EA200300691A1 - DERIVATIVES 2,3-BENZODIAZEPINA AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES AS AN ACTIVE INGREDIENT - Google Patents

DERIVATIVES 2,3-BENZODIAZEPINA AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES AS AN ACTIVE INGREDIENT

Info

Publication number
EA200300691A1
EA200300691A1 EA200300691A EA200300691A EA200300691A1 EA 200300691 A1 EA200300691 A1 EA 200300691A1 EA 200300691 A EA200300691 A EA 200300691A EA 200300691 A EA200300691 A EA 200300691A EA 200300691 A1 EA200300691 A1 EA 200300691A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
active ingredient
pharmaceutical compositions
compositions containing
benzodiazepina
Prior art date
Application number
EA200300691A
Other languages
Russian (ru)
Other versions
EA005867B1 (en
Inventor
Иштван Линг
Йожеф Баркоци
Дьюла Шимиг
Зольтан Грефф
Зольтан Раткаи
Геза Сабо
Миклош Вег
Габор Гиглер
Габор Сенаши
Марко Бернадетт Мартонне
Дьердь Леваи
Ласло Габор Харшинг
Original Assignee
Эгиш Дьёдьсердьяр Рт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Рт filed Critical Эгиш Дьёдьсердьяр Рт
Publication of EA200300691A1 publication Critical patent/EA200300691A1/en
Publication of EA005867B1 publication Critical patent/EA005867B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к новым производным 2,3-бензодиазепина формулы I и фармацевтическим композициям, содержащим эти производные в качестве активного ингредиента. Эти новые производные обладают противоспазматическим, расслабляющим мышцы и нейропротекторным действием. В формуле I X - водород, хлор или метоксигруппа, Y - водород или галоген, Z - метил или хлор, R - Cалкил или группа формулы -NRR, где Rи Rнезависимо представляют собой водород, Cалкил, Cалкоксил или Cциклоалкил.Международная заявка была опубликована вместе с отчетом о международном поиске.The invention relates to new derivatives of 2,3-benzodiazepine of the formula I and pharmaceutical compositions containing these derivatives as an active ingredient. These new derivatives have antispasmodic, muscle relaxant and neuroprotective effects. In formula IX, it is hydrogen, chlorine or methoxy, Y is hydrogen or halogen, Z is methyl or chlorine, R is C1-6 alkyl or a group of the formula —NRR, where R1 and R2 independently represent hydrogen, C1-4 alkyl, C1-6 alkoxy or Ccycloalkyl. The international application was published together with international search report.

EA200300691A 2000-12-21 2001-12-19 Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient EA005867B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0004994A HU225100B1 (en) 2000-12-21 2000-12-21 2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and their use
PCT/HU2001/000151 WO2002050044A1 (en) 2000-12-21 2001-12-19 Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

Publications (2)

Publication Number Publication Date
EA200300691A1 true EA200300691A1 (en) 2003-12-25
EA005867B1 EA005867B1 (en) 2005-06-30

Family

ID=89978876

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300691A EA005867B1 (en) 2000-12-21 2001-12-19 Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

Country Status (20)

Country Link
US (1) US7189711B2 (en)
EP (1) EP1351942B1 (en)
JP (1) JP4201252B2 (en)
AT (1) ATE271548T1 (en)
AU (1) AU2002217356A1 (en)
BG (1) BG66199B1 (en)
CA (1) CA2431761C (en)
CZ (1) CZ301371B6 (en)
DE (1) DE60104448T2 (en)
DK (1) DK1351942T3 (en)
EA (1) EA005867B1 (en)
ES (1) ES2225412T3 (en)
HU (1) HU225100B1 (en)
PL (1) PL211495B1 (en)
PT (1) PT1351942E (en)
RO (1) RO121268B1 (en)
SK (1) SK286620B6 (en)
TR (1) TR200402493T4 (en)
UA (1) UA74615C2 (en)
WO (1) WO2002050044A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
EP1979308A1 (en) * 2005-12-30 2008-10-15 EGIS Gyógyszergyár Nyrt Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
CA2881996A1 (en) * 2012-08-16 2014-02-20 Bayer Pharma Aktiengesellschaft 2,3-benzodiazepines
CN105492436A (en) * 2013-06-17 2016-04-13 拜耳制药股份公司 Substituted phenyl-2,3-benzodiazepines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU219778B (en) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Process for producing n-acyl-2,3-benzodiazepine derivatives, their acid additional salts and pharmaceutical compositions containing them and a grop of the compounds and pharmaceutical compositions containing them
DE19604920A1 (en) * 1996-02-01 1997-08-07 Schering Ag New 2,3-benzodiazepine derivatives, their production and use as medicines
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
RU2325811C2 (en) 2006-06-28 2008-06-10 Общество С Ограниченной Ответственностью "Фито-Маг" Method of storing fruits, vegetables and crop products

Also Published As

Publication number Publication date
SK286620B6 (en) 2009-02-05
EA005867B1 (en) 2005-06-30
HUP0004994A2 (en) 2002-11-28
ATE271548T1 (en) 2004-08-15
TR200402493T4 (en) 2004-12-21
WO2002050044A1 (en) 2002-06-27
HU225100B1 (en) 2006-06-28
EP1351942B1 (en) 2004-07-21
DE60104448T2 (en) 2005-07-28
BG107932A (en) 2004-02-27
HU0004994D0 (en) 2001-03-28
CA2431761C (en) 2010-05-25
EP1351942A1 (en) 2003-10-15
PT1351942E (en) 2004-11-30
ES2225412T3 (en) 2005-03-16
CA2431761A1 (en) 2002-06-27
PL211495B1 (en) 2012-05-31
AU2002217356A1 (en) 2002-07-01
JP2004516284A (en) 2004-06-03
CZ20031680A3 (en) 2003-11-12
BG66199B1 (en) 2012-01-31
CZ301371B6 (en) 2010-02-03
DE60104448D1 (en) 2004-08-26
US20040092510A1 (en) 2004-05-13
PL362029A1 (en) 2004-10-18
RO121268B1 (en) 2007-02-28
DK1351942T3 (en) 2004-11-22
UA74615C2 (en) 2006-01-16
JP4201252B2 (en) 2008-12-24
SK7882003A3 (en) 2003-11-04
US7189711B2 (en) 2007-03-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU