EA019058B1 - Способ получения кристаллических форм а и в илапразола и способ превращения указанных кристаллических форм - Google Patents

Способ получения кристаллических форм а и в илапразола и способ превращения указанных кристаллических форм Download PDF

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Publication number
EA019058B1
EA019058B1 EA201200716A EA201200716A EA019058B1 EA 019058 B1 EA019058 B1 EA 019058B1 EA 201200716 A EA201200716 A EA 201200716A EA 201200716 A EA201200716 A EA 201200716A EA 019058 B1 EA019058 B1 EA 019058B1
Authority
EA
Eurasian Patent Office
Prior art keywords
ilaprazole
acid
solvent
crystalline form
reaction
Prior art date
Application number
EA201200716A
Other languages
English (en)
Russian (ru)
Other versions
EA201200716A1 (ru
Inventor
Донг Йеон Ким
Джае Соо Шин
Джун Йеоун Лее
Кви Хьюнг Чо
Сунг Тае Парк
Юнг Воо Ким
Санг Дон Нам
Хее Юн Ким
Original Assignee
Ил-Янг Фармасьютикал Компани Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ил-Янг Фармасьютикал Компани Лтд. filed Critical Ил-Янг Фармасьютикал Компани Лтд.
Publication of EA201200716A1 publication Critical patent/EA201200716A1/ru
Publication of EA019058B1 publication Critical patent/EA019058B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
EA201200716A 2009-12-08 2010-12-08 Способ получения кристаллических форм а и в илапразола и способ превращения указанных кристаллических форм EA019058B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090121209A KR101144600B1 (ko) 2009-12-08 2009-12-08 일라프라졸의 결정형 ａ, ｂ의 제조방법 및 이들 결정형의 변환방법
PCT/KR2010/008767 WO2011071314A2 (en) 2009-12-08 2010-12-08 Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms

Publications (2)

Publication Number Publication Date
EA201200716A1 EA201200716A1 (ru) 2012-10-30
EA019058B1 true EA019058B1 (ru) 2013-12-30

Family

ID=44146052

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200716A EA019058B1 (ru) 2009-12-08 2010-12-08 Способ получения кристаллических форм а и в илапразола и способ превращения указанных кристаллических форм

Country Status (7)

Country Link
KR (1) KR101144600B1 (zh)
BR (1) BR112012012212A2 (zh)
CO (1) CO6541539A2 (zh)
EA (1) EA019058B1 (zh)
IN (1) IN2012DN03176A (zh)
UA (1) UA102787C2 (zh)
WO (1) WO2011071314A2 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204843B (zh) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 结晶型艾普拉唑钠乙醇化物及其制备方法
CN103204842B (zh) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 结晶型艾普拉唑钠水合物及其制备方法
WO2013114232A1 (en) 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746277B (zh) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 一种结晶形式的艾普拉唑钠及其制备方法
CN102746276B (zh) * 2012-06-21 2014-07-02 丽珠医药集团股份有限公司 一种艾普拉唑钠晶型及其制备方法
CN102746275B (zh) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 结晶型艾普拉唑钠及其制备方法
CN113045544A (zh) * 2014-09-04 2021-06-29 江苏奥赛康药业有限公司 艾普拉唑钠化合物及其药物组合物
CN107857756B (zh) * 2017-11-06 2022-08-30 丽珠医药集团股份有限公司 一种艾普拉唑镁晶型及其制备方法
KR102027388B1 (ko) * 2017-11-15 2019-10-01 주식회사 다산제약 고순도 일라프라졸 결정형 b의 제조방법
CN111187255B (zh) * 2020-01-13 2021-07-20 丽珠医药集团股份有限公司 右旋艾普拉唑钾盐的制备方法和右旋艾普拉唑的制备方法
KR20220065235A (ko) 2020-11-13 2022-05-20 주식회사 파마코스텍 일라프라졸 혼형 결정의 신규한 제조방법
KR102250509B1 (ko) * 2020-12-09 2021-05-11 유니셀랩 주식회사 새로운 일라프라졸/자일리톨 공결정
KR20210019469A (ko) 2021-02-02 2021-02-22 주식회사 파마코스텍 일라프라졸 나트륨 결정형 및 신규한 제조방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200515A1 (en) * 2006-12-29 2008-08-21 Tap Pharmaceutical Products Inc. Solid state forms of enantiopure ilaprazole
KR20090086121A (ko) * 2006-12-29 2009-08-10 일양약품주식회사 용매화 일라프라졸의 결정형

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200515A1 (en) * 2006-12-29 2008-08-21 Tap Pharmaceutical Products Inc. Solid state forms of enantiopure ilaprazole
KR20090086121A (ko) * 2006-12-29 2009-08-10 일양약품주식회사 용매화 일라프라졸의 결정형
KR20090086615A (ko) * 2006-12-29 2009-08-13 일양약품주식회사 라세믹 일라프라졸의 고체상 형태

Also Published As

Publication number Publication date
UA102787C2 (ru) 2013-08-12
WO2011071314A3 (en) 2011-11-10
IN2012DN03176A (zh) 2015-09-25
WO2011071314A2 (en) 2011-06-16
EA201200716A1 (ru) 2012-10-30
CO6541539A2 (es) 2012-10-16
KR20110064545A (ko) 2011-06-15
KR101144600B1 (ko) 2012-05-16
BR112012012212A2 (pt) 2015-09-08

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU