EA016495B1 - Гетероциклические соединения, содержащие их композиции и способы их применения - Google Patents
Гетероциклические соединения, содержащие их композиции и способы их применения Download PDFInfo
- Publication number
- EA016495B1 EA016495B1 EA200970818A EA200970818A EA016495B1 EA 016495 B1 EA016495 B1 EA 016495B1 EA 200970818 A EA200970818 A EA 200970818A EA 200970818 A EA200970818 A EA 200970818A EA 016495 B1 EA016495 B1 EA 016495B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- hydrogen
- compound
- compounds
- compound according
- Prior art date
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- 238000000034 method Methods 0.000 title abstract description 26
- 239000000203 mixture Substances 0.000 title abstract description 26
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 39
- 208000035475 disorder Diseases 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims description 153
- 239000001257 hydrogen Substances 0.000 claims description 62
- 229910052739 hydrogen Inorganic materials 0.000 claims description 62
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 41
- 125000000623 heterocyclic group Chemical group 0.000 claims description 34
- 125000000217 alkyl group Chemical group 0.000 claims description 30
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- 201000010099 disease Diseases 0.000 claims description 24
- 150000002431 hydrogen Chemical class 0.000 claims description 19
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 4
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- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 3
- CIISBYKBBMFLEZ-UHFFFAOYSA-N 1,2-oxazolidine Chemical compound C1CNOC1 CIISBYKBBMFLEZ-UHFFFAOYSA-N 0.000 claims description 2
- FJRPOHLDJUJARI-UHFFFAOYSA-N 2,3-dihydro-1,2-oxazole Chemical group C1NOC=C1 FJRPOHLDJUJARI-UHFFFAOYSA-N 0.000 claims description 2
- OYJGEOAXBALSMM-UHFFFAOYSA-N 2,3-dihydro-1,3-thiazole Chemical compound C1NC=CS1 OYJGEOAXBALSMM-UHFFFAOYSA-N 0.000 claims description 2
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- 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 2
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- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
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- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims description 2
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- 125000005037 alkyl phenyl group Chemical group 0.000 claims 3
- UUSUFQUCLACDTA-UHFFFAOYSA-N 1,2-dihydropyrene Chemical group C1=CC=C2C=CC3=CCCC4=CC=C1C2=C43 UUSUFQUCLACDTA-UHFFFAOYSA-N 0.000 claims 1
- 239000013256 coordination polymer Substances 0.000 claims 1
- 125000005047 dihydroimidazolyl group Chemical group N1(CNC=C1)* 0.000 claims 1
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- 238000011282 treatment Methods 0.000 abstract description 10
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- -1 hydrates) Chemical class 0.000 description 53
- 125000003118 aryl group Chemical group 0.000 description 41
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- 238000007429 general method Methods 0.000 description 7
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
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- ALWBGUNCNDFMFE-QKULBLGOSA-N [(3as,4r,6ar)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] n-[(2s,3r)-3-hydroxy-4-[[4-(hydroxymethyl)phenyl]sulfonyl-[(2s)-2-methylbutyl]amino]-1-phenylbutan-2-yl]carbamate Chemical compound C([C@@H]([C@H](O)CN(C[C@@H](C)CC)S(=O)(=O)C=1C=CC(CO)=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)C1=CC=CC=C1 ALWBGUNCNDFMFE-QKULBLGOSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
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- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 4
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
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Classifications
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90435707P | 2007-03-01 | 2007-03-01 | |
| PCT/US2008/055210 WO2008109314A1 (en) | 2007-03-01 | 2008-02-28 | Heterocyclic compounds, compositions comprising them and methods of their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200970818A1 EA200970818A1 (ru) | 2010-02-26 |
| EA016495B1 true EA016495B1 (ru) | 2012-05-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200970818A EA016495B1 (ru) | 2007-03-01 | 2008-02-28 | Гетероциклические соединения, содержащие их композиции и способы их применения |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US7598280B2 (enExample) |
| EP (1) | EP2125788B9 (enExample) |
| JP (1) | JP5610772B2 (enExample) |
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| AT (1) | ATE504585T1 (enExample) |
| AU (1) | AU2008223210B2 (enExample) |
| BR (1) | BRPI0808172A2 (enExample) |
| CA (1) | CA2679101C (enExample) |
| CO (1) | CO6220950A2 (enExample) |
| DE (1) | DE602008006045D1 (enExample) |
| DK (1) | DK2125788T3 (enExample) |
| EA (1) | EA016495B1 (enExample) |
| EC (1) | ECSP099675A (enExample) |
| ES (1) | ES2364116T3 (enExample) |
| IL (1) | IL200387A (enExample) |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3322772B2 (ja) | 1995-05-22 | 2002-09-09 | 日本エム・ケー・エス株式会社 | 制御弁 |
| US7649098B2 (en) * | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
| TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
| TW201002698A (en) * | 2008-06-18 | 2010-01-16 | Lexicon Pharmaceuticals Inc | Methods of preparing imidazole-based bicyclic compounds |
| UY31900A (es) * | 2008-06-18 | 2010-01-29 | Lexicon Pharmaceuticals Inc | Formas solidas de ( 1r, 2s, 3r)-1-(2-(usoxazol-3-il)-1h-imidazol-4-il)butano-1, 2, 3, 4-tetraol y metodos de uso. |
| AU2009282907A1 (en) * | 2008-08-22 | 2010-02-25 | Lexicon Pharmaceuticals, Inc. | Combinations comprising bicyclic S1P lyase inhibitors |
| AR074061A1 (es) * | 2008-10-31 | 2010-12-22 | Lexicon Pharmaceuticals Inc | Inhibidores de s1p liasa para el tratamiento de la malaria cerebral y formulacion farmaceutica |
| JP5645318B2 (ja) | 2010-02-18 | 2014-12-24 | 第一三共株式会社 | イミダゾール誘導体 |
| JP5757635B2 (ja) | 2010-06-28 | 2015-07-29 | 第一三共株式会社 | 培養細胞を用いたｓ１ｐリアーゼ阻害剤のスクリーニング方法 |
| WO2012097330A2 (en) * | 2011-01-14 | 2012-07-19 | University Of Washington | Compositions and methods for treating degenerative muscle conditions |
| EP2727926A4 (en) | 2011-06-28 | 2015-03-04 | Daiichi Sankyo Co Ltd | PHOSPHORIC ESTER DERIVATIVE |
| WO2013049272A2 (en) | 2011-09-29 | 2013-04-04 | Theraceutix, Llc | Composition and method for treatment of symptoms associated with various skin conditions |
| US20230121797A1 (en) * | 2020-03-27 | 2023-04-20 | Ac Bioscience Sa | A combination of flavonoids and sphingosine 1 phosphate lyase inhibitors for the treatment of lung inflammation |
Citations (2)
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| WO1997046543A1 (en) * | 1996-05-31 | 1997-12-11 | The University Of Wollongong | Acetyl derivatives of thiazoles and analogues |
| WO2007002458A2 (en) * | 2005-06-28 | 2007-01-04 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
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|---|---|---|---|---|
| US4567194A (en) * | 1983-03-10 | 1986-01-28 | The Coca-Cola Company | 2-Acylimidazole compounds, their synthesis and use as medicinal agents |
| US6423527B1 (en) | 1997-09-29 | 2002-07-23 | Children's Hospital Medical Center Of Northern California | Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor |
| CN1834095B (zh) * | 2005-03-18 | 2011-04-20 | 中国科学院上海药物研究所 | 一类非核苷类抗病毒抑制剂及其制备方法和用途 |
| US7649098B2 (en) | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
| TWI412362B (zh) | 2007-04-12 | 2013-10-21 | Lexicon Pharmaceuticals Inc | （ｅ）-１-（４-（（１ｒ，２ｓ，３ｒ）-１，２，３，４-四羥丁基）-１ｈ-咪唑-２-基）乙酮肟的固體形式 |
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- 2008-02-28 MX MX2009009190A patent/MX2009009190A/es active IP Right Grant
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- 2008-02-28 WO PCT/US2008/055210 patent/WO2008109314A1/en not_active Ceased
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- 2008-02-28 PL PL08730902T patent/PL2125788T3/pl unknown
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- 2008-02-28 US US12/038,872 patent/US7598280B2/en active Active
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997046543A1 (en) * | 1996-05-31 | 1997-12-11 | The University Of Wollongong | Acetyl derivatives of thiazoles and analogues |
| WO2007002458A2 (en) * | 2005-06-28 | 2007-01-04 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
Non-Patent Citations (1)
| Title |
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| SWEENY J. G. ET AL.: "Synthesis, of 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imid azole" JOURNAL OF ORGANIC CHEMISTRY, vol. 50, no. 7, 1985, pages 1133-1134, XP002487552 scheme 2, compound 6 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE602008006045D1 (de) | 2011-05-19 |
| ECSP099675A (es) | 2009-11-30 |
| TW200848029A (en) | 2008-12-16 |
| KR20090117763A (ko) | 2009-11-12 |
| BRPI0808172A2 (pt) | 2014-11-04 |
| AU2008223210B2 (en) | 2013-08-22 |
| US7825142B2 (en) | 2010-11-02 |
| US20110082178A1 (en) | 2011-04-07 |
| ATE504585T1 (de) | 2011-04-15 |
| IL200387A (en) | 2013-10-31 |
| ZA200905671B (en) | 2010-10-27 |
| WO2008109314A1 (en) | 2008-09-12 |
| ES2364116T3 (es) | 2011-08-25 |
| EP2125788A1 (en) | 2009-12-02 |
| JP2010520214A (ja) | 2010-06-10 |
| CO6220950A2 (es) | 2010-11-19 |
| US20090312375A1 (en) | 2009-12-17 |
| US7598280B2 (en) | 2009-10-06 |
| PL2125788T3 (pl) | 2011-09-30 |
| AR065509A1 (es) | 2009-06-10 |
| DK2125788T3 (da) | 2011-07-11 |
| AU2008223210A1 (en) | 2008-09-12 |
| EA200970818A1 (ru) | 2010-02-26 |
| IL200387A0 (en) | 2010-04-29 |
| CA2679101A1 (en) | 2008-09-12 |
| US20090030050A1 (en) | 2009-01-29 |
| MX2009009190A (es) | 2009-09-04 |
| EP2125788B1 (en) | 2011-04-06 |
| JP5610772B2 (ja) | 2014-10-22 |
| CA2679101C (en) | 2015-11-24 |
| EP2125788B9 (en) | 2011-07-20 |
| NZ578974A (en) | 2011-11-25 |
| PT2125788E (pt) | 2011-07-05 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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