EA200100491A1 - Покрытые оболочкой частицы гранулированного кристаллического ибупрофена - Google Patents
Покрытые оболочкой частицы гранулированного кристаллического ибупрофенаInfo
- Publication number
- EA200100491A1 EA200100491A1 EA200100491A EA200100491A EA200100491A1 EA 200100491 A1 EA200100491 A1 EA 200100491A1 EA 200100491 A EA200100491 A EA 200100491A EA 200100491 A EA200100491 A EA 200100491A EA 200100491 A1 EA200100491 A1 EA 200100491A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ibuprofen
- ethylcellulose
- relative
- particles
- weight
- Prior art date
Links
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 6
- 229960001680 ibuprofen Drugs 0.000 title abstract 6
- 239000010420 shell particle Substances 0.000 title 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 3
- 229920001249 ethyl cellulose Polymers 0.000 abstract 3
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000013081 microcrystal Substances 0.000 abstract 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
- 238000005470 impregnation Methods 0.000 abstract 1
- 230000000622 irritating effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 230000009747 swallowing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Developing Agents For Electrophotography (AREA)
- Glanulating (AREA)
Abstract
Изобретение относится к покрытым оболочкой частицам на основе гранулированных микрокристаллов ибупрофена, его фармацевтически приемлемых изомеров и солей, отличающимся тем, что они содержат оболочку, полученную в аппарате псевдоожиженного слоя с водноспиртовой дисперсной системой, состоящей из смеси, включающей следующие компоненты:А) от 5 до 50 мас.% этилцеллюлозы относительно массы ибупрофена; Б) от 10 до 60 мас.% гидроксипропил метилцеллюлозы относительно массы этилцеллюлозы; и В) от 0,1 до 40 мас.% относительно массы этилцеллюлозы кремнезема, обладающего свойствами антистатика и способствующего пропитыванию; полученная в результате оболочка, по крайней мере, один из компонентов которой может быть использован для гранулирования микрокристаллов ибупрофена и получения в результате этого упомянутых частиц, вследствие этого маскирует неприятый вкус ибупрофена, значительно уменьшает его раздражающее действие на горло после глотания и обеспечивает, по существу, немедленное высвобождение ибупрофена при помещении частиц в водную среду.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9814033A FR2785539B1 (fr) | 1998-11-06 | 1998-11-06 | Particules enrobees d'ibuprofene cristallin granule |
| PCT/FR1999/002682 WO2000027368A1 (fr) | 1998-11-06 | 1999-11-03 | Particules enrobees d'ibuprofene cristallin granule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200100491A1 true EA200100491A1 (ru) | 2001-12-24 |
| EA002897B1 EA002897B1 (ru) | 2002-10-31 |
Family
ID=9532492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100491A EA002897B1 (ru) | 1998-11-06 | 1999-11-03 | Покрытые оболочкой частицы гранулированного кристаллического ибупрофена |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6951657B1 (ru) |
| EP (1) | EP1126829B1 (ru) |
| JP (1) | JP3987282B2 (ru) |
| KR (1) | KR100586059B1 (ru) |
| CN (1) | CN1154482C (ru) |
| AT (1) | ATE265206T1 (ru) |
| AU (1) | AU765765B2 (ru) |
| BR (1) | BR9915111A (ru) |
| CA (1) | CA2349503C (ru) |
| CZ (1) | CZ292290B6 (ru) |
| DE (1) | DE69916876T2 (ru) |
| DK (1) | DK1126829T3 (ru) |
| EA (1) | EA002897B1 (ru) |
| ES (1) | ES2219073T3 (ru) |
| FR (1) | FR2785539B1 (ru) |
| HK (1) | HK1039890B (ru) |
| HU (1) | HU229936B1 (ru) |
| IL (1) | IL142787A (ru) |
| MX (1) | MXPA01004517A (ru) |
| NZ (1) | NZ511479A (ru) |
| PL (1) | PL194527B1 (ru) |
| PT (1) | PT1126829E (ru) |
| SK (1) | SK283944B6 (ru) |
| TR (1) | TR200101230T2 (ru) |
| WO (1) | WO2000027368A1 (ru) |
| ZA (1) | ZA200103630B (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2795962B1 (fr) | 1999-07-08 | 2003-05-09 | Prographarm Laboratoires | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif |
| FR2824477B1 (fr) * | 2001-05-09 | 2005-09-09 | Ethypharm Lab Prod Ethiques | Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes |
| FR2850275B1 (fr) * | 2003-01-24 | 2005-04-08 | Scherer Technologies Inc R P | Capsules molles a macher contenant une substance active a gout masque |
| EP1800667A1 (en) | 2005-12-23 | 2007-06-27 | Losan Pharma GmbH | Rapidly solubilizing ibuprofen granulate |
| ES2546258T3 (es) | 2005-03-22 | 2015-09-22 | Stada Arzneimittel Ag | Ibuprofeno solubilizado |
| US20080020040A1 (en) * | 2006-07-18 | 2008-01-24 | Horizon Therapeutics, Inc. | Unit dose form for administration of ibuprofen |
| US8067451B2 (en) * | 2006-07-18 | 2011-11-29 | Horizon Pharma Usa, Inc. | Methods and medicaments for administration of ibuprofen |
| US20070043097A1 (en) * | 2005-07-18 | 2007-02-22 | Horizon Therapeutics, Inc. | Medicaments containing famotidine and ibuprofen and administration of same |
| DE102005049001A1 (de) * | 2005-10-11 | 2007-04-12 | Basf Ag | Verfahren zur Herstellung von direkttablettierbaren Ibuprofen-Formulierungen |
| US8067033B2 (en) * | 2007-11-30 | 2011-11-29 | Horizon Pharma Usa, Inc. | Stable compositions of famotidine and ibuprofen |
| CA2658915A1 (en) * | 2006-07-27 | 2008-01-31 | University Of Sunderland | Coating composition comprising starch |
| TWI564008B (zh) | 2010-09-30 | 2017-01-01 | 鹽野義製藥股份有限公司 | 難溶性藥物之溶解性改善製劑 |
| WO2014198999A1 (en) * | 2013-06-13 | 2014-12-18 | Opes Corporation Oy | Matrix |
| US9474699B2 (en) * | 2014-03-31 | 2016-10-25 | Johnson & Johnson Consumer Inc. | Compostions and methods for enhancing the topical application of a basic benefit agent |
| DK3220913T3 (da) * | 2014-11-19 | 2021-12-13 | Kiromic Biopharma Inc | Nanopartikel-baseret vaccine, som er målrettet cancer/testikelantigener (CTA) og dennes anvendelse ved solide og hæmatologiske lidelser |
| EP3701937A4 (en) | 2017-10-26 | 2021-07-28 | Zhejiang Yuejia Pharmaceuticals Co., Ltd | STABLE PHARMACEUTICAL COMPOSITION CONTAINING A NON-STEROID ANTI-INFLAMMATORY DERIVATIVE |
| WO2020169991A1 (en) | 2019-02-22 | 2020-08-27 | Catalent U.K. Swindon Zydis Limited | Preserving functionally-coated api particles produced by solventless mixing processes in aqueous suspension |
| CN113490486A (zh) | 2019-02-22 | 2021-10-08 | 康特伦英国斯温顿捷迪斯有限公司 | 最小化团聚、曝气和保持包含布洛芬的药物组合物的包衣 |
| AU2020225448A1 (en) | 2019-02-22 | 2021-10-14 | Catalent U.K. Swindon Zydis Limited | Minimizing agglomeration of drug particle coating material during storage to stabilize disintegration times of pharmaceutical products |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4308251A (en) * | 1980-01-11 | 1981-12-29 | Boots Pharmaceuticals, Inc. | Controlled release formulations of orally-active medicaments |
| US4588612A (en) * | 1985-04-24 | 1986-05-13 | Scm Corporation | Pretreatment in encapsulation process |
| GB8519310D0 (en) * | 1985-07-31 | 1985-09-04 | Zyma Sa | Granular active substances |
| US4835187A (en) * | 1987-06-15 | 1989-05-30 | American Home Products Corporation | Spray dried ibuprofen |
| US4835186A (en) | 1987-06-15 | 1989-05-30 | American Home Products Corporation | Spray dried ibuprofen |
| US5084278A (en) * | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
| NZ234587A (en) * | 1989-08-04 | 1991-11-26 | Mcneil Ppc Inc | A chewable pharmaceutical tablet of compressed coated granules |
| IT1241417B (it) * | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
| WO1991015194A1 (en) * | 1990-04-11 | 1991-10-17 | The Upjohn Company | Taste masking of ibuprofen by fluid bed coating |
| FR2679451B1 (fr) * | 1991-07-22 | 1994-09-09 | Prographarm Laboratoires | Comprime multiparticulaire a delitement rapide. |
| US5191114A (en) * | 1991-10-09 | 1993-03-02 | Sage Pharmaceuticals, Inc. | Process for enhancing the flow characteristics of ibuprofen |
| ZA945944B (en) * | 1993-08-13 | 1996-02-08 | Eurand America Inc | Procedure for encapsulating nsaids |
| US5567439A (en) * | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
-
1998
- 1998-11-06 FR FR9814033A patent/FR2785539B1/fr not_active Expired - Lifetime
-
1999
- 1999-11-03 MX MXPA01004517A patent/MXPA01004517A/es active IP Right Grant
- 1999-11-03 ES ES99954047T patent/ES2219073T3/es not_active Expired - Lifetime
- 1999-11-03 DK DK99954047T patent/DK1126829T3/da active
- 1999-11-03 PT PT99954047T patent/PT1126829E/pt unknown
- 1999-11-03 CZ CZ20011434A patent/CZ292290B6/cs not_active IP Right Cessation
- 1999-11-03 EA EA200100491A patent/EA002897B1/ru not_active IP Right Cessation
- 1999-11-03 TR TR2001/01230T patent/TR200101230T2/xx unknown
- 1999-11-03 HU HU0104394A patent/HU229936B1/hu unknown
- 1999-11-03 DE DE69916876T patent/DE69916876T2/de not_active Expired - Lifetime
- 1999-11-03 BR BR9915111-1A patent/BR9915111A/pt not_active Application Discontinuation
- 1999-11-03 SK SK566-2001A patent/SK283944B6/sk not_active IP Right Cessation
- 1999-11-03 WO PCT/FR1999/002682 patent/WO2000027368A1/fr active IP Right Grant
- 1999-11-03 AU AU10508/00A patent/AU765765B2/en not_active Expired
- 1999-11-03 NZ NZ511479A patent/NZ511479A/xx not_active IP Right Cessation
- 1999-11-03 CA CA2349503A patent/CA2349503C/fr not_active Expired - Fee Related
- 1999-11-03 AT AT99954047T patent/ATE265206T1/de active
- 1999-11-03 EP EP99954047A patent/EP1126829B1/fr not_active Expired - Lifetime
- 1999-11-03 US US09/830,101 patent/US6951657B1/en not_active Expired - Lifetime
- 1999-11-03 CN CNB998138002A patent/CN1154482C/zh not_active Expired - Lifetime
- 1999-11-03 KR KR1020017005749A patent/KR100586059B1/ko not_active IP Right Cessation
- 1999-11-03 JP JP2000580599A patent/JP3987282B2/ja not_active Expired - Lifetime
- 1999-11-03 PL PL99347549A patent/PL194527B1/pl unknown
-
2001
- 2001-04-25 IL IL142787A patent/IL142787A/en not_active IP Right Cessation
- 2001-05-04 ZA ZA200103630A patent/ZA200103630B/en unknown
-
2002
- 2002-02-01 HK HK02100786.6A patent/HK1039890B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MK4A | Patent expired |
Designated state(s): RU |