EA008389B1 - Способ получения производных 5-(1,3-оксазол-2-ил)бензойной кислоты - Google Patents

Способ получения производных 5-(1,3-оксазол-2-ил)бензойной кислоты Download PDF

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Publication number
EA008389B1
EA008389B1 EA200401510A EA200401510A EA008389B1 EA 008389 B1 EA008389 B1 EA 008389B1 EA 200401510 A EA200401510 A EA 200401510A EA 200401510 A EA200401510 A EA 200401510A EA 008389 B1 EA008389 B1 EA 008389B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
formula
alkyl
compounds
reaction mixture
Prior art date
Application number
EA200401510A
Other languages
English (en)
Russian (ru)
Other versions
EA200401510A1 (ru
Inventor
Майкл Р. Ридер
Рик Дж. Имбордино
Original Assignee
Фармация Энд Апджон Компани Ллс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани Ллс filed Critical Фармация Энд Апджон Компани Ллс
Publication of EA200401510A1 publication Critical patent/EA200401510A1/ru
Publication of EA008389B1 publication Critical patent/EA008389B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
EA200401510A 2002-06-20 2003-06-20 Способ получения производных 5-(1,3-оксазол-2-ил)бензойной кислоты EA008389B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39028502P 2002-06-20 2002-06-20
US45047803P 2003-02-27 2003-02-27
PCT/US2003/019585 WO2004000821A1 (en) 2002-06-20 2003-06-20 Process for preparing 5-(1, 3-oxazol-2-yl) benzoic acid derivatives

Publications (2)

Publication Number Publication Date
EA200401510A1 EA200401510A1 (ru) 2005-06-30
EA008389B1 true EA008389B1 (ru) 2007-04-27

Family

ID=30003150

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401510A EA008389B1 (ru) 2002-06-20 2003-06-20 Способ получения производных 5-(1,3-оксазол-2-ил)бензойной кислоты

Country Status (17)

Country Link
US (2) US7115747B2 (enExample)
EP (1) EP1532123B1 (enExample)
JP (1) JP2005533811A (enExample)
CN (1) CN1324017C (enExample)
AT (1) ATE370131T1 (enExample)
AU (1) AU2003249344A1 (enExample)
BR (1) BR0312439A (enExample)
CA (1) CA2489988A1 (enExample)
CO (1) CO5670350A2 (enExample)
DE (1) DE60315664D1 (enExample)
EA (1) EA008389B1 (enExample)
IL (1) IL165763A0 (enExample)
MX (1) MXPA04012630A (enExample)
NO (1) NO20045497L (enExample)
NZ (1) NZ537390A (enExample)
PL (1) PL374999A1 (enExample)
WO (1) WO2004000821A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0316629A (pt) * 2002-11-27 2005-10-11 Elan Pharm Inc Uréias e carbamatos substituìdos
TW200738701A (en) * 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
AU2006316620B2 (en) 2005-11-21 2011-03-03 Amgen Inc. Beta-secretase modulators and methods of use
US7838676B2 (en) 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
US7872009B2 (en) 2005-11-21 2011-01-18 Amgen Inc. Beta-Secretase modulators and methods of use
US7745484B2 (en) * 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
WO2008137954A2 (en) * 2007-05-07 2008-11-13 Environmental Packaging Technologies Limited Universal shipping container
WO2008147544A1 (en) 2007-05-25 2008-12-04 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
CL2008001500A1 (es) 2007-05-25 2008-12-26 Amgen Inc Compuestos derivados de hidroxietil amina sustituidas, moduladores de betasecretasa; proceso de preparacion de dichos c ompuestos; composicion farmaceutica que los comprende; y su uso para tratar un trastorno neurologico, tal como alzheimer, sindrome de down, demencia degenerativa, entre otros.
US7803809B2 (en) 2008-11-12 2010-09-28 Amgen Inc. Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
WO2010030954A1 (en) 2008-09-11 2010-03-18 Amgen Inc. Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use
US9296698B2 (en) 2009-11-23 2016-03-29 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
US8822485B2 (en) 2009-11-23 2014-09-02 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
US8735384B2 (en) 2010-01-19 2014-05-27 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
ES2450568T3 (es) 2010-03-15 2014-03-25 Amgen Inc. Compuestos espiero de amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso médico
CA2791281A1 (en) 2010-03-15 2011-09-22 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators
US9346827B2 (en) 2011-02-07 2016-05-24 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
WO2013044092A1 (en) 2011-09-21 2013-03-28 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US9725469B2 (en) 2012-11-15 2017-08-08 Amgen, Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US11272751B2 (en) 2016-03-01 2022-03-15 Nicholas Popejoy Protective headgear, impact diffusing systems and methods
US9462841B1 (en) 2016-03-01 2016-10-11 William Popejoy Protective headgear and shoulder pad apparatus and methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002512A2 (en) * 2000-06-30 2002-01-10 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
WO2003029169A2 (en) * 2001-10-04 2003-04-10 Elan Pharmaceuticals, Inc. Hydroxypropylamines
WO2003040096A2 (en) * 2001-11-08 2003-05-15 Elan Pharmaceuticals, Inc. N, n'-substituted-1,3-diamino-2-hydroxypropane derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0325830D0 (en) * 2003-11-05 2003-12-10 Novartis Ag Organic compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002512A2 (en) * 2000-06-30 2002-01-10 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
WO2003029169A2 (en) * 2001-10-04 2003-04-10 Elan Pharmaceuticals, Inc. Hydroxypropylamines
WO2003040096A2 (en) * 2001-11-08 2003-05-15 Elan Pharmaceuticals, Inc. N, n'-substituted-1,3-diamino-2-hydroxypropane derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
B.J. ANDERSON, N.K. HARN: SYNTHESIS, 1996, pages 583-585, XP001154931, cited in the application, the whole document *

Also Published As

Publication number Publication date
CN1662510A (zh) 2005-08-31
BR0312439A (pt) 2005-05-10
IL165763A0 (en) 2006-01-15
CA2489988A1 (en) 2003-12-31
EP1532123A1 (en) 2005-05-25
MXPA04012630A (es) 2005-09-30
AU2003249344A1 (en) 2004-01-06
US20040063965A1 (en) 2004-04-01
DE60315664D1 (de) 2007-09-27
CN1324017C (zh) 2007-07-04
NO20045497L (no) 2005-03-07
CO5670350A2 (es) 2006-08-31
US20070105921A1 (en) 2007-05-10
NZ537390A (en) 2006-07-28
ATE370131T1 (de) 2007-09-15
NO20045497D0 (no) 2004-12-16
EP1532123B1 (en) 2007-08-15
WO2004000821A1 (en) 2003-12-31
JP2005533811A (ja) 2005-11-10
EA200401510A1 (ru) 2005-06-30
HK1081543A1 (zh) 2006-05-19
US7115747B2 (en) 2006-10-03
PL374999A1 (en) 2005-11-14

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