PT1126829E - Particulas revestidas de ibuprofeno cristalino granulado - Google Patents

Particulas revestidas de ibuprofeno cristalino granulado

Info

Publication number
PT1126829E
PT1126829E PT99954047T PT99954047T PT1126829E PT 1126829 E PT1126829 E PT 1126829E PT 99954047 T PT99954047 T PT 99954047T PT 99954047 T PT99954047 T PT 99954047T PT 1126829 E PT1126829 E PT 1126829E
Authority
PT
Portugal
Prior art keywords
ibuprofen
ethylcellulose
weight
particles
relative
Prior art date
Application number
PT99954047T
Other languages
English (en)
Inventor
Charles Andre Chauveau
Jean-Marc Zuccarelli
Gilles Demichelis
Karine Jean
Original Assignee
Ethypharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Sa filed Critical Ethypharm Sa
Publication of PT1126829E publication Critical patent/PT1126829E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Glanulating (AREA)
PT99954047T 1998-11-06 1999-11-03 Particulas revestidas de ibuprofeno cristalino granulado PT1126829E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9814033A FR2785539B1 (fr) 1998-11-06 1998-11-06 Particules enrobees d'ibuprofene cristallin granule

Publications (1)

Publication Number Publication Date
PT1126829E true PT1126829E (pt) 2004-08-31

Family

ID=9532492

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99954047T PT1126829E (pt) 1998-11-06 1999-11-03 Particulas revestidas de ibuprofeno cristalino granulado

Country Status (26)

Country Link
US (1) US6951657B1 (pt)
EP (1) EP1126829B1 (pt)
JP (1) JP3987282B2 (pt)
KR (1) KR100586059B1 (pt)
CN (1) CN1154482C (pt)
AT (1) ATE265206T1 (pt)
AU (1) AU765765B2 (pt)
BR (1) BR9915111A (pt)
CA (1) CA2349503C (pt)
CZ (1) CZ292290B6 (pt)
DE (1) DE69916876T2 (pt)
DK (1) DK1126829T3 (pt)
EA (1) EA002897B1 (pt)
ES (1) ES2219073T3 (pt)
FR (1) FR2785539B1 (pt)
HK (1) HK1039890B (pt)
HU (1) HU229936B1 (pt)
IL (1) IL142787A (pt)
MX (1) MXPA01004517A (pt)
NZ (1) NZ511479A (pt)
PL (1) PL194527B1 (pt)
PT (1) PT1126829E (pt)
SK (1) SK283944B6 (pt)
TR (1) TR200101230T2 (pt)
WO (1) WO2000027368A1 (pt)
ZA (1) ZA200103630B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2795962B1 (fr) 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
FR2824477B1 (fr) * 2001-05-09 2005-09-09 Ethypharm Lab Prod Ethiques Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes
FR2850275B1 (fr) * 2003-01-24 2005-04-08 Scherer Technologies Inc R P Capsules molles a macher contenant une substance active a gout masque
JP2008534477A (ja) 2005-03-22 2008-08-28 ロザン ファルマ ゲゼルシャフトミットベシュレンクテルハフツンク 可溶化イブプロフェン
EP1800667A1 (en) 2005-12-23 2007-06-27 Losan Pharma GmbH Rapidly solubilizing ibuprofen granulate
US8067451B2 (en) * 2006-07-18 2011-11-29 Horizon Pharma Usa, Inc. Methods and medicaments for administration of ibuprofen
US20080020040A1 (en) * 2006-07-18 2008-01-24 Horizon Therapeutics, Inc. Unit dose form for administration of ibuprofen
WO2007012022A2 (en) * 2005-07-18 2007-01-25 Horizon Therapeutics, Inc. Unit dose form with ibuprofen-famotidine admixture
DE102005049001A1 (de) * 2005-10-11 2007-04-12 Basf Ag Verfahren zur Herstellung von direkttablettierbaren Ibuprofen-Formulierungen
US8067033B2 (en) 2007-11-30 2011-11-29 Horizon Pharma Usa, Inc. Stable compositions of famotidine and ibuprofen
CA2658915A1 (en) * 2006-07-27 2008-01-31 University Of Sunderland Coating composition comprising starch
TWI564008B (zh) * 2010-09-30 2017-01-01 鹽野義製藥股份有限公司 難溶性藥物之溶解性改善製劑
WO2014198999A1 (en) * 2013-06-13 2014-12-18 Opes Corporation Oy Matrix
US9474699B2 (en) * 2014-03-31 2016-10-25 Johnson & Johnson Consumer Inc. Compostions and methods for enhancing the topical application of a basic benefit agent
EP3220913B1 (en) * 2014-11-19 2021-09-08 Kiromic BioPharma, Inc. Nanoparticle-based vaccine targeting cancer/testis antigens (cta) and its use in solid and hematological malignancies
US20200360335A1 (en) 2017-10-26 2020-11-19 Zhejiang Yuejia Pharmaceuticals Co., Ltd Stable pharmaceutical composition containing non-steroidal anti-inflammatory drug derivative
EP3927314B1 (en) 2019-02-22 2023-08-23 Catalent U.K. Swindon Zydis Limited Minimizing agglomeration of drug particle coating material during storage to stabilize disintegration times of pharmaceutical products
AU2020225818A1 (en) 2019-02-22 2021-10-14 Catalent U.K. Swindon Zydis Limited Preserving functionally-coated API particles produced by solventless mixing processes in aqueous suspension
CA3129395A1 (en) 2019-02-22 2020-08-27 Catalent U.K. Swindon Zydis Limited Minimizing agglomeration, aeration, and preserving the coating of pharmaceutical compositions comprising ibuprofen

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308251A (en) * 1980-01-11 1981-12-29 Boots Pharmaceuticals, Inc. Controlled release formulations of orally-active medicaments
US4588612A (en) * 1985-04-24 1986-05-13 Scm Corporation Pretreatment in encapsulation process
GB8519310D0 (en) * 1985-07-31 1985-09-04 Zyma Sa Granular active substances
US4835186A (en) 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
US4835187A (en) * 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
NZ234587A (en) * 1989-08-04 1991-11-26 Mcneil Ppc Inc A chewable pharmaceutical tablet of compressed coated granules
IT1241417B (it) * 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
DE69109282T2 (de) * 1990-04-11 1995-09-28 Upjohn Co Verfahren zum geschmacksabdecken von ibuprofen.
FR2679451B1 (fr) * 1991-07-22 1994-09-09 Prographarm Laboratoires Comprime multiparticulaire a delitement rapide.
US5191114A (en) * 1991-10-09 1993-03-02 Sage Pharmaceuticals, Inc. Process for enhancing the flow characteristics of ibuprofen
ZA945944B (en) * 1993-08-13 1996-02-08 Eurand America Inc Procedure for encapsulating nsaids
US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)

Also Published As

Publication number Publication date
NZ511479A (en) 2003-02-28
EA200100491A1 (ru) 2001-12-24
PL194527B1 (pl) 2007-06-29
SK283944B6 (sk) 2004-05-04
PL347549A1 (en) 2002-04-08
US6951657B1 (en) 2005-10-04
TR200101230T2 (tr) 2001-10-22
DE69916876T2 (de) 2005-03-31
DE69916876D1 (de) 2004-06-03
HUP0104394A3 (en) 2002-12-28
MXPA01004517A (es) 2003-06-09
BR9915111A (pt) 2001-11-27
FR2785539A1 (fr) 2000-05-12
CZ20011434A3 (cs) 2001-09-12
CN1328450A (zh) 2001-12-26
KR100586059B1 (ko) 2006-06-07
WO2000027368A1 (fr) 2000-05-18
HU229936B1 (en) 2015-01-28
CA2349503C (fr) 2010-07-13
ZA200103630B (en) 2002-05-06
ATE265206T1 (de) 2004-05-15
SK5662001A3 (en) 2001-11-06
KR20010090830A (ko) 2001-10-19
FR2785539B1 (fr) 2004-04-09
AU1050800A (en) 2000-05-29
HK1039890A1 (en) 2002-05-17
EA002897B1 (ru) 2002-10-31
CA2349503A1 (fr) 2000-05-18
AU765765B2 (en) 2003-09-25
DK1126829T3 (da) 2004-08-09
HK1039890B (zh) 2005-01-07
EP1126829A1 (fr) 2001-08-29
IL142787A (en) 2007-06-03
CZ292290B6 (cs) 2003-08-13
HUP0104394A2 (hu) 2002-03-28
JP2002529399A (ja) 2002-09-10
EP1126829B1 (fr) 2004-04-28
JP3987282B2 (ja) 2007-10-03
CN1154482C (zh) 2004-06-23
ES2219073T3 (es) 2004-11-16

Similar Documents

Publication Publication Date Title
PT1126829E (pt) Particulas revestidas de ibuprofeno cristalino granulado
DE69529050T2 (de) Orale dosierungsformen mit pulverschicht
ES2125099T3 (es) Composiciones que comprenden nanoparticulas de un antiinflamatorio no estereoideo.
AP1526A (en) Sertraline salts and sustained-release dosage forms of sertraline.
HUP0301192A2 (hu) Topiramátot tartalmazó gyógyászati készítmény és eljárás az előállítására
EP0149920A3 (en) Pharmaceutical formulation
ATE245023T1 (de) Kaubare zusammensetzung zur arzneimittelfreisetzung
HUP0004433A2 (hu) Granulált édesítőszer
ES2099438T3 (es) Polvo seco y estable de cefalosporina hidratada para formulacion de suspension oral.
IS2789B (is) Lyfjablöndur sem innihalda mónóamínoxídasa B hemla
AU3877693A (en) Use of 3-aryl-substituted 5-alkyl-isoxazole-4-carboxylic acid derivatives for combating endoparasites, new 3-aryl-substituted 5-alkyl-isoxazole-4-carboxylic acid derivatives, and process for their preparation
MX9204637A (es) Nuevos derivados de pirazina y procedimiento para su preparacion.
ATE220321T1 (de) Feste flupirtin enthaltende orale darreichungsformen mit kontrollierter wirkstoffabgabe
BR9607541A (pt) Tratamento de doenças que tem por causa o fator de crescimento da citoquina
JPS5714589A (en) Benzothiazine derivative, its preparation and drug composition
IT1229223B (it) Composizioni veterinarie sinergisticamente attive e procedimento per la loro preparazione.
DE69830078D1 (de) Suesstoffzusammensetzung
GB2264639B (en) Modified Release Formulation
JPS5521733A (en) Production of antibiotic y-12278 and carcinostatic preparation containing the same as the effective ingredient
EP0170024A3 (en) Use of 2-acylaminomethyl-1,4-benzodiazepine derivatives for the production of pharmaceutical compositions and process for the preparation for pharmaceutical compositions
AP2002002662A0 (en) Sertraline salts and sustained-release dosage forms of sertraline
CA2099667A1 (en) Agent for treating hepatic diseases
WO1996015798A3 (de) Verwendung von bio-assimilierbaren borverbindungen zur bekämpfung subviröser krankheitserreger
ITMI912238A1 (it) Composti ad attivita' mucolitica e antisettica, procedimento per la loro preparazione e relative composizioni farmaceutiche