EA025182B1 - Композиция, включающая афлиберцепт, фолиновую кислоту, 5-фторурацил (5-fu) и ириноцетан (folfiri), для лечения колоректального рака - Google Patents

Композиция, включающая афлиберцепт, фолиновую кислоту, 5-фторурацил (5-fu) и ириноцетан (folfiri), для лечения колоректального рака Download PDF

Info

Publication number
EA025182B1
EA025182B1 EA201391577A EA201391577A EA025182B1 EA 025182 B1 EA025182 B1 EA 025182B1 EA 201391577 A EA201391577 A EA 201391577A EA 201391577 A EA201391577 A EA 201391577A EA 025182 B1 EA025182 B1 EA 025182B1
Authority
EA
Eurasian Patent Office
Prior art keywords
aflibercept
patient
fluorouracil
dose
irinocetan
Prior art date
Application number
EA201391577A
Other languages
English (en)
Russian (ru)
Other versions
EA201391577A1 (ru
Inventor
Реми Кастан
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46001286&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA025182(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Санофи filed Critical Санофи
Publication of EA201391577A1 publication Critical patent/EA201391577A1/ru
Publication of EA025182B1 publication Critical patent/EA025182B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/178Lectin superfamily, e.g. selectins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EA201391577A 2011-04-26 2012-04-25 Композиция, включающая афлиберцепт, фолиновую кислоту, 5-фторурацил (5-fu) и ириноцетан (folfiri), для лечения колоректального рака EA025182B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11305490 2011-04-26
EP11306154 2011-09-15
PCT/EP2012/057542 WO2012146610A1 (en) 2011-04-26 2012-04-25 Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri)

Publications (2)

Publication Number Publication Date
EA201391577A1 EA201391577A1 (ru) 2014-03-31
EA025182B1 true EA025182B1 (ru) 2016-11-30

Family

ID=46001286

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391577A EA025182B1 (ru) 2011-04-26 2012-04-25 Композиция, включающая афлиберцепт, фолиновую кислоту, 5-фторурацил (5-fu) и ириноцетан (folfiri), для лечения колоректального рака

Country Status (39)

Country Link
US (1) US11033606B2 (enExample)
EP (2) EP3210617A1 (enExample)
JP (1) JP6114257B2 (enExample)
KR (2) KR20190088568A (enExample)
CN (1) CN103608029A (enExample)
AR (1) AR086051A1 (enExample)
AU (1) AU2012247530B2 (enExample)
BR (1) BR112013027356A2 (enExample)
CA (1) CA2833592A1 (enExample)
CL (1) CL2013003082A1 (enExample)
CO (1) CO6811861A2 (enExample)
CR (1) CR20130547A (enExample)
CY (1) CY1120382T1 (enExample)
DK (1) DK2701724T3 (enExample)
DO (1) DOP2013000248A (enExample)
EA (1) EA025182B1 (enExample)
EC (1) ECSP13013044A (enExample)
ES (1) ES2637074T3 (enExample)
GT (1) GT201300260A (enExample)
HR (1) HRP20171216T1 (enExample)
HU (1) HUE034288T2 (enExample)
IL (2) IL228947B (enExample)
JO (1) JO3283B1 (enExample)
LT (1) LT2701724T (enExample)
MA (1) MA35130B1 (enExample)
MX (1) MX341348B (enExample)
NI (1) NI201300112A (enExample)
PE (2) PE20171516A1 (enExample)
PH (1) PH12013502195A1 (enExample)
PL (1) PL2701724T3 (enExample)
PT (1) PT2701724T (enExample)
RS (1) RS56177B1 (enExample)
SG (2) SG194613A1 (enExample)
SI (1) SI2701724T1 (enExample)
TW (1) TWI599369B (enExample)
UA (1) UA114708C2 (enExample)
UY (1) UY34036A (enExample)
WO (1) WO2012146610A1 (enExample)
ZA (1) ZA201308821B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) * 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
JP2015526430A (ja) * 2012-08-02 2015-09-10 サノフイ アフリベルセプトまたはziv−アフリベルセプトを含む製造物品
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
MA40354A (fr) * 2014-07-18 2017-05-24 Sanofi Sa Procédé permettant de prédire le résultat d'un traitement avec de l'aflibercept d'un patient suspecté de souffrir d'un cancer
CN107076749B (zh) 2014-09-16 2020-12-29 瑞泽恩制药公司 转移性结直肠癌抗血管发生治疗相关预测和预后生物标志
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
PL3337467T3 (pl) 2015-08-20 2021-06-14 Ipsen Biopharm Ltd. Terapia skojarzona z zastosowaniem liposomalnego irynotekanu i inhibitora parp do leczenia nowotworu
IL257149B2 (en) 2015-08-21 2024-11-01 Ipsen Biopharm Ltd Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin
KR101936049B1 (ko) * 2015-10-15 2019-01-08 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 생산방법
BR112018013407A2 (en) 2015-12-30 2018-12-18 Kodiak Sciences Inc. antibodies and conjugates thereof
ES2908848T3 (es) * 2016-01-25 2022-05-04 Sanofi Sa Método de predicción del resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer midiendo el nivel de un biomarcador de plasma
EP3535026A1 (en) 2016-11-02 2019-09-11 Ipsen Biopharm Limited Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)
SG11202008242XA (en) 2018-03-02 2020-09-29 Kodiak Sciences Inc Il-6 antibodies and fusion constructs and conjugates thereof
SG11202010684YA (en) 2018-05-10 2020-11-27 Regeneron Pharma High concentration vegf receptor fusion protein containing formulations
CA3101694A1 (en) * 2018-05-30 2019-12-05 David MACHOVER Methods and pharmaceutical compositions for treating cancer
WO2021050094A1 (en) * 2019-09-11 2021-03-18 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006059012A1 (fr) * 2004-12-03 2006-06-08 Aventis Pharma S.A. Combinaisons antitumorales contenant un agent inhibiteur de vegf et du 5fu ou un de ses derives
WO2009024667A2 (fr) * 2007-07-05 2009-02-26 Aventis Pharma S.A. Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019790B2 (ja) 1977-11-18 1985-05-17 株式会社日立製作所 光硬化型接着性組成物とそれを用いて被着体を接着する方法
US4353887A (en) 1979-08-16 1982-10-12 Ciba-Geigy Corporation Divisible tablet having controlled and delayed release of the active substance
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
WO1993000807A1 (en) 1991-07-03 1993-01-21 Cryolife, Inc. Method for stabilization of biomaterials
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US6749853B1 (en) 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
DE69333928T2 (de) 1992-04-30 2006-08-17 Probitas Pharma Inc., Los Angeles Verbesserte solubilisierung und stabilisierung des faktor viii-komplexes
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
ATE281469T1 (de) 1993-03-25 2004-11-15 Merck & Co Inc Inhibitor des wachstumsfaktors für gefäss- endothelzellen
US6811779B2 (en) 1994-02-10 2004-11-02 Imclone Systems Incorporated Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
US6040157A (en) 1994-03-08 2000-03-21 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
GB9410533D0 (en) 1994-05-26 1994-07-13 Lynxvale Ltd In situ hybridisation and immuno-Chemical localisation of a growth factor
GB9410534D0 (en) 1994-05-26 1994-07-13 Lynxvale Ltd Improvements in or relating to growth factor inhibitors
TW438775B (en) 1995-04-07 2001-06-07 Pharmacia & Upjohn Co Llc Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
JPH09154588A (ja) 1995-10-07 1997-06-17 Toagosei Co Ltd Vegf結合性ポリペプチド
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US5763401A (en) 1996-07-12 1998-06-09 Bayer Corporation Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
AU738806B2 (en) 1996-09-24 2001-09-27 Merck & Co., Inc. Gene therapy for inhibition of angiogenesis
US7312196B2 (en) 1997-01-08 2007-12-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
DE19724793A1 (de) 1997-06-06 1998-12-10 Schering Ag D-mutierte Peptide mit VEGF-Rezeptor blockierenden Eigenschaften
US6075007A (en) 1997-07-17 2000-06-13 Regeneron Pharmaceuticals, Inc. Modified noggin polypeptide and compositions
JPH1180024A (ja) 1997-09-12 1999-03-23 Toagosei Co Ltd 角膜血管新生阻害剤
US6436897B2 (en) 1998-06-01 2002-08-20 Celtrix Pharmaceuticals, Inc. Pharmaceutical formulations for IGF/IGFBP
DE19841985A1 (de) 1998-09-03 2000-03-09 Schering Ag Dialkylsulfonsäure- und Dialkylcarbonsäure-Derivate
US6472179B2 (en) 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
WO2000034337A1 (en) 1998-12-10 2000-06-15 Tsukuba Research Laboratory, Toagosei Co., Ltd. Humanized monoclonal antibodies against vascular endothelial cell growth factor
AP1243A (en) 1999-02-01 2004-02-02 Servier Lab Core tablet for controlled release of gliclazide after oral administration.
ES2223705T3 (es) 1999-04-28 2005-03-01 Board Of Regents, The University Of Texas System Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf.
AU4564200A (en) 1999-04-29 2000-11-17 Aventis Pharma S.A. Method for treating cancer using camptothecin derivatives and 5-fluorouracil
US6833349B2 (en) 1999-06-08 2004-12-21 Regeneron Pharmaceuticals, Inc. Methods of treating inflammatory skin diseases
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
RS50073B (sr) 1999-06-08 2009-01-22 Regeneron Pharmaceuticals I.N.C., Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama
US7001892B1 (en) 1999-06-11 2006-02-21 Purdue Research Foundation Pharmaceutical materials and methods for their preparation and use
DE19938724A1 (de) 1999-08-16 2001-02-22 Tetra Laval Holdings & Finance Vorrichtung zur Herstellung von Kunststoffbehältern mittels Streckblasformen
GB0008269D0 (en) 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
US6500633B1 (en) 2000-04-26 2002-12-31 Atairgin Technologies, Inc. Method of detecting carcinomas
GT200100079A (es) 2000-05-10 2001-12-31 Metodo para regular la angiogenesis utilizando proteina ryk
PT1324776E (pt) 2000-10-12 2009-12-23 Genentech Inc Formulações de proteína concentradas de viscosidade reduzida
US20030092019A1 (en) 2001-01-09 2003-05-15 Millennium Pharmaceuticals, Inc. Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia
US20040023864A1 (en) 2001-05-09 2004-02-05 Steve Roczniak Method of regulating angiogenesis using ryk protein
WO2003009817A2 (en) 2001-07-25 2003-02-06 Protein Design Labs, Inc. Stable lyophilized pharmaceutical formulation of igg antibodies
ES2287495T3 (es) 2002-03-01 2007-12-16 Pfizer Italia S.R.L. Forma polimorfa cristalina de clorhidrato de irinotecan.
JP2004006671A (ja) 2002-03-22 2004-01-08 Sanyo Electric Co Ltd 電荷結合素子およびその製造方法
PT1608685E (pt) 2003-03-28 2007-05-31 Regeneron Pharma Anatagonistas de vegf para o tratamento de diabetes.
HRP20050934B1 (hr) 2003-04-04 2014-09-26 Genentech, Inc. Formulacije s visokom koncentracijom antitijela i proteina
US7300654B2 (en) 2003-05-28 2007-11-27 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection in high risk keratoplasty patients
CA2519835A1 (en) 2003-05-28 2004-12-09 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection
US7186699B2 (en) 2003-06-03 2007-03-06 Cell Genesys, Inc. Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
CA2519875C (en) 2003-06-06 2014-01-14 Regeneron Pharmaceuticals, Inc. Method of tumor regression with vegf inhibitors
US7399612B2 (en) 2003-06-30 2008-07-15 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
AR046510A1 (es) 2003-07-25 2005-12-14 Regeneron Pharma Composicion de un antagonista de vegf y un agente anti-proliferativo
US20050196340A1 (en) 2003-08-06 2005-09-08 Jocelyn Holash Use of a VEGF antagonist in combination with radiation therapy
US20050112061A1 (en) 2003-08-06 2005-05-26 Jocelyn Holash Use of a VEGF antagonist in combination with radiation therapy
CN1802627B (zh) 2003-08-14 2010-04-28 富士通株式会社 计算机装置和集群服务器装置
AU2004268614C1 (en) 2003-08-27 2010-10-28 Ophthotech Corporation Combination therapy for the treatment of ocular neovascular disorders
DE60326353D1 (de) 2003-11-06 2009-04-09 Nestle Waters Man & Technology Herstellungsverfahren von Behältern aus Polyesterharz
WO2005046602A2 (en) 2003-11-10 2005-05-26 Greenville Hospital System Vegf receptor antagonists
WO2005072772A1 (en) 2004-01-30 2005-08-11 Suomen Punainen Risti Veripalvelu Pharmaceutical compositions
JP2008502738A (ja) 2004-06-10 2008-01-31 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトの癌を処置するための、vegfインヒビターの使用
MXPA06014689A (es) 2004-06-18 2008-03-11 Regeneron Pharma Inhibidores del vegf para el tratamiento de efusion pleural maligna.
MX2007001241A (es) 2004-07-30 2007-07-11 Regeneron Pharma Metodos para tratar diabetes tipo i mediante el bloqueo de la actividad mediada de vegf.
RS52539B (sr) 2004-10-21 2013-04-30 Genentech Inc. Metod za tretiranje intraokularnih neovaskularnih bolesti
EP1877438A2 (en) 2005-02-02 2008-01-16 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a vegf inhibitor
EP1853298A2 (en) 2005-02-11 2007-11-14 Regeneron Pharmaceuticals, Inc. Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent
CA2598452A1 (en) 2005-03-11 2006-09-21 Regeneron Pharmaceuticals, Inc. Treating anemia by inhibition of vegf
EP2586459B1 (en) 2005-03-25 2017-05-24 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations
CN101237880B (zh) 2005-08-12 2011-09-21 瑞泽恩制药公司 通过vegf拮抗剂的皮下给药治疗疾病
US7354582B2 (en) 2006-03-10 2008-04-08 Regeneron Pharmaceuticals, Inc. Use of VEGF antagonists for the treatment of malignant gliomas
EP3753548A1 (en) 2006-06-16 2020-12-23 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations suitable for intravitreal administration
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
EP2136630A4 (en) 2007-03-23 2010-06-02 Precision Therapeutics Inc METHOD FOR EVALUATING THE ANGIOGENIC POTENTIAL IN CULTURE
CN100546578C (zh) * 2007-08-10 2009-10-07 河北医科大学 一种抗癌药物组合物及其在制备抗癌药物中的应用
JP5734656B2 (ja) 2007-10-04 2015-06-17 オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. ペプチドエポキシケトンプロテアーゼ阻害剤結晶及びアミノ酸ケトエポキシドの調製
AU2008334070B2 (en) 2007-11-30 2015-04-16 Genentech, Inc. VEGF polymorphisms and anti-angiogenesis therapy
EP2143542A1 (fr) 2008-07-07 2010-01-13 Nestec S.A. Procédé et dispositif de conditionnement d'un liquide alimentaire
FR2933702A1 (fr) 2008-07-08 2010-01-15 Sanofi Aventis Antagonistes specifiques du recepteur fgf-r4
WO2010022201A2 (en) 2008-08-22 2010-02-25 Osteogenex Inc. Folinic acid derivatives for promoting bone growth
US20100093552A1 (en) 2008-10-09 2010-04-15 Asit Panja Use and identification of biomarkers for gastrointestinal diseases
EP2356250A2 (en) 2008-11-05 2011-08-17 Genentech, Inc. Genetic polymorphisms in age-related macular degeneration
CA2754646A1 (en) 2009-03-31 2010-10-07 Roche Glycart Ag Treatment of cancer with a humanized anti-egfr igg1 antibody and irinotecan
WO2010124264A2 (en) 2009-04-24 2010-10-28 University Of Southern California Genetic variants in angiogenesis pathway associated with clinical outcome
WO2011014759A2 (en) 2009-07-31 2011-02-03 Amcor Limited Hot-fill container
US8221753B2 (en) * 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
WO2012123227A1 (en) 2011-02-23 2012-09-20 Sanofi Single nucleotide polymorphisms in the promoter of vegfa gene and their use as predictive markers for anti-vegf treatments
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
JP6019790B2 (ja) 2012-06-19 2016-11-02 富士電機株式会社 接合方法及び接合部材
JP2015526430A (ja) 2012-08-02 2015-09-10 サノフイ アフリベルセプトまたはziv−アフリベルセプトを含む製造物品
MA40354A (fr) 2014-07-18 2017-05-24 Sanofi Sa Procédé permettant de prédire le résultat d'un traitement avec de l'aflibercept d'un patient suspecté de souffrir d'un cancer
ES2908848T3 (es) 2016-01-25 2022-05-04 Sanofi Sa Método de predicción del resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer midiendo el nivel de un biomarcador de plasma

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006059012A1 (fr) * 2004-12-03 2006-06-08 Aventis Pharma S.A. Combinaisons antitumorales contenant un agent inhibiteur de vegf et du 5fu ou un de ses derives
WO2009024667A2 (fr) * 2007-07-05 2009-02-26 Aventis Pharma S.A. Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HURWITZ H, ET AL.: "BAVACIZUMAB PLUS IRINOTECAN, FLUOROURACIL, AND LEUCOVORIN FOR METASTATIC COLORECTAL CANCER", NEW ENGLAND JOURNAL OF MEDICINE, THE - NEJM, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 350, no. 23, 3 June 2004 (2004-06-03), US, pages 2335 - 2342, XP009038752, ISSN: 1533-4406, DOI: 10.1056/NEJMoa032691 *
SANOFI-REGENERON: "Aflibercept Versus Placebo in Combination With Irinotecan and 5-FU in theTreatment of Patients With Metastatic Colorectal Cancer After Failure of an Oxaliplatin Based Regimen", 17 February 2011 (2011-02-17), pages 1 - 3, XP002677282, Retrieved from the Internet <URL:http://clinicaltrials.gov/archive/NCT00561470/2011_02_17>> [retrieved on 20120605] *

Also Published As

Publication number Publication date
AR086051A1 (es) 2013-11-13
IL228947A0 (en) 2013-12-31
JP2014513089A (ja) 2014-05-29
KR102002653B1 (ko) 2019-07-24
CO6811861A2 (es) 2013-12-16
MA35130B1 (fr) 2014-05-02
SI2701724T1 (sl) 2017-10-30
CL2013003082A1 (es) 2014-05-16
NZ617573A (en) 2015-11-27
TWI599369B (zh) 2017-09-21
US20140051642A1 (en) 2014-02-20
IL228947B (en) 2018-01-31
AU2012247530A1 (en) 2013-05-02
EP2701724B1 (en) 2017-05-24
CR20130547A (es) 2014-02-18
CN103608029A (zh) 2014-02-26
AU2012247530B2 (en) 2017-05-11
SG10201610829UA (en) 2017-02-27
PL2701724T3 (pl) 2017-11-30
KR20140036193A (ko) 2014-03-25
HUE034288T2 (en) 2018-02-28
EP3210617A1 (en) 2017-08-30
US11033606B2 (en) 2021-06-15
GT201300260A (es) 2015-02-09
JP6114257B2 (ja) 2017-04-12
ECSP13013044A (es) 2014-01-31
WO2012146610A1 (en) 2012-11-01
LT2701724T (lt) 2017-09-11
PH12013502195A1 (en) 2022-04-08
EA201391577A1 (ru) 2014-03-31
ZA201308821B (en) 2015-01-28
MX341348B (es) 2016-08-17
JO3283B1 (ar) 2018-09-16
RS56177B1 (sr) 2017-11-30
SG194613A1 (en) 2013-12-30
UY34036A (es) 2012-11-30
PT2701724T (pt) 2017-08-18
KR20190088568A (ko) 2019-07-26
BR112013027356A2 (pt) 2016-11-29
TW201247220A (en) 2012-12-01
MX2013012387A (es) 2014-12-05
NI201300112A (es) 2014-02-28
HRP20171216T1 (hr) 2017-10-20
DOP2013000248A (es) 2014-02-28
IL257179A (en) 2018-03-29
ES2637074T3 (es) 2017-10-10
CY1120382T1 (el) 2019-07-10
CA2833592A1 (en) 2012-11-01
EP2701724A1 (en) 2014-03-05
UA114708C2 (uk) 2017-07-25
PE20171516A1 (es) 2017-10-20
DK2701724T3 (en) 2017-09-11
PE20140616A1 (es) 2014-05-24

Similar Documents

Publication Publication Date Title
EA025182B1 (ru) Композиция, включающая афлиберцепт, фолиновую кислоту, 5-фторурацил (5-fu) и ириноцетан (folfiri), для лечения колоректального рака
JP7482180B2 (ja) 癌のための併用療法
KR20250134209A (ko) 키메라 항원 수용체에 관한 방법 및 조성물
RS57520B1 (sr) Postupci za lečenje atopijskog dermatitisa primenom antagonista il-4r
JP2018525438A (ja) がんの処置における免疫調節剤とpd−1またはpd−l1チェックポイント阻害剤との組合せ
US20140017264A1 (en) Dosage and administration of bispecific scfv conjugates
NL2024544B1 (en) Compositions And Methods For Cancer Therapy
EP3819312A1 (en) Dosing regimen for anti-dll3 agents
JP2019517508A5 (enExample)
EP3976193A1 (en) Dosing of bispecific t cell engager
JP2011506436A (ja) 細胞傷害性tリンパ球抗原4(ctla4)に対する抗体と組み合わせられたアルファチモシンペプチドによる黒色腫の処置の方法
EP4021940A1 (en) Methods and combinations for the treatment of cancer using immune checkpoint inhibitor antibodies
US20210196744A1 (en) Compositions for cancer therapy and methods
WO2018187259A1 (en) Methods and compositions for stimulating the immune system
ES2880950T3 (es) Terapia de anticuerpos contra el VIH como sustituto del tratamiento
WO2017176565A1 (en) Combinations of an anti-b7-h1 antibody and a cxcr4 peptide antagonist for treating a solid tumor
KR102624844B1 (ko) 암의 향상된 치료
US20200093789A1 (en) Cancer Treatment with a CXCL12 Signaling Inhibitor and an Immune Checkpoint Inhibitor
JP7504106B2 (ja) がんの処置のための組合せ物
EP4493185A1 (en) Treatment of breast cancer with amcenestrant
TW202304512A (zh) 雙特異性t細胞銜接體之給藥
Trédaniel et al. Final results of the IFCT-0803 study, a phase II study of cetuximab, pemetrexed, cisplatin, and concurrent radiotherapy in patients with locally advanced, unresectable, stage III, non-squamous, non-small-cell lung cancer
US20250019441A1 (en) Treatment of cancer with anti-ilt2 antibodies
Frasci et al. Gemcitabine/cyclophosphamide/5-fluorouracil/folinic acid triplet combination in anthracycline-and taxane-refractory breast cancer patients: a Southern Italy Cooperative Oncology Group phase I/II study
WO2018060418A1 (en) Substance selected among irinotecan, an irinotecan active metabolite, 5-fluoro-uracile, a pharmaceutical salt thereof and a mixture thereof, for use in the treatment of fibrosis

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ