EA029283B1 - Антагонисты il-17a - Google Patents

Антагонисты il-17a Download PDF

Info

Publication number
EA029283B1
EA029283B1 EA201290254A EA201290254A EA029283B1 EA 029283 B1 EA029283 B1 EA 029283B1 EA 201290254 A EA201290254 A EA 201290254A EA 201290254 A EA201290254 A EA 201290254A EA 029283 B1 EA029283 B1 EA 029283B1
Authority
EA
Eurasian Patent Office
Prior art keywords
zeg
tug
antibody
azr
amino acid
Prior art date
Application number
EA201290254A
Other languages
English (en)
Russian (ru)
Other versions
EA201290254A1 (ru
Inventor
Майкл Насо
Рэймонд Свит
Цзиньцюань Ло
Шэн-Дзюн Ву
Мерле Эллосо
Даниэла Делла Дуката
Роберт Раухенбергер
Марк Рутц
Хуан Карлос Альмагро
Сузанн Таудте
Бинюань Ву
Галина Обмолова
Томас Малиа
Original Assignee
Янссен Байотек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43922991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA029283(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Байотек, Инк. filed Critical Янссен Байотек, Инк.
Publication of EA201290254A1 publication Critical patent/EA201290254A1/ru
Publication of EA029283B1 publication Critical patent/EA029283B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EA201290254A 2009-10-30 2010-10-29 Антагонисты il-17a EA029283B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25686209P 2009-10-30 2009-10-30
US31091910P 2010-03-05 2010-03-05
PCT/US2010/054662 WO2011053763A2 (fr) 2009-10-30 2010-10-29 Antagonistes de l'il-17a

Publications (2)

Publication Number Publication Date
EA201290254A1 EA201290254A1 (ru) 2012-12-28
EA029283B1 true EA029283B1 (ru) 2018-03-30

Family

ID=43922991

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290254A EA029283B1 (ru) 2009-10-30 2010-10-29 Антагонисты il-17a

Country Status (21)

Country Link
US (1) US8519107B2 (fr)
EP (1) EP2493506B1 (fr)
JP (1) JP5922025B2 (fr)
KR (1) KR101836217B1 (fr)
CN (1) CN102905727B (fr)
AU (1) AU2010313304B2 (fr)
BR (1) BR112012010280B1 (fr)
CA (1) CA2779257C (fr)
CL (1) CL2012001141A1 (fr)
CO (1) CO6541541A2 (fr)
CR (1) CR20120298A (fr)
EA (1) EA029283B1 (fr)
EC (1) ECSP12011871A (fr)
ES (1) ES2728115T3 (fr)
GT (1) GT201200132A (fr)
IL (1) IL219390B (fr)
MX (1) MX2012005086A (fr)
NI (1) NI201200080A (fr)
NZ (1) NZ599737A (fr)
PE (1) PE20121363A1 (fr)
WO (1) WO2011053763A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG175276A1 (en) 2009-05-05 2011-11-28 Novimmune Sa Anti-il-17f antibodies and methods of use thereof
EP2571901B1 (fr) 2010-05-20 2019-01-02 Ablynx N.V. Matériaux biologiques associés à her3
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
WO2013116682A1 (fr) 2012-02-02 2013-08-08 Ensemble Therapeutics Corporation Composés macrocycliques pour une modulation d'il-17
CN103509118B (zh) * 2012-06-15 2016-03-23 郭怀祖 胰岛素-Fc融合蛋白
WO2014001368A1 (fr) * 2012-06-25 2014-01-03 Orega Biotech Anticorps antagonistes de l'il-17
CA3185317A1 (fr) 2013-02-08 2014-08-14 Novartis Ag Anticorps anti-il-17a et leur utilisation dans le traitement de troubles auto-immuns et inflammatoires
ES2818074T3 (es) * 2013-11-18 2021-04-09 Shanghai hengrui pharmaceutical co ltd Agente de unión a IL-17A y sus usos
WO2015127405A2 (fr) 2014-02-21 2015-08-27 Genentech, Inc. Anticorps bispécifiques anti-il-13/il-17 et leurs utilisations
CN103936854B (zh) * 2014-04-30 2016-08-17 北京精益泰翔技术发展有限公司 抗il-17a单克隆抗体及其制备与应用
US10799584B2 (en) 2014-06-09 2020-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health Combination therapies using agents that target tumor-associated stroma or tumor cells and alkylating agents
WO2015191568A2 (fr) * 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Polythérapies utilisant des agents qui ciblent des stromas associés à une tumeur ou des cellules tumorales et la vasculature tumorale
WO2015191617A2 (fr) * 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Polythérapies utilisant des anti-métabolites et des agents qui ciblent un stroma associé à une tumeur ou des cellules tumorales
US11033620B2 (en) 2014-06-09 2021-06-15 Biomed Valley Discoveries, Inc. Combination therapies targeting tumor-associated stroma or tumor cells and microtubules
US10758526B2 (en) 2014-06-09 2020-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health Combination therapies using agents that target tumor-associated stroma or tumor cells and other pathways
WO2015191602A2 (fr) * 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Polythérapies ciblant un stroma associé à une tumeur ou des cellules tumorales
US10758614B2 (en) 2014-06-09 2020-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health Combination therapies targeting tumor-associated stroma or tumor cells and topoisomerase
US10434174B2 (en) 2014-06-09 2019-10-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination therapies using platinum agents and agents that target tumor-associated stroma or tumor cells
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
CA2970759A1 (fr) * 2014-12-15 2016-06-23 Morphosys Ag Anticorps anti-il-17 c
CN107407677B (zh) * 2015-01-28 2020-07-17 豪夫迈·罗氏有限公司 多发性硬化的基因表达标志和治疗
CN105315371B (zh) * 2015-03-05 2018-05-29 北京百特美博生物科技有限公司 抗人il-17单克隆抗体
CN106336459B (zh) * 2015-07-13 2020-12-08 三生国健药业（上海）股份有限公司 抗人白细胞介素-17a单克隆抗体、其制备方法和应用
US20170218092A1 (en) * 2016-01-28 2017-08-03 Janssen Biotech, Inc. Bispecific Anti-TNF-Alpha/IL17A Antibodies and Anti-TNF-Alpha Antibodies and Methods of Their Use
AU2017250191A1 (en) * 2016-04-13 2018-11-08 Orimabs Ltd. Anti-PSMA antibodies and use thereof
ES2905917T3 (es) * 2016-09-14 2022-04-12 Beijing Hanmi Pharmaceutical Co Ltd Anticuerpo que se une específicamente a IL-17A y fragmento funcional del mismo
CN108359011B (zh) * 2017-07-21 2019-06-25 华博生物医药技术（上海）有限公司 靶向于白介素17a的抗体、其制备方法和应用
JP2021519589A (ja) * 2018-03-29 2021-08-12 アールイーエムディー バイオセラピューティクス，インコーポレイテッドＲＥＭＤ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ インターロイキン１７ａ（ｉｌ−１７ａ）に結合する抗体を用いた自己免疫障害及び炎症障害の治療
CA3100092A1 (fr) * 2018-05-17 2019-11-21 Jiangsu Qyuns Therapeutics Co., Ltd. Anticorps monoclonal anti-interleukine 17a humaine et son application
CN111303283A (zh) * 2018-12-12 2020-06-19 上海君实生物医药科技股份有限公司 抗il-17a抗体及其应用
EP3689907A1 (fr) * 2019-01-31 2020-08-05 Numab Therapeutics AG Anticorps dirigés contre il-17a et leurs procédés d'utilisation
WO2021018191A1 (fr) * 2019-07-30 2021-02-04 江苏恒瑞医药股份有限公司 Méthode de traitement d'une maladie auto-immune par un antagoniste de l'il-17
MX2022003815A (es) 2019-09-30 2022-05-06 Janssen Pharmaceutica Nv Composiciones y metodos para un ensayo de acoplamiento diana de il-17 con moduladores de molecula peque?a.
JP2022549464A (ja) 2019-09-30 2022-11-25 ヤンセン ファーマシューティカ エヌ．ベー． 大分子モジュレータを用いたｉｌ－１７標的結合アッセイのための組成物及び方法
IT202200016722A1 (it) * 2022-08-04 2024-02-04 Paolo Grieco Nuovo peptide derivato da interleuchina-17A (IL-17A) e anticorpo neutralizzante (Ab17-IPL-1)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026667A1 (fr) * 1998-10-30 2000-05-11 Miller Jonathan L Regions variables de chaine lourde et de chaine legere d'anticorps diriges contre la glycoproteine plaquettaire humaine ib alpha
US20020086014A1 (en) * 1999-08-24 2002-07-04 Korman Alan J. Human CTLA-4 antibodies and their uses
US20030099647A1 (en) * 2001-10-05 2003-05-29 Deshpande Rajendra V. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
US20050150002A1 (en) * 2004-01-02 2005-07-07 Dellapenna Dean Novel carotenoid hydroxylases for use in engineering carotenoid metabolism in plants
US20050208558A1 (en) * 1999-10-19 2005-09-22 Applera Corporation Detection kits, such as nucleic acid arrays, for detecting the expression or 10,000 or more Drosophila genes and uses thereof
WO2007076524A2 (fr) * 2005-12-29 2007-07-05 Centocor, Inc. Anticorps humains anti-il-23, compositions, procedes et utilisations afferents
US20070271630A1 (en) * 2005-02-24 2007-11-22 Boukharov Andrey A Methods for genetic control of plant pest infestation and compositions thereof
US20080095775A1 (en) * 2006-06-13 2008-04-24 Lewis Katherine E Il-17 and il-23 antagonists and methods of using the same
US20080095770A1 (en) * 2006-08-09 2008-04-24 Glycart Biotechnology Ag Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
US20090105461A1 (en) * 2004-03-15 2009-04-23 Wyeth Calicheamicin conjugates
US20090175881A1 (en) * 2006-08-11 2009-07-09 Presta Leonard G Antibodies to il-17a

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
WO1988007089A1 (fr) 1987-03-18 1988-09-22 Medical Research Council Anticorps alteres
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
ES2087997T3 (es) 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1994004679A1 (fr) 1991-06-14 1994-03-03 Genentech, Inc. Procede pour fabriquer des anticorps humanises
DK0590058T3 (da) 1991-06-14 2004-03-29 Genentech Inc Humaniseret heregulin-antistof
US5885793A (en) 1991-12-02 1999-03-23 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
TWI313299B (en) 2000-11-30 2009-08-11 Medarex Inc Transgenic transchromosomal rodents for making human antibodies
JP4406206B2 (ja) * 2001-04-24 2010-01-27 バイエル コーポレーション ヒトｔｉｍｐ−１抗体
WO2002102973A2 (fr) * 2001-06-20 2002-12-27 Prochon Biotech Ltd. Anticorps bloquant l'activation de proteine tyrosine kinase recepteur, procedes de criblage et utilisations
US6649055B1 (en) 2002-05-07 2003-11-18 The United States Of America As Represented By The United States Department Of Energy Pump station for radioactive waste water
US7501247B2 (en) 2004-05-03 2009-03-10 Schering Corporation Method of treating skin inflammation
JP2008501035A (ja) 2004-05-28 2008-01-17 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 妊孕性関連障害の治療におけるｉｌ−１７の使用
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
GB0525214D0 (en) * 2005-12-12 2006-01-18 Bioinvent Int Ab Biological materials and uses thereof
AU2006325860B2 (en) 2005-12-13 2011-09-22 Eli Lilly And Company Anti-IL-17 antibodies
CA2646478A1 (fr) * 2006-03-10 2007-09-20 Zymogenetics, Inc. Anticorps se liant a la fois avec il-17a et il-17f et procedes d'utilisation
TW200815469A (en) 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
WO2009003096A2 (fr) 2007-06-26 2008-12-31 Centocor, Inc. Mutéines il-17, anticorps, compositions, procédés et utilisations
DE112008003232T5 (de) 2007-11-30 2011-02-24 Glaxo Group Limited, Greenford Antigen-Bindungskonstrukte
WO2009082624A2 (fr) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonistes de il-17a, il-17f et il-23 et procédés d'utilisation de ceux-ci
CA2710373A1 (fr) * 2007-12-19 2009-07-09 Ping Tsui Conception et generation de banques d'exposition sur phage humain pix de novo au moyen d'une fusion vers pix ou pvii, vecteur, anticorps et procedes
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
CN102617735B (zh) 2008-09-29 2015-09-09 罗氏格黎卡特股份公司 针对人il17的抗体及其应用
WO2010045340A1 (fr) 2008-10-14 2010-04-22 Centocor Ortho Biotech Inc. Procédés d’humanisation et de maturation d’affinité d’anticorps

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026667A1 (fr) * 1998-10-30 2000-05-11 Miller Jonathan L Regions variables de chaine lourde et de chaine legere d'anticorps diriges contre la glycoproteine plaquettaire humaine ib alpha
US20020086014A1 (en) * 1999-08-24 2002-07-04 Korman Alan J. Human CTLA-4 antibodies and their uses
US20050208558A1 (en) * 1999-10-19 2005-09-22 Applera Corporation Detection kits, such as nucleic acid arrays, for detecting the expression or 10,000 or more Drosophila genes and uses thereof
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
US20030099647A1 (en) * 2001-10-05 2003-05-29 Deshpande Rajendra V. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
US20050150002A1 (en) * 2004-01-02 2005-07-07 Dellapenna Dean Novel carotenoid hydroxylases for use in engineering carotenoid metabolism in plants
US20090105461A1 (en) * 2004-03-15 2009-04-23 Wyeth Calicheamicin conjugates
US20070271630A1 (en) * 2005-02-24 2007-11-22 Boukharov Andrey A Methods for genetic control of plant pest infestation and compositions thereof
WO2007076524A2 (fr) * 2005-12-29 2007-07-05 Centocor, Inc. Anticorps humains anti-il-23, compositions, procedes et utilisations afferents
US20080095775A1 (en) * 2006-06-13 2008-04-24 Lewis Katherine E Il-17 and il-23 antagonists and methods of using the same
US20080095770A1 (en) * 2006-08-09 2008-04-24 Glycart Biotechnology Ag Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
US20090175881A1 (en) * 2006-08-11 2009-07-09 Presta Leonard G Antibodies to il-17a

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
UMMC, Ulcerative colitis - Introduction, 2011 [online]. [Retrieved on 2011.06.03]. Retrieved from the Internet: <URL: http://www.umm.edu/patiented/articles/what_ulcerative_colitis_inflammatory_bowel_disease_00069_1.htm> *
UniProt_ B9CX49, Dipeptide transport protein DppA1, 24 March 2009 [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/B9CX49> amino acid residues 118-126, that is 79.3% identical to the claimed SEQ ID NO: 18 *
UniProt_A0D7C4, Chromosome undetermined scaffold_4, whole genome shotgun sequence, 28 November 2006 [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/A0D7C4> amino acid residues 62-71, that is 84.6% identical to the claimed SEQ ID NO: 15 *
UniProt_A5ICM5, Putative uncharacterized protein, 26 June 2007 [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/A5ICM5> amino acid residues 419-427 that is 80.8% identical to the claimed SEQ ID NO: 8 *
UniProt_A7XA61, DRF-like transcription factor DRFL2a, 23 October 2007 [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/A7XA61> amino acid residues 46-55, that is 86.5% identical to the claimed SEQ ID NO: 16 *
UniProt_B4HXQ5, GM14347, 23 September 2008 [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/B4HXQ5> amino acid residues 128-137, that is 80% identical to the claimed SEQ ID NO: 12 *
UniProt_C5A772, Permease, major facilitator superfamily, 28 July 2009 [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/C5A772> amino acid residues 89-100 that is 71.9% identical to the claimed SEQ ID NO: 2 *
UniProt_Q5DF07, SJCHGC06558 protein, 29 March 2005 [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/Q5DF07> amino acid residues 275-284, that is 81.2% identical to the claimed SEQ ID NO: 13 *
UniProt_Q8BCV6, Uncharacterized 55 kDa protein, 01 March 2003, [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/Q8BCV6> amino acid residues 260-266 that is 100% identical to the claimed SEQ ID NO: 6 *
UniProt_Q8PJC9, Putative uncharacterized protein, 01 October 2001, [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/Q8PJC9> amino acid residues 12-18 that 100% identical to the claimed SEQ ID NO: 24 *
UniProt_Q92TP0 (for C96025), Hypothetical exported protein, TonB-dependent receptor protein, 01 December 2001 [online]. [Retrieved on 2011.05.25]. Retrieved from the Internet: <URL: http://www.uniprot.org/uniprot/Q92TP0> amino acid residues 367-374 is 88.9% identical to the claimed SEQ ID NO: 7 *

Also Published As

Publication number Publication date
US8519107B2 (en) 2013-08-27
EP2493506A2 (fr) 2012-09-05
KR101836217B1 (ko) 2018-03-08
CA2779257A1 (fr) 2011-05-05
CL2012001141A1 (es) 2012-11-30
EP2493506B1 (fr) 2019-04-10
WO2011053763A3 (fr) 2011-10-06
NI201200080A (es) 2013-04-22
BR112012010280A2 (pt) 2017-06-20
EA201290254A1 (ru) 2012-12-28
ES2728115T3 (es) 2019-10-22
CN102905727A (zh) 2013-01-30
AU2010313304A1 (en) 2012-05-24
IL219390A0 (en) 2012-06-28
EP2493506A4 (fr) 2013-11-20
GT201200132A (es) 2014-01-17
AU2010313304B2 (en) 2015-08-20
PE20121363A1 (es) 2012-10-15
CA2779257C (fr) 2019-03-12
CO6541541A2 (es) 2012-10-16
MX2012005086A (es) 2012-09-28
CN102905727B (zh) 2016-12-07
ECSP12011871A (es) 2012-08-31
KR20120102662A (ko) 2012-09-18
JP2013509193A (ja) 2013-03-14
JP5922025B2 (ja) 2016-05-25
WO2011053763A2 (fr) 2011-05-05
IL219390B (en) 2019-01-31
CR20120298A (es) 2014-01-09
BR112012010280B1 (pt) 2020-09-24
US20110236390A1 (en) 2011-09-29
NZ599737A (en) 2015-02-27

Similar Documents

Publication Publication Date Title
EA029283B1 (ru) Антагонисты il-17a
RU2742691C2 (ru) Cd3-связывающий домен
DK1257648T4 (en) Antagonistic selective binding agents of osteoprotegerin binding protein
JP6258194B2 (ja) 抗神経成長因子抗体並びに前記の製造及び使用方法
ES2704036T3 (es) Anticuerpos anti-factor de crecimiento nervioso y procedimientos de preparación y uso de los mismos
JP6109571B2 (ja) 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体
US20180179294A1 (en) Toll-like receptor 3 antagonists
JP2021533779A (ja) 操作された二重特異性タンパク質
EP1257648B2 (fr) Agents de liaison selectifs antagonistes de proteine de liaison d&#39;osteoprotegerine
CN109311997A (zh) 抗axl拮抗抗体
CN103601806B (zh) Il-6结合分子
JP5727463B2 (ja) Ｔｏｌｌ様受容体３アンタゴニスト
JP2016500656A (ja) 代謝性疾患及び心臓血管疾患を治療するためのｔｏｌｌ様受容体３アンタゴニスト
CN109929035A (zh) 抗人ngf抗体及其制备方法和用途
CN111819201A (zh) Pd1结合剂
BR112021004686A2 (pt) proteínas de ligação de antígeno anti-flt3 melhoradas
CN109721656A (zh) 靶向rankl的治疗性抗体
WO2013039471A1 (fr) Antagonistes du récepteur 3 de type toll utilisables en vue du traitement de maladies métaboliques et cardiovasculaires
TW202210513A (zh) 抗ｉｇｆ－１受體人源化抗體
WO2024153223A1 (fr) Procédé de traitement du lupus érythémateux disséminé
JP2023504974A (ja) 抗ｔｉｒｃ７抗原結合タンパク質
WO2015176104A1 (fr) Protéines de liaison bak