EA036736B1 - Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj - Google Patents

Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj Download PDF

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Publication number
EA036736B1
EA036736B1 EA201891336A EA201891336A EA036736B1 EA 036736 B1 EA036736 B1 EA 036736B1 EA 201891336 A EA201891336 A EA 201891336A EA 201891336 A EA201891336 A EA 201891336A EA 036736 B1 EA036736 B1 EA 036736B1
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EA
Eurasian Patent Office
Prior art keywords
independently selected
methyl
substituents
hydroxy
dihydropyrimidin
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EA201891336A
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English (en)
Russian (ru)
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EA201891336A1 (ru
Inventor
Майкл С. Майерс
Р. Майкл Лоренс
Донна М. Байлдер
Вей Менг
Зулан Пай
Роберт Пол Бриганс
Хизер Финлэй
Original Assignee
Бристол-Майерс Сквибб Компани
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Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201891336A1 publication Critical patent/EA201891336A1/ru
Publication of EA036736B1 publication Critical patent/EA036736B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
EA201891336A 2015-12-16 2016-12-15 Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj EA036736B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562267997P 2015-12-16 2015-12-16
PCT/US2016/066750 WO2017106396A1 (en) 2015-12-16 2016-12-15 Heteroarylhydroxypyrimidinones as agonists of the apj receptor

Publications (2)

Publication Number Publication Date
EA201891336A1 EA201891336A1 (ru) 2019-01-31
EA036736B1 true EA036736B1 (ru) 2020-12-14

Family

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EA201891336A EA036736B1 (ru) 2015-12-16 2016-12-15 Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj

Country Status (21)

Country Link
US (1) US10669261B2 (enExample)
EP (1) EP3390400B1 (enExample)
JP (1) JP6948322B2 (enExample)
KR (1) KR102742744B1 (enExample)
CN (1) CN108602813B (enExample)
AR (1) AR107061A1 (enExample)
AU (1) AU2016372048B2 (enExample)
BR (1) BR112018012112A2 (enExample)
CA (1) CA3008630A1 (enExample)
CL (1) CL2018001621A1 (enExample)
CO (1) CO2018007221A2 (enExample)
EA (1) EA036736B1 (enExample)
ES (1) ES2854733T3 (enExample)
HK (1) HK1255163A1 (enExample)
IL (1) IL259947B (enExample)
MX (1) MX380669B (enExample)
PE (1) PE20181487A1 (enExample)
SG (1) SG11201804674UA (enExample)
TW (1) TW201725203A (enExample)
UY (1) UY37026A (enExample)
WO (1) WO2017106396A1 (enExample)

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US10392347B2 (en) 2015-10-14 2019-08-27 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as APJ agonists
AR106948A1 (es) 2015-12-04 2018-03-07 Bristol Myers Squibb Co Agonistas del receptor de apelina y método de uso
CN114605327B (zh) 2015-12-16 2025-03-11 洛克索肿瘤学股份有限公司 可用作激酶抑制剂的化合物
MY189454A (en) 2016-03-24 2022-02-14 Bristol Myers Squibb Co 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists
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KR102521956B1 (ko) 2016-10-14 2023-04-14 브리스톨-마이어스 스큅 컴퍼니 3-술포닐-5-아미노피리딘-2,4-디올 apj 효능제
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
EP3541803B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
EP3541802B1 (en) 2016-11-16 2025-01-01 Amgen Inc. Alkyl substituted triazole compounds as agonists of the apj receptor
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
EP3541792B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
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Also Published As

Publication number Publication date
WO2017106396A1 (en) 2017-06-22
US20180362508A1 (en) 2018-12-20
US10669261B2 (en) 2020-06-02
EP3390400B1 (en) 2021-01-20
CN108602813B (zh) 2021-10-29
CN108602813A (zh) 2018-09-28
MX2018007155A (es) 2018-08-15
IL259947B (en) 2020-10-29
ES2854733T3 (es) 2021-09-22
AU2016372048B2 (en) 2021-02-04
IL259947A (en) 2018-07-31
JP2018538304A (ja) 2018-12-27
KR20180095577A (ko) 2018-08-27
TW201725203A (zh) 2017-07-16
SG11201804674UA (en) 2018-06-28
HK1255163A1 (zh) 2019-08-09
UY37026A (es) 2017-06-30
AU2016372048A1 (en) 2018-08-02
JP6948322B2 (ja) 2021-10-13
CL2018001621A1 (es) 2018-08-03
KR102742744B1 (ko) 2024-12-12
EA201891336A1 (ru) 2019-01-31
BR112018012112A2 (pt) 2018-12-04
CO2018007221A2 (es) 2018-07-19
AR107061A1 (es) 2018-03-14
PE20181487A1 (es) 2018-09-18
EP3390400A1 (en) 2018-10-24
CA3008630A1 (en) 2017-06-22
MX380669B (es) 2025-03-12

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