EA036736B1 - Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj - Google Patents

Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj Download PDF

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Publication number
EA036736B1
EA036736B1 EA201891336A EA201891336A EA036736B1 EA 036736 B1 EA036736 B1 EA 036736B1 EA 201891336 A EA201891336 A EA 201891336A EA 201891336 A EA201891336 A EA 201891336A EA 036736 B1 EA036736 B1 EA 036736B1
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EA
Eurasian Patent Office
Prior art keywords
independently selected
methyl
substituents
hydroxy
dihydropyrimidin
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EA201891336A
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English (en)
Russian (ru)
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EA201891336A1 (ru
Inventor
Майкл С. Майерс
Р. Майкл Лоренс
Донна М. Байлдер
Вей Менг
Зулан Пай
Роберт Пол Бриганс
Хизер Финлэй
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Бристол-Майерс Сквибб Компани
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Publication of EA201891336A1 publication Critical patent/EA201891336A1/ru
Publication of EA036736B1 publication Critical patent/EA036736B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
EA201891336A 2015-12-16 2016-12-15 Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj EA036736B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562267997P 2015-12-16 2015-12-16
PCT/US2016/066750 WO2017106396A1 (en) 2015-12-16 2016-12-15 Heteroarylhydroxypyrimidinones as agonists of the apj receptor

Publications (2)

Publication Number Publication Date
EA201891336A1 EA201891336A1 (ru) 2019-01-31
EA036736B1 true EA036736B1 (ru) 2020-12-14

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EA201891336A EA036736B1 (ru) 2015-12-16 2016-12-15 Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj

Country Status (21)

Country Link
US (1) US10669261B2 (enExample)
EP (1) EP3390400B1 (enExample)
JP (1) JP6948322B2 (enExample)
KR (1) KR102742744B1 (enExample)
CN (1) CN108602813B (enExample)
AR (1) AR107061A1 (enExample)
AU (1) AU2016372048B2 (enExample)
BR (1) BR112018012112A2 (enExample)
CA (1) CA3008630A1 (enExample)
CL (1) CL2018001621A1 (enExample)
CO (1) CO2018007221A2 (enExample)
EA (1) EA036736B1 (enExample)
ES (1) ES2854733T3 (enExample)
HK (1) HK1255163A1 (enExample)
IL (1) IL259947B (enExample)
MX (1) MX380669B (enExample)
PE (1) PE20181487A1 (enExample)
SG (1) SG11201804674UA (enExample)
TW (1) TW201725203A (enExample)
UY (1) UY37026A (enExample)
WO (1) WO2017106396A1 (enExample)

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US9988369B2 (en) 2016-05-03 2018-06-05 Amgen Inc. Heterocyclic triazole compounds as agonists of the APJ receptor
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US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
WO2018097944A1 (en) 2016-11-16 2018-05-31 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
WO2018093577A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the apj receptor
US10689367B2 (en) 2016-11-16 2020-06-23 Amgen Inc. Triazole pyridyl compounds as agonists of the APJ receptor
US11191762B2 (en) 2016-11-16 2021-12-07 Amgen Inc. Alkyl substituted triazole compounds as agonists of the APJ Receptor
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
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Also Published As

Publication number Publication date
US10669261B2 (en) 2020-06-02
AR107061A1 (es) 2018-03-14
MX2018007155A (es) 2018-08-15
KR102742744B1 (ko) 2024-12-12
CL2018001621A1 (es) 2018-08-03
KR20180095577A (ko) 2018-08-27
SG11201804674UA (en) 2018-06-28
MX380669B (es) 2025-03-12
EA201891336A1 (ru) 2019-01-31
TW201725203A (zh) 2017-07-16
ES2854733T3 (es) 2021-09-22
PE20181487A1 (es) 2018-09-18
US20180362508A1 (en) 2018-12-20
WO2017106396A1 (en) 2017-06-22
UY37026A (es) 2017-06-30
EP3390400B1 (en) 2021-01-20
BR112018012112A2 (pt) 2018-12-04
CN108602813B (zh) 2021-10-29
JP6948322B2 (ja) 2021-10-13
CO2018007221A2 (es) 2018-07-19
IL259947A (en) 2018-07-31
HK1255163A1 (zh) 2019-08-09
CN108602813A (zh) 2018-09-28
AU2016372048B2 (en) 2021-02-04
JP2018538304A (ja) 2018-12-27
EP3390400A1 (en) 2018-10-24
IL259947B (en) 2020-10-29
CA3008630A1 (en) 2017-06-22
AU2016372048A1 (en) 2018-08-02

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