EA034110B1 - Противораковые вакцины и способы лечения с их применением - Google Patents

Противораковые вакцины и способы лечения с их применением Download PDF

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EA034110B1
EA034110B1 EA201591674A EA201591674A EA034110B1 EA 034110 B1 EA034110 B1 EA 034110B1 EA 201591674 A EA201591674 A EA 201591674A EA 201591674 A EA201591674 A EA 201591674A EA 034110 B1 EA034110 B1 EA 034110B1
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sequence
antigen
consensus
amino acid
seq
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EA201591674A
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Russian (ru)
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EA201591674A1 (ru
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Дэвид Уэйнер
Каруппиах Мутхумани
Джуэлл Уолтерс
Цзянь Янь
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Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of EA201591674A1 publication Critical patent/EA201591674A1/ru
Publication of EA034110B1 publication Critical patent/EA034110B1/ru

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EA201591674A 2013-03-15 2014-03-14 Противораковые вакцины и способы лечения с их применением EA034110B1 (ru)

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Application Number Priority Date Filing Date Title
US201361799952P 2013-03-15 2013-03-15
PCT/US2014/029479 WO2014144885A2 (en) 2013-03-15 2014-03-14 Cancer vaccines and methods of treatment using the same

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EA201591674A1 EA201591674A1 (ru) 2016-01-29
EA034110B1 true EA034110B1 (ru) 2019-12-27

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EA201992251A EA201992251A1 (ru) 2013-03-15 2014-03-14 Противораковые вакцины и способы лечения с их применением

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US (2) US11419925B2 (OSRAM)
EP (2) EP2968607B1 (OSRAM)
JP (5) JP6769865B2 (OSRAM)
KR (4) KR20210123426A (OSRAM)
CN (2) CN114225019A (OSRAM)
AU (5) AU2014228405B2 (OSRAM)
BR (1) BR112015022367B1 (OSRAM)
CA (1) CA2898126A1 (OSRAM)
EA (2) EA034110B1 (OSRAM)
MX (2) MX369709B (OSRAM)
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Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1951281B1 (en) 2005-10-17 2015-04-15 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
EP3117836A1 (en) 2006-04-10 2017-01-18 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and uses thereof
EP2802347B1 (en) 2012-01-13 2019-01-09 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and methods of use thereof
MX364732B (es) * 2012-12-13 2019-05-06 Univ Pennsylvania Vacuna contra el tumor de wilms 1.
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
SI2945647T1 (sl) 2013-01-15 2021-01-29 Memorial Sloan Kettering Cancer Center Imunogeni peptidi WT-1 in postopki za uporabo le-teh
MX369709B (es) * 2013-03-15 2019-11-19 Univ Pennsylvania Vacunación mejorada contra tirosinasa.
EP3092004A4 (en) * 2014-01-06 2017-02-22 The Trustees Of The University Of Pennsylvania Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy
CN114081946A (zh) 2014-03-12 2022-02-25 耶达研究与开发有限公司 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
US10618963B2 (en) 2014-03-12 2020-04-14 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
WO2015200728A1 (en) 2014-06-25 2015-12-30 Selecta Biosciences, Inc. Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors
CN107427567A (zh) 2015-01-29 2017-12-01 宾夕法尼亚大学理事会 检查点抑制剂和疫苗组合物及其用于免疫疗法的用途
WO2016168361A1 (en) * 2015-04-14 2016-10-20 Polynoma, Llc Polyvalent vaccines and combination therapy for the treatment of melanoma
ES2809508T3 (es) * 2015-10-06 2021-03-04 Invectys Estructuras artificiales de poliepítopos para uso en inmunoterapia
TWI705972B (zh) * 2015-11-04 2020-10-01 臺北榮民總醫院 惡性病變的組合治療
CA3005896C (en) * 2015-11-20 2025-09-23 Memorial Sloan Kettering Cancer Center METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BY MEANS OF THE COMBINATION OF A WT1 PEPTIDE AND A CHECKPOINT INHIBITOR
PT3405212T (pt) 2016-01-19 2020-08-25 Pfizer Vacinas para o cancro
JP2019502741A (ja) * 2016-01-22 2019-01-31 エックス4 ファーマシューティカルズ, インコーポレイテッド がんを処置するための方法
CA3013718C (en) 2016-02-05 2023-09-26 Jian Yan Cancer vaccines and methods of treatment using the same
EP3439670A4 (en) 2016-04-08 2019-11-27 The Regents of the University of California MODIFIED HYALURONIC ACID HYGELS AND PROTEINS FOR THE TEMPORARY RELEASE OF BIOLOGICAL ACTIVE SUBSTANCES
RS65007B1 (sr) 2016-06-02 2024-01-31 Ultimovacs Asa Vakcina u kombinaciji sa inhibitorom imunološke kontrolne tačke za primenu u lečenju kancera
EP3516390A1 (en) 2016-09-23 2019-07-31 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Manipulation of immune activity by modulation of expression
JP7781511B2 (ja) * 2016-09-30 2025-12-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Tert免疫原性組成物及びそれを用いた治療方法
EP3560513A4 (en) * 2016-12-26 2020-10-14 National University Corporation Kobe University ANTICANCER THERAPY USING A COMBINATION OF AN ORAL TUMOR VACCINE AND AN IMMUNOSUPPRESSION INHIBITOR
US11229668B2 (en) 2017-02-07 2022-01-25 Nantcell, Inc. Maximizing T-cell memory and compositions and methods therefor
MY192920A (en) * 2017-03-15 2022-09-15 Cancer Res Malaysia Immunogenic peptide composition
US11154602B2 (en) 2017-12-13 2021-10-26 Inovio Pharmaceuticals, Inc. Cancer vaccines targeting mesothelin and uses thereof
BR112020011443A2 (pt) * 2017-12-13 2020-12-01 Inovio Pharmaceuticals, Inc. molécula de ácido nucleico e seu uso, vetor e seu uso, composição, proteína e vacina
FR3078536A1 (fr) * 2018-03-05 2019-09-06 Peptinov Sas Composition vaccinale anti-pd-1
US11564980B2 (en) * 2018-04-23 2023-01-31 Nantcell, Inc. Tumor treatment method with an individualized peptide vaccine
TWI787500B (zh) 2018-04-23 2022-12-21 美商南特細胞公司 新抗原表位疫苗及免疫刺激組合物及方法
US20210361755A1 (en) * 2018-05-25 2021-11-25 The Wistar Institute Tumor-specific neoantigens and methods of using the same
WO2020020444A1 (en) * 2018-07-24 2020-01-30 Biontech Rna Pharmaceuticals Gmbh Individualized vaccines for cancer
EP3725370A1 (en) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
WO2021051065A1 (en) * 2019-09-12 2021-03-18 Inovio Pharmaceuticals, Inc. Tert, wt-1, pmsa immunogenic compositions and methods of treatment using the same
MX2022007398A (es) * 2019-12-19 2022-09-19 Wistar Inst Vacunas contra el virus de la fiebre porcina africana y métodos para usarlas.
CA3171250A1 (en) 2020-03-10 2021-09-16 E. Lynne KELLEY Methods for treating neutropenia
PE20230349A1 (es) 2020-05-14 2023-03-02 Inovio Pharmaceuticals Inc Vacunas para la papilomatosis respiratoria recurrente y metodos para usar estas
CN111647066B (zh) * 2020-07-01 2020-12-18 维肽瀛(上海)生物技术有限公司 Wt1多肽肿瘤抑制剂
CN114113611B (zh) * 2021-12-13 2023-07-14 郑州大学 一种用于肝癌诊断的生物标志物及检测试剂盒
EP4463151A4 (en) * 2022-01-19 2025-10-01 Univ Northwestern Agents Targeting Telomerase Reverse Transcriptase (TERT) to Treat Cancer and Sensitize Cancer Cells to Genotoxic Therapy
KR20240128985A (ko) * 2022-03-08 2024-08-27 이뮤니티바이오, 인크. 종양 내 주사된 효모 백신
CN115845039A (zh) * 2022-07-01 2023-03-28 可蓝赛生物医药(上海)有限公司 一种广谱多肽肿瘤疫苗组成
EP4601687A1 (en) * 2022-10-13 2025-08-20 Inovio Pharmaceuticals, Inc. Vaccines for recurrent respiratory papillomatosis and methods of using the same
CN118141903B (zh) * 2024-03-11 2025-09-23 上海申锐联生物医药有限公司 一种治疗犬黑色素瘤的环状rna疫苗

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138808A1 (en) * 1998-02-19 2003-07-24 Simard John J.L. Expression vectors encoding epitopes of target-associated antigens
US20040132972A1 (en) * 2001-02-26 2004-07-08 Xiaoqiang Kang Tri-hybrid melanoma antigen
US20050158332A1 (en) * 1995-09-26 2005-07-21 Government Of The Usa, Represented By The Secretary, Dept. Of Health & Human Services MHC-Class II restricted melanoma antigens and their use in therapeutic methods
US20080171711A1 (en) * 2004-07-21 2008-07-17 Curevac Gmbh Mrna Mixture For Vaccinating Against Tumoral Diseases
US20110070290A1 (en) * 2006-09-26 2011-03-24 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US20110091498A1 (en) * 1996-03-20 2011-04-21 The Usa As Represented By The Secretary, Dept. Of Health And Human Services Methods of stimulating an immune response against prostate specific antigen

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077044A (en) 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
US5110587A (en) 1981-12-24 1992-05-05 Health Research, Incorporated Immunogenic composition comprising synthetically modified vaccinia virus
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
ZA858044B (en) 1984-11-01 1987-05-27 American Home Prod Oral vaccines
US5643579A (en) 1984-11-01 1997-07-01 American Home Products Corporation Oral vaccines
US5036006A (en) 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
GB8508845D0 (en) 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
US5223424A (en) 1985-09-06 1993-06-29 Prutech Research And Development Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence
US4790987A (en) 1985-11-15 1988-12-13 Research Corporation Viral glycoprotein subunit vaccine
US5310668A (en) 1986-06-20 1994-05-10 Merck & Co., Inc. Varicella-zoster virus as a live recombinant vaccine
US5242829A (en) 1986-09-23 1993-09-07 Therion Biologics Corporation Recombinant pseudorabies virus
US5387744A (en) 1987-06-04 1995-02-07 Washington University Avirulent microbes and uses therefor: Salmonella typhi
US5294441A (en) 1987-06-04 1994-03-15 Washington University Avirulent microbes and uses therefor: salmonella typhi
IL86583A0 (en) 1987-06-04 1988-11-15 Molecular Eng Ass Vaccine containing a derivative of a microbe and method for the production thereof
US5112749A (en) 1987-10-02 1992-05-12 Praxis Biologics, Inc. Vaccines for the malaria circumsporozoite protein
US5225336A (en) 1989-03-08 1993-07-06 Health Research Incorporated Recombinant poxvirus host range selection system
NL9020389A (nl) 1989-03-08 1991-12-02 Health Research Inc Systeem voor het in de gastheer selecteren van recombinant-pokkenvirussen.
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5591439A (en) 1989-03-24 1997-01-07 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
ES2090129T3 (es) 1989-03-31 1996-10-16 Univ Washington Vacunas que contienen microorganismos tipo phop avirulentos.
DE69016956T2 (de) 1989-12-04 1995-07-20 Akzo Nobel Nv Rekombinantes Truthahn-Herpesvirus und davon abgeleiteter Lebendimpfstoffvektor.
US5294548A (en) 1990-04-02 1994-03-15 American Biogenetic Sciences, Inc Recombianant Hepatitis a virus
WO1991018088A1 (en) 1990-05-23 1991-11-28 The United States Of America, Represented By The Secretary, United States Department Of Commerce Adeno-associated virus (aav)-based eucaryotic vectors
US5462734A (en) 1990-11-02 1995-10-31 Wisconsin Alumni Research Foundation Bovine herpesvirus vaccine and method of using same
US5240703A (en) 1991-03-01 1993-08-31 Syntro Corporation Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof
US5925729A (en) * 1991-05-23 1999-07-20 Ludwig Institute For Cancer Research Tumor rejection antigen precursors, tumor rejection antigens and uses thereof
US6034298A (en) 1991-08-26 2000-03-07 Prodigene, Inc. Vaccines expressed in plants
US5955088A (en) 1992-02-03 1999-09-21 Cedars-Sinai Medical Center Pharmaceutical compsition of herpes simplex virus type-1 (HSV-1), glycoproteins
EP0646178A1 (en) 1992-06-04 1995-04-05 The Regents Of The University Of California expression cassette with regularoty regions functional in the mammmlian host
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
DE69434469T2 (de) 1993-01-26 2006-06-14 Univ Pennsylvania Zusammensetzungen und verfahren zur verabreichung von genetischem material
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5981505A (en) 1993-01-26 1999-11-09 The Trustees Of The University Of Pennsylvania Compositions and methods for delivery of genetic material
US5864027A (en) 1993-06-07 1999-01-26 Genentech, Inc. HIV envelope polypeptides
US5739118A (en) 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
US6156319A (en) 1994-07-25 2000-12-05 The Trustees Of The University Of Pennsylvania Soluble herpesvirus glycoprotein complex vaccine
NL9401820A (nl) 1994-11-02 1996-06-03 Meyn Maschf Inrichting voor het bewerken van aan zijn poten opgehangen gevogelte.
US5843648A (en) * 1995-01-10 1998-12-01 The United States Of America As Represented By The Secretary, Department Of Health And Human Services P15 and tyrosinase melanoma antigens and their use in diagnostic and therapeutic methods
US5962428A (en) 1995-03-30 1999-10-05 Apollon, Inc. Compositions and methods for delivery of genetic material
US5650309A (en) 1995-05-16 1997-07-22 The Regents Of The University Of California Viral vectors
US5698202A (en) 1995-06-05 1997-12-16 The Wistar Institute Of Anatomy & Biology Replication-defective adenovirus human type 5 recombinant as a rabies vaccine carrier
US5840839A (en) * 1996-02-09 1998-11-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
BR9712852A (pt) * 1996-10-23 1999-11-16 Univ Pennsylvania Plasmìdeo, composição, processo de imunização de um indivìduo contra um patógeno, vacina recombinante, patógeno vivo atenuado, proteìna bl-1 substancialmente pura, vetor recombinante de expressão, e, anticorpo isolado
CN1198665C (zh) 1997-04-03 2005-04-27 依莱克脱罗弗克脱联合股份有限公司 将药物和核酸导入骨骼肌的方法
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
JP2002507985A (ja) 1997-06-30 2002-03-12 ローヌ−プーラン・ロレ・エス・アー 横紋筋に核酸を導入する改良法およびその組合せ
CA2337652C (en) 1998-07-13 2013-03-26 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6589529B1 (en) 1998-10-30 2003-07-08 Children's Hospital Medical Center Rotavirus subunit vaccine
BR0008645A (pt) * 1999-03-03 2002-01-22 Univ Pennsylvania Métodos de induzir uma resposta imunológica contra um imunógeno em um indivìduo, de reduzir rejeição de células, tecido ou órgão doadores nã0-assemelhados em um indivìduo e uma resposta imunológica dominante em um indivìduo e de expandir uma subpopulação de células t associadas com uma resposta imunológica especìfica, plasmìdeo, e, composição
US20030215425A1 (en) * 2001-12-07 2003-11-20 Simard John J. L. Epitope synchronization in antigen presenting cells
ES2347762T3 (es) * 2000-04-28 2010-11-04 Mannkind Corporation Sincronizacion de epitopos en celulas que presentan antigenos.
US8771702B2 (en) * 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
EP1260229A3 (en) 2001-05-18 2002-12-11 Sumitomo Pharmaceuticals Company, Limited Anti-autoimmune composition comprising inhibitors of growth hormone-releasing factor activity
JP4273293B2 (ja) * 2001-05-18 2009-06-03 大日本住友製薬株式会社 Grf作用の阻害による新規抗自己免疫疾患剤、及びそのスクリーニング方法
EP1270732A1 (en) * 2001-06-21 2003-01-02 Schuler, Gerold Improved transfection of eukaryontic cells with linear polynucleotides by electroporation
JP3543326B2 (ja) 2001-08-30 2004-07-14 ソニー株式会社 情報処理装置および方法、情報処理システム、情報配信装置、記録媒体、並びにプログラム
EP1453471B1 (en) 2001-11-07 2011-01-05 Mannkind Corporation Expression vectors encoding epitopes of antigens and methods for their design
US7245963B2 (en) 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
AU2003249357A1 (en) * 2002-06-27 2004-01-19 Geron Corporation Cancer vaccine containing cross-species epitopes of telomerase reverse transcriptase
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
AU2003256912A1 (en) * 2002-08-16 2004-03-03 Yeda Research And Development Co. Ltd. Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines
US7223408B2 (en) * 2002-10-03 2007-05-29 Wyeth Holdings Corporation Human papillomavirus polypeptides and immunogenic compositions
US20040175727A1 (en) 2002-11-04 2004-09-09 Advisys, Inc. Synthetic muscle promoters with activities exceeding naturally occurring regulatory sequences in cardiac cells
US20040253606A1 (en) 2002-11-26 2004-12-16 Protein Design Labs, Inc. Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators
MXPA05010255A (es) * 2003-03-24 2005-12-14 Scripps Research Inst Vacunas de adn contra crecimiento tumoral y metodos de uso de las mismas.
DK2364769T3 (en) 2003-05-30 2016-04-11 Vgxi Inc Apparatus and methods for biomaterialeproduktion
EP1687432A4 (en) 2003-11-13 2008-08-27 Sloan Kettering Inst Cancer COMPOSITIONS AND METHODS FOR SYNERGISTIC INDUCTION OF ANTITUMOR IMMUNITY
EP2301428B1 (en) * 2003-12-09 2016-11-30 Dexcom, Inc. Signal processing for continuous analyte sensor
GB0401876D0 (en) 2004-01-28 2004-03-03 Vereniging Het Nl Kanker I New use for cancer antigen
AU2013203229C1 (en) * 2006-07-28 2015-10-29 The Trustees Of The University Of Pennsylvania Improved vaccines and methods for using the same
EP2594576B1 (en) 2006-07-28 2015-07-01 The Trustees of The University of Pennsylvania Improved HIV vaccines
AU2007342338A1 (en) 2006-09-20 2008-07-17 The Johns Hopkins University Combinatorial therapy of cancer and infectious diseases with anti-B7-H1 antibodies
US8097256B2 (en) 2006-09-28 2012-01-17 Cedars-Sinai Medical Center Cancer vaccines and vaccination methods
AU2007306368B2 (en) * 2006-10-12 2012-05-03 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof
WO2008053573A1 (fr) 2006-10-30 2008-05-08 National University Corporation Hokkaido University Remède pour néoplasme malin
CN101702938A (zh) 2007-05-23 2010-05-05 Vgx药品公司 包含高浓度的生物活性分子的组合物及其制备工艺
WO2010050939A1 (en) 2008-10-29 2010-05-06 The Trustees Of The University Of Pennsylvania Improved hcv vaccines and methods for using the same
AU2009313714B2 (en) 2008-11-17 2016-05-19 Inovio Pharmaceuticals, Inc. Antigens that elicit immune response against flavivirus and methods of using same
WO2010068680A1 (en) 2008-12-10 2010-06-17 Mount Sinai School Of Medicine Of New York University Thelper cell type 17 lineage-specific adjuvants, compositions and methods
CA2653478A1 (en) 2009-01-23 2010-07-23 Gregg Martin Automated wash system for industrial vehicles
EP2440575B1 (en) * 2009-06-09 2014-11-05 Vaxon Biotech Identification, optimization and use of shared hla-b*0702 epitopes for immunotherapy
US20110070212A1 (en) 2009-08-14 2011-03-24 Allergan, Inc. Methods of Treating Cancer Using Glucagon-Like Hormone Retargeted Endopeptidases
WO2011073901A1 (en) * 2009-12-14 2011-06-23 Koninklijke Philips Electronics N.V. Novel tumor markers
KR101784177B1 (ko) * 2010-02-08 2017-10-11 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Rantes를 암호화하는 핵산 분자, 그리고 이를 포함하는 조성물 및 이의 사용 방법
WO2011130566A2 (en) * 2010-04-16 2011-10-20 Bellicum Pharmaceuticals, Inc. Method for treating solid tumors
WO2011160042A2 (en) * 2010-06-18 2011-12-22 Makoto Life Sciences, Inc. Prpk-tprkb modulators and uses thereof
WO2012065164A2 (en) * 2010-11-12 2012-05-18 The Trustees Of The University Of Pennsylvania Consensus prostate antigens nucleic acid molecule encoding the same and vaccine and uses comprising the same
US20140236070A1 (en) * 2011-07-29 2014-08-21 Kate Broderick Linear expression cassettes and uses thereof
NZ701324A (en) * 2012-05-04 2016-09-30 Pfizer Prostate-associated antigens and vaccine-based immunotherapy regimens
SI2932264T1 (sl) * 2012-12-14 2019-05-31 Biontech Rna Pharmaceuticals Gmbh Novi MHC-neodvisni, s tumorjem povezani antigeni
MX369709B (es) * 2013-03-15 2019-11-19 Univ Pennsylvania Vacunación mejorada contra tirosinasa.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050158332A1 (en) * 1995-09-26 2005-07-21 Government Of The Usa, Represented By The Secretary, Dept. Of Health & Human Services MHC-Class II restricted melanoma antigens and their use in therapeutic methods
US20110091498A1 (en) * 1996-03-20 2011-04-21 The Usa As Represented By The Secretary, Dept. Of Health And Human Services Methods of stimulating an immune response against prostate specific antigen
US20030138808A1 (en) * 1998-02-19 2003-07-24 Simard John J.L. Expression vectors encoding epitopes of target-associated antigens
US20040132972A1 (en) * 2001-02-26 2004-07-08 Xiaoqiang Kang Tri-hybrid melanoma antigen
US20080171711A1 (en) * 2004-07-21 2008-07-17 Curevac Gmbh Mrna Mixture For Vaccinating Against Tumoral Diseases
US20110070290A1 (en) * 2006-09-26 2011-03-24 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BUONAGURO et al. Translating Tumor Antigens into Cancer Vaccines, Clin Vaccine Immunol., 2011, Vol. 18(1), p. 23-34, Abstract; p. 24, col. 1, last para and col. 2, top para; and p. 25, col. 2, last para, and Table 1 *
KRAYNYAK et al. Plasmid-Encoded Interleukin-15. Receptor a Enhances Specific Immune Responses Induced by a DNA Vaccine In Vivo, Hum Gene Ther., 2009, Vol. 20(10), p. 1143-1156, Abstract *

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