EA018356B1 - Микросферы эстрадиола и холестерина - Google Patents
Микросферы эстрадиола и холестерина Download PDFInfo
- Publication number
- EA018356B1 EA018356B1 EA200900451A EA200900451A EA018356B1 EA 018356 B1 EA018356 B1 EA 018356B1 EA 200900451 A EA200900451 A EA 200900451A EA 200900451 A EA200900451 A EA 200900451A EA 018356 B1 EA018356 B1 EA 018356B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- estradiol
- microspheres
- cholesterol
- particles
- progesterone
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A61P15/18—Feminine contraceptives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US47793903P | 2003-06-13 | 2003-06-13 |
Publications (2)
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Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
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| EA200900451A EA018356B1 (ru) | 2003-06-13 | 2004-06-10 | Микросферы эстрадиола и холестерина |
| EA201201221A EA026709B1 (ru) | 2003-06-13 | 2004-06-10 | Способ получения композиции эстрадиола с медленным высвобождением (варианты) |
| EA200600029A EA012783B1 (ru) | 2003-06-13 | 2004-06-10 | Фармацевтическая композиция для контрацепции и заместительной гормональной терапии |
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| EA201201221A EA026709B1 (ru) | 2003-06-13 | 2004-06-10 | Способ получения композиции эстрадиола с медленным высвобождением (варианты) |
| EA200600029A EA012783B1 (ru) | 2003-06-13 | 2004-06-10 | Фармацевтическая композиция для контрацепции и заместительной гормональной терапии |
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| EP (3) | EP1663161B1 (enExample) |
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| CN (2) | CN100594907C (enExample) |
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| AU (1) | AU2004246870B2 (enExample) |
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| SI (3) | SI1820494T1 (enExample) |
| TW (1) | TWI336623B (enExample) |
| WO (1) | WO2004110408A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE454885T1 (de) | 2003-06-13 | 2010-01-15 | Skendi Finance Ltd | Mikrosphären von estradiol und cholesterol |
| US20110104289A1 (en) * | 2008-04-14 | 2011-05-05 | Posi Visionary Solutions Llp | Method and pharmaceutical composition for obtaining the plasmatic progesterone levels required for different therapeutic indications |
| UY33103A (es) * | 2009-12-15 | 2011-07-29 | Techsphere S A De C V | Formulacion farmaceutica parenteral en suspension, de liberacion sostenida, en dosis baja y ultra baja, en terapia hormonal en el sindrome climaterico |
| WO2012129305A1 (en) * | 2011-03-23 | 2012-09-27 | Pop Test Cortisol Llc | Combination therapy |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| AU2015296609A1 (en) | 2014-07-29 | 2016-12-22 | Therapeuticsmd, Inc. | Transdermal cream |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| ITUB20153652A1 (it) * | 2015-09-16 | 2017-03-16 | Fatro Spa | Microsfere contenenti lattoni macrociclici antielminitici |
| JP2019514852A (ja) * | 2016-04-01 | 2019-06-06 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | ステロイドホルモン薬学的組成物 |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| PL3272732T3 (pl) | 2016-07-19 | 2020-03-31 | Evonik Degussa Gmbh | Sposób alkoksykarbonylowania etylenowo nienasyconych związków za pomocą ligandów monofosfinowych |
| KR20210114399A (ko) * | 2018-11-29 | 2021-09-23 | 인시그나 인크. | 불임제로서의 에스트라디올 벤조에이트 |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| EP3954364A1 (en) | 2020-08-14 | 2022-02-16 | Chemo Research, S.L. | New modified release oral contraceptive composition |
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| US3800038A (en) * | 1972-04-21 | 1974-03-26 | Biolog Concepts Inc | Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier |
| GB1367608A (en) * | 1973-03-09 | 1974-09-18 | Biolog Concepts Inc | Oral pharmaceutical dosage form |
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| US4218255A (en) * | 1976-08-30 | 1980-08-19 | University Of Dayton | Porous ceramic carriers for controlled release of proteins, polypeptide hormones, and other substances within human and/or other mamillian species and method |
| EP0508969A1 (en) * | 1991-04-11 | 1992-10-14 | Astra Aktiebolag | Process for conditioning of water-soluble substances |
| US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
| US5633014A (en) * | 1990-06-14 | 1997-05-27 | Aplicaciones Farmaceuticas S.A. De C.V. | Injectable pharmaceutical composition |
| US5643604A (en) * | 1990-06-14 | 1997-07-01 | Aplicaciones Farmaceuticas S.A. De C.V. | Parenteral dosage form |
| US6287693B1 (en) * | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
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-
2004
- 2004-06-10 AT AT07008942T patent/ATE454885T1/de active
- 2004-06-10 HU HUE04736545A patent/HUE025147T2/hu unknown
- 2004-06-10 OA OA1200500357A patent/OA13307A/en unknown
- 2004-06-10 DK DK07008942T patent/DK1820494T3/da active
- 2004-06-10 EP EP20040736545 patent/EP1663161B1/en not_active Expired - Lifetime
- 2004-06-10 SI SI200431384T patent/SI1820494T1/sl unknown
- 2004-06-10 PL PL07008942T patent/PL1820494T3/pl unknown
- 2004-06-10 PT PT07008942T patent/PT1820494E/pt unknown
- 2004-06-10 CN CN200480023175A patent/CN100594907C/zh not_active Expired - Fee Related
- 2004-06-10 JP JP2006516535A patent/JP4956185B2/ja not_active Expired - Fee Related
- 2004-06-10 ES ES07008938.8T patent/ES2537563T3/es not_active Expired - Lifetime
- 2004-06-10 EA EA200900451A patent/EA018356B1/ru not_active IP Right Cessation
- 2004-06-10 WO PCT/IB2004/001930 patent/WO2004110408A2/en not_active Ceased
- 2004-06-10 SI SI200432238T patent/SI1844765T1/sl unknown
- 2004-06-10 US US10/864,470 patent/US7589082B2/en not_active Expired - Fee Related
- 2004-06-10 EP EP20070008942 patent/EP1820494B1/en not_active Expired - Lifetime
- 2004-06-10 DK DK04736545.7T patent/DK1663161T3/en active
- 2004-06-10 PT PT70089388T patent/PT1844765E/pt unknown
- 2004-06-10 MX MX2008014654A patent/MX2008014654A/es active IP Right Grant
- 2004-06-10 ES ES07008942T patent/ES2340422T3/es not_active Expired - Lifetime
- 2004-06-10 CA CA2528545A patent/CA2528545C/en not_active Expired - Fee Related
- 2004-06-10 SI SI200432235T patent/SI1663161T1/sl unknown
- 2004-06-10 CA CA2849228A patent/CA2849228C/en not_active Expired - Fee Related
- 2004-06-10 BR BRPI0411335 patent/BRPI0411335A/pt not_active Application Discontinuation
- 2004-06-10 PL PL04736545T patent/PL1663161T3/pl unknown
- 2004-06-10 PL PL07008938T patent/PL1844765T3/pl unknown
- 2004-06-10 AU AU2004246870A patent/AU2004246870B2/en not_active Ceased
- 2004-06-10 CN CN200910258692.9A patent/CN101816662B/zh not_active Expired - Fee Related
- 2004-06-10 EA EA201201221A patent/EA026709B1/ru not_active IP Right Cessation
- 2004-06-10 PT PT47365457T patent/PT1663161E/pt unknown
- 2004-06-10 ES ES04736545.7T patent/ES2537551T3/es not_active Expired - Lifetime
- 2004-06-10 DK DK07008938.8T patent/DK1844765T3/en active
- 2004-06-10 EP EP20070008938 patent/EP1844765B1/en not_active Expired - Lifetime
- 2004-06-10 EA EA200600029A patent/EA012783B1/ru not_active IP Right Cessation
- 2004-06-10 DE DE200460025156 patent/DE602004025156D1/de not_active Expired - Lifetime
- 2004-06-14 TW TW93117058A patent/TWI336623B/zh not_active IP Right Cessation
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2005
- 2005-12-08 IL IL172466A patent/IL172466A/en active IP Right Grant
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2006
- 2006-01-13 NO NO20060200A patent/NO341540B1/no not_active IP Right Cessation
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2008
- 2008-12-02 US US12/326,316 patent/US8163722B2/en not_active Expired - Fee Related
-
2010
- 2010-04-12 CY CY101100328T patent/CY1109967T1/el unknown
-
2011
- 2011-01-25 IL IL210851A patent/IL210851A/en active IP Right Grant
- 2011-04-06 JP JP2011084716A patent/JP2011157386A/ja active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3800038A (en) * | 1972-04-21 | 1974-03-26 | Biolog Concepts Inc | Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier |
| GB1367608A (en) * | 1973-03-09 | 1974-09-18 | Biolog Concepts Inc | Oral pharmaceutical dosage form |
| US4218255A (en) * | 1976-08-30 | 1980-08-19 | University Of Dayton | Porous ceramic carriers for controlled release of proteins, polypeptide hormones, and other substances within human and/or other mamillian species and method |
| US4180560A (en) * | 1976-10-26 | 1979-12-25 | Syntex Corporation | Inert core implant pellet |
| US5633014A (en) * | 1990-06-14 | 1997-05-27 | Aplicaciones Farmaceuticas S.A. De C.V. | Injectable pharmaceutical composition |
| US5643604A (en) * | 1990-06-14 | 1997-07-01 | Aplicaciones Farmaceuticas S.A. De C.V. | Parenteral dosage form |
| EP0508969A1 (en) * | 1991-04-11 | 1992-10-14 | Astra Aktiebolag | Process for conditioning of water-soluble substances |
| US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
| US6287693B1 (en) * | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
| US20020168395A1 (en) * | 1998-02-25 | 2002-11-14 | John-Claude Savoir | Stable shaped particles of crystalline organic compounds |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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