EA035063B1 - Соединения в качестве модуляторов ror гамма - Google Patents
Соединения в качестве модуляторов ror гамма Download PDFInfo
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- EA035063B1 EA035063B1 EA201890329A EA201890329A EA035063B1 EA 035063 B1 EA035063 B1 EA 035063B1 EA 201890329 A EA201890329 A EA 201890329A EA 201890329 A EA201890329 A EA 201890329A EA 035063 B1 EA035063 B1 EA 035063B1
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 89
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- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
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Landscapes
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| BR122020020657B1 (pt) * | 2014-04-14 | 2022-12-20 | Boehringer Ingelheim International Gmbh | Compostos, composição farmacêutica e seus usos como moduladores de ror gama |
| FR3030518B1 (fr) * | 2014-12-19 | 2018-03-23 | Galderma Research & Development | Derives sulfonamides en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t) |
| KR102702236B1 (ko) | 2015-05-15 | 2024-09-04 | 오리진 온콜로지 리미티드 | Ror 감마 조절제로서의 치환된 테트라하이드로퀴놀리논 화합물 |
| US10450314B2 (en) | 2015-10-01 | 2019-10-22 | Boehringer Ingelheim International Gmbh | Pteridine derivatives as modulators of ROR gamma |
| KR101947976B1 (ko) | 2015-12-15 | 2019-02-13 | 아스트라제네카 아베 | 이소인돌 화합물 |
| EP3405470B1 (en) * | 2016-01-20 | 2020-07-15 | Boehringer Ingelheim International GmbH | Pyrazinedihydropyrimidinone or pyridazinedihydropyrimidinone compounds as modulators of ror gamma |
| AR110481A1 (es) | 2016-12-05 | 2019-04-03 | Lead Pharma Holding Bv | MODULADORES DE ROR g (RORg) |
| US20200031753A1 (en) | 2017-04-06 | 2020-01-30 | Boehringer Ingelheim International Gmbh | Cyclopropyl alkyl amines and process for their preparation |
| EP3638661A1 (en) | 2017-06-14 | 2020-04-22 | Astrazeneca AB | 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators |
| CN109206346A (zh) * | 2017-07-01 | 2019-01-15 | 复旦大学 | 叔胺类衍生物或其盐及其制备方法和用途 |
| CN107903263B (zh) * | 2017-12-28 | 2019-11-12 | 山东铂源药业有限公司 | 一种帕布昔利布中间体的合成方法 |
| SMT202300212T1 (it) | 2018-05-03 | 2023-09-06 | Shanghai hengrui pharmaceutical co ltd | Derivati di benzimidazolo come modulatori del recettore gamma orfano correlato al retinoide (rory) e usi farmaceutici di essi |
| US20210395185A1 (en) | 2018-10-18 | 2021-12-23 | Boehringer Ingelheim International Gmbh | Scalable synthesis of optically active 1-cyclopropylalkyl-1-amines |
| WO2021061803A1 (en) | 2019-09-23 | 2021-04-01 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Phosphodiesterase inhibitors and use |
| US20230014730A1 (en) | 2019-09-23 | 2023-01-19 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Phosphodiesterase inhibitors and use |
| BR112022008293A2 (pt) | 2019-10-31 | 2022-07-26 | Jiangsu Hengrui Medicine Co | Sal de adição de ácido de regulador de ror?, composições farmacêuticas, uso dos mesmos e métodos para preparar forma cristalina e composição farmacêutica |
| WO2022106548A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Solid forms of a ror gamma inhibitor |
| WO2022106549A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Crystalline salts of a ror gamma inhibitor |
| WO2022106547A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Process for synthesising a ror gamma inhibitor |
| WO2022106550A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Crystalline polymorphic form of a ror gamma inhibitor |
| WO2022106551A1 (en) | 2020-11-19 | 2022-05-27 | Boehringer Ingelheim International Gmbh | Co-crystals of a ror gamma inhibitor |
| CN117003757A (zh) * | 2022-05-07 | 2023-11-07 | 苏州浦合医药科技有限公司 | 取代的双环杂芳基化合物作为usp1抑制剂 |
| WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
| CN116178279A (zh) * | 2023-03-15 | 2023-05-30 | 上海药坦药物研究开发有限公司 | 一种5-溴-4-环丙基-6-甲氧基嘧啶及其中间体的制备方法 |
| AU2024267864A1 (en) * | 2023-05-09 | 2025-11-06 | 11949098 Canada Inc. | Inverse agonists of rar related orphan receptors (rors) |
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| WO2003024966A1 (en) * | 2001-08-14 | 2003-03-27 | Astrazeneca Ab | Pteridinone derivatives as modulators of chemokine receptor activity |
| WO2009022185A2 (en) * | 2007-08-16 | 2009-02-19 | Astrazeneca Ab | 6, 6-fused heterocycles, their pharmaceutical compositions and methos of use |
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| PE20110854A1 (es) | 2008-09-26 | 2011-12-23 | Boehringer Ingelheim Int | DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1 |
| AP2012006204A0 (en) | 2009-10-21 | 2012-04-30 | Boehringer Ingelheim Int | Indazole and pyrazolopyridine compounds as CCR1 receptor antagonists. |
| BR112013030894A2 (pt) * | 2011-06-01 | 2016-08-16 | Janus Biotherapeutics Inc | moduladores do sistema imune |
| CN106008511B (zh) * | 2012-05-14 | 2018-08-14 | 华东理工大学 | 蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用 |
| BR122020020657B1 (pt) * | 2014-04-14 | 2022-12-20 | Boehringer Ingelheim International Gmbh | Compostos, composição farmacêutica e seus usos como moduladores de ror gama |
| US10450314B2 (en) * | 2015-10-01 | 2019-10-22 | Boehringer Ingelheim International Gmbh | Pteridine derivatives as modulators of ROR gamma |
| EP3405470B1 (en) * | 2016-01-20 | 2020-07-15 | Boehringer Ingelheim International GmbH | Pyrazinedihydropyrimidinone or pyridazinedihydropyrimidinone compounds as modulators of ror gamma |
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