KR20090117763A - 헤테로시클릭 화합물, 그를 포함하는 조성물 및 그의 사용 방법 - Google Patents
헤테로시클릭 화합물, 그를 포함하는 조성물 및 그의 사용 방법 Download PDFInfo
- Publication number
- KR20090117763A KR20090117763A KR1020097018102A KR20097018102A KR20090117763A KR 20090117763 A KR20090117763 A KR 20090117763A KR 1020097018102 A KR1020097018102 A KR 1020097018102A KR 20097018102 A KR20097018102 A KR 20097018102A KR 20090117763 A KR20090117763 A KR 20090117763A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- hydrogen
- optionally substituted
- halogen
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 77
- 125000003118 aryl group Chemical group 0.000 claims description 72
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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Landscapes
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| TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
| TW201002698A (en) * | 2008-06-18 | 2010-01-16 | Lexicon Pharmaceuticals Inc | Methods of preparing imidazole-based bicyclic compounds |
| UY31900A (es) * | 2008-06-18 | 2010-01-29 | Lexicon Pharmaceuticals Inc | Formas solidas de ( 1r, 2s, 3r)-1-(2-(usoxazol-3-il)-1h-imidazol-4-il)butano-1, 2, 3, 4-tetraol y metodos de uso. |
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| AR074061A1 (es) * | 2008-10-31 | 2010-12-22 | Lexicon Pharmaceuticals Inc | Inhibidores de s1p liasa para el tratamiento de la malaria cerebral y formulacion farmaceutica |
| JP5645318B2 (ja) | 2010-02-18 | 2014-12-24 | 第一三共株式会社 | イミダゾール誘導体 |
| JP5757635B2 (ja) | 2010-06-28 | 2015-07-29 | 第一三共株式会社 | 培養細胞を用いたｓ１ｐリアーゼ阻害剤のスクリーニング方法 |
| WO2012097330A2 (en) * | 2011-01-14 | 2012-07-19 | University Of Washington | Compositions and methods for treating degenerative muscle conditions |
| EP2727926A4 (en) | 2011-06-28 | 2015-03-04 | Daiichi Sankyo Co Ltd | PHOSPHORIC ESTER DERIVATIVE |
| WO2013049272A2 (en) | 2011-09-29 | 2013-04-04 | Theraceutix, Llc | Composition and method for treatment of symptoms associated with various skin conditions |
| US20230121797A1 (en) * | 2020-03-27 | 2023-04-20 | Ac Bioscience Sa | A combination of flavonoids and sphingosine 1 phosphate lyase inhibitors for the treatment of lung inflammation |
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| US4567194A (en) * | 1983-03-10 | 1986-01-28 | The Coca-Cola Company | 2-Acylimidazole compounds, their synthesis and use as medicinal agents |
| AU2881797A (en) * | 1996-05-31 | 1998-01-05 | University Of Wollongong, The | Acetyl derivatives of thiazoles and analogues |
| US6423527B1 (en) | 1997-09-29 | 2002-07-23 | Children's Hospital Medical Center Of Northern California | Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor |
| CN1834095B (zh) * | 2005-03-18 | 2011-04-20 | 中国科学院上海药物研究所 | 一类非核苷类抗病毒抑制剂及其制备方法和用途 |
| EP1898928A2 (en) * | 2005-06-28 | 2008-03-19 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| US7649098B2 (en) | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
| TWI412362B (zh) | 2007-04-12 | 2013-10-21 | Lexicon Pharmaceuticals Inc | （ｅ）-１-（４-（（１ｒ，２ｓ，３ｒ）-１，２，３，４-四羥丁基）-１ｈ-咪唑-２-基）乙酮肟的固體形式 |
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| TW200848029A (en) | 2008-12-16 |
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| WO2008109314A1 (en) | 2008-09-12 |
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| JP2010520214A (ja) | 2010-06-10 |
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| US7598280B2 (en) | 2009-10-06 |
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| EP2125788B9 (en) | 2011-07-20 |
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