EA037698B1 - Композиции, содержащие короткие пептиды, полученные из pedf, и их применение - Google Patents

Композиции, содержащие короткие пептиды, полученные из pedf, и их применение Download PDF

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Publication number
EA037698B1
EA037698B1 EA201990885A EA201990885A EA037698B1 EA 037698 B1 EA037698 B1 EA 037698B1 EA 201990885 A EA201990885 A EA 201990885A EA 201990885 A EA201990885 A EA 201990885A EA 037698 B1 EA037698 B1 EA 037698B1
Authority
EA
Eurasian Patent Office
Prior art keywords
pdsp
peptide
cells
stress
mice
Prior art date
Application number
EA201990885A
Other languages
English (en)
Russian (ru)
Other versions
EA201990885A1 (ru
Inventor
Куаньинь Карен Линь
Йоу-Пин Тсао
Тсун-Чуань Хо
Фрэнк Вэнь-Чи Ли
Original Assignee
Брим Байотекнолоджи, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Брим Байотекнолоджи, Инк. filed Critical Брим Байотекнолоджи, Инк.
Publication of EA201990885A1 publication Critical patent/EA201990885A1/ru
Publication of EA037698B1 publication Critical patent/EA037698B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
EA201990885A 2016-10-07 2017-08-24 Композиции, содержащие короткие пептиды, полученные из pedf, и их применение EA037698B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662405522P 2016-10-07 2016-10-07
PCT/US2017/048340 WO2018067244A1 (en) 2016-10-07 2017-08-24 Compositions comprising pedf-derived short peptides and uses thereof

Publications (2)

Publication Number Publication Date
EA201990885A1 EA201990885A1 (ru) 2019-08-30
EA037698B1 true EA037698B1 (ru) 2021-05-12

Family

ID=61831898

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990885A EA037698B1 (ru) 2016-10-07 2017-08-24 Композиции, содержащие короткие пептиды, полученные из pedf, и их применение

Country Status (10)

Country Link
US (1) US11760784B2 (enExample)
EP (1) EP3596104A4 (enExample)
JP (2) JP7573967B2 (enExample)
KR (2) KR20230169375A (enExample)
CN (1) CN110312732A (enExample)
AU (2) AU2017340245B2 (enExample)
EA (1) EA037698B1 (enExample)
IL (1) IL265796B2 (enExample)
TW (1) TWI878203B (enExample)
WO (2) WO2018067244A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210244791A1 (en) * 2018-04-08 2021-08-12 Brim Biotechnology, Inc. Application of pedf-derived short peptides in tendon healing
EA202092366A1 (ru) * 2018-04-08 2021-01-26 Брим Байотекнолоджи, Инк. Применение происходящих из pedf коротких пептидов при лечении остеоартрита
KR20210005696A (ko) * 2018-05-04 2021-01-14 브림 바이오테크놀로지, 인코퍼레이티드 마이봄 샘 재생을 촉진하기 위한 pedf-유래 펩타이드 및 그것의 사용
CN111632128B (zh) * 2019-02-14 2022-07-05 三凡生技研发股份有限公司 短链胜肽组合物在预防或治疗干眼症的应用
TWI759610B (zh) * 2019-06-27 2022-04-01 晶碩光學股份有限公司 具有角膜修護功能的眼用產品
KR102798478B1 (ko) * 2019-08-27 2025-04-18 요우 핑 차오 짧은 합성 펩티드 및 망막 변성 질환 및/또는 조직 손상 치료를 위한 용도
TWI744683B (zh) * 2019-08-27 2021-11-01 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 短合成胜肽及其治療視網膜退化性疾病和/或組織損傷的用途
KR20230106115A (ko) * 2019-10-06 2023-07-12 브림 바이오테크놀로지, 인코퍼레이티드 Pedf-유래된 짧은 펩타이드 (pdsp)를 포함하는 조성물 및 그것의 사용
CN112206312A (zh) * 2020-11-19 2021-01-12 北京大学第三医院（北京大学第三临床医学院） 一种包含pedf的用于治疗干眼的药物组合物
CN115364199A (zh) * 2021-05-19 2022-11-22 远大医药（中国）有限公司 包含pedf衍生的短肽的组合物及其制备方法和用途
JP2025519647A (ja) * 2022-06-13 2025-06-26 ブリム バイオテクノロジー インク ドライアイ疾患の治療のためのｐｅｄｆ由来短鎖ペプチドを含む組成物
TW202400628A (zh) * 2022-06-24 2024-01-01 全福生物科技股份有限公司 用於治療神經營養性角膜炎疾病之包含pedf衍生短肽之組合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260180A1 (en) * 2004-03-12 2005-11-24 Genvec, Inc. Materials and methods for treating vascular leakage in the eye
US20130333068A1 (en) * 2008-04-29 2013-12-12 Marie Coffin Genes and uses for plant enhancement
US20150079094A1 (en) * 2013-09-13 2015-03-19 The Penn State Research Foundation Functional Peptide Analogs of PEDF

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451763B1 (en) * 1992-06-04 2002-09-17 The United States Of America As Represented By The Department Of Health And Human Services Retinal pigmented epithelium derived neurotrophic factor and methods of use
US6797691B1 (en) * 1997-07-23 2004-09-28 Northwestern University Methods and compositions for inhibiting angiogenesis
CN101014358A (zh) * 2003-10-29 2007-08-08 约翰·霍普金斯大学 色素上皮所衍生因子的生物活性及使用方法
EP1986676A4 (en) * 2006-02-15 2009-11-04 Univ Yale Inc COMPOSITIONS AND METHODS FOR USE OF PEDF (PIGMENT-BASED EPITHELIC DERIVED FACTOR) PEPTIDE FRAGMENTS
EP2486128A4 (en) * 2009-10-08 2013-10-09 Neurotech Usa Inc USE OF THE PEDF IN AN ENCAPSULATED CELL DELIVERY SYSTEM
EP2508196B1 (en) * 2011-03-23 2018-09-26 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing
TWI554521B (zh) * 2011-10-19 2016-10-21 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 色素上皮衍生因子衍生之多胜肽於治療禿髮和／或毛髮脫色之用途
AU2012387503B2 (en) * 2012-08-09 2016-11-03 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting muscle or tendon regeneration or arteriogenesis
KR101830926B1 (ko) * 2012-09-19 2018-02-22 맥케이 메모리얼 호스피탈 피부 노화를 방지 및/또는 개선하기 위해 사용되는 pedf-유도 폴리펩티드의 용도
EP2897974B1 (en) * 2012-09-20 2018-03-28 Mackay Memorial Hospital Use of pedf-derived polypeptides for treating osteoarthritis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260180A1 (en) * 2004-03-12 2005-11-24 Genvec, Inc. Materials and methods for treating vascular leakage in the eye
US20130333068A1 (en) * 2008-04-29 2013-12-12 Marie Coffin Genes and uses for plant enhancement
US20150079094A1 (en) * 2013-09-13 2015-03-19 The Penn State Research Foundation Functional Peptide Analogs of PEDF

Also Published As

Publication number Publication date
IL265796B2 (en) 2025-02-01
WO2018067217A2 (en) 2018-04-12
KR20190066030A (ko) 2019-06-12
IL265796B1 (en) 2024-10-01
JP2019533722A (ja) 2019-11-21
US20190248859A1 (en) 2019-08-15
JP2022185042A (ja) 2022-12-13
WO2018067217A3 (en) 2019-05-02
KR20230169375A (ko) 2023-12-15
WO2018067244A1 (en) 2018-04-12
EP3596104A1 (en) 2020-01-22
US11760784B2 (en) 2023-09-19
TWI878203B (zh) 2025-04-01
AU2022204557A1 (en) 2022-07-21
TW201822785A (zh) 2018-07-01
EA201990885A1 (ru) 2019-08-30
AU2017340245B2 (en) 2022-07-21
IL265796A (en) 2019-06-30
AU2017340245A1 (en) 2019-05-23
JP7573967B2 (ja) 2024-10-28
CN110312732A (zh) 2019-10-08
EP3596104A4 (en) 2021-02-17

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