EA200100671A1 - ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C - Google Patents
ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2CInfo
- Publication number
- EA200100671A1 EA200100671A1 EA200100671A EA200100671A EA200100671A1 EA 200100671 A1 EA200100671 A1 EA 200100671A1 EA 200100671 A EA200100671 A EA 200100671A EA 200100671 A EA200100671 A EA 200100671A EA 200100671 A1 EA200100671 A1 EA 200100671A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbon atoms
- alkyl
- represents hydrogen
- disorders
- aroyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21347198A | 1998-12-17 | 1998-12-17 | |
PCT/US1999/029894 WO2000035922A1 (fr) | 1998-12-17 | 1999-12-16 | Derives de 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one utilises en tant qu'agonistes de 5ht2c |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200100671A1 true EA200100671A1 (ru) | 2001-12-24 |
Family
ID=22795247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100671A EA200100671A1 (ru) | 1998-12-17 | 1999-12-16 | ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1140940A1 (fr) |
JP (1) | JP2002532504A (fr) |
KR (1) | KR20010108025A (fr) |
CN (1) | CN1240701C (fr) |
AR (1) | AR022687A1 (fr) |
AU (1) | AU3123400A (fr) |
BR (1) | BR9916326A (fr) |
CA (1) | CA2351385A1 (fr) |
CZ (1) | CZ20012193A3 (fr) |
EA (1) | EA200100671A1 (fr) |
HU (1) | HUP0104773A3 (fr) |
IL (1) | IL143323A0 (fr) |
NO (1) | NO20013001D0 (fr) |
NZ (1) | NZ512765A (fr) |
PL (1) | PL348815A1 (fr) |
SK (1) | SK8192001A3 (fr) |
WO (1) | WO2000035922A1 (fr) |
ZA (1) | ZA200104598B (fr) |
Families Citing this family (52)
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US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
US6956036B1 (en) | 2000-03-17 | 2005-10-18 | Alcon, Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
US7012090B1 (en) | 2000-03-17 | 2006-03-14 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
US6806285B1 (en) | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
ES2250459T3 (es) | 2000-07-31 | 2006-04-16 | F. Hoffmann-La Roche Ag | Derivados de piperazina. |
AR031197A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de derivados de 1,2,3,4,8,9,10,10a-octahidro-7bh-ciclopenta(b) diazepino(6,7,1-hi)indol |
AR031196A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de ciclopenta (b) (1,4)-diazepino (6,7,1-hi) indoles y derivados |
AR031200A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados |
ES2230382T3 (es) * | 2000-11-03 | 2005-05-01 | Wyeth | Ciclopental(b)(1,4)diazpino(6,7,1-hi)indoles como antagonistas de 5ht2c. |
AR031202A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados |
US6858604B2 (en) | 2000-11-03 | 2005-02-22 | Wyeth | Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
AR031195A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de derivados de 1,2,3,4,8,9,10,10a-octahidro-7bh-ciclopenta (b) (1,4) diazepino (6,7,1) diazepino (6,7,1-hi) indol |
SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
EA005975B1 (ru) | 2000-11-20 | 2005-08-25 | Биовитрум Аб | Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора |
GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
MXPA03005437A (es) * | 2000-12-20 | 2003-09-10 | Bristol Myers Squibb Pharma Co | Derivados substituidos de pirazino quinoxalina como agonistas y antagonistas del receptor de serotonina. |
CA2432085C (fr) * | 2000-12-27 | 2009-02-24 | F. Hoffmann-La Roche Ag | Derives d'indole et leur utilisation en tant que ligands de recepteurs 5-ht2b et 5-ht2c |
JPWO2002074746A1 (ja) * | 2001-03-16 | 2004-07-08 | 山之内製薬株式会社 | ベンゾアゼピン誘導体 |
WO2002098860A1 (fr) | 2001-06-01 | 2002-12-12 | Alcon, Inc. | Indazoles et indoles nouveaux fusionnes et leur utilisation dans le traitement de glaucomes |
MXPA03010806A (es) | 2001-06-01 | 2004-11-22 | Alcon Inc | Nuevos analogos de arilaminopropano y su uso para el tratamiento de glaucoma. |
KR100626255B1 (ko) | 2001-06-01 | 2006-09-21 | 알콘, 인코퍼레이티드 | 피라노인다졸 및 녹내장의 치료를 위한 그의 용도 |
TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
TW200307540A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
CA2485537A1 (fr) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Nouveaux composes, leur utilisation et leur preparation |
CA2506204A1 (fr) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Nouveaux analogues de benzopyranne et leur utilisation pour le traitement du glaucome |
EP1581221B1 (fr) | 2002-12-19 | 2011-05-18 | Bristol-Myers Squibb Company | Gamma-carbolines tricycliques substituees utilisees comme agonistes et antagonistes du recepteur de la serotonine |
CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
KR20060065584A (ko) * | 2003-06-20 | 2006-06-14 | 아레나 파마슈티칼스, 인크. | N-페닐-피페라진 유도체 및 5ht2c 수용체 관련 질환의예방 또는 치료 방법 |
GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
WO2005053688A1 (fr) | 2003-11-26 | 2005-06-16 | Alcon, Inc. | Furo[2,3-g] indazoles substitues destines au traitement du glaucome |
US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
AR046890A1 (es) | 2003-12-15 | 2005-12-28 | Alcon Inc | [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma. |
US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
JP2008514662A (ja) * | 2004-09-30 | 2008-05-08 | エフ.ホフマン−ラ ロシュ アーゲー | ベンゾオキサジン及びキノキサリン誘導体並びに使用 |
GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
WO2006062839A1 (fr) | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Utilisation de dioxindoindazoles et de dioxoloindazoles pour traiter le glaucome |
AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
JP5528699B2 (ja) | 2006-05-16 | 2014-06-25 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
EP2216023A4 (fr) | 2007-11-15 | 2013-03-13 | Takeda Pharmaceutical | Dérivé de pyridine condensé et son utilisation |
KR101062376B1 (ko) | 2008-04-10 | 2011-09-06 | 한국화학연구원 | 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
KR101110199B1 (ko) | 2009-05-18 | 2012-03-14 | 한국화학연구원 | 피페라진-퀴놀린 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 중추신경계 질환의 예방 또는 치료용 약학적 조성물 |
WO2011044134A1 (fr) | 2009-10-05 | 2011-04-14 | Albany Molecular Research, Inc. | Dérivés d'épiminocycloalkyl(b)indole utilisés en tant que modulateurs du récepteur de la sérotonine de sous-type 6 (5-ht6) et leurs utilisations |
EP2510949A4 (fr) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | Agent thérapeutique pour la fibromyalgie |
JP5810099B2 (ja) | 2010-02-04 | 2015-11-11 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイThe Board Of Trustees Of The University Of Illinois | 5−ht(2b)受容体でアンタゴニスト活性を有する高選択性5−ht(2c)受容体アゴニスト |
US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
AU2012207335A1 (en) | 2011-01-19 | 2013-07-25 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
WO2015066344A1 (fr) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | Agonistes du récepteur 5-ht2c et compositions et procédés d'utilisation |
EP3250549B1 (fr) | 2015-01-29 | 2021-06-23 | The Board of Trustees of the University of Illinois | Cyclopropylméthanamines utilisées comme agonistes sélectifs des récepteurs 5-ht(2c) |
WO2019131902A1 (fr) | 2017-12-27 | 2019-07-04 | 武田薬品工業株式会社 | Agent thérapeutique pour incontinence urinaire de stress et incontinence fécale |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4032639A (en) * | 1976-03-22 | 1977-06-28 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension |
US4089958A (en) * | 1976-12-20 | 1978-05-16 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof |
US4203987A (en) * | 1979-05-21 | 1980-05-20 | American Home Products Corporation | 3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones |
GB8917333D0 (en) * | 1989-07-28 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
EP0539209A1 (fr) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Dérivés de benzo-isoquinoléine et analogues et leur utilisation en thérapeutique |
WO1996023789A1 (fr) * | 1995-02-03 | 1996-08-08 | Sankyo Company, Limited | Derives d'hexahydropyrazinoquinoline |
-
1999
- 1999-12-16 PL PL99348815A patent/PL348815A1/xx not_active Application Discontinuation
- 1999-12-16 SK SK819-2001A patent/SK8192001A3/sk unknown
- 1999-12-16 HU HU0104773A patent/HUP0104773A3/hu unknown
- 1999-12-16 EA EA200100671A patent/EA200100671A1/ru unknown
- 1999-12-16 CZ CZ20012193A patent/CZ20012193A3/cs unknown
- 1999-12-16 BR BR9916326-8A patent/BR9916326A/pt not_active IP Right Cessation
- 1999-12-16 AU AU31234/00A patent/AU3123400A/en not_active Abandoned
- 1999-12-16 EP EP99965285A patent/EP1140940A1/fr not_active Withdrawn
- 1999-12-16 CA CA002351385A patent/CA2351385A1/fr not_active Abandoned
- 1999-12-16 CN CNB998144169A patent/CN1240701C/zh not_active Expired - Fee Related
- 1999-12-16 NZ NZ512765A patent/NZ512765A/en unknown
- 1999-12-16 WO PCT/US1999/029894 patent/WO2000035922A1/fr not_active Application Discontinuation
- 1999-12-16 AR ARP990106455A patent/AR022687A1/es not_active Application Discontinuation
- 1999-12-16 IL IL14332399A patent/IL143323A0/xx unknown
- 1999-12-16 JP JP2000588181A patent/JP2002532504A/ja not_active Withdrawn
- 1999-12-16 KR KR1020017007583A patent/KR20010108025A/ko not_active Application Discontinuation
-
2001
- 2001-06-05 ZA ZA200104598A patent/ZA200104598B/en unknown
- 2001-06-15 NO NO20013001A patent/NO20013001D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20010108025A (ko) | 2001-12-07 |
AR022687A1 (es) | 2002-09-04 |
WO2000035922A1 (fr) | 2000-06-22 |
SK8192001A3 (en) | 2001-12-03 |
BR9916326A (pt) | 2001-10-02 |
AU3123400A (en) | 2000-07-03 |
CN1240701C (zh) | 2006-02-08 |
ZA200104598B (en) | 2002-09-05 |
NO20013001L (no) | 2001-06-15 |
HUP0104773A3 (en) | 2004-10-28 |
NZ512765A (en) | 2003-10-31 |
CN1330652A (zh) | 2002-01-09 |
HUP0104773A2 (hu) | 2002-04-29 |
CZ20012193A3 (cs) | 2001-12-12 |
JP2002532504A (ja) | 2002-10-02 |
IL143323A0 (en) | 2002-04-21 |
CA2351385A1 (fr) | 2000-06-22 |
PL348815A1 (en) | 2002-06-17 |
NO20013001D0 (no) | 2001-06-15 |
EP1140940A1 (fr) | 2001-10-10 |
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