EA200300691A1 - Производные 2,3-бензодиазепина и фармацевтические композиции, содержащие эти производные в качестве активного ингредиента - Google Patents

Производные 2,3-бензодиазепина и фармацевтические композиции, содержащие эти производные в качестве активного ингредиента

Info

Publication number
EA200300691A1
EA200300691A1 EA200300691A EA200300691A EA200300691A1 EA 200300691 A1 EA200300691 A1 EA 200300691A1 EA 200300691 A EA200300691 A EA 200300691A EA 200300691 A EA200300691 A EA 200300691A EA 200300691 A1 EA200300691 A1 EA 200300691A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
active ingredient
pharmaceutical compositions
compositions containing
benzodiazepina
Prior art date
Application number
EA200300691A
Other languages
English (en)
Other versions
EA005867B1 (ru
Inventor
Иштван Линг
Йожеф Баркоци
Дьюла Шимиг
Зольтан Грефф
Зольтан Раткаи
Геза Сабо
Миклош Вег
Габор Гиглер
Габор Сенаши
Марко Бернадетт Мартонне
Дьердь Леваи
Ласло Габор Харшинг
Original Assignee
Эгиш Дьёдьсердьяр Рт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Рт filed Critical Эгиш Дьёдьсердьяр Рт
Publication of EA200300691A1 publication Critical patent/EA200300691A1/ru
Publication of EA005867B1 publication Critical patent/EA005867B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к новым производным 2,3-бензодиазепина формулы I и фармацевтическим композициям, содержащим эти производные в качестве активного ингредиента. Эти новые производные обладают противоспазматическим, расслабляющим мышцы и нейропротекторным действием. В формуле I X - водород, хлор или метоксигруппа, Y - водород или галоген, Z - метил или хлор, R - Cалкил или группа формулы -NRR, где Rи Rнезависимо представляют собой водород, Cалкил, Cалкоксил или Cциклоалкил.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300691A 2000-12-21 2001-12-19 Производные 2,3-бензодиазепина и фармацевтические композиции, содержащие эти производные в качестве активного ингредиента EA005867B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0004994A HU225100B1 (hu) 2000-12-21 2000-12-21 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
PCT/HU2001/000151 WO2002050044A1 (en) 2000-12-21 2001-12-19 Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

Publications (2)

Publication Number Publication Date
EA200300691A1 true EA200300691A1 (ru) 2003-12-25
EA005867B1 EA005867B1 (ru) 2005-06-30

Family

ID=89978876

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300691A EA005867B1 (ru) 2000-12-21 2001-12-19 Производные 2,3-бензодиазепина и фармацевтические композиции, содержащие эти производные в качестве активного ингредиента

Country Status (20)

Country Link
US (1) US7189711B2 (ru)
EP (1) EP1351942B1 (ru)
JP (1) JP4201252B2 (ru)
AT (1) ATE271548T1 (ru)
AU (1) AU2002217356A1 (ru)
BG (1) BG66199B1 (ru)
CA (1) CA2431761C (ru)
CZ (1) CZ301371B6 (ru)
DE (1) DE60104448T2 (ru)
DK (1) DK1351942T3 (ru)
EA (1) EA005867B1 (ru)
ES (1) ES2225412T3 (ru)
HU (1) HU225100B1 (ru)
PL (1) PL211495B1 (ru)
PT (1) PT1351942E (ru)
RO (1) RO121268B1 (ru)
SK (1) SK286620B6 (ru)
TR (1) TR200402493T4 (ru)
UA (1) UA74615C2 (ru)
WO (1) WO2002050044A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
WO2007077469A1 (en) * 2005-12-30 2007-07-12 Egis Gyógyszergyár Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
WO2014026997A1 (de) * 2012-08-16 2014-02-20 Bayer Pharma Aktiengesellschaft 2,3-benzodiazepine
CN105492436A (zh) * 2013-06-17 2016-04-13 拜耳制药股份公司 取代的苯基-2,3-苯并二氮杂环庚三烯

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
RU2325811C2 (ru) 2006-06-28 2008-06-10 Общество С Ограниченной Ответственностью "Фито-Маг" Способ хранения плодоовощной и растениеводческой продукции

Also Published As

Publication number Publication date
CA2431761C (en) 2010-05-25
DK1351942T3 (da) 2004-11-22
EP1351942A1 (en) 2003-10-15
BG66199B1 (bg) 2012-01-31
SK286620B6 (sk) 2009-02-05
SK7882003A3 (en) 2003-11-04
CA2431761A1 (en) 2002-06-27
JP4201252B2 (ja) 2008-12-24
EP1351942B1 (en) 2004-07-21
ES2225412T3 (es) 2005-03-16
PL211495B1 (pl) 2012-05-31
EA005867B1 (ru) 2005-06-30
BG107932A (bg) 2004-02-27
HUP0004994A2 (hu) 2002-11-28
PL362029A1 (en) 2004-10-18
DE60104448T2 (de) 2005-07-28
CZ20031680A3 (cs) 2003-11-12
US7189711B2 (en) 2007-03-13
UA74615C2 (en) 2006-01-16
AU2002217356A1 (en) 2002-07-01
TR200402493T4 (tr) 2004-12-21
HU0004994D0 (en) 2001-03-28
RO121268B1 (ro) 2007-02-28
DE60104448D1 (de) 2004-08-26
JP2004516284A (ja) 2004-06-03
HU225100B1 (hu) 2006-06-28
ATE271548T1 (de) 2004-08-15
WO2002050044A1 (en) 2002-06-27
US20040092510A1 (en) 2004-05-13
CZ301371B6 (cs) 2010-02-03
PT1351942E (pt) 2004-11-30

Similar Documents

Publication Publication Date Title
YU8703A (sh) Derivati 4-fenil-piridina kao antagonisti receptora neurokinina-1
EA200201179A1 (ru) Производные 2-аминокарбонил-9h-пурина
ES2121441T3 (es) Nuevos derivados de 3,5 -dioxo - (2h,4h) - 1,2,4 - triazina,su preparacion y aplicacion como farmaco
EA200100972A1 (ru) Новые соединения и композиции как ингибиторы протеаз
DE60140456D1 (de) Aza heterocyclische derivate und ihre therapeutische verwendung
CO5271675A1 (es) Derivados de decahidro-isoquinolinas, proceso para su preparacion, composicion y compuestos farmaceuticos que los contienen
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
CY1106522T1 (el) Ετepοκυκλικη ενωση και αντικαρκινικο μεσο που πepιεχει την ιδια ως δραστικο συστατικο
TNSN03110A1 (en) Azaindoles.
AP2002002637A0 (en) Novel piperazine
YU40997A (sh) Novi oksadiazoli, postupci za njihovo pripremanje
DE60307179D1 (de) Vor UV-Strahlen schützende Zusammensetzungen
HUP0402649A2 (hu) 6-Fluor-biciklo[3.1.0]hexán-származékok
IL151172A0 (en) Amine derivatives, their preparation and use as bax modulators
NO20026094D0 (no) Fusjonerte azepinderivater og deres anvendelse som antidiuretiske midler
HUP9903216A2 (hu) Helyettesített benzamidok, valamint alkalmazásuk hatóanyagként gyógyászati készítményekben
JO2321B1 (en) 4-phenyl-pyridine derivatives
AR029343A1 (es) USO DE UN ANTAGONISTA DE NMDA DE BAJA AFINIDAD PARA EL TRATAMIENTO DE LA DEPRESIoN
RS50229B (sr) Analozi vitamina d3
EA200300044A1 (ru) Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
BG105710A (en) 5ht1 antagonists for antidepressant therapy
EA200400806A1 (ru) Способ получения эхинокандиновых соединений
BG106847A (en) Substituted piperazine derivatives as mtp inhibitors
EA200300691A1 (ru) Производные 2,3-бензодиазепина и фармацевтические композиции, содержащие эти производные в качестве активного ингредиента
PT1430047E (pt) Derivados de alquilaminopiridazinona substituida, processo para a sua preparacao e composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU