino-aril bifenilo sustituido caracterizado porque es de formula (1),: donde A se selecciona del grupo que consiste de las formulas (2) a (8), R es H, halo, -COOH, o -CH2COOH; R1 es fenilo opcionalmente sustituido con una primer sustituyente seleccionado del grupo que consiste de halo, ciano, acilo C1-4, -COOH, -NHR3, alquilo C1-2 sustituido con -NHCH3, -N(SO2(alquilo C1-3)2, -COOH, -CONH2, ciano, hidroxi, o tetrazol-5-ilo, - OCH2COOH, -SCH2COOH, -C(O)CH2CH2COOH, -SO2NH2, tetrazol-5-ilo, y 1,2,4-triazol-1-ilo; opcionalmente además sustituido con un segundo sustituyente seleccionado del grupo que consiste de: halo, trifluorometilo, ciano, nitro, alcoxi C1-4, hidroxi, alquilo C1-4, alquiltio C1-4, -NHCH2CN, -OCH2CN, -NHSO2CH(CH3)2, y -C(O)NHR4; opcionalmente además sustituido con un tercer sustituyente seleccionado del grupo que consiste de halo y ciano; opcionalmente además sustituido con una cuarto sustituyente seleccionado del grupo que consiste de halo; R2 es alquilo C1-4 o dimetilamino; R3 es -SO2(alquilo C1-3), acilo C1-4, alquilo C1-4, o hidrogeno; R4 es hidrogeno, alquilo C1-C4, o -SO2(alquilo C1-4); o una sal del mismo farmacéuticamente aceptable.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05380117 | 2005-06-06 | ||
| EP05380187 | 2005-08-18 | ||
| US72420605P | 2005-10-06 | 2005-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057347A1 true AR057347A1 (es) | 2007-11-28 |
Family
ID=37227734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102320A AR057347A1 (es) | 2005-06-06 | 2006-06-02 | Compuesto sulfonilamino-aril bifenilo sustituido, formulacion farmaceutica que lo comprende, su uso para la manufactura de un medicamento y compuesto de utilidad como intermediario en la sintesis del mismo |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7393868B2 (es) |
| AR (1) | AR057347A1 (es) |
| CR (1) | CR9574A (es) |
| CY (1) | CY1108718T1 (es) |
| DE (1) | DE602006003661D1 (es) |
| DO (1) | DOP2006000124A (es) |
| EC (1) | ECSP077979A (es) |
| HK (1) | HK1116182A1 (es) |
| IL (1) | IL187157A0 (es) |
| JO (1) | JO2539B1 (es) |
| MA (1) | MA29910B1 (es) |
| MY (1) | MY140858A (es) |
| NO (1) | NO20080079L (es) |
| PE (1) | PE20070107A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006003661D1 (de) * | 2005-06-06 | 2008-12-24 | Lilly Co Eli | Ampa-rezeptoren-verstärker |
| CN101600436A (zh) * | 2006-08-31 | 2009-12-09 | 艾伯塔大学校董 | 使用正变构ampa受体调节剂抑制呼吸抑制的方法 |
| CN102395270B (zh) * | 2008-07-07 | 2014-11-12 | 法斯根公司 | 化合物、含有其的药物组合物、其使用方法及其制备方法 |
| US20110218190A1 (en) * | 2008-11-10 | 2011-09-08 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| US9527807B2 (en) | 2011-04-05 | 2016-12-27 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| CN105579575A (zh) | 2013-06-13 | 2016-05-11 | 维罗技术有限责任公司 | 用于治疗代谢失调的组合物和方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9702194D0 (en) | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
| AU5235699A (en) | 1998-07-31 | 2000-02-21 | Eli Lilly And Company | Sulfonamide derivatives |
| EP1246797B1 (en) | 1999-12-08 | 2008-07-23 | Eli Lilly And Company | Cyclopentyl sulfonamide derivatives |
| EP1334087A1 (en) | 2000-10-13 | 2003-08-13 | Eli Lilly And Company | Cycloalkylfluorosulfonamide derivatives |
| US20040087604A1 (en) * | 2001-01-22 | 2004-05-06 | Tatsuo Tsuri | Hetero-tricyclic compounds having substituted amino groups |
| EP1395550B1 (en) | 2001-05-30 | 2005-06-29 | Eli Lilly And Company | Cycloalkenylsulfonamide derivatives |
| AP1753A (en) | 2001-06-11 | 2007-07-18 | Shire Biochem Inc | Thiophene derivatives as antiviral agents for flavvivirus infection |
| SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| US7642361B2 (en) | 2004-01-09 | 2010-01-05 | Eli Lilly And Company | Thiophene and furan compounds |
| EP1786769A1 (en) | 2004-08-09 | 2007-05-23 | Glaxo Group Limited | Compounds which potentiate glutamate receptor and uses thereof in medicine |
| DE602006003661D1 (de) * | 2005-06-06 | 2008-12-24 | Lilly Co Eli | Ampa-rezeptoren-verstärker |
-
2006
- 2006-05-25 DE DE602006003661T patent/DE602006003661D1/de active Active
- 2006-06-01 DO DO2006000124A patent/DOP2006000124A/es unknown
- 2006-06-02 AR ARP060102320A patent/AR057347A1/es not_active Application Discontinuation
- 2006-06-02 PE PE2006000603A patent/PE20070107A1/es not_active Application Discontinuation
- 2006-06-05 US US11/446,840 patent/US7393868B2/en not_active Expired - Fee Related
- 2006-06-05 MY MYPI20062598A patent/MY140858A/en unknown
- 2006-06-06 US US11/422,473 patent/US7652064B2/en not_active Expired - Fee Related
- 2006-06-06 JO JO2006164A patent/JO2539B1/en active
-
2007
- 2007-11-05 IL IL187157A patent/IL187157A0/en unknown
- 2007-12-03 EC EC2007007979A patent/ECSP077979A/es unknown
- 2007-12-06 CR CR9574A patent/CR9574A/es unknown
-
2008
- 2008-01-04 MA MA30543A patent/MA29910B1/fr unknown
- 2008-01-04 NO NO20080079A patent/NO20080079L/no not_active Application Discontinuation
- 2008-06-12 HK HK08106513.7A patent/HK1116182A1/xx not_active IP Right Cessation
-
2009
- 2009-01-21 CY CY20091100077T patent/CY1108718T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20080079L (no) | 2008-01-04 |
| US7652064B2 (en) | 2010-01-26 |
| CR9574A (es) | 2008-05-30 |
| PE20070107A1 (es) | 2007-02-09 |
| MA29910B1 (fr) | 2008-11-03 |
| US7393868B2 (en) | 2008-07-01 |
| DOP2006000124A (es) | 2007-02-15 |
| HK1116182A1 (en) | 2008-12-19 |
| IL187157A0 (en) | 2008-02-09 |
| US20070142441A1 (en) | 2007-06-21 |
| JO2539B1 (en) | 2010-09-05 |
| ECSP077979A (es) | 2008-01-23 |
| DE602006003661D1 (de) | 2008-12-24 |
| CY1108718T1 (el) | 2014-04-09 |
| MY140858A (en) | 2010-01-29 |
| US20060276532A1 (en) | 2006-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |